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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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熊胆消痔灵治疗混合痔的疗效观察及安全性分析

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中医药导报 2017年第7期23卷 106-108页

作者：宾东华翦闽涛严建曹晖王爱华湖南中医药大学第一附属医院湖南长沙410007 湖南中医药大学湖南长沙401028

目的:评价熊胆消痔灵促混合痔术后创面修复的临床疗效及安全性。方法:将362例混合痔术后患者按照随机数字表法分成3组,治疗组121例采用熊胆消痔灵纱条外敷换药,肛泰软膏组122例采用肛泰软膏纱条外敷换药,凡士林组119例采用凡士林纱条外... 详细信息

目的:评价熊胆消痔灵促混合痔术后创面修复的临床疗效及安全性。方法:将362例混合痔术后患者按照随机数字表法分成3组,治疗组121例采用熊胆消痔灵纱条外敷换药,肛泰软膏组122例采用肛泰软膏纱条外敷换药,凡士林组119例采用凡士林纱条外敷换药,观察21 d,对3组临床疗效、换药后疼痛积分及持续时间、术后并发症情况及术后3年复发情况进行比较分析。结果:治疗组治愈率为94.2%,肛泰软膏组治愈率为74.5%,凡士林组治愈率为58.8%,治疗组优于其余两组,差异有统计学意义(P<0.05);治疗组首次排便换药后疼痛积分及持续时间优于其余两组,差异有统计学意义(P<0.05);治疗组术后出血发生例数少于其余两组、水肿发生例数少于凡士林组,差异有统计学意义(P<0.05)。结论:熊胆消痔灵在促混合痔术后创面修复及防治痔术后并发症方面疗效确切。

关键词：混合痔术后熊胆消痔灵外敷临床应用

考虑权值减少的局域世界网络模型上的病毒传播研究

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计算机安全 2013年第6期 66-68页

作者：朱鹏鹏董建民李慧嘉阜阳师范学院安徽阜阳236000 山东工业职业学院山东淄博256414 中国科学院数学与系统科学研究院北京100190

深入分析了局域加权网络的演化机制,建立了一个新的局域世界加权网络模型。对网络结构变化对病毒在网络上的传播行为进行了研究,发现网络中病毒传播行为和网络拓扑结构的参数变化存在密切关系。

关键词：复杂网络拓扑结构病毒传播加权网络

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节点重要性指标在加权网络中的应用

计算机安全 2013年第4期 47-49页

作者：朱鹏鹏董建民李慧嘉阜阳师范学院安徽阜阳236000 山东工业职业学院山东淄博256414 中国科学院数学与系统科学研究院北京100190

复杂网络的中心化有助于发现复杂网络中的重要节点,因而具有重要的应用价值。将中心化的研究推广到了加权网络,首先在一个小的加权网络模型上刻画了几种重要的中心化指标,通过定量分析,指出了不同中心化指标的特点;并将三种节点重要性... 详细信息

复杂网络的中心化有助于发现复杂网络中的重要节点,因而具有重要的应用价值。将中心化的研究推广到了加权网络,首先在一个小的加权网络模型上刻画了几种重要的中心化指标,通过定量分析,指出了不同中心化指标的特点;并将三种节点重要性指标应用于BBV网络,分别对这三种中心化指标最大的节点进行目标免疫,通过模拟病毒传播趋势,得出节点的强度指标对这种网络的传播影响最大。

关键词：节点重要性度紧密度介数

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零线中断导致UPS停机事故分析

制造业自动化 2010年第3期32卷 7-7,132页

作者：张大鹏张金浩董建民李存国邢梅娟中石化中原油田石油化工总厂濮阳457165

本文分析了同一个原因导致一台UPS发生两次停机事故的原因,并从中总结了具有普遍意义的经验教训。

关键词： UPS 零线

Characteristics of Fluid Flow and Temperature Field of Twin-roll Steel Strip Casting with a Novel-type Delivery System

