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Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating SIRT1-PGC-1αin Mice

Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： LI Xiao hong LIU Yu Mei SHAN Hui TAN Jin Feng ZHOU Jian SONG yuan Jin LI Si Qi LIU Chen XU dong Qun YU Li LI Wan Wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina Weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of Chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of SIRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and SIRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,SIRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the SIRT1-PGC-1α *** SAL can activate SIRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis SIRT1-PGC-1α

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Insights and implications of sexual dimorphism in osteoporosis

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Bone Research 2024年第1期12卷 20-49页

作者： yuan-yuan Zhang Na Xie Xiao-dong Sun Edouard C.Nice Yih-Cherng Liou Canhua Huang Huili Zhu Zhisen Shen Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China West China School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengdu 610041China Department of Biochemistry and Molecular Biology Monash UniversityClaytonVIC 3800Australia Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117543Republic of Singapore Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education Department of Reproductive MedicineWest China Second University Hospital of Sichuan UniversityChengduChina Department of Otorhinolaryngology and Head and Neck Surgery The Affiliated Lihuili HospitalNingbo University315040 NingboZhejiangChina

Osteoporosis,a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture,has led to a high risk of fatal osteoporotic fractures *** evidence has revealed that sexual dimorphism is a notable feature of osteoporosis,with sex-specific differences in epidemiology and ***,females are more susceptible than males to osteoporosis,while males are more prone to disability or death from the *** date,sex chromosome abnormalities and steroid hormones have been proven to contribute greatly to sexual dimorphism in osteoporosis by regulating the functions of bone *** the sex-specific differences in osteoporosis and its related complications is essential for improving treatment strategies tailored to women and *** literature review focuses on the mechanisms underlying sexual dimorphism in osteoporosis,mainly in a population of aging patients,chronic glucocorticoid administration,and ***,we highlight the implications of sexual dimorphism for developing therapeutics and preventive strategies and screening approaches tailored to women and ***,the challenges in translating bench research to bedside treatments and future directions to overcome these obstacles will be discussed.

关键词： osteoporosis epidemiology overcome

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C-F insertion reaction sheds new light on the construction of fluorinated compounds

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Chinese Chemical Letters 2024年第8期35卷 163-169页

作者： dong-Sheng Deng Su-Qin Tang Yong-Tu yuan Ding-Xiong Xie Zhi-yuan Zhu Yue-Mei Huang Yun-Lin Liu Henan Key Laboratory of Function-Oriented Porous Materials and College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The atom-economical C-F insertion chemistry is emerged as a promising technology for the synthesis of various fluorinated scaffolds,which have wide applications both in the academic and the industrial *** past three years have witnessed rapid developments in this *** highlight provides an overview on the evolution according to the fluorinating agents used.

关键词： C-F insertion Benzyl fluoride Acyl fluoride gem-Difluorocyclopropane Fluorinated scaffold

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Polysaccharides from Chinese herbal medicine:a review on the hepatoprotective and molecular mechanism

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Chinese Journal of Natural Medicines 2024年第1期22卷 4-14页

作者： LI Jifeng GUO Haolin dong Ying yuan Shuo WEI Xiaotong ZHANG Yuxin dong Lu WANG Fei BAI Ting YANG Yong Dalian Key Laboratory of Chronic Disease Research Center Dalian UniversityDalian 116622China Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationCollege of PharmacyYanbian UniversityYanji 133002China

Polysaccharides,predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum,Angelica sinensis,Astragalus membranaceus,Dendrobium officinale,Ganoderma lucidum,and Poria cocos,represent principal bioactive constituents extensively utilized in Chinese *** compounds have demonstrated significant anti-inflammatory capabilities,especially anti-liver injury activities,while exhibiting minimal adverse *** review summarized recent studies to elucidate the hepatoprotective efficacy and underlying molecular mechanisms of these herbal *** underscored the role of these polysaccharides in regulating hepatic function,enhancing immunological responses,and improving antioxidant capacities,thus contributing to the attenuation of hepatocyte apoptosis and liver *** of molecular pathways in these studies revealed the intricate and indispensable functions of traditional Chinese herbal polysaccharides in liver injury ***,this review provides a thorough examination of the hepatoprotective attributes and molecular mechanisms of these medicinal polysaccharides,thereby offering valuable insights for the advancement of polysaccharide-based therapeutic research and their potential clinical applications in liver disease treatment.

关键词： Polysaccharides Hepatoprotective Chinese herbal medicine Mechanism

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Dynamic Response of A Group of Cylindrical Storage Tanks with Baffles Considering the Effect of Soil Foundation

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China Ocean Engineering 2024年第1期38卷 129-143页

作者： SUN Ying WANG Jia-dong HUO Rui-li ZHOU Ding GU Zhen-yuan QIAN Wang-ping School of Transportation and Civil Engineering Nantong UniversityNantong 226019China Faculty of Civil Engineering and Mechanics Jiangsu UniversityZhenjiang 212013China College of Civil Engineering Nanjing Tech UniversityNanjing 211816China

The sloshing in a group of rigid cylindrical tanks with baffles and on soil foundation under horizontal excitation is studied *** solutions for the velocity potential are derived out by the liquid subdomain *** models with mass-spring oscillators are established to replace continuous *** with the least square technique,Chebyshev polynomials are employed to fit horizontal,rocking and horizontal-rocking coupling impedances of soil,respectively.A lumped parameter model for impedance is presented to describe the effects of soil on tank structures.A mechanical model for the soil-foundation-tank-liquid-baffle system with small amount of calculation and high accuracy is proposed using the substructure *** analytical solutions are in comparison with data from reported literature and numerical codes to validate the effectiveness and correctness of the *** dynamic properties and seismic responses of the soil-tank system are given for the baffle number,size and location as well as soil parameter.

关键词： cylindrical tanks multiple annular baffles equivalent analytical model soil−structure interaction subdomain method dynamic response

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多年冻土区宽幅路基热效应防治对策研究

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中国公路学报 2015年第12期28卷 26-32页

作者：汪双杰刘戈叶莉董元宏袁堃中交第一公路勘察设计研究院有限公司陕西西安710075

为了解决多年冻土区由于路基加宽而产生的热效应问题,采用数值模拟方法,通过分析融化深度、融化速率以及融化盘形态随路基宽度的变化规律,对宽幅路基热效应特征进行了系统阐述,基于对传统单一工程措施的综合评价,根据各自的适应条件及... 详细信息

为了解决多年冻土区由于路基加宽而产生的热效应问题,采用数值模拟方法,通过分析融化深度、融化速率以及融化盘形态随路基宽度的变化规律,对宽幅路基热效应特征进行了系统阐述,基于对传统单一工程措施的综合评价,根据各自的适应条件及作用机理提出了2种工程防治对策,并对13.5m幅宽实体工程的地温观测数据进行了分析。结果表明：块石-通风管路基活动层范围内地温有明显下降,降幅为0.1℃~0.4℃;热棒-XPS板路基在路面下2~5m范围内,观测断面地温明显低于对比断面,最大相差约0.8℃,2种复合工程措施都具有良好的地温调控效果,对宽幅沥青路面的热效应可起到防治作用,目前已在共和至玉树高速公路建设中进行了推广应用。

关键词：道路工程复合路基数值模拟实体工程对策多年冻土

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Effect of electrolyte cation-mediated mechanism on electrocatalytic carbon dioxide reduction

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Chinese Chemical Letters 2024年第7期35卷 139-146页

作者： yuan dong Mutian Ma Zhenyang Jiao Sheng Han Likun Xiong Zhao Deng Yang Peng Soochow Institute of Energy and Material Innovations College of EnergyJiangsu Key Laboratory of Advanced Carbon Materials and Wearable Energy TechnologiesSoochow UniversitySoochow 215006China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySoochow 215123China School of Chemistry and Chemical Engineering Shihezi UniversityShihezi 832003China School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China

The steep reduction in costs and systematic optimization of renewable electricity has ignited an intensifying interest in harnessing electroreduction of carbon dioxide(CO_(2)RR)for the generation of chemicals and *** focus of research over the past few decades has been on the optimization of the electrode and the electrolyte ***,cation species in the latter have recently been found to dramatically alter the selectivity of CO_(2)RR and even their catalytic activity by multiple orders of *** a result,the selection of cations is a critical factor in designing catalytic interfaces with high selectivity and efficiency for targeted *** decision-making regarding cation selection relies on a comprehensive understanding of prevailing electrolyte effect models that have been used to elucidate observed experimental *** this perspective,we review the hypotheses that explain how electrolyte cations influence CO_(2)RR by mechanisms such as through tuning of the interfacial electric field,buffering of the local pH,stabilization of the key intermediates and regulation of the interfacial *** endeavor is to elucidate the molecular mechanisms underpinning cation effects,thus fostering the evolution of more holistic and universally applicable predictive *** this regard,we highlight the current challenges in this area of research,while also identifying potential avenues for future investigations.

