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The putative NAD(P)H Nitroreductase,Rv3131,is the Probable Activating Enzyme for Metronidazole in Mycobacterium Tuberculosis

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Biomedical and Environmental Sciences 2022年第7期35卷 652-656页

作者： dong wen zhu SHI Jin CHU Ping LIU Rong Mei wen Shu An ZHANG Ting Ting PANG Yu LU Jie Department of Infectious Diseases The First People's Hospital of ZiyangZiyang 641300SichuanChina Department of Bacteriology and Immunology Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor InstituteBeijing 101149China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing 101149China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryMOE Key Laboratory of Major Diseases in ChildrenBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 101149China

Tuberculosis(TB),which is caused by the intracellular pathogen,Mycobacterium tuberculosis(Mtb),remains one of the deadliest infectious diseases worldwide,accounting for 1.45 million deaths in 2018[1].Thus,there is an increasing need to develop new antibiotics or to repurpose old drugs that have the potential to shorten the current duration of ***(MTZ)is a 5-nitroimidazole antibiotic that is mainly used in the treatment of anaerobic and protozoal infections[2].The action of mechanism for metronidazole has not been fully *** a prodrug,MTZ is inactive until taken up and reduced by anaerobic bacteria and *** is possible that the reduction of Mtz leads to the production of toxic metabolites,which bind to deoxyribonucleic acid and electron-transport proteins of microbial pathogens,thus blocking nucleic acid synthesis[3].The impressive potency of MTZ against anaerobic bacteria indicates the potential for killing Mtb under anaerobic conditions.A previous in vitro study demonstrated that MTZ has potent activity against tubercle bacilli under anaerobic conditions[4].In a non-human primate model,MTZ has been shown to prevent reactivation of latent Mtb infection,indicating the in vivo role in targeting Mtb within an anaerobic environment[5].Although there is strong evidence for the role of MTZ in affecting anaerobic bacilli,the mechanism of action has not been elucidated in Mtb considering that MTZ must be catalyzed to a nitro-free radical form with endogenous *** provide insight=into how MTZ is activated in anaerobic Mtb bacilli,we first characterized the nitroreductase gene,Rv3131,and identified the key residue conferring the activation of MTZ in Mtb.

关键词： Tuberculosis action latent

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掺杂PbS纳米粒子的有机改性硅酸盐玻璃

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无机材料学报 1999年第4期14卷 548-552页

作者：董文庭朱从善中国科学院上海光学精密机械研究所上海201800

本文报道了用溶胶凝胶法将表面修饰的ＰｂＳ纳米粒子均匀固化于有机改性硅酸盐玻璃中的制备方法，制得的ＰｂＳ在改性硅酸盐玻璃中的掺杂浓度为０５ｗｔ％，ＨＲＴＥＭ显示ＰｂＳ纳米粒子的尺寸为３～４ｎｍ在吸... 详细信息

本文报道了用溶胶凝胶法将表面修饰的ＰｂＳ纳米粒子均匀固化于有机改性硅酸盐玻璃中的制备方法，制得的ＰｂＳ在改性硅酸盐玻璃中的掺杂浓度为０５ｗｔ％，ＨＲＴＥＭ显示ＰｂＳ纳米粒子的尺寸为３～４ｎｍ在吸收光谱中，可以观察到明显的量子尺寸效应，

关键词：有机改性硅酸盐硫化铅改性玻璃纳米粒子

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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中国的城市化:进展、问题与对策

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学术探索 2005年第4期 31-34页

作者：董文柱中国社会科学院科研局北京100732

改革开放以来,中国的城市化水平不断提高,城市综合实力不断增强,城市在国家和地区经济社会发展中的带动辐射作用日益突出。当前中国城市化发展中存在的主要问题是:城市化发展存在地区不平衡性、城市化滞后于工业化、城市化发展存在制度... 详细信息

改革开放以来,中国的城市化水平不断提高,城市综合实力不断增强,城市在国家和地区经济社会发展中的带动辐射作用日益突出。当前中国城市化发展中存在的主要问题是:城市化发展存在地区不平衡性、城市化滞后于工业化、城市化发展存在制度性障碍等。今后20年是中国城市化加速发展的时期。为了顺应中国城市化发展的基本趋势,促进中国城市化的快速健康发展,必须在城市的可持续发展、城市建设的投融资体制、城市的户籍制度和就业制度、城市的社会福利及保障制度方面进行改革、调整和完善。

关键词：城市化中国对策

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai zhu dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Multi-source and multi-temporal remote sensing image classification for flood disaster monitoring

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Global Geology 2025年

作者： LI zhu JIA Zhenyang dong Jing LIU Zhenghong College of Earth Sciences Jilin University Dandong No.2 High School

Flood disasters can have a serious impact on people's production and lives, and can cause huge ***-sourceremotesensingdata,thisstudyestablished decision tree classification rules through multi-source and multi-temporal feature fusion, classified ground objects before the disaster and extracted flood information in the disaster area based on optical images during the disaster, so as to achieve rapid acquisition of the disaster situation of each disaster bearing *** the case of Qianliang Lake, which suffered from flooding in 2020, the results show that decision tree classification algorithms based on multi-temporal features can effectively integrate multi-temporal and multispectral information to overcome the shortcomings of single-temporal image classification and achieve ground-truth object classification.

