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Postural instability after lumbar spinal surgery:are there any predictive factors? A case control study

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Chinese Neurosurgical Journal 2019年第1期5卷 1-5页

作者： domenico Chirchiglia Pasquale Chirchiglia domenico Murrone department of Neurosurgery University of CatanzaroCampus GermanetoVLE Europa88100 CatanzaroItaly department of Neurosurgery Divenere Hospital70121 BariItaly

Background:The surgical spinal degenerative pathology mainly concerns the herniated intervertebral *** is indicated when the pain becomes chronic and intense,and when motor signs *** results are positive in about 90%of cases,leading to the solution of the ***,an estimated percentage of 4%to 20%reported residual pain and postural instability after the surgical treatment of ***:We have examined a sample of patients,retrospectively registered,undergoing surgical treatment for degenerative lumbar *** of them developed postural *** were subjected to cycles of postural *** gymnastics has proved to be a tool capable of solving unstable post-surgical *** included an exercise of breathing,one or two of muscular distension,one of muscular reinforcement,and one of postural *** used an evaluation form we created in agreement with the physiatrist for postural exercises that was based on some basic parameters such as muscle and respiratory *** each cycle,a score was attributed to the performance of muscular and respiratory exercise to evaluate the function and therefore the degree of instability(1–3=mild,4–7=medium,8–10=severe).Results:Results were satisfactory,with return to normal *** improvement of postural instability has been demonstrated both by the score of the evaluation forms that have highlighted the transition from a state of severe intensity to one of normality and by a clinical aspect,concerning the static and dynamic ***:The postural instability has a multifactorial genesis,and different mechanisms are involved:the vertebral bone structures and the pelvis,the paraspinal muscular structures,and the nerve *** structures are altered after surgery due to predisposing factors,and for the action of conditions acquired as obesity.

关键词： Spine disease Lumbar pain Postural instability

Optical coherence tomography angiography in retinal cavernous hemangioma

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1945-1946页

作者： Gilda Cennamo Francesca Amoroso domenico Solari Mariacristina Alfier Giuseppe de Crecchio Eye Clinic Department of Public HealthUniversity of Naples Fedefico IINaples 80100Italy Eye Clinic Department of NeurosciencesReproductive Sciences and DentistryUniversity of Naples Federico IINaples 80100Italy division of Neurosurgery Department of NeurosciencesReproductive Sciences and DentistryUniversity of Naples Federico IINaples 80100Italy UOC Ophthalmology Pellegrini Hospital Naples 80100Italy

Citation： Cennamo G, Amoroso F, Solari d, Alfieri MC, de Crecchio G. Optical coherence tomography angiography in retinal cavernous hernangioma, lnt J Ophthalmol 2017; 10（12）： 1945-1946

关键词： Figure Optical coherence tomography angiography in retinal cavernous hemangioma

diagnostic accuracy of enhanced liver fibrosis test to assess liver fibrosis in patients with chronic hepatitis C

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Hepatobiliary & Pancreatic diseases International 2013年第5期12卷 500-507页

作者： Roberto Catanzaro Michele Milazzo Silvia Arona Chiara Sapienza dario Vasta domenico Arcoria Francesco Marotta department of Medical and Pediatric Sciences Institute of Internal Medicine "A. Francaviglia"Section of Gastro-enterologyUniversity of Catania"G. Rodolico" Hospital Laboratory analysis "MedLab-Analisi Cliniche" Specialist in diabetes and metabolic diseases ReGenera Research Group for Aging Intervention

BACKGROUNd:The prognosis and clinical management of patients with chronic liver diseases are closely related to the severity of liver *** biopsy is considered the gold standard for the staging of liver ***,it is an invasive test sometimes related to *** study aimed to assess the diagnostic value of enhanced liver fibrosis(ELF) test to predict liver fibrosis in patients with chronic hepatitis ***:This study included 162 patients with liver disease and 67 healthy *** acid,tissue inhibitor of matrix metalloproteinase type 1,and amino-terminal propeptide type III procollagen were measured by enzymelinked immunosorbent assay with the ELF test AdVIA Centaur(Siemens Healthcare diagnostics Inc.).Fibrosis stage was determined using the Metavir scoring ***:In our study,for the diagnosis of significant fibrosis(Metavir F≥2) a cut-off value >7.72 provides a sensitivity of 93.0% and a specificity of 83.0%.The areas under the receiver operator characteristic curve,sensitivity,specificity,and positive and negative predictive values were 0.94,93.3%,81.0%,93.3%,and 81.0%,respectively(Pdiagnosis of cirrhosis(Metavir F=4) a cut-off value >9.3 provides a sensitivity of 93.0% and a specificity of 86.0%.The areas under the receiver operator characteristic curve,sensitivity,specificity,and positive and negative predictive values were 0.94,79.1%,90.8%,75.6%,and 92.3%,respectively(Pd for assessing liver fibrosis in patients with chronic hepatitis *** is effective in the diagnosis of both fibrosis and cirrhosis.

关键词： enhanced liver fibrosis test non-invasive diagnosis liver fibrosis blood marker

Event Scenario Analysis for the design of Rockslide Countermeasures

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Journal of Mountain Science 2014年第6期11卷 1521-1530页

作者： GIGLI Giovanni INTRIERI Emanuele LOMBARdI Luca NOCENTINI Massimiliano FROdELLA William BALdUCCI Marco VENANTI Luca domenico CASAGLI Nicola department of Earth Science University of Studies of Florence Area Progetto Associati Studio Geologi Associati

The Torgiovannetto quarry(Assisi municipality,central Italy) is an example of a site where the natural equilibrium was altered by human activity,causing current slope instability phenomena which threaten two roadways important for the local *** quarry front,having a height of about 140 m,is affected by a 182,000 m3 rockslide developed in intensely fractured limestone and is too large to be *** 2003 some tension cracks were detected in the vegetated area above the quarry upper *** then on,several monitoring campaigns were carried out by means of different instrumentations(topographic total station,extensometers,inclinometers,ground-based interferometric radar,laser scanner and infrared thermal camera),allowing researchers to accurately define the landslide area and *** latter's major displacements are localized in the eastern *** deformational field appears to be related to the seasonal *** landslide hazard associated with the worst case scenario was evaluated in terms of magnitude,intensity and triggering *** the definition of the possible runout process the dAN 3d code was *** simulation results were used in order to design and construct a retaining ***,in order to preserve both the safety of the personnelinvolved in its realization and of the roadways users,an early warning system was *** early warning system is based on daily-averaged displacement velocity *** alarm level is reached if the prediction based on the methods of Saito(1969) and Fukuzono(1985) forecasts an imminent rupture.

关键词： Risk scenarios Risk management Landslides Monitoring Rock avalanche

Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells

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World Journal of Gastroenterology 2020年第33期26卷 4900-4918页

作者： Michela Anna Polidoro Joanna Mikulak Valentina Cazzetta Ana Lleo domenico Mavilio Guido Torzilli Matteo donadon Hepatobiliary Immunopathology Laboratory Humanitas Clinical and Research Center–IRCCSRozzano 20089MilanItaly Laboratory of Clinical and Experimental Immunology Humanitas Clinical and Research Center-IRCCSRozzano 20089MilanItaly department of Medical Biotechnologies and Translational Medicine(BioMeTra) University of MilanRozzano 20089MilanItaly department of Biomedical Science Humanitas UniversityPieve Emanuele 20090MilanItaly department of Internal Medicine Humanitas Clinical and Research Center–IRCCSRozzano 20089MilanItaly department of Hepatobiliary and General Surgery Humanitas Clinical and Research Center-IRCCSRozzano 20089MilanItaly

In the last years,several studies have been focused on elucidate the role of tumor microenvironment(TME)in cancer development and *** TME,cells from adaptive and innate immune system are one of the main abundant *** dynamic interactions between immune and cancer cells lead to the activation of complex molecular mechanisms that sustain tumor *** important cross-talk has been elucidate for several kind of tumors and occurs also in patients with liver cancer,such as hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA).Liver is well-known to be an important immunological organ with unique ***,in normal conditions,the rich immune-infiltrating cells cooperate with non-parenchymal cells,such as liver sinusoidal endothelial cells and Kupffer cells,favoring self-tolerance against gut *** presence of underling liver immunosuppressive microenvironment highlights the importance to dissect the interaction between HCC and iCCA cells with immune infiltrating cells,in order to understand how this cross-talk promotes tumor *** attention is,in fact,focused on immune-based therapy for these tumors,as promising approach to counteract the intrinsic anti-tumor activity of this *** this review,we will examine the key pathways underlying TME cell-cell communications,with deeper focus on the role of natural killer cells in primary liver tumors,such as HCC and iCCA,as new opportunities for immune-based therapeutic strategies.

