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Immunogenetic basis of chicken’s heterophil to lymphocyte ratio revealed by genome-wide indel variants analysis

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农业科学学报:英文版 2023年第9期22卷 2810-2823页

作者： ZHANG jin WANG Jie WANG Qiao CUI Huan-xian ding Ji-qiang WANG Zi-xuan Mamadou Thiam LI Qing-he ZHAO Gui-ping institute of Animal sciences Chinese Academy of Agricultural SciencesBeijing 100193P.R.China Poultry institute Shandong Academy of Agricultural SciencesJinan 250023P.R.China

Enhancing host immunity is an effective way to reduce morbidity in *** to lymphocyte ratio(H/L)is associated with host disease resistance in *** with different H/L levels show different disease ***,the utility of the H/L as an indicator of immune function needs to be further *** this study,a H/L directional breeding chicken line(jingxing yellow chicken)was constructed,which has been bred for 12.*** compared the function of heterophils,and combined statistical analysis to explore the candidate genes and pathways related to H/*** oxidative burst function of the heterophils isolated from the H/L selection line(G12.was increased(P=0.044)compared to the non-selection line(NS).The 2..44 Mb genomic regions which annotated 300 protein-coding genes were selected in the genome of G9(n=92.compared to NS(n=92.based on a genome-wide selective *** selective regions were identified containing genes like interferon induced with helicase C domain 1(IFIH1)and moesin(MSN)associated with the intracellular receptor signaling pathway,C–C motif chemokine receptor 6(CCR6),dipeptidyl peptidase 4(DPP4)and hemolytic complement(HC)associated with the negative regulation of leukocyte chemotaxis and tight junction protein 1(TJP1)associated with actin cytoskeleton *** addition,45 genome-wide significant indels containing 2. protein-coding genes were also identified as associated with the H/L based on genome-wide association study(GWAS).The expression of protein tyrosine phosphatase non-receptor type 5(PTPN5)(r=0.75,P=0.033)and oxysterol binding protein like 5(OSBPL5)(r=0.89,P=0.002.)were positively correlated with H/*** to the high H/L group,the expressions of PTPN5 and OSBPL5 were decreased(Pbeijing you *** A/A allelic frequency of indel 5_13108985(P=3.85E–06)within OSBPL5 gradually increased from the NS to G5 and G9,and the individuals with A/A exhibited lower H/L t

关键词： H/L ratio heterophil indel selective sweep GWAS

A survey of neural network accelerator with software development environments

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Journal of Semiconductors 2020年第2期41卷 20-28页

作者： jin Song Xuemeng Wang zhipeng Zhao Wei Li Tian zhi SKL of Computer Architecture Institute of Computing TechnologyChinese Academy of SciencesBeijing 100190China University of chinese academy of sciences Beijing 100049China Cambricon Tech.Ltd Beijing 100191China University of Science and technology of china Hefei 230026China

Recent years,the deep learning algorithm has been widely deployed from cloud servers to terminal *** researchers proposed various neural network accelerators and software development *** this article,we have reviewed the representative neural network *** an entirety,the corresponding software stack must consider the hardware architecture of the specific accelerator to enhance the end-to-end *** we summarize the programming environments of neural network accelerators and optimizations in software ***,we comment the future trend of neural network accelerator and programming environments.

关键词： neural network accelerator compiling optimization programming environments

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面向时空图建模的图小波卷积神经网络模型

软件学报 2021年第3期32卷 726-741页

作者：姜山丁治明朱美玲严瑾徐馨润中国科学院大学北京100049 中国科学院软件研究所北京100190 大规模流数据集成与分析技术北京市重点实验室北京100190

时空图建模是分析图形结构系统中各要素空间关系与时间趋势的一个基础工作.传统的时空图建模方法主要基于图中节点与节点关系固定的显式结构进行空间关系挖掘,这严重限制了模型的灵活性.此外,未考虑节点间的时空依赖关系的传统建模方法... 详细信息

