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Yb^(3+)-Doped Double-Clad Fibre Laser Pumped by Rectangular Inner Cladding

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Chinese Physics Letters 2001年第12期18卷 1592-1594页

作者： NING Ding LI yi-Gang HUANG Bang-Cai SUN Jian-Jun LU Ke-Cheng YUAN Shu-Zhong dong xiao-yi Institute of Modern Optics Nankai UniversityTianjin 300071 Electronic 46th Institute Ministry of Information IndustryTianjin 300220 College of Physics Science Nankai UniversityTianjin 300071

A novel Yb3+-doped double-clad silica fibre with rectangular inner cladding was designed and developed by using the modified chemical vapour deposition process, solution-doping and optical machining all together. The dimensions of the inner cladding are 100 × 70 μm, and Yb^(3+)-doped concentration in the core is about 0.24 wt. %. The operation of the fibre laser pumped by inner cladding is reported. The threshold of the laser is *** the pump power launched is 141mW, the laser output is 84mW at the wavelength 1075.6nm, and the slope efficiency is 77%.

关键词： pumped pump cladding

A Four-Wavelength All-Fiber Laser for Wavelength Division Multiplexing System

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Chinese Physics Letters 2001年第3期18卷 376-378页

作者： DING Lei KAI Gui-Yun XU Yan-Jun GUAN Bai-Ou YUAN Shu-Zhong dong xiao-yi GE Chun-Feng Institute of Modern Optics Nankai UniversityTianjin 300071 College of Precision Instrument&Optoelectronics Tianjin UniversityTianjin 300072

A novel four-wavelength all-fiber laser based on fiber Bragg gratings is *** four wavelengths are 1555.8,1556.6,1557.4 and 1558.2 nm,*** output laser is1 mW in *** suppression ratio between adjacent wavelengths is>30 *** laser was applied in a wavelength division multiplexing(WDM)system and the 100 km transmission of 1.2 Gb/s nonreturn-to-zero code,1.2 Gb/s return-to-zero code,2.5 GHz analogue signal and 5 GHz analogue signal was realized with it.

关键词： Gb/s fiber laser

Near-Infrared emission from PbS Quantum Dots in polymer matrix

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Optoelectronics Letters 2007年第5期3卷 337-338页

作者： ZHANG xiao-song dong xiao-yi LIU Yan-ge KAI Gui-yun WANG Zhi LI Lan HAN Xu LI Yan Insititute of Modern Optics Nankai University Tianjin 300071China Institute of Material Physics lianjin University of Technology Tianjin 300191 China

PbS quantum dots were prepared in the aqueous medium from readily available precursors. The shape of the particles isapproximately spherical, and the average particle size observed from HRTEM image was 7-8 nm. We applied PbS quantumdots and PMMA polymer to fabricate PbS quantum dots-PMMA composites, and investigate the photoluminescence PbSquantum dots in PMMA matrix with different mass ratio. PbS quantum dots in PMMA matrix have broad emission be-tween 900 nm and 1 500 nm and photoluminescence peak at 1 179 nm. Additionally, the photoluminescence intensityincreases with increasing the dopant concentration. PbS quantum dots-PMMA polymer composites can be potentially usedfor polymer optical fiber and electroluminescence (EL) in optical communication.

关键词：近红外线发射量子点聚合体矩阵光学器件

Multi-wavelength fiber laser based on broadband fiber grating and HiBi fiber loop mirror

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Optoelectronics Letters 2007年第1期3卷 30-33页

作者： JIN Yan-li LIU Yan-ge LIU Jian-guo LI Yan YUAN Shu-zhong dong xiao-yi Institute of Modern Optics Nankai University Tianjin 300071 China

A fiber laser based on broadband C-band fiber grating (CFG) and high birefringence (HiBi) fiber loop mirror (FLM) is demonstrated, which uses the comb-like reflection performance of the HiBi FLM. Under different polarization states, different output lasers are gained by choosing the polarization states of the light in the cavity using the polarization controller. By this method, a single wavelength or dual wavelength laser beam can be output, and multi-wavelength oscillates can be achieved.

关键词：多波长光纤激光器宽带光纤光栅 HiBi光纤环镜极化控制器

800nm FBG sensing interrogation system based on tilted FBG

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Optoelectronics Letters 2007年第1期3卷 62-64页

作者： LIU Bo SUO Rui ZHOU Kai-ming JIN Long ZHANG Jian LIU Yan-ge KAI Gui-yun dong xiao-yi Institute of Modern Optics Nankai Univ. Tianjin 300071 P.R.China Photonics Research Group Aston University Birmingham UK B4 7ET

An 800 nm band fiber Bragg grating sensing interrogation system using tilted FBG as the core wavelength division compo- nent is presented. A charge coupled device (CCD) linear array is put on the focal plane of the lens to detect the light. TFBG is used to tap light out of the fiber core to fiber cladding. The sensing wavelength is 795 to 830 nm, with accuracy of 20 pm and scan speed 100Hz. Using FBG sensor, we achieve the temperature sensitivity of 1.8 ℃ and strain sensitivity of 18 με.

