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Research advances in the treatment of Alzheimer＇s disease with polysaccharides from traditional Chinese medicine

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Chinese Journal of Natural Medicines 2017年第9期15卷 641-652页

作者： LIU Qin WANG Shun-Chun ding kan Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Glycochemistry and Glycobiology Lab Shanghai Institute ofMateria Medica Chinese Academy of Sciences Shanghai 201203China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Receptor Research Shanghai Institute ofMateria Medica Chinese Academy of Sciences Shanghai 201203China

Alzheimer's disease(AD) is a neurodegenerative disorder characterized by the loss of patients' memory and their cognitive abilities and the mechanism is not completely clear. Although a variety of drugs have been approved for the AD treatment, substances which can prevent and cure AD are still in great need. The effect of polysaccharides from traditional Chinese medicine(TCM) on anti-AD has gained great progress and attained more and more attention in recent years. In this review, research advances in TCM-polysaccharides on AD made in this decade are summarized.

关键词： Alzheimer’s disease Polysaccharides Traditional Chinese medicine

Temperature Profile of Black Hole Accretion Disc with Magnetic Coupling

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Communications in Theoretical Physics 2002年第8期38卷 247-252页

作者： LEI Wei-Hua WANG ding-Xiong XIAO kan Department of Physics Huazhong University of Science and Technology Wuhan 430074 China Department of Physics Huazhong University of Science and Technology Wuhan 430074 China Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

Two new mapping relations between the angular coordinate on the black hole (BH) horizon and radialcoordinate on the disc are given according to the requirement of general relativity and Maxwell's equations, and theeffects of magnetic coupling (MC) on temperature of accretion disc are investigated by comparing with pure *** is shown that the MC effects on the temperature profile are related intimately to the BH spin, and the influenceon the peak value of disc temperature based on the modified mapping relations is not as great as that based on thelinear *** peak value and the corresponding radius of peak value ring of disc temperature do not increasemonotonically as the increasing spin of BH, each containing a maximum for the fast-spinning BH. The value ranges ofthe bolometric luminosity and color temperature of the disc are both extended by the MC effects.

关键词： black hole, accretion disc, magnetic coupling

Chemical approaches for the stereocontrolled synthesis of 1,2-cis-β-D-rhamnosides

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Chinese Journal of Natural Medicines 2023年第12期21卷 886-901页

作者： CAI Juntao YUAN Xin KONG Yuanfang HU Yulong LI Jieming JIANG Shiqing DONG Chunhong ding kan Henan Polysaccharide Research Center Henan Key Laboratory of Chinese Medicine for Polysaccharides and Drugs ResearchAcademy of Chinese Medical SciencesHenan University of Chinese MedicineZhengzhou 450046China College of Pharmacy Henan University of Chinese MedicineZhengzhou 450046China Department of Oncology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000China Carbohydrate-Based Drug Research Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

In carbohydrate chemistry,the stereoselective synthesis of 1,2-cis-glycosides remains a formidable *** complexity is comparable to the synthesis of 1,2-cis-β-D-mannosides,primarily due to the adverse anomeric andΔ-2 *** the past decades,to attainβ-stereoselectivity in D-rhamnosylation,researchers have devised numerous direct and indirect methodologies,including the hydrogen-bond-mediated aglycone delivery(HAD)method,the synthesis ofβ-D-mannoside paired with C6 deoxygenation,and the combined approach of 1,2-trans-glycosylation and C2 *** review elaborates on the advancements inβ-Drhamnosylation and its implications for the total synthesis of tiacumicin B and other physiologically relevant glycans.

关键词： Carbohydrate Glycosylation 1,2-cis-Glycoside Stereoselectivity Total synthesis β-Rhamnoside

Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling

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Chinese Journal of Natural Medicines 2020年第5期18卷 345-355页

作者： LI Xue-Ying TAO Hong JIN Can DU Zhen-Yun LIAO Wen-Feng TANG Qing-Jiu ding kan Glycochemistry&Glycobiology Lab Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203University of Chinese Academy of SciencesBeijing 100049China College of Pharmacy Nanchang UniversityNanchang 330006China Institute of Edible Fungi Shanghai Academy of Agricultural ScienceShanghai 201203China