时空图建模是分析图形结构系统中各要素空间关系与时间趋势的一个基础工作.传统的时空图建模方法主要基于图中节点与节点关系固定的显式结构进行空间关系挖掘,这严重限制了模型的灵活性.此外,未考虑节点间的时空依赖关系的传统建模方法不能捕获节点间的长时时空趋势.为了克服这些缺陷,研究并提出了一种新的用于时空图建模的图神经网络模型,即面向时空图建模的图小波卷积神经网络模型(graph wavelet convolutional neural network for spatiotemporal graph modeling,简称GWNN-STGM).在GWNN-STGM中设计了一个图小波卷积神经网络层,并在该网络层中设计并引入了自适应邻接矩阵进行节点嵌入学习,使得模型能够在不需要结构先验知识的情况下,从数据集中自动发现隐藏的结构信息.此外,GWNN-STGM还包含了一个堆叠的扩张因果卷积网络层,使模型的感受野能够随着卷积网络层数的增加呈指数增长,从而能够处理长时序列.GWNN-STGM成功将图小波卷积神经网络层和扩张因果卷积网络层两个模块进行有效集成.通过在公共交通网络数据集上实验发现,提出的GWNNSTGM的性能优于其他的基准模型,这表明设计的图小波卷积神经网络模型在从输入数据集中探索时空结构方面具有很大的潜力.

关键词：图小波卷积图卷积神经网络时空图建模时空结构图神经网络

Analysis of risk factors for early stent thrombosis in the chinese population:A multicenter restrospective study

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World Journal of Emergency Medicine 2021年第3期12卷 192-197页

作者： Yu-peng Wang Lei ding Rui-tao Zhang Xiao-zeng Wang Dan-qing Yu Shou-yan Hao jin-wei Tian Zhen-yu Liu Xiang-qian Qi Hu Tan Hong-yi Wu Feng-hua ding Li-jun Guo Ya-ling Han Department of Cardiology and institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptor ResearchBeijing 100191China Department of Cardiology General Hospital of Northern Theatre CommandShenyang 110016China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Cardiology the First Hospital of Jilin UniversityChangchun 130021China Department of Cardiology the Second Affi liated Hospital of Harbin Medical UniversityKey Laboratory of Myocardial IschemiaMinistry of EducationHarbin 150001China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China TEDA International Cardiovascular Hospital Tianjin 300457China institute of Cardiovascular Diseases of PLA the Second Affi liated HospitalArmy Medical UniversityChongqing 400037China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Cardiology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China

BACKGROUND:The predictive scoring systems for early stent thrombosis(EST)remains blank in *** study aims to evaluate the risk factors and conduct a prediction model of EST in the chinese ***:EST was defined as thrombosis that occurs within the first 30 days after primary percutaneous coronary intervention(PCI).Patients from ten chinese hospitals diagnosed as stent thrombosis(ST)from January {2.0 to December {2.6 were retrospectively included as the study group.A control group(1 case:2.controls)was created by including patients without ST,major adverse cardiovascular events,or cerebrovascular events during *** present study evaluated 42. patients with single-vessel lesions and ultimately included 40 patients with EST and 80 control patients,who were included to identify factors that predicted EST and to develop a prediction scoring *** other 171 patients without integrated 1:2.pair were used for external ***:EST was independently associated with a low hemoglobin concentration(adjusted odds ratio[OR]0.946,95%confi dence interval[95%CI]0.901-0.993,P=0.02.),a high pre-PCI Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery(SYNTAX)score(OR 1.166,95%CI 1.049-1.2.7,P=0.004),and a DAPT(DAPT)duration of30 days(OR 2..033,95%CI 5.302.2.2.834,P1).The simple EST prediction score provided an area under the curve(AUC)of 0.854(95%CI 0.777-0.932.P1)with 70.0%sensitivity and 90.0%specifi city,and 0.742.95%CI 0.649-0.835,P1)with 54.5%sensitivity and 81.0%specifi city for external validation ***:EST may be independently associated with DAPT discontinuation within 30 days,a low hemoglobin concentration,and a high SYNTAX *** scoring system also has a good ability to predict the risk of EST and may be useful in the clinical setting.

