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Ultrafast Nonlinear Optical Response of Two-dimensional MoS_(2)/Bi_(2)Te_(3) Heterostructure

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Chinese Journal of Structural Chemistry 2021年第11期40卷 1496-1504,1408页

作者： dong jun-hao PAN Jia YE Chen-Yu WANG Ru HUANG Yong-Feng ZHENG Jing-Ying ZHAN Hong-Bing WANG Qian-Ting School of Materials Science and Engineering Fujian University of TechnologyFuzhou 350118China Fujian Provincial Key Laboratory of Advanced Materials Processing and Application Fuzhou 350108China School of Electronic Electrical Engineering and PhysicsFujian University of TechnologyFuzhou 350118China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350118China

Controlled stacking of different two-dimensional(2D)atomic layers hold great promise for significantly optimizing the optical properties of 2D materials and broadening their ***,vertical 2DMoS_(2)/Bi_(2)Te_(3) heterostructures with high crystallinity and optical quality have been successfully constructed,through drop-casting 2D Bi_(2)Te_(3) flakes on chemical vapor deposition(CVD)-grown MoS_(2) *** on our homebuilt micro Z-scan and pump-probe measurement,we precisely investigated and compared the nonlinear optical(NLO)performance of an individual micro-sized MoS_(2) flake before and after stacking 2D Bi_(2)Te_(3) ***,layer-dependent ultrafast carrier dynamics of CVD-grown MoS_(2) flakes were also *** to the efficient charge transfer from the monolayer(1 L)MoS_(2) to 2D Bi_(2)Te_(3),the 1L MoS_(2)/Bi_(2)Te_(3) heterostructure demonstrated excellent NLO performance with superior nonlinear saturable absorption coefficient and ultrashort carrier *** work greatly enriches our understanding of 2D heterostructure and paves the way for designing new type of tunable 2D photonics materials by combining the optical advantages of different 2D materials.

关键词： two-dimensional materials nonlinear optics ultrafast response

Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU Lin LI Xue XIE jun dong Ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi dong Bangxiang Xie Qian hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

Enhanced rate capability and cycle stability of Ti2C MXene for sodium storage through an aniline molecules welding strategy

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Tungsten 2025年第1期7卷 161-171页

作者： hao Chen Ya-Qin Wang dong-Ting Zhang Bei Zhao Min-Peng Li Chen-Yang Li Tian-Peng Xu Mao-Cheng Liu State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology School of Computer and Communication Technology Lanzhou University of Technology

MXenes obtained significant attention in the field of energy storage devices due to their characteristic layered structure,modifiable surface functional groups,large electrochemically active surface,and regulable interlayer ***,the self-restacking and sluggish ions diffusion kinetics performance of MXenes during the alkali metal ions insertion/extraction process severely impedes their cycle stability and rate *** paper proposes an aniline molecule welding strategy for welding p-phenylenediamine（PPDA） into the interlayers of Ti2C through a dehydration condensation *** welded PPDA molecules can contribute pillar effect to the layered structure of *** pillar effect effectively maintains the structural stability during the sodium ions insertion/extraction process and effectively expands the interlayer spacing of Ti2C from 1.16 to 1.38 nm,thereby enhancing ions diffusion kinetics performance and improving the long-term cycle *** Ti2C-PPDA demonstrates outstanding Na+storage capability,exhibiting a specific capacity of 100.2 mAh·g-1at a current density of 0.1 A·g-1over 960 cycles and delivering a remarkable rate capability 81.2 mAh·g-1at a current density of 5 A·*** study demonstrates that expanding interlayer spacing is a promising strategy to enhance the Na+storage capacity and improve long-term cycling stability,which provides significant guidance for the design of two-dimensional Na+storage materials with high-rate capability and cycle stability.

关键词： Diffusion kinetics Expanding interlayer spacing Rate capability Sodium ions storage Ti2C

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-dong Wu Xiao-Jiang hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

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Tungsten 2025年第1期7卷 80-87页

作者： Fang-Qian Wang Yin Zhang Wei-Wei Wang Mei-Qian Fu Hong-Bing Mo Wei-dong Yu Chao Liu jun Yan College of Chemistry and Chemical Engineering Central South University junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

关键词： Arsenic CO2 conversion Oxazolidinone Polyoxometalates Vanadium

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基于校园贷乱象下大学生消费观教育路径探索

湖北函授大学学报 2018年第10期31卷 69-70,76页

作者：董濠鋆肇庆学院经济与管理学院广东肇庆526061

校园贷乱象问题成为近几年全国高校关注的重点。之所以校园贷在高校内生存,与"双重"监管不力、大学生需求量大、缺乏合理的价值引导密切相关。基于当前校园贷乱象情况,可以通过加强消费观教育、提高大学生的理财能力、建立正确的消费观... 详细信息

校园贷乱象问题成为近几年全国高校关注的重点。之所以校园贷在高校内生存,与"双重"监管不力、大学生需求量大、缺乏合理的价值引导密切相关。基于当前校园贷乱象情况,可以通过加强消费观教育、提高大学生的理财能力、建立正确的消费观观念、鼓励大学生经济自立等路径来引导大学生理性消费、适度消费、合理消费。

关键词：大学生校园贷消费观教育路径

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建筑工程造价超预算的影响因素与控制研究

建筑技术开发 2018年第7期45卷 92-94页

作者：董钧颢山东省水利勘测设计院济南250014

建筑工程造价预算管理涉及到的内容繁杂,在具体施工中受到的影响因素也有很多,因而在建筑工程施工中很容易出现建筑工程造价超预算的现象。建筑工程造价超预算的出现会影响整个建筑工程施工效益,不利于建筑工程建设发展。为此,通过阐述... 详细信息

建筑工程造价预算管理涉及到的内容繁杂,在具体施工中受到的影响因素也有很多,因而在建筑工程施工中很容易出现建筑工程造价超预算的现象。建筑工程造价超预算的出现会影响整个建筑工程施工效益,不利于建筑工程建设发展。为此,通过阐述建筑工程造价超预算工作重要性,结合建筑工程造价超预算的影响因素,对如何完善建筑工程造价超预算控制措施进行策略分析。

关键词：建筑工程造价超预算