关键词： Primary liver cancer Natural killer cells Tumor microenvironment Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Immune cells

Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction

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Journal of Geriatric Cardiology 2015年第4期12卷 346-352页

作者： Flora Pirozzi AntoneUa Paglia Laura Sasso Pasquale Abete Angelo Carlomagno Carlo G Tocchetti domenico Bonaduce Mario Petretta department of Translational Medical Sciences Section of Internal Medicine Federico Ⅱ University Naples ltaly

Objective doppler derived mitral peak early diastolic filling velocity to deceleration time ratio （E/dT） has been proposed as parameter for predicting prognosis in general population. This study prospectively investigates the incremental prognostic value of E/dT over clinical, conven- tional eehocardiographic and mitral-doppler variables in patients hospitalized for decompensated heart failure （HF）. Methods We analyzed 95 HF patients （mean age 64.8 ± 12.2 years） hospitalized at our institution from January 2010 to March 2012. The primary end-point was cardiac death or hospitalization, whichever occurred first. Cox regression analysis was performed to identify significant predictors of outcomes. Results during follow-up （median 37.7 months） 13 patients died and 44 were hospitalized for a cardiac event. At univariable analysis, New York Heart Association （NYHA） functional class, furosemide dosage, lateral tricuspidal annular plane systolic excursion, deceleration lime and E/dT were predictive of outcome. At multivariable analysis, E/dT was the only predictor of prognosis （hazard ratio = 1.02, P = 0.018）, giving incremental prognostic information to clinical and other echocardio-graphic measures （global chi-square from 15.4 to 25.2; P = 0.032）. Conclusions FJdT gives independent and incremental prognostic information in HF patients.

关键词： Echocardiographic evaluation Left venlricular function Risk stratification

Estrogens and the pathophysiology of the biliary tree

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World Journal of Gastroenterology 2006年第22期12卷 3537-3545页

作者： domenico Alvaro Maria Grazia Mancino Paolo Onori Antonio Franchitto Gianfranco Alpini Heather Francis Shannon Glaset Eugenio Gaudio division of Gastroenterology University of Rome "La Sapienza"RomeItaly University of Rome "La Sapienza"Polo PontinoLatinaItaly division of Gastroenterology University of Rome "La Sapienza"RomeItaly department of Experimental Medicine Section of Human and Clinical Anatomy State University of L'AquilaL'AquilaItaly department of Anatomy University of Rome "La Sapienza" RomeItaly department of Medicine The Texas A&M University System Health Science Center College of Medicine Scott & White HospitalTempleTX 76504United States ResearchCentral Texas Veterans Health Care SystemScott & White HospitalTempleTX 76504United States Systems Biology and Translational MedicineThe Texas A&M University System Health Science Center College of MedicineTX 76504United States division of R&E Scott & White Hospital TempleTX 76504United States Eugenio Gaudio department of Anatomy University of Rome "La Sapienza"RomeItaly

The scientific framework concerning estrogen effects on different tissues has expanded enormously during the last decades, when estrogen receptor （ER） subtypes were identified. Estrogens are not only essential for the female reproductive system, but they also control fundamental functions in other tissues including the cardiovascular system, bone, brain and liver. Recently, estrogens have been shown to target the biliary tree, where they modulate the proliferative and secretory activities of cholangiocytes, the epithelial cells lining bile ducts. By acting on both estrogen receptors （ER-α） and （ER-β） subtypes, and by activating either genomic or non-genomic pathways, estrogens play a key role in the complex loop of growth factors and cytokines, which modulates the proliferative response of cholangiocytes to damage. Specifically, estrogens activate intracellular signalling cascades JERK1/2 （extracellular regulated　kinases 1/2, PI3-kinase/AKT （phosphatidylinositol-3＇ kinase/AKT）] typical of growth factors such as insulin like growth factor （IGF1）, nerve growth factor （NGF） and vascular endothelial growth factor （VEGF）, thus potentiating their action. In addition, estrogens stimulate the secretion of different growth factors in proliferating cholangiocytes. This review specifically deals with the recent advances related to the role and mechanisms by which estrogens modulate cholangiocyte functions in normal and pathological conditions.

关键词： Estrogens Cholangiocytes IGF1 Proliferation APdKd PBC Cholangiocarcinoma SERMs

Cholangiocytes and blood supply

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World Journal of Gastroenterology 2006年第22期12卷 3546-3552页

作者： Eugenio Gaudio Antonio Franchitto Luigi Pannarale Guido Carpino Gianfranco Alpini Heather Francis Shannon Glaser domenico Alvaro Paolo Onori department of Human Anatomy University of Rome "La Sapienza" RomeItaly Central Texas Veterans Health Care System and department of Medicine and Systems Biology and Translational Medicine College of MedicineTempleTXUnited States division of Research and Education Scott & White Hospital and The Texas A&M University System Health Science Center College of MedicineTempleTXUnited States department of Medicine and division of Research and Education Scott & White Hospital and The Texas A&M University System Health Science Center College of MedicineTempleTXUnited States division of Gastroenterology University of Rome "La Sapienza" RomeItaly University of Rome "La Sapienza" Polo PontinoLatinaItaly department of Experimental Medicine Section of Human and Clinical Anatomy State University of L'AquilaL'AquilaItaly

The microvascular supply of the biliary tree, the peribiliary plexus （PBP）, stems from the hepatic artery branches and flows into the hepatic sinusoids. A detailed three-dimensional study of the PBP has been performed by using the Scanning Electron Microscopy vascular corrosion casts （SEMvcc） technique. Considering that the PBP plays a fundamental role in supporting the secretory and absorptive functions of the biliary epithelium, their organization in either normalcy and pathology is explored. The normal liver shows the PBP arranged around extra-and intrahepatic biliary tree. In the small portal tract PBP was characterized by a single layer of capillaries which progressively continued with the extrahepatic PBP where it showed a morecomplex vascular network. After common duct ligation （BdL）, progressive modifications of bile duct and PBP proliferation are observed. The PBP presents a three-dimensional network arranged around many bile ducts and appears as bundles of vessels, composed by capillaries of homogeneous diameter with a typical round mesh structure. The PBP network is easily distinguishable from the sinusoidal network which appears normal. Considering the enormous extension of the PBP during BdL, the possible role played by the Vascular Endothelial Growth Factor （VEGF） is evaluated. VEGF-A,VEGF-C and their related receptors appeared highly immunopositive in proliferating cholangiocytes of BdL rats. The administration of anti-VEGF-A or anti-VEGF-C antibodies to BdL rats as well as hepatic artery ligation induced a reduced bile duct mass. The administration of rVEGF-A to BdL hepatic artery ligated rats prevented the decrease of cholangiocyte proliferation and VEGF-A expression as compared to BdL control rats. These data suggest the role of arterial blood supply of the biliary tree in conditions of cholangiocyte proliferation, such as it occurs during chronic cholestasis. On the other hand,the role played by VEGF as a tool of cross-talk between cholangiocytes

关键词： Peribiliary plexus Periportal plexus Cholangiocytes

Ultra-deep carbonate basement reservoirs formed by polyphase fracture-related karstification in the Offshore Bohai Bay Basin, China

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Petroleum Science 2023年第4期20卷 2009-2025页

作者： Jian Luo Hai-Yang Cao domenico Chiarell Ru-Lin Miao Tao Ye Yun-Long Xu An-Qing Chen Xiao-Ping Luo State Key Laboratory of Oil&Gas Reservoir Geology and Exploration(Chengdu University of Technology) ChengduSichuan610059China Key Laboratory of deep-time Geography and Environment Reconstruction and Applications MNR&Institute of Sedimentary GeologyChengdu University of TechnologyChengduSichuan610059China department of Earth Sciences Royal Holloway University of LondonSurreyTW200EXUnited Kingdom Tianjin Branch of China National Offshore Oil Company Ltd. Tianjin300452China Exploration and development Research Institute Zhongyuan Oilfield CompanySINOPECPuyangHenan457001China

The Palaeozoic carbonate basement of the Offshore Bohai Bay Basin (OBBB) presents considerable potential for hydrocarbon exploration. However, the multistage tectonism and complex superimposed palaeo-karstification in the area are unclear, which leads to a lack of understanding on the formation mechanism and distribution of the deep carbonate basement reservoirs. In this study, the occurrence of a fracture-vug network and its fillings in carbonate reservoirs were investigated based on borehole cores, thin sections, and image logs from the southwestern slope of the OBBB's Bozhong Sag. Then the diagenetic fluid properties of the carbonate matrix and fillings were analysed via the data of carbon, oxygen, and strontium isotopes, and major, rare elements from coring intervals. The results revealed that fracture-related karst reservoirs have lithologic selectivity inclined toward dolomite strata. The intersecting relationships, widths, and strikes of the fractures and the regional tectonic background indicate three structural fracture families: NW-, NNE-, and NNW- trending, related to the Indosinian, middle Yanshanian, and late Yanshanian orogeny, respectively. The Indosinian NW- and end-Mesozoic NNE-trending fractures produced by compressional tectonic stress mainly contributed to the formation of the basement reservoirs. The geochemistry of the calcite veins filling these fractures suggests two main types of diagenetic fluids. The fluid of autogenic recharge related to the earlier fills is karstification diffuse flow dominated by internal runoff from rainfall in the highland setting of the Indosinian thrusting orogenic belt. The other fluid of allogenic recharge related to the later fills is the main lateral freshwater flow dominated by external runoff from the catchment in the setting of the horst-lowland within the rifting basin, induced by the Yanshanian destruction of the North China Craton. Finally, the relationship between the three fracture families and two kinds

关键词： Carbonate basement reservoirs Buried hill diagenetic fluid Fracture system Karstification Bohai bay basin