检索结果-南通市图书馆

Percutaneous balloon mitral valvuloplasty during pregnancy:A clinical analysis of 14 cases

在线全文

学校读者我要写书评

暂无评论

South China Journal of Cardiology 2020年第1期21卷 47-52页

作者： LIU Yan-li HAN Feng-zhen dong hao-jian OU Yan-qiu Department of Obstetrics Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080GuangdongChina Department of Epidemiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080GuangdongChina

Background Although acute rheumatic fever and rheumatic heart disease are now rare in affluent populations,they remain major health issues in developing countries such as China. Rheumatic mitral stenosis is the most common valvular disease during pregnancy. Some patients can receive percutaneous balloon mitral valvuloplastyduring pregnancy and obtain good outcomes. Methods A retrospective study of 14 women undergoing percutaneous balloon mitral valvuloplasty with rheumatic mitral valve stenosis during pregnancy in our hospital from Jan 2014 to Oct 2019 was conducted. The maternal and fetal outcomes were analyzed. Results Percutaneous balloon mitral valvuloplasty was successful in all patients with significant improvement in their mitral valve area(pre-operation:0.83±0.21 cm^2 and post-operation:1.64±0.27 cm^2,P<0.05). Pulmonary artery systolic pressure(pre-operation:69.62±28.27 mmHg and post-operation:37.23±12.65 mmHg,P<0.05)was significantly decreased. All 14 patients had an uneventful course afterthe operation. The total number of newborns was 14,none of whom required intensive care monitoring,and no malformations were found. Conclusions Percutaneous balloon mitral valvuloplasty performed during pregnancy with necessary precautions is feasible and effectivefor the mother and mightbe safe forthe fetus. There is marked symptomatic relief,along with good maternal and fetal outcomes.

关键词： percutaneous balloon mitral valvuloplasty mitral valve stenosis pregnancy outcome

同方期刊数据库

Perioperative aortic dissection rupture after endovascular stent graft placement for treatment of type B dissection

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第9期126卷 1636-1641页

作者： HUANG Wen-hui LUO Song-yuan LUO jian-fang LIU Yuan FAN Rui-xin XUE Ling YANG Fang KANG Hui-yuan GU Meng-nan LIU Zhen XIE Nian-jin dong hao-jian NI Zhong-han HUANG Mei-ping CHEN Ji-yan Department of Cardiology Department of CardiovascularGuangdong Cardiovascular InstituteGuangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China Southern Medical University Guangzhou Guangdong 510515China Department of Pharmacology Zhongshan School of Medicine SunYat-Sen University Guangzhou Guangzhou 510080 China Department of Radiology Guangdong General Hospital Guangdong Academy of Medical Sciences GuangzhouGuangdong 510080 China

Background The perioperative aortic dissection （AD） rupture is a severe event after endovascular stent graft placement for treatment of type B AD. However, this life-threatening complication has not undergone systematic investigation. The aim of the study is to discuss the reasons clAD rupture after the procedure. Methods The medical record data of 563 Stanford type B AD patients who received thoracic endovascular repair from 2004 to December 2011 at our institution were collected and analyzed. Double entry and consistency checking were performed with Epidata software. Results Twelve patients died during the perioperation after thoracic endovascular repair, with an incidence of 2.1%, 66.6% were caused by aortic rupture and half of the aortic rupture deaths were caused by retrograde type A AD. In our study, 74% of the non-rupture surviving patients had the free-flow bare spring proximal stent implanted, compared with 100% of the aortic rupture patients （74% vs. 100%, P=-0.213）. The aortic rupture patients are more likely to have ascending aortic diameters 〉4 cm （62.5% vs. 9.0%, P=0.032）, involvement the aortic arch concavity （62% vs. 27%, P=-0.041） and have had multiple stents placed （P=0.039）. Conclusions Thoracic AD endovascular repair is a safe and effective treatment option for AD with relative low in-hospital mortality. AD rupture may be more common in arch stent-graft patients with an ascending aortic diameter 〉4 cm and with severe dissection that needs multi-stent placement. Attention should be paid to a proximal bare spring stent that has a higher probability of inducing an AD rupture. Post balloon dilation should be performed with serious caution, particularly for the migration during dilation.