关键词：倾斜FBG 光纤布拉格光栅传感解调系统波长温度敏感性

Switchable dual-wavelength erbium-doped fiber laser with a tilted fiber grating

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Optoelectronics Letters 2007年第1期3卷 27-29页

作者： JIN Long KAI Gui-yun XU Ling-ling LIU Bo ZHANG Jian LIU Yan-ge YUAN Shu-zhong dong xiao-yi Institute of Modern Optics Nankai University Tianjin 300071 China

A dual-wavelength erbium doped fiber laser with a tilted fiber Bragg grating and photonic crystal fiber is proposed and demonstrated. In the laser, a 2W EDFA provides gain for all the laser lines; the highly nonlinear photonic crystal fiber introduces dynamic energy transfer between the two wavelengths caused by four wave mixing effect, so that a stable dual- wavelength oscillation at room temperature is implemented. Different switching modes can be achieved by adjusting the lateral offset between the fiber grating and the guiding single mode fiber or by varying the state of polarization in the laser cavity. The maximum of output power of the laser has reached 314mW.

关键词：开关双波长铒掺杂光纤激光器倾斜光纤光栅光子晶体光纤

CKLF1 aggravates focal cerebral ischemia injury at early stage partly by modulating microglia/macrophage toward M1 polarization

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中国药理学与毒理学杂志 2018年第9期32卷 673-674页

作者： CHEN Chen CHU Shi-feng AI Qi-di ZHANG Zhao GUAN Fei-fei WANG Sha-sha dong yi-xiao ZHU Jie JIAN Wen-xuan CHEN Nai-hong State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica & Neuroscience Center Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China Hunan University of Tradi

OBJECTIVE To investigate the CKLF1 mediated expression of microglia/macrophage phenotypes in vitro and in vivo,discussing the involved *** In vitro,primary microglia isolated from mice cortex were used to study the effects of CKLF1 by qPCR analysis and immunofluorescence *** vivo,WT C57 and CKLF1 deficient mice were used to explore the effects of *** staining,MRI and Nissl staining were applied to examine the infarction or neuron *** longa test was used to evaluate the neurological deficit of *** blotting was used to investigate the changes of specific protein and discuss the involved *** also used qPCR analysis and immunofluorescence staining for polarization markers to determine the effects of *** CKLF1 could drive primary microglia to M1 phenotype for 24 h stimulation in primary *** mice transient ischemic stroke model,CKLF1 attenuated ischemic injury,and accompanied by promoting microglia/macrophage toward M1 *** expression of pro-inflammatory cytokines and decreased expression of neurotropic factors and anti-inflammatory cytokines were observed in mice subjected to cerebral ischemia with ***,NF-κB activation enhancement was detected in C27 modulated M1 polarization *** CKLF1 is an important mediator of driving M1 phenotype of microglia/macrophage at early stage of cerebral ischemic injury,contributing to aggravation of cerebral ischemia injury,which closely related to microglia/macrophage M1 polarization guided inflammatory *** CKLF1 has the potential to treat ischemic stroke.

关键词： chemokine cerebral ischemia ischemic stroke

Novel intra-cavity self-organization coherent erbium-doped fiber laser

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Optoelectronics Letters 2007年第2期3卷 106-108页

作者： JIA Xiu-jie LIU Feng-nian FU Sheng-gui ZHANG Jian LIU Yan-ge GUO Zhan-cheng YUAN Shu- zhong KAI Gui-yun dong xiao-yi Institute of Modern Optics Nankai University Tianjin 300071 China

A novel all-fiber self-organization coherent Erbium-doped fiber laser is proposed and demonstrated. The laser system is composed of two independent lasers. When each of the two branch lasers operates independently, the output power is 10. 41mW and 8.69 mW respectively. By adjusting a polarization controller (PC), the two lasers achieve coherent coupling, and the output power is 24.4 mW, which is more than two times that the single laser yields. Furthermore, we bring forward and discuss the factor estimating the effect of coherent combination—coherent coupling factor. The value of growth factor to evaluate the effect of coherent combining is 1.27. The coherent fiber laser has the advantages of simple structure, high efficiency and single frequency, which conduce to coherent coupling easily.

关键词：腔内自组织相干耦合铒掺杂光纤激光器极化控制器

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-xiao yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches