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The role of the T follicular helper cells in allergic disease

Cellular & Molecular Immunology 2012年第5期9卷 386-389页

作者： dm kemeny Department of Microbiology and Immunology Programme National University of Singapore Singapore

T follicular helper （Tfh） cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 （Th2） effector cells.

关键词： allergy asthma IgE follicular helper T cells

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Anterior segment parameters associated with extramuscular manifestations in polymyositis and dermatomyositis

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1443-1450页

作者： Zoltan Griger Katalin Danko Gabor Nemeth Ziad Hassan Zsuzsa Aszalos Katalin Szabo Levente Bodoki Rudolf Gesztelyi Judit Zsuga Peter Szodoray Adam kemeny-Beke Division of Clinical Immunology Faculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Ophthalmology Faculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Ophthalmology Borsod-Abauj-Zemplen County Hospital and University Teaching HospitalMiskolc 3526Hungary Orbi-Dent Refractive Surgery and Medical Center Debrecen 4032Hungary Department of Rheumatology Institute of MedicineFaculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Pharmacology and Pharmacotherapy Faculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Health Systems Management and Quality Management in Health Care Faculty of Public HealthUniversity of DebrecenDebrecen 4032Hungary Department of Immunology RikshospitaletOslo University HospitalOslo 0372Norway

AIM:To evaluate detailed anterior segment parameters of patients with idiopathic inflammatory myopathies(IIM),including polymyositis(PM),and dermatomyositis(dm),and to clarify the associations between these data and clinical variables of ***:Totally 57 PM,41 dm patients and 62 controls were enrolled in this cross-sectional,observational,case-control *** study participants underwent Pentacam *** investigations consisted of different antibody assays,while extramuscular clinical assessments included Raynaud’s phenomenon,dysphagia,interstitial lung disease,arthritis/arthralgia,and weight *** signs and subjective symptoms of dry eye disease(DED)were also ***:All pachymetric parameters[center,apex,thinnest and maximal keratometry(Kmax)]and corneal volume(CV)of both sides of PM patients proved to be significantly *** pachymetric data were also noticed as significantly decreased compared to those of *** significant differences were traced between anterior segment values and extramuscular manifestations of myositis,largely in case of arthritis/arthralgia and weight loss,whereas associations between anterior segment parameters and antibodies were *** clinical tests of DED were also significantly decreased in IIM ***:The results suggest that all IIM patients have thinner corneas compared with those of controls,and decreased corneal parameters are significantly associated with the occurrence of some extramuscular *** addition,IIM patients tend to develop objective signs of DED.

关键词： dry eye extramuscular manifestations dermatomyositis polymyositis Scheimpflug imaging

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