关键词：

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang wen-Jie Shi Yu-Xin Yang Bao-Xia dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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评价区域规划方案异同的一个方法

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林业科学 1983年第3期 302-309页

作者：董文泉石柱鲜吉林大学

林业区划的研究,是提高林业科技水平的一项措施。其中,对某一种区划或对某几种区划进行定量的评价比较,是大家都十分关注的问题。本文提出了一项数量化理论及电算模拟方法,虽然距离“评价问题”的解决尚远,但作为初步探索希望引起大家注... 详细信息

林业区划的研究,是提高林业科技水平的一项措施。其中,对某一种区划或对某几种区划进行定量的评价比较,是大家都十分关注的问题。本文提出了一项数量化理论及电算模拟方法,虽然距离“评价问题”的解决尚远,但作为初步探索希望引起大家注意,并盼有更多的同志来共同探索这一课题。

关键词：程度坐标代表连通分支关联系数判定系数矩阵数学分析

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胃黏膜“血清学活检”在胃癌前疾病筛查中的临床应用

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中国临床研究 2023年第2期36卷 186-190页

作者：董文珠梁越赵琦于海涛李栋陈燕王群英中国人民解放军海军第九七一医院消化科山东青岛266071 海军军医大学附属长海医院消化科上海200433

目的分析胃黏膜“血清学活检”,即血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、PGⅠ/PGⅡ比值(PGR)、胃泌素-17(G-17)和幽门螺杆菌抗体(HP-IgG),与组织学慢性胃炎分级评估系统(OLGA/OLGIM)的相关性,评价其对胃癌前疾病筛查的效力。方... 详细信息

目的分析胃黏膜“血清学活检”,即血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、PGⅠ/PGⅡ比值(PGR)、胃泌素-17(G-17)和幽门螺杆菌抗体(HP-IgG),与组织学慢性胃炎分级评估系统(OLGA/OLGIM)的相关性,评价其对胃癌前疾病筛查的效力。方法选取2019年1月至2021年12月中国人民解放军海军第971医院因消化不良症状行胃镜检查的417例患者,根据OLGA/OLGIM胃炎评估系统对其进行分组评估,对各组患者血清PG及G-17、HP-IgG进行检测及比较。结果在OLGA/OLGIM分组中,PGⅠ和PGR随分组等级升高呈降低趋势(P<0.01),而G-17和HP感染率随分组等级升高呈升高趋势(P<0.01)。Kendall相关性分析显示联合评分法与OLGA分期、OLGIM分期之间均呈正相关(r=0.44、0.43,P<0.01)。此外,HP-IgG阳性组PGⅡ、G-17水平显著高于阴性组,PGⅠ、PGR水平显著低于阴性组,差异有统计学意义(P<0.01)。结论胃黏膜“血清学活检”与组织学OLGA/OLGIM胃炎评价标准密切相关,在胃癌前疾病的筛查评估展现出极大的潜力。

关键词：胃蛋白酶原胃泌素幽门螺杆菌抗体胃癌前疾病筛查血清学活检

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多功能无人旋翼机在公共安全方面的应用

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现代电子技术 2011年第20期34卷 128-130页

作者：徐慧张伯虎董文柱石婷武警工程学院研究生管理大队37队陕西西安710086 武警工程学院通信工程系陕西西安710086 浙江省武警总队浙江杭州311200

在处突、反恐、维稳等多样化任务中,为了成功应对各种突发状况,遂行作战任务,在此提出无人旋翼机在公共安全方面的应用。与直升机和固定翼相比,无人旋翼机对起飞场地的要求较低,具有低能耗,高功效,不易受环境因素影响等优点,适合安保部... 详细信息

在处突、反恐、维稳等多样化任务中,为了成功应对各种突发状况,遂行作战任务,在此提出无人旋翼机在公共安全方面的应用。与直升机和固定翼相比,无人旋翼机对起飞场地的要求较低,具有低能耗,高功效,不易受环境因素影响等优点,适合安保部队的任务需要。同时,为了进一步提高其作战性能,这里研究以无人自转旋翼机为平台,添加多种操作功能,完成宣传威慑、高空监控、杀伤性与非杀伤性攻击等任务,进而实现无人自转旋翼机的多功能化。

关键词：无人旋翼机公共安全高功效宣传威慑

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