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Absorption characteristics of the total alkaloids from Mahonia bealei in an in situ single-pass intestinal perfusion assay

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Chinese Journal of Natural Medicines 2014年第7期12卷 554-560页

作者： SUN Yu-He HE Xin YANG Xiao-Lin dong cui-lan ZHANG Chun-Feng SONG Zi-Jing LU Ming-Xing YANG Zhong-Lin LI Ping State Key Laboratory of Natural Medicines China Pharmaceutical University School of pharmacy Nanjing University of Chinese Medicine Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University The People's Hospital of Zhangqiu City

AIM: To investigate the absorption characteristics of the total alkaloids from Mahoniae Caulis(TAMC) through the administration of monterpene absorption enhancers or protein inhibitors. METHOD: The absorption behavior was investigated in an in situ single-pass intestinal perfusion(SPIP) assay in rats. RESULTS: The intestinal absorption of TAMC was much more than that of a single compound or a mixture of compounds(jatrorrhizine, palmatine, and berberine). Promotion of absorption by the bicyclic monoterpenoids(borneol or camphor) was higher than by the monocyclic monoterpenes(menthol or menthone), and promotion by compounds with a hydroxyl group(borneol or menthol) was higher than those with a carbonyl group(camphor or menthone). The apparent permeability coefficient(Papp) of TAMC was increased to 1.8-fold by verapamil, while it was reduced to one half by thiamine. The absorption rate constant(Ka) and Papp of TAMC were unchanged by probenecid and pantoprazole. CONCLUSION: The intestinal absorption characteristics of TAMC might be passive transport, and the intestinum tenue was the best absorptive site. In addition, TAMC might be likely a substrate of P-glycoprotein(P-gp) and organic cation transporters(OCT), rather than multidrug resistance protein(MRP) and breast cancer resistance protein(BCRP). Compared with a single compound and a mixture of compounds, TAMC was able to be absorbed in the blood circulation effectively.

关键词： Mahoniae Caulis Total alkaloids In situ single-pass intestinal perfusion Absorption enhancers Protein inhibitors

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-cui Mao Hui-Lin Jiang Bao-Xia dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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BacTAlert240全自动血培养仪病原菌分布与药敏分析

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医学检验与临床 2010年第5期21卷 31-33页

作者：崔东岚广东省佛山市第一人民医院广东佛山528000

目的了解血培养阳性常见病原菌分布及其耐药情况,为临床正确选用抗生素提供依据.方法用BacT/Alert 240全自动血培养仪对4458份血液标本进行检测,用VITEK-32鉴定系统对细菌进行鉴定,药敏试验采取K-B纸片扩散法按CLSI 规定的标准进行.结... 详细信息

目的了解血培养阳性常见病原菌分布及其耐药情况,为临床正确选用抗生素提供依据.方法用BacT/Alert 240全自动血培养仪对4458份血液标本进行检测,用VITEK-32鉴定系统对细菌进行鉴定,药敏试验采取K-B纸片扩散法按CLSI 规定的标准进行.结果从4458份血培养中共检出430株病原菌,阳性率为8.8%.主要致病菌有凝固酶阴性葡萄球菌、大肠埃希菌、金黄色葡萄球菌、肺炎克雷伯菌、铜绿假单胞菌5种,占菌株总检出率59%,其中耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）占凝固酶阴性葡萄球菌的70.8%,耐甲氧西林金黄色葡萄球菌（MRSA）占金黄色葡萄球菌的43.2%,未发现耐万古霉素的葡萄球菌.大肠埃希菌和肺炎克雷伯菌产超广谱β-内酰胺酶（ESBLs）的菌株分别为46.7%和28.3%.结论血培养中病原菌复杂多样,耐药率高及时检测血液中病原菌的耐药性对于指导临床合理用药,防止滥用抗生素减少耐药菌株的产生是十分必要的.

关键词：血培养主要病原菌药敏试验

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自拟温经疏肝活血通络汤对原发性痛经患者血清前列腺素、β-内啡肽水平的影响研究

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中国医药指南 2020年第12期18卷 27-29页

作者：董翠兰济南市章丘区人民医院山东济南250200

目的探讨温经疏肝活血通络汤治疗原发性痛经对血清前列腺素、β-内啡肽水平的影响。方法选取我院(2017年2月至2019年11月)收治的发性痛经患者108例,均表现为不同程度的经前或经期下腹阵发性或持续性疼痛,根据不同治疗分为两组,对照组(n=... 详细信息

目的探讨温经疏肝活血通络汤治疗原发性痛经对血清前列腺素、β-内啡肽水平的影响。方法选取我院(2017年2月至2019年11月)收治的发性痛经患者108例,均表现为不同程度的经前或经期下腹阵发性或持续性疼痛,根据不同治疗分为两组,对照组(n=54)接受益母草冲剂治疗,观察组(n=54)接受温经疏肝活血通络汤治疗,两组患者均连续治疗3个月经周期。对比两组患者临床疗效和治疗前后血清前列腺素[前列腺素F2α(PGF2α)、前列腺素E2(PGE2)]、β-内啡肽(β-EP)水平、痛经情况以及不良反应(消化不良、厌食、恶心呕吐)发生情况。结果观察组患者总有效率为94.44%(51/54),对照组患者总有效率为77.78%(42/54),两组患者临床疗效对比差异明显(χ^2=11.6028,P0.05)。结论温经疏肝活血通络汤治疗原发性痛经对血清前列腺素、β-内啡肽水平具有显著的改善作用,可有效缓解痛经症状,该方还具有较高安全性,值得临床推广。

关键词：温经疏肝活血通络汤原发性痛经血清前列腺素 β-内啡肽痛经症状安全性

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6×29Fi钢丝绳股用钢丝直径比的计算

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金属制品 2010年第6期36卷 14-16页

作者：曹玉德董翠兰宁夏石嘴山市河滨工业园宁夏石嘴山753200 宁夏恒力钢丝绳股份有限公司宁夏石嘴山753202

对6×29Fi钢丝绳股进行几何分析,利用余弦定理、正弦定理、同心层钢丝螺旋捻角公式、同心层钢丝螺旋半径公式计算出该股不同层钢丝的捻角与螺旋半径,并根据钢丝椭圆任意半径公式计算出捻制状态下钢丝椭圆截面切点处相应曲率半径,最终得... 详细信息

对6×29Fi钢丝绳股进行几何分析,利用余弦定理、正弦定理、同心层钢丝螺旋捻角公式、同心层钢丝螺旋半径公式计算出该股不同层钢丝的捻角与螺旋半径,并根据钢丝椭圆任意半径公式计算出捻制状态下钢丝椭圆截面切点处相应曲率半径,最终得出:未捻制状态下,由内向外各层钢丝直径比为1.435 4∶1.099 9∶0.434 4∶1;捻制状态下,由内向外各层钢丝直径比为1.538 9∶1.150 3∶0.453 4∶1;给出精确计算后股捻距倍数为7.0,7.5,8.0,8.5,9.0,9.5时各层钢丝直径比,用于钢丝绳配丝计算及生产。

关键词：钢丝绳结构曲率半径螺旋半径捻角配丝计算

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-dong Qian Qiao Gao Sheng-lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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粪肠球菌的临床分布及耐药性探讨

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实用医技杂志 2007年第31期14卷 4283-4284页

作者：崔东岚马均宝佛山市第一人民医院广东佛山528000

目的:本文旨在了解粪肠球菌在临床上分布特点,分析其对16种常用抗生素的耐药特点,指导临床合理选用抗生素。方法:采用全自动微生物鉴定仪VITEK-32鉴定系统,对临床标本中分离出的242株粪肠球菌进行鉴定,使用K-B法对242株粪肠球菌进行药... 详细信息

目的:本文旨在了解粪肠球菌在临床上分布特点,分析其对16种常用抗生素的耐药特点,指导临床合理选用抗生素。方法:采用全自动微生物鉴定仪VITEK-32鉴定系统,对临床标本中分离出的242株粪肠球菌进行鉴定,使用K-B法对242株粪肠球菌进行药敏试验,对其药敏数据进行统计分析。结果:在242株粪肠球菌中,泌尿系统感染最高(50.7%),其次为腹腔胆道感染(20.4%)、伤口感染(16.5%)、其他感染(12.4%);肠球菌耐药率最低者为替考拉宁(0%),其次为万古霉素(2%)、左旋氧氟沙星(11.1%)、呋喃妥因(11.5%);最高是头孢唑啉(100%),其次为复方新诺明(97.5%)、丁胺卡那霉素(95%)、克林霉素(94.6%)。结论:粪肠球菌是泌尿道、腹腔、胆道等感染的重要病原菌,且在医院感染的重要性越来越受到临床的重视,在抗感染治疗时应根据药敏试验的实际情况综合临床各方面资料,合理选用抗生素,减少耐药菌株的产生和耐药基因的传播。

关键词：粪肠球菌药敏试验耐药性院内获得性感染

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Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel dong Jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Acid-base Hybrid membrane Proton conductivity Polymer electrolyte fuel cell Single-cell performance

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绿色高效合成特殊异氰酸酯TMXDI前体——四甲基间苯二亚甲基二氨基甲酸酯

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科学技术与工程 2017年第2期17卷 243-246,266页

作者：雒冬梅崔建兰孟建杨帆李修冒孟洋中北大学化工与环境学院太原030051 蓬莱华美精细化工有限公司蓬莱265600

四甲基间苯二亚甲基二氨基甲酸酯(TMXDU)是合成特殊异氰酸酯四甲基间苯二亚甲基二异氰酸酯(TMXDI)的中间体。TMXDI是一种低毒特异的二异氰酸酯,具有脂肪族和芳香族两者异氰酸酯的特性,其制备的弹性体柔软,具有较高的强度、黏附力、外观... 详细信息

四甲基间苯二亚甲基二氨基甲酸酯(TMXDU)是合成特殊异氰酸酯四甲基间苯二亚甲基二异氰酸酯(TMXDI)的中间体。TMXDI是一种低毒特异的二异氰酸酯,具有脂肪族和芳香族两者异氰酸酯的特性,其制备的弹性体柔软,具有较高的强度、黏附力、外观、柔韧性和耐久性。TMXDI可以通过热裂解TMXDU来合成。采用氨基甲酸甲酯(MC)和1,3-二异丙烯基苯(DIPEB)为原料,在对甲苯磺酸催化下制备TMXDU。通过单因素实验,研究了反应温度、反应时间、原料配比、催化剂种类、及催化剂用量对TMXDU收率的影响。其最佳工艺条件为,反应温度为130℃,反应时间7 h,n_(MC)∶n_(DIPEB)=10∶1,对甲苯磺酸用量为DIPEB的3 mol%时,TMXDU收率可以达到87.6%。

关键词：四甲基间苯二亚甲基二异氰酸酯氨基甲酸甲酯 1,3-二异丙烯基苯四甲基间苯二亚甲基二氨基甲酸酯对甲苯磺酸

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Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao Zou Yanwu dong Zhouhua Jiang Shuyang Du Yushuo Li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

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