关键词： CO_(2)electrocatalytic reduction Cation effects Catalytic mechanisms Catalytic interfaces Electric double layer

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Enhanced cycling stability and rate performance of Co-doped and La_(2)O_(3)-coated LiNi_(0.9)Mn_(0.1)O_(2) toward power battery

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Rare Metals 2024年第2期43卷 658-670页

作者： Jia-Qi Peng yuan-yuan Wei dong-Ming Liu Yun Li Bin Hu Bin Huang Jian-Wen Yang Shun-Hua Xiao Ren-Heng Wang Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

Ultra-high nickel layered oxide cathode material with high energy density is the most promising material to improve the electrochemical performance of lithium-ion batteries(LIBs).However,the poor structural stability and severe surface/interface side reactions of the material lead to poor rate performance and cyclic stability,which limits its application in *** this paper,the dual-modification strategy of Co doping and La_(2)O_(3) coating is used to meet the above *** doping can effectively widen layer spacing and reduce Li^(+)/Ni^(2+) mixing,and La_(2)O_(3) coating can effectively eliminate the residual alkali on the surface of active material,inhibit the thickening of cathode electrolyte interphase(CEI)film and reduce surface/interface side ***,the modified material(NM90-CL)with excellent electrochemical properties is achieved through the synergistic enhancement of Co doping and La_(2)O_(3) *** capacity retention rate can reach 77.9%after 200 cycles at 1.0℃ and 75.7%after 200 cycles at 5.0℃.Its reversible capacity can up to 153.5 mAh·g^(–1) at 10.0℃.This dual-modification strategy will provide theoretical guidance and technical support for the synthesis of other high-performance electrode materials.

关键词： High nickel cathode material Co doping La_(2)O_(3) coating Electrochemical performance Electrochemical mechanism

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Application of non-mydriatic fundus photography-assisted telemedicine in diabetic retinopathy screening

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World Journal of Diabetes 2024年第2期15卷 251-259页

作者： Wan Zhou Xiao-Jing yuan Jie Li Wei Wang Hao-Qiang Zhang yuan-yuan Hu Shan-dong Ye Department of Endocrinology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology Anhui Provincial HospitalAffiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND Early screening and accurate staging of diabetic retinopathy(DR)can reduce blindness risk in type 2 diabetes ***’s complex pathogenesis involves many factors,making ophthalmologist screening alone insufficient for prevention and ***,endocrinologists are the first to see diabetic patients and thus should screen for retinopathy for early *** To explore the efficacy of non-mydriatic fundus photography(NMFP)-enhanced telemedicine in assessing DR and its various *** This retrospective study incorporated findings from an analysis of 93 diabetic patients,examining both NMFP-assisted telemedicine and fundus fluorescein angiography(FFA).It focused on assessing the concordance in DR detection between these two ***,receiver operating characteristic(ROC)curves were generated to determine the optimal sensitivity and specificity of NMFP-assisted telemedicine,using FFA outcomes as the standard *** In the context of DR diagnosis and staging,the kappa coefficients for NMFPassisted telemedicine and FFA were recorded at 0.775 and 0.689 respectively,indicating substantial intermethod ***,the NMFP-assisted telemedicine’s predictive accuracy for positive FFA outcomes,as denoted by the area under the ROC curve,was remarkably high at 0.955,within a confidence interval of 0.914 to 0.995 and a statistically significant P-value of less than *** predictive model exhibited a specificity of 100%,a sensitivity of 90.9%,and a Youden index of *** NMFP-assisted telemedicine represents a pragmatic,objective,and precise modality for fundus examination,particularly applicable in the context of endocrinology inpatient care and primary healthcare settings for diabetic *** implementation in these scenarios is of paramount significance,enhancing the clinical accuracy in the diagnosis and therapeutic management of *** methodology not only streamlines patient evaluation

关键词： Diabetes Diabetic retinopathy Non-mydriatic fundus photography-assisted telemedicine Fundus fluorescein angiography

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Wireless Positioning:Technologies,Applications,Challenges,and Future Development Trends

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1135-1166页

作者： Xingwang Li Hua Pang Geng Li Junjie Jiang Hui Zhang Changfei Gu dong yuan School of Physics and Electronic Information Engineering University of Henan PolytechnicJiaozuo454000China Jiaozuo Key Laboratory of Crow-Sensing Network Jiaozuo454000China Institute of Mining Engineering Guizhou Institute of TechnologyGuiyang550003China Coal Supervision Department Panzhou Energy BureauPanzhou553599China

The development of the fifth-generation(5G)mobile communication systems has entered the commercialization stage.5G has a high data rate,low latency,and high reliability that can meet the basic demands of most industries and daily life,such as the Internet of Things(IoT),intelligent transportation systems,positioning,and *** continuous progress and development of society have aroused wide *** accuracy is the core demand for the applications,especially in complex environments such as airports,warehouses,supermarkets,and ***,many factors also affect the accuracy of positioning in those environments,for example,multipath effects,non-line-of-sight,and clock synchronization *** paper provides a comprehensive review of the existing works about positioning for the future wireless network and discusses its key techniques and algorithms,as well as the current development and future *** first outline the current traditional positioning technologies and algorithms,which are discussed and analyzed with the relevant *** addition,we also discuss application scenarios for wireless *** comparing different positioning systems,the challenges and future development directions of existing wireless positioning systems are prospected.

关键词： 5G wireless positioning reconfigurable intelligent surface Internet of Vehicles

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