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Yield, Leaf Senescence, and Cry1Ac Expression in Response to Removal of Early Fruiting Branches in Transgenic Bt Cotton

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Agricultural Sciences in China 2008年第6期7卷 692-702页

作者： dong he-zhong tang wei li wei-jiang li zhen-huai niu yue-hua zhang dong-mei Cotton Research Center Shandong Academy of Agricultural Sciences/Shandong Provincial Key Lab for Cotton Culture and PhysiologyJinan 250100 P.R.China

Two-year field experiments were conducted at linqing, Yellow River valley of China, to study the plant response to the removal of early fruiting branches in transgenic Bt （Bacillus thuringiensis） cotton （Gossypium hirsutum L.） from 2003 to 2004. Plants were undamaged and treated by removing two basal fruiting branches （FB） at squaring to form the control and the removal treatment, respectively. The plant height, leaf area （LA）, dry weight of fruiting forms （DWFF）, the number of fruiting nodes （NFN）, photosynthetic （Pn） rate, and levels of leaf chlorophyll （Chl）, N, P, K, and Cry lAc protein in main- stem leaves were measured at a 10- or 20-d interval after FB removal, and the sink/source ratio as indicated by NFN/LA and DWFF/LA was determined. FB removal significantly increased the plant height, LA, and plant biomass in both years. lint yields were increased 7.5 and 5.2% by removal compared with their controls in 2003 and 2004, respectively. Significant increases in boll size （5.7 and 5.1%） were also observed in removal than in control for both years. Either NFN/LA or DWFF/LA was significantly reduced by removal before 40 d after removal; however, both NFN/LA and DWFF/LA were significantly enhanced by FB removal at 80 d after removal compared to the untreated control. There was no significant difference in fiber quality in the first two harvests between removal and control, but fiber strength and micronarie in the third harvest were significantly improved by FB removal. In terms of leaf Chl, Pn rate, levels of total N, P, and K in late season, leaf senescence was considerably delayed by FB removal. Levels of CrylAc protein in the fully expanded young leaves were considerably higher in FB-excised plants than in control, indicating FB removal enhanced CrylAc expression. It is suggested that the yield and quality improvement with FB removal may be attributed to the increased NFN/LA or DWFF/LA in late season and delayed leaf senescence, respectively. FB removal can be a

关键词： branch removal Bt cotton Cry lAc protein leaf senescence photosynthetic rate sink/source ratio

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不同整枝方式对棉花源库关系的调节效应

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应用生态学报 2008年第4期19卷 819-824页

作者：董合忠牛曰华李维江唐薇李振怀张冬梅山东省农业科学院棉花研究中心山东省棉花栽培生理重点实验室济南250100

以去叶枝留早果枝的正常整枝方式为对照，于2005-2006年研究了整枝对大田棉花源库关系的调节效应．结果表明：去叶枝去早果枝（Ⅰ）、留叶枝去早果枝（Ⅱ）和留叶枝留早果枝（Ⅲ）3种整枝方式都显著促进了棉花叶面积扩展，最大叶面积系... 详细信息

以去叶枝留早果枝的正常整枝方式为对照，于2005-2006年研究了整枝对大田棉花源库关系的调节效应．结果表明：去叶枝去早果枝（Ⅰ）、留叶枝去早果枝（Ⅱ）和留叶枝留早果枝（Ⅲ）3种整枝方式都显著促进了棉花叶面积扩展，最大叶面积系数分别比对照平均提高了10．3％、28．3％和9．5％，导致叶面积载荷量减少，源库比降低．Ⅰ和Ⅱ处理显著提高了叶片叶绿素含量，降低了始絮期的黄叶率和功能叶的C／N，表现出显著地延缓衰老的作用，但Ⅱ处理易导致贪青晚熟；而Ⅲ处理对衰老的延缓作用不大．Ⅰ处理的籽棉产量与对照相当，Ⅱ处理比对照降低了6．4％-15．6％，Ⅲ处理比对照增产6．3％．表明去早果枝和留叶枝皆是调节棉花源库关系、碳氮代谢和延缓棉花早衰的有效手段．