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Journal of Iron and Steel Research International 2015年第10期22卷 885-891页

作者： jian-hong dong min CHEN Nan WANG School of Materials and Metallurgy Northeastern University

A novel-type delivery system consisting of a special feeding device and delivery device was developed and applied to a φ600 mm× 1 000 mm twin-roll casting system for producing the steel strip of 2 mm in thickness, and the characteristics of fluid flow and temperature field in the casting pool were investigated by mathematical simulation. The results showed that the melt from the novel-type delivery system was distributed to the casting pool along the width direction smoothly and uniformly. At the casting speed of 80 m/min, the difference of minimum residence time （groin） and actual average residence time （tave） among different ports of the delivery device was less than 0.18 s and 0.26 s respectively, and the average amplitude of level fluctuation was 0.3 mm to 0.6 mm on the free surface of casting pool. In addition, the difference of temperature on the free surface of the pool was below 20 K and the difference across the width direction of roll in different pool depths was less than 13 K, which indicates that the uniformity of temperature distribution was obtained in the casting pool to maintain the casting process and the defect-free steel strip can also be obtained.

关键词： twin-roll strip casting novel-type delivery system fluid flow temperature field mathematical simulation

季铵盐类表面活性剂对细菌ATP提取作用的研究

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江西农业学报 2008年第9期20卷 124-125页

作者：伍季朱海华章建军董建民河南省食品质量安全控制工程技术研究中心河南郑州450002

通过研究几种季铵盐类表面活性剂在ATP生物发光法中不同浓度、不同提取时间对细菌ATP的提取效果,确定了浓度为0.2%的苯扎氯铵(BAC)提取细菌ATP 2 min,检测发光值效果最佳;与传统的TCA法进行对比,BAC法对细菌ATP的提取率更高。

关键词：季铵盐类表面活性剂生物发光法 ATP提取快速检测

On Connected Components of Skew Group Algebras

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Acta Mathematica Sinica,English Series 2023年第5期39卷 799-813页

作者： jian min CHEN Qiang dong Ya Nan LIN School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China

Let A be a basic connected finite dimensional associative algebra over an algebraically closed field k and G be a cyclic *** is a quiver QGwith relationsρG such that the skew group algebras A[G]is Morita equivalent to the quotient algebra of path algebra kQGmodulo ideal(ρG).Generally,the quiver QGis not *** this paper we develop a method to determine the number of connect components of ***,we introduce the notion of weight for underlying quiver of A such that A is G-graded and determine the connect components of smash product A#kG*.

关键词： Smash product skew group algebra n-translation algebra path algebra connected component

Development and Control of Underwater Gliding Robots:A Review

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IEEE/CAA Journal of Automatica Sinica 2022年第9期9卷 1543-1560页

作者： jian Wang Zhengxing Wu Huijie dong min Tan Junzhi Yu the State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 the School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China the State Key Laboratory for Turbulence and Complex System Department of Mechanics and Engineering ScienceBIC-ESATCollege of EngineeringPeking UniversityBeijing 100871China

As one of the most effective vehicles for ocean development and exploration,underwater gliding robots(UGRs)have the unique characteristics of low energy consumption and strong ***,by borrowing the motion principles of current underwater robots,a variety of novel UGRs have emerged with improving their maneuverability,concealment,and environmental friendliness,which significantly broadens the ocean *** this paper,we provide a comprehensive review of underwater gliding robots,including prototype design and their key *** the perspective of motion characteristics,we categorize the underwater gliding robots in terms of traditional underwater gliders(UGs),hybrid-driven UGs,bio-inspired UGs,thermal UGs,and ***,their buoyancy driven system,dynamic and energy model,and motion control are concluded with detailed ***,we have discussed the current critical issues and future *** review offers valuable insight into the development of next-generation underwater robots well-suited for various oceanic applications,and aims to gain more attention of researchers and engineers to this growing field.

关键词： Buoyancy driven motion control oceanic applications system development underwater gliding robots