Cordycepin(3′-deoxyadenosine) from Cordyceps militaris has been reported to have anti-tumor effects. However, the molecular target and mechanism underlying cordycepin impeding pancreatic cancer cell growth in vitro and in vivo remain vague. In this study, we reported functional target molecule of cordycepin which inhibited pancreatic cancer cells growth in vitro and in *** was confirmed to induce apoptosis by activating caspase-3, caspase-9 and cytochrome c. Further studies suggested that MAPK pathway was blocked by cordycepin via inhibiting the expression of Ras and the phosphorylation of Erk. Moreover, cordycepin caused S-phase arrest and DNA damage associated with activating Chk2(checkpoint kinase 2) pathway and downregulating cyclin A2 and CDK2 phosphorylation. Very interestingly, we showed that cordycepin could bind to FGFR2(KD = 7.77 × 10-9) very potently to inhibit pancreatic cancer cells growth by blocking Ras/Er K pathway. These results suggest that cordycepin could potentially be a leading compound which targeted FGFR2 to inhibit pancreatic cells growth by inducing cell apoptosis and causing cell cycle arrest via blocking FGFR/Ras/ERK signaling for anti-pancreatic cancer new drug development.

关键词： Cordycepin FGFR2 Apoptosis Pancreatic cancer Ras/Erk

Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through Microbial Metabolite 2-Hydroxybutyric Acid in Obese Mice

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Engineering 2022年第2期8卷 111-122页

作者： Bingbing Li Ying Hong Yu Gu Shengjie Ye Kaili Hu Jian Yao kan ding Aihua Zhao Wei Jia Houkai Li Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China University of Hawaii Cancer Center HonoluluHI 96813USA

Polysaccharides are widely present in herbs with multiple activities,especially immunity regulation and metabolic benefits for metabolic ***,the underlying mechanisms are not well *** metabolomics is increasingly used to investigate systemic effects on the host by iden-tifying metabolites with particular *** study explores the mechanisms underlying the metabolic benefits of Astragalus polysaccharides(APS)by adopting a functional metabolomics *** effects of APS were determined in eight-week high-fat diet(HFD)-fed obese ***,gas chromatography–time-of-flight mass spectrometry(GC–TOFMS)-based untargeted metabolomics was performed for an analysis of serum and liver tissues,and liquid chromatography–tandem mass spectrom-etry(LC–MS/MS)-based targeted metabolomics was *** potential functions of the metabo-lites were tested with in vitro and in vivo models of metabolic *** results first confirmed the metabolic benefits of APS in obese ***,metabolomics analysis revealed that APS supplemen-tation reversed the HFD-induced metabolic changes,and identified 2-hydroxybutyric acid(2-HB)as a potential functional metabolite for APS activity that was significantly decreased by a HFD and reversed by *** study indicated that 2-HB inhibited oleic acid(OA)-induced triglyceride(TG)*** was also found to stimulate the expression of proteins in lipid degradation in hepatocytes and TG lipolysis in 3T3-L1 ***,it was found to reduce serum TG and regulate the proteins involved in lipid degradation in high-fat and high-sucrose(HFHS)-fed *** conclusion,our study demonstrates that the metabolic benefits of APS are at least partially due to 2-HB generation,which modulated lipid metabolism both in vitro and in *** results also highlight that functional metabolomics is practical for investigating the mechanism underlying the systemic benefits of plant polysaccharides.

关键词： Astragalus polysaccharides(APS) Functional metabolomics 2-Hydroxybutyric acid Obesity

A novel heterogalactan from Antrodia camphorata and antiangiogenic activity of its sulfated derivative

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A novel heterogalactan from Antrodia camphorata and antiangi...

Structural characterization of three homogeneous polysaccharides from fruit of Lycium barbarum L.

中国化学会·2016全国多糖研讨会

作者： Yaqi ding Danbi Tian kan ding Glycochemistry and Glycobiology Lab Shanghai Institute of Materia Medica Chinese Academy of Sciences Department of chemical and molecular engineering Nanjing Tech University

Antrodia camphorata, a rare and expensive mushroom native to Taiwan has been considered to own diverse medicinal benefits. To obtain the homogeneous polysaccharide ACW0 and evaluate its biological functions, the lyophilized powders of A. camphorata mycelium were extracted with hot water and purified by anion exchange and gel permeation chromatography. The single symmetrical peak appeared on HPGPC indicated the homogeneous polysaccharide we have got and its molecular weight was also estimated to be 14.5kD a. Based on monosaccharide composition by GC, ACW0 predominantly contained galactose（94.98%）, traces of mannose（2.41%）, and fucose（2.61%）. The polysaccharide was shown to be a mannofucogalactan with a backbone chain of ɑ-D-1,6-linked Gal, nonreducing terminal ɑ-D-Man and ɑ-L-Fuc substituted at O-2 for nearly every six ɑ-D-1,6-linked Gal. The bioactivity study indicated that the native polysaccharide ACW0 had no inhibition on in vitro matrigel tube formation, thereby ACW0 was sulfated, designated as ACW0-Sul, to change its chemical structure. The degree of sulfation was calculated to be 2.43, suggesting that almost every sugar residue was fully sulfated and sulfation position was also determined by the obvious change of chemical shifts in the 13 C NMR *** find that C-2, C-3 and C-4 of 1,6-linked Gal, C-3 and C-4 of 1,2,6-linked Gal were ***, the peaks of terminal Man and Fuc disappeared, which possibly indicated the degradation of them during sulfation. Most importantly, the sulfate derivative ACW0-Sul could disrupt tube formation and inhibit the migration of human microvascular endothelial cells（HMEC-1） dose-dependently. Besides, phosphorylation of Er K and FAK were also significantly inhibited by ACW0-Sul. These results suggested that introduction of sulfate group could enhance the bioactivity of polysaccharide from A. Camphorata and its sulfate derivative could be a potent antiangiogenic inhibitor for anti-cancer therapy.

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Structural characterization of three homogeneous polysacchar...

Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing

中国生物工程学会第十一届学术年会暨2017年全国生物技术大会

作者：周立爽 kan ding School of Pharmacy Zunyi Medical University Glycochemistry and Glycobiology Lab Shanghai Institute of Materia Medica Chinese Academy of Sciences

Lycium barbarum *** been used historically in the countries as antipyretic,nourishing liver and kindy,moistening lung,anti-inflammation and improving eyesight for more than thoustands of ***,three kinds of homogeneous polysaccharides (designated LBP1B-S-2,LBP1B-S-1 and LBP1A1-1) have been fractionated and purified by DEAE-cellulose,Sephacryl S-200 HR and Sephacryl S-300 HR columns from the dried mature fruits of Lycium barbarum L..LBP1B-S-2,an acidic polysaccharide,with an average molecular weight of 60 kD was consisted of rhamnose,galactose,arabinose,glucuronic acid,mannose in the molar ratio of 2:37:57:3:*** on the results of methylation analysis and NMR specturm,LBP1B-S-2 was mainly composed of 1,5-linked Araf,1,3,

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Synthetic and Systems Biotechnology 2023年第1期8卷 11-19页

作者： Lan Jiang Tianji Zhang Hongzhong Lu Saijuan Li kangjie Lv Alex Tuffour Lixin Zhang kan ding Jin-Ping Li Hongmei Li Xueting Liu Department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical UniversityNanjing210093China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China Division of Chemistry and Analytical Science Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market RegulationNational Institute of MetrologyBeijing100029China State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology Shanghai Jiao Tong UniversityShanghai200240China Glycochemistry&Glycobiology Lab Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China International Research Center for Soft Matter Beijing University of Chemical TechnologyBeijing100029China Department of Medical Biochemistry and Microbiology University of UppsalaUppsalaSweden

The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global ***,after more than 2 years,many populations are still under pressure of ***,a broader perspective in developing antiviral strategies is still of great *** by the observed multiple benefits of heparin in the treatment of thrombosis,the potential of low molecular weight heparin(LMWH)for the treatment of COVID-19 have been *** applications found that LMWH decreased the level of inflammatory cytokines in COVID-19 patients,accordingly reducing ***,several in vitro studies have demonstrated the important roles of heparan sulfate in SARS-CoV-2 infection and the inhibitory effects of heparin and heparin mimetics in viral *** clinical observations and designed studies argue for the potential to develop heparin mimetics as anti-SARS-CoV-2 drug *** this review,we summarize the properties of heparin as an anticoagulant and the pharmaceutical possibilities for the treatment of virus infection,focusing on the perspectives of developing heparin mimetics via chemical synthesis,chemoenzymatic synthesis,and bioengineered production by microbial cell *** ultimate goal is to pave the eminent need for exploring novel compounds to treat coronavirus infection-caused diseases.

关键词： Heparin Biosynthesis Biological activities Bio-production

RN1, a novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways

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RN1, a novel galectin-3 inhibitor, inhibits pancreatic cance...