关键词：棉花留叶枝去早果枝源库关系 C、N代谢叶片衰老子棉产量

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留叶枝对抗虫杂交棉库源关系的调节效应和对叶片衰老与皮棉产量的影响

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中国农业科学 2007年第5期40卷 909-915页

作者：董合忠李维江唐薇李振怀牛曰华张冬梅山东省棉花研究中心/山东省棉花栽培生理重点实验室山东省棉花研究中心/山东省棉花栽培生理重点实验室济南250100 济南250100 莱阳农学院植物科技学院青岛266109

【目的】去叶枝是我国传统的棉田管理技术,但现有研究认为叶枝具有保留利用的价值。因此进一步探索棉花留叶枝的可行性及对库源关系、叶片衰老和产量、品质的影响与机理十分必要。【方法】于2004～2005年在山东临清比较研究了大田稀植(... 详细信息

【目的】去叶枝是我国传统的棉田管理技术,但现有研究认为叶枝具有保留利用的价值。因此进一步探索棉花留叶枝的可行性及对库源关系、叶片衰老和产量、品质的影响与机理十分必要。【方法】于2004～2005年在山东临清比较研究了大田稀植(3.0株/m2)条件下3个转Bt基因抗虫杂交棉去叶枝和留叶枝后的形态和生理变化。【结果】与去叶枝相比,留叶枝棉花的衣分变化不大,全株平均铃重有所降低,铃数显著增多,2004和2005年的皮棉单产分别比去叶枝的对照提高了9.8%和6.2%,但纤维长度和比强度略低于去叶枝的对照。留叶枝棉株的绿叶比例和冠层叶绿素含量高于去叶枝的棉株,但主茎功能叶的叶绿素含量和光合速率却显著低于对照。留叶枝具有中前期增源、后期扩库的作用,但对中前期的“流”似有不利影响。【结论】抗虫杂交棉在稀植条件下保留叶枝具有一定的增产作用,这与留叶枝增源、扩库的作用有关;留叶枝没有从根本上延缓棉花冠层的衰老,也没有改善纤维品质的作用。

关键词： Bt杂交棉叶枝库源关系叶片衰老皮棉产量

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不同基因型抗虫棉的光合生产与叶源特征

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棉花学报 2005年第6期17卷 328-333页

作者：董合忠李维江唐薇张冬梅李振怀牛曰华山东棉花研究中心济南250100 山东省棉花栽培生理重点实验室济南250100

以33B为对照,对早发型常规Bt棉鲁棉研17、鲁棉研21,晚发型Bt棉鲁棉研22,杂交Bt棉鲁棉研15、鲁棉研20进行了2年的种植和比较。早发型品种中前期干物质积累和叶面积增长快,但后期干物质积累慢、叶面积下降快,表现出明显的早发早熟和干旱... 详细信息

以33B为对照,对早发型常规Bt棉鲁棉研17、鲁棉研21,晚发型Bt棉鲁棉研22,杂交Bt棉鲁棉研15、鲁棉研20进行了2年的种植和比较。早发型品种中前期干物质积累和叶面积增长快,但后期干物质积累慢、叶面积下降快,表现出明显的早发早熟和干旱年份易早衰的特点;晚发型品种前期干物质积累和叶面积增长慢,但后期增长快,表现出明显的晚发甚至贪青晚熟的特点。两个杂交棉品种表现出与早发型品种基本相同的生育规律,但中前期叶面积系数和干物质积累量显著高于其它供试品种。盛铃期以前,未见品种间功能叶光合速率的显著差异,但在干旱年份,早发型品种在始絮期功能叶的光合速率显著低于晚发型品种。早发型品种中后期的根冠比和功能叶含K量显著低于晚发型品种,而叶面积载荷量却显著高于晚发型品种。不同品种干物质产量和熟相的差异可能分别与叶面积系数大小和库源比例不同有关。

关键词： Bt棉基因型光合干物质积累源库早衰晚熟

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Expert consensus on the diagnosis and treatment of solid tumors with BRAF mutations

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The Innovation 2024年第6期5卷 100-116页

作者： Wenxian Wang Bin lian Chunwei Xu Qian Wang Ziming li Nan zheng Aijun liu Jinpu Yu Wenzhao zhong Zhijie Wang Yongchang zhang Jingjing liu Shirong zhang Xiuyu Cai Anwen liu Wen li lili Mao Ping Zhan Hongbing liu tangfeng Lv liyun Miao lingfeng Min Yu Chen Jingping Yuan Feng Wang Zhansheng jiang Gen lin Long huang Xingxiang Pu Rongbo lin weifeng liu Chuangzhou Rao dongqing Lv Zongyang Yu Xiaoyan li Chuanhao tang Chengzhi Zhou Junping zhang Junli Xue Hui Guo Qian Chu Rui Meng Xuewen liu Jingxun Wu Rui zhang Jin Zhou zhengfei Zhu Yongheng li Hong Qiu Fan Xia Yuanyuan Lu Xiaofeng Chen Jian Feng Rui Ge Enyong Dai Yu Han weiwei Pan Fei Pang Xin huang meizhen Hu Qing Hao Kai Wang Fan Wu Binbin Song Bingwei Xu liping Wang Youcai Zhu li lin Yanru Xie Xinqing lin Jing Cai ling Xu Jisheng li Xiaodong Jiao Kainan li Jia wei Huijing Feng lin Wang Yingying Du Wang Yao Xuefei Shi Xiaomin niu dongmei Yuan Yanwen Yao Jianhui huang yue Feng Yinbin zhang Pingli Sun Hong Wang Mingxiang Ye dong Wang Zhaofeng Wang yue Hao zhen Wang Bin Wan donglai Lv Shengjie Yang Jin Kang Jiatao zhang Chao zhang Wenfeng li Jianfei Fu lizhi Wu Shijie Lan Juanjuan Ou lin Shi Zhanqiang Zhai Yina Wang Bihui li zhang zhang Ke Wang Xuelei Ma zhongwu li Zhefeng liu Nong Yang lin Wu Huijuan Wang Gu Jin Guansong Wang Jiandong Wang Hubing Shi meiyu Fang Yong Fang Yuan li Xiaojia Wang Jing Chen Yiping zhang Xixu Zhu Yi Shen Shenglin Ma Biyun Wang Yong Song zhengbo Song Wenfeng Fang Yuanzhi Lu Lu Si Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital)HangzhouZhejiang 310022P.R.China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Melanoma and SarcomaPeking University Cancer Hospital&InstituteBeijing 100142P.R.China Institute of Cancer and Basic Medicine(ICBM) Chinese Academy of SciencesHangzhouZhejiang 310022P.R.China Department of Respiratory Medicine Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210002P.R.China Department of Respiratory Medicine Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210029P.R.China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030P.R.China Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 200030China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 200030China Senior Department of Pathology the 7th Medical Center of PLA General HospitalBeijing 100700P.R.China Department of Cancer Molecular Diagnostics Core Tianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China Guangdong Lung Cancer Institute Guangdong Provincial Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSchool of MedicineGuangzhouGuangdong 510080P.R.China State Key Laboratory of Molecular Oncology Department of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Medical Oncology Lung Cancer and Gastrointestinal UnitHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School

The BRAF gene is an important signaling molecule in human cells that is involved in the regulation of cell growth,differentiation,and *** the BRAF gene mutates,it can lead to abnormal activation of the signaling pathway,which promotes cell proliferation,inhibits cell apoptosis,and ultimately contributes to the occurrence and development of *** mutations are widely present in various cancers,including malignant melanoma,thyroid cancer,colorectal cancer,non-small cell lung cancer,and hairy cell leukemia,among *** is an important target for the treatment of various solid tumors,and targeted combination therapies,represented by BRAF inhibitors,have become one of the main treatment modalities for a variety of BRAF-mutation-positive solid tumors.

关键词： BRAF diagnosis treatment

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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