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Nicotine Weakens the Osteogenic Differentiation and Immune Regulation Capabilities of Periodontal Ligament Stem Cells

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Biomedical and Environmental Sciences 2022年第4期35卷 375-379页

作者： ZHANG Lu Dan CUI Shu Yue CHENG Chen ding xiao ling ding Gang School of Stomatology Weifang Medical UniversityWeifang 261053ShandongChina Clinical Competency Training Center Weifang Medical UniversityWeifang 261053ShandongChina

Periodontitis is a chronic inflammatory disease resulting in the loss of periodontal tissues and ultimately teeth,thus posing a substantial public-health burden worldwide[1].With the widespread increase in mesenchymal stem cell(MSC)therapy and the discovery of MSCs in periodontal ligaments[2],periodontal ligament stem cells(PDLSCs)have been used to reconstruct periodontal tissue and repair bone defects[2,3].Furthermore.

关键词： ligament Immune periodontal

Quasi-attractors in a Piece-Wise Smooth Area-Preserving Map

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Chinese Physics Letters 2001年第1期18卷 13-15页

作者： WANG Jian ding xiao-ling WANG Bing-Hong HE Da-Ren Institute of Plasma Physics Chinese Academy of SciencesHefei 230031 Complexity Science Center Yangzhou UniversityYangzhou 225002 CCAST(World Laboratory) P.O.Box 8730Beijin100080 Department of Modern Physics University of Science and Technology ofChinaHefei 230026

In a two-dimensional area-preserving map we found a kind of noninvertibility that is induced by a piece-wise smooth property of the *** can lead to the appearance of such kinds of elliptic islands that attract the iterations from a set of initial values outside themselves,while behaving regularly *** suggest calling such islands quasi-attractors.

关键词： preserving outside elliptic

A Crisis with a Special Scaling Behavior

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Chinese Physics Letters 1999年第3期16卷 167-168页

作者： ding xiao-ling WU Shun-guang YIN Yue-cai HE Da-ren Department of Physics Teachers CollegeYangzhou UniversityYangzhou 225002 Institute of Low Energy Nuclear Physics Beijing Normal UniversityBeijing 100875 Department of Physics Shenyang Teachers CollegeShenyang 110031 CCAST(World Laboratory) P.O.Box 8730Beijing 100080

A kind of crisis with special scaling properties has been observed in a discontinuous *** crisis happens via a collision between a discontinuity of the mapping function and an unstable periodic orbit locating on the basin boundary of the chaotic *** scaling property of the crisis is∝∈-1.8,whereand∈stand for the average characteristic time and the control parameter value crossing the critical point,respectively.

关键词： scaling locating chaotic

Protective effects of MCP-1 inhibitor on a rat model of severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 201-207页

作者： Zhou, Guo-Xiong Zhu, Xue-Juan ding, xiao-ling Zhang, Hong Chen, Jian-Ping Qiang, Hui Zhang, Hai-Feng Wei, Qun Nantong Univ Affiliated Hosp Dept Gastroenterol Nantong 226001 Peoples R China

BACKGROUND: Chemokines and their receptors play key roles in the pathogenesis of acute pancreatitis. This study aimed to establish a rat model of severe acute pancreatitis (SAP) for investigating monocyte chemotactic protein-1 (MCP-1) expression in the pathogenesis of the disease. We assessed the effects of the inhibitor of MCP-1, Bindarit, on SAP and explored the mechanisms underlying SAP. METHODS: Seventy-two Sprague-Dawley rats were randomly divided into a saline control group (group S), an SAP group (group P), and a Bindarit group (group T). The SAP model was induced by retrograde infusion of 4% sodium taurocholate into the bilio-pancreatic duct. Based on the SAP model, Bindarit was injected intraperitoneally in group T, and 0.5% methyl cellulose was injected intraperitoneally in groups S and P. In group S, saline was retrogradely infused into the bilpancreatic duct. Serum amylase levels and the histological changes in the pancreas were assessed at different time-points in each group. Expression of MCP-1 in serum was measured by enzyme-linked immunoadsorbent assay (ELISA). MCP-1 protein and mRNA expression levels were detected by immunohistochemistry, Western blotting, and semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: Serum amylase levels in groups P and T were higher than those in group S. Serum amylase levels were significantly lower in group T than in group P at 6 and 12 hours after operation. The levels of MCP-1 in serum at 6 and 12 hours after operation in group P were significantly higher than in group S, and significantly lower in group T than in group P at 6 and 12 hours after operation. The pathological damage in the pancreas was milder in group T than in group P. MCP-1 protein and mRNA expression levels in the pancreas were higher in groups P and T than in group S. These expression levels were positively correlated with the pathological damage of pancreatic tissues. The activity of MCP-1 in group T was significant

关键词： severe acute pancreatitis monocyte chemotactic protein-1 Bindarit pathogenesis

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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地方师范院校教师教育实践性特征的时代变化

北方民族大学学报（哲学社会科学版） 2019年第6期 160-163页

作者：丁晓玲宁夏教育厅教学研究室

随着教师教育改革的不断深化,传统的刚性教育实践已不适应教师专业发展的要求,新时代对教师提出了新要求,必须强化教育实践的弹性和柔性。教育实践是适应性的教育实践,教师教育的职前职后教育实践都要强化弹性和柔性,增强教师教育的有效... 详细信息

随着教师教育改革的不断深化,传统的刚性教育实践已不适应教师专业发展的要求,新时代对教师提出了新要求,必须强化教育实践的弹性和柔性。教育实践是适应性的教育实践,教师教育的职前职后教育实践都要强化弹性和柔性,增强教师教育的有效性,促进师范生和中小学教师的专业发展。

关键词：教师教育改革教育实践弹性柔性

Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang xiao ding Huang Yunyi Yiyu Liu Jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao Wang Jia Zeng Donglin Gan Kun ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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配电装置中PLC的应用

山东农业大学学报（自然科学版） 2008年第2期39卷 309-314页

作者：丁筱玲赵立新山东农业大学机电学院山东泰安271018

该产品系全国首台采用进口工业可编程序控制器(PLC)和人机屏(GOT)的矿用隔爆型高压真空配电装置,具有独立的高压隔离开关和前级6KV高压电源指示,配套移动变电站采用国际流行的低压侧故障分断高压侧电源的运行模式。该产品既吸纳了国际... 详细信息

该产品系全国首台采用进口工业可编程序控制器(PLC)和人机屏(GOT)的矿用隔爆型高压真空配电装置,具有独立的高压隔离开关和前级6KV高压电源指示,配套移动变电站采用国际流行的低压侧故障分断高压侧电源的运行模式。该产品既吸纳了国际先进的智能化技术和结构形式,又有机地结合了中国煤矿配套电气设备的特性,可与进口变压器和国产变压器配套使用。同时该产品符合GB3836-2000《爆炸性环境防爆电气设备》最新国家标准规定。因此,该产品技术指标、性能和结构等各方面均优于国内同类产品,它为我国煤矿井下提供了一种性能优良、安全可靠的电气设备,是矿山开采业同类产品的最佳选择。

关键词：配电装置压敏电阻器闭锁 PLC