关键词： aortic dissection aortic rupture stent graft

在线全文

学校读者我要写书评

暂无评论

不锈钢长丝包芯纱织物屏蔽效能测试与研究

上海纺织科技 2011年第12期39卷 56-58页

作者：董建毫李瑞洲河北科技大学纺织服装学院河北石家庄050018 天津工业大学纺织学院天津300160 河北省纺织服装工程技术研究中心河北石家庄050026

模拟了不锈钢长丝包芯纱单双向织物的屏蔽效能,以及不同织物组织对屏蔽效能的影响。通过对实验数据的方差分析与研究,得出了纬密、单双向以及织物组织对织物屏蔽效能的影响。

关键词：电磁波防辐射织物织物组织包芯纱屏蔽效能

2005年国际心肺复苏和心血管急救共识会议

在线全文

学校读者我要写书评

暂无评论

实用医学杂志 2006年第19期22卷 2209-2218页

作者：董豪坚广东省心血管病研究所心内科广州市510080

译自: 2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Circulation. November 29, 2005; Volume 112 (22) Supplement. ISSN: 0009 -7322 1引言 1.1关于国际共识会议International Liasion Committee on Resuscitation(ILCOR)成立于1993年.其任务是明确与回顾有关心肺复苏(CPR)和心血管急救(ECC)的国际性科研知识成果,并在处理方面达成共识.ECC包括了有关影响心血管与呼吸系统的危及生命的突发事件的所有内容,尤其着重于心脏骤停的处理.在1999年,美国心脏病协会(AHA)举办了第一次ILCOR会议,会议评价了复苏学并制定了一般的复苏指导意见,后发表于Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cariovascular Care.此后,ILCOR委员会的研究者们继续有序地评价复苏学直至此文发表.本文摘录了这个证据评价过程所得出的结论与推荐意见.……[第一段]

关键词：心跳骤停高级生命支持心脏按压除颤器心脏骤停心搏骤停心律失常 CPR 新生儿心肺复苏急救人员抗心律失常药心血管

Transcatheter aortic valve replacement(TAVR) for severe aortic valve stenosis with left main artery disease:A case report

在线全文

学校读者我要写书评

暂无评论

South China Journal of Cardiology 2022年第3期23卷 240-243页

作者： WANG Pei-ning Maimaitishawuti Yimamu Abudureyimu Alimujiang LI Guang dong hao-jian The Cardiovascular Department The First People's Hospital of KashiXinjiang 844099China TheC ardiovascular Department the Guangdong Provincial People's HospitalGuangzhouGuangdong510100China

Introduction: This is the first case of Transcatheter Aortic Valve Replacement(TAVR) in the prefecture level hospital of Xinjiang Province in China. It also proves that severe left main coronary artery disease(LM)is not the contraindication to this operation of TAVR. Patient concerns:The patient had dyspnea for two years, with the 4/6 spurious murmur at the aortic valve. The cardiac ultrasound revealed a severe aortic valve stenosis(AS) and severe mitral regurgitation(MR). Coronary angiography(CAG)showed 80% stenosis of the left main artery. Diagnosis: The severe aortic valve stenosis(AS). Interventions: He received the TAVR, which also is the first case in the First People's Hospital of Kashi Prefecture. Outcomes: The patient's symptoms were significantly improved. The cardiac ultrasound showed that no obvious regurgitation was found in the implanted artificial aortic valve and the MR was significantly reduced. So far, the patient has recovered well for five months after TAVR. Conclusion:TAVR is an effective method for the severe AS patients with serve LM and loss of surgical opportunity.

关键词： Transcatheter Aortic Valve Replacement left main coronary artery disease aortic valve stenosis

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi dong Bangxiang Xie Qian hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词：

同方期刊数据库

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

塑料-无烟煤混合还原剂对含碳球团还原的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国冶金 2021年第2期31卷 90-94,108页

作者：董剑豪王广张浩王静松薛庆国北京科技大学钢铁冶金新技术国家重点实验室北京100083

为了解决废塑料的污染问题,提出了将塑料与无烟煤一起进行低温热处理来制得含碳球团混合还原剂的思路,以达到钢铁工业协同处理废塑料的目的。通过研究还原温度和反应时间对含碳球团宏观形貌、金属化率及其微观结构的影响,对比分析了混... 详细信息

为了解决废塑料的污染问题,提出了将塑料与无烟煤一起进行低温热处理来制得含碳球团混合还原剂的思路,以达到钢铁工业协同处理废塑料的目的。通过研究还原温度和反应时间对含碳球团宏观形貌、金属化率及其微观结构的影响,对比分析了混合还原剂对含碳球团直接还原的影响。结果表明,以氧化铁粉末试剂为含铁原料,加入无烟煤与PE塑料热处理后的混合还原剂,在1 100和1 150℃,反应5~15 min时,能提高含碳球团的反应速率。当反应温度为1 150℃,反应接近还原终点时,混合还原剂含碳球团的金属化率为95.63%,基本接近无烟煤含碳球团的金属化率,但是在含碳球团中加入混合还原剂会引起一定程度的球团膨胀。

关键词：废塑料热处理还原剂含碳球团直接还原

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury