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BEARS:Radioactive Ion Beams Experiment at Berkeley

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BEARS:Radioactive Ion Beams Experiment at Berkeley

correlation of climatic events between East Asia and Norwegian Sea during last deglaciation

ccAST“放射性束物理”研讨会

作者： X.J.Xu. J Powell R.Josten c.A donahue R.F.Fairchild F.Q.Guo P.E Jaustein R,M.Larimer c,M Lyneis P.Mcnahan D.M Moltz E,B Norman J P ONeil M.W.Rowe H.F.Vanbrocklin D.Wutte Z.Q.Xie J,cemy Lawrence Berkeley National Laborqtory USA Institute of Modem Physics chinese Academy of Sciences Brooljanven National Laboratory USA

＜正＞BEARS, or Berkeley Experiments with Accelerated Radioactive Species, is aninitiative to develop a radioactive ion-beam capability at Lawrence Berkeley NationalLaboratory. The basic concept for BEANS involves the coupling of radioisotopeproduction at an existing medical cyclotron with post-acceleration by the 88”cyclotron. These accelerators are separated by distance of about 350 *** be transported between the two via a gas-jet capillary（Fig.1）

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Science china Earth Sciences 1997年第5期40卷 496-501页

作者：周卫建安芷生 S.c.Porter D.donahue A.J.T.Jull Department of Geology Northwest University Xi'an 710069 China State Key Laboratory of Loess and Quaternary Geology Chinese Academy of Sciences Xi'an 710054 China Quaternary Research center University of Washington Seattle 98195 USA NSF-AMS-Facility University of Arizona Tucson 85721 USA

Using a high resolution 14c chronology, Sl c values and organic carbon content, from loess/paleosol and peat profiles in china, we can demonstrate century scale warm-cold East Asian monsoon paleoclimatic fluctuation events and significant precipitation variability within the last deglaciation. The major climatic events recognized are the Boiling (1 300-12 500 a B. P.), Older Dryas (12 500-11 750 a B. P. ), Allerod (11 750-11 200 a B. P.) and Younger Dryas (11 200-10 000 a B.P. ). The stratigraphic structure of the last deglaciation sediments is characterized by frequent changes in sedimentation phases reflecting climatic instability. These high frequency, rapid climatic events can correlate with fluctuations recorded by sea surface temperatures in the Norwegian Sea. This indicates a pale-oclimate teleconnection between polar, high latitude areas and East Asian monsoon areas through westerlies and the related atmospheric pressure system.

关键词： last rieglaciation East Asian monsoon paleoclimatic fluctuation loess-paleosol

基于自旋标记MR成像原理无创性显示淋巴液流动评估淋巴水肿的临床可行性

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国际医学放射学杂志 2014年第1期 81-81页

作者： S.Rane P.M.c.donahue T.Towse S.Ridner M.chappell J.Jordi 魏榕辰 Department of Radiology and Radiological Sciences Vanderbilt University 1161 21st Ave South

目的将常用于血液流动测量的无创性动脉自旋标记MRI扩展到淋巴流动评估。方法所有志愿者均按伦理委员会和HIPAA规定签署知情同意书。在3.0 T设备上测定

关键词：自旋标记动脉淋巴液淋巴水肿象皮肿淋巴疾病 MR 无创性

Preliminary study on radiocarbon AMS dating of pollen

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Science china Earth Sciences 1999年第5期42卷 524-530页

作者：周卫建周杰萧家仪 D.donahue A.J.T.Jull NSF-AMS Facility University of Arizona

17 samples were collected from aeolian and lacustrine profiles within the environment sensitive zone of the Loess Plateau, and an experimental method was established which is suitable for pollen extraction from aeolian sediment. A comparative study of pollen dating was carried out using the accelerator mass spectrometry (AMS)14c dating of known age samples, and then an experiment with the pollen concentrates was performed. The results indicate that pollen that has been deposited simultaneously with sediment in a stable environment can provide reliable ages. This technique will provide a way of improving the chronological framework for the Loess Plateau since the late Pleistocene. TheI4c dating was combined with field investigations, and from the geological record within this zone, evidence was extracted of four major monsoon precipitation changes during the transition from the late Pleistocene to Holocene.

关键词： pollen concentrates AMSl4c dating, paleomonsoon precipitation environment sensitive zone

南海全新世珊瑚礁AMS^(14)c,^(230)Th/^(234)U和ESR年龄的对比研究

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海洋科学 1993年第2期17卷 63-65页

作者：业渝光 D.J.donahue 地质矿产部海洋地质研究所青岛266071 美国亚利桑那大学

用^(14)c(AMS和稀释技术),铀系和ESR方法对南海珊瑚礁进行了测年对比研究,表明这些珊瑚礁形成于全新世早、中期。此外,对测年方法的一些有关问题也进行了讨论。

关键词：珊瑚礁 AMS^14c ESR 铀系年龄

A targetable pathway to eliminate TRA-1-60^(+)/TRA-1-81^(+)chemoresistant cancer cells

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Journal of Molecular cell Biology 2023年第6期15卷 25-39页

作者： Lei Tan Xiaohua Duan Pratyusha Mutyala Ting Zhou Sadaf Amin Tuo Zhang Brian Herbst Gokce Askan Tomer Itkin Zhaoying Xiang Fabrizio Michelassi Michael D.Lieberman christine AIacobuzio-donahue Steven DLeach Todd Evans Shuibing chen Department of Surgery Weill Cornell MedicineNew YorkNY 10065USA center for Energy Metabolism and Reproduction Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China center for Genomic Health Weill Cornell MedicineNew YorkNY 10065USA The SKI Stem cell Research Facility The Center for Stem Cell Biology and Developmental Biology ProgramMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Genomic Resource core Facility Weill Cornell Medical CollegeNew YorkNY 10065USA Rubenstein center for Pancreatic cancer Research Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Division of Regenerative Medicine Hartman Institute for Therapeutic Organ RegenerationAnsary Stem Cell InstituteDepartment of MedicineWeill Cornell MedicineNew YorkNY 10065USA Dartmouth cancer center Darmouth CollegeHanoverNH 03755USA

chemoresistance is a primary cause of treatment failure in pancreatic *** cell surface markers specifically expressed in chemoresistant cancer cells(cccs)could facilitate targeted therapies to overcome *** performed an antibody-based screen and found that TRA-1-60 and TRA-1-81,two‘stemness’cell surface markers,are highly enriched in ***-more,TRA-1-60^(+)/TRA-1-81^(+)cells are chemoresistant compared to TRA-1-60^(-)/TRA-1-81^(-)*** profiling identified UGT1A10,shown to be both necessary and sufficient to maintain TRA-1-60/TRA-1-81 expression and *** a high-content chemical screen,we identified cymarin,which downregulates UGT1A10,eliminates TRA-1-60/TRA-1-81 expression,and increases chemosensitivity both in vitro and in ***,TRA-1-60/TRA-1-81 expression is highly specific in primary cancer tissue and positively correlated with chemoresistance and short survival,which highlights their potentiality for targeted ***,we discovered a novel ccc surface marker regulated by a pathway that promotes chemoresistance,as well as a leading drug candidate to target this pathway.

关键词： pancreatic cancer TRA-1-60/TRA-1-81 chemoresistance UGT1A10 cymarin

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末次冰消期东亚和挪威海气候事件的对比

中国科学（D辑） 1997年第3期27卷 260-264页

作者：周卫建安芷生 S.c.Porter D.donahue A.J.T.Jull 中国科学院黄土与第四纪地质国家重点实验室西安710054 Quaternary Research center University of Washington USA98195 NSF-AMS Facility University of Arizona USA85721

通过对黄土-古土壤和泥炭剖面的高分辨率~14c年代学以及有机质的δ^(13)c值和有机碳百分含量的研究,揭示了末次冰消期百年尺度温暖-寒冷的东亚季风气候颤动事件及其反映的有意义的降水变率.它们由波令(Bolling13～12.5ka BP),老仙女木(O... 详细信息

通过对黄土-古土壤和泥炭剖面的高分辨率~14c年代学以及有机质的δ^(13)c值和有机碳百分含量的研究,揭示了末次冰消期百年尺度温暖-寒冷的东亚季风气候颤动事件及其反映的有意义的降水变率.它们由波令(Bolling13～12.5ka BP),老仙女木(Older Dryas 12.5～11.75ka BP),阿勒鲁德(Allerod 11.75～11.2 ka BP)和新仙女木(Younger Dryas 11.2～10 ka BP)事件构成.其地层结构表现出多种沉积相的变化,反映了气候的不稳定性.这些高频、快速的气候事件可与挪威海海面温度记录的气候事件—一对比.反映了东亚季风气候通过西风带及与其相关的气压系统与极地.高纬地区古气候的遥相关.

关键词：末次冰消期东亚季风气候黄土古土壤古气候

Overexpression of OGFr Downregulates Ovarian cancer cell Proliferation <i>In Vitro</i>and Inhibits Tumorigenesis

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Journal of cancer Therapy 2011年第4期2卷 579-594页

作者： Renee N. donahue Patricia J. McLaughlin Ian S. Zagon 不详

The opioid growth factor (OGF) and its receptor (OGFr) regulate human ovarian cancer cell proliferation through a tonically active inhibitory axis. We investigated the effect of OGFr overexpression on ovarian tumorigenesis. clonal cell lines of SKOV-3 human ovarian cancer were established to stably overexpress OGFr. shRNA constructs were evaluated for antitumor activity in vitro, as well as in vivo using mouse models of s.c. and i.p. tumor transplantation. The 5 clonal cell lines were characterized by increases in OGFr protein (62% to 245%) and binding capacity (51% - 154%), and decreases (36% - 185%) in cell number, relative to untransfected wild-type (WT) cells and empty vector (EV) transfected clones. Nude mice receiving s.c. injection of 2 overexpressing OGFr cell lines (OGFr-3 and OGFr-22) had reduced tumor incidence, delayed tumor appearance (up to 12 days), and decreased tumor volume (up to 87%) relative to WT and EV controls. Mice injected i.p. with these clonal lines displayed reduced formation of tumor nodules (up to 95%), and depressed tumor weights (up to 99%) compared to WT and EV groups. DNA synthesis, but not cell survival, was depressed in cells and s.c. tumors overexpressing OGFr in comparison to the WT and EV groups. Angiogenesis was reduced up to 86% in clonal tumors compared to WT and EV groups. This preclinical evidence demonstrates that OGFr expression is a molecular determinant of ovarian cancer progression, and has important relevance to understanding the pathogenesis and treatment of this deadly disease.

关键词： cell Proliferation Opioids [Met5]-Enkephalin OGF OGFr Ovarian cancer

The cosmic Perspective

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