关键词： Coronary heart disease Stent thrombosis Risk stratifi cation Predictive scoring system

Variational characteristics of shear-wave splitting on the 2.01 Shidian earthquakes in Yunnan, china

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Acta Seismologica Sinica(English Edition) 2004年第6期17卷 635-641页

作者： GAO Yuan LIANG Wei ding Xiang XUE Yan CAI Ming-jun LIU Xi-qiang SU You-jin PENG Li-guo institute of Earthquake Science China Earthquake Administration Beijing 100036 China Graduate Schoo1chinese academy of sciences Beijing 100039China Earthquake Administration ofYunnan Province Kunming 650041China Earthquake Administration of Shandong Province Jinan 250014 China Center for Comprehensive Surveying China Earthquake AdministrationBeijing 100039China

In 2.01 three earthquakes occurred in Shidian in Yunnan Province, which were the MS=5.2.on April 10, the MS=5.9 on April 12.and the MS=5.3 on June 8. Based on the data from the station Baoshan of Yunnan Telemetry Digital Seismograph Network, the variational characteristics of shear-wave splitting on these series of strong earthquakes has been studied by using the systematic analysis method (SAM) of shear-wave splitting. The result shows the time delays of shear-wave splitting basically increase with earthquake activity intensifying. However the time delays abruptly decrease immediately before strong aftershocks. It accords with the stress relaxation before earthquakes, which was found recently in study on shear-wave splitting. The result suggests it is significant for reducing the harm degree of earthquakes to develop the stress-forecasting on earthquake in strong active tectonic zones and economic developed regions or big cities under the danger of strong earthquakes.

关键词： shear-wave splitting temporal change earthquake stress-forecasting Shidian earthquakes SAM analysis

Exploring Seasonal and Circadian Rhythms in Structural Traits of Field Maize from LiDAR Time Series

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Plant Phenomics 2021年第1期3卷 389-403页

作者： Shichao jin Yanjun Su Yongguang Zhang Shilin Song Qing Li Zhonghua Liu Qin Ma Yan Ge LingLi Liu Yanfeng ding Frédéric Baret Qinghua Guo Plant Phenomics Research Centre Academy for Advanced Interdisciplinary StudiesCollaborative Innovation Centre for Modern Crop Production Co-Sponsored by Province and MinistryJiangsu Key Laboratory for Information AgricultureNanjing Agricultural UniversityNanjing 210095China Jiangsu Provincial Key Laboratory of Geographic Information Science and technology International Institute for Earth System SciencesNanjing UniversityNanjingJiangsu 210023China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China University of chinese academy of sciences Beijing 100049China National Technique Innovation Center for Regional Wheat Production/Key Laboratory of Crop Ecophysiology Ministry of AgricultureNanjing Agricultural UniversityNanjing210095 JiangsuChina Department of Forestry Mississippi State UniversityMississippi State 39759USA Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes(EMMAH) Institut National de la Recherche AgronomiqueUnitéMixte de Recherche 1114 Domaine Saint-PaulAvignon Cedex 84914France Department of Ecology College of Environmental Sciencesand Key Laboratory of Earth Surface Processes of the Ministry of EducationPeking UniversityBeijing 100871China

Plant growth rhythm in structural traits is important for better understanding plant response to the ever-changing *** laser scanning(TLS)is a well-suited tool to study structural rhythm under field *** studies have used TLS to describe the structural rhythm of trees,but no consistent patterns have been ***,whether TLS can capture structural rhythm in crops is ***,we aim to explore the seasonal and circadian rhythms in maize structural traits at both the plant and leaf levels from time-series *** seasonal rhythm was studied using TLS data collected at four key growth periods,including jointing,bell-mouthed,heading,and maturity *** rhythms were explored by using TLS data acquired around every 2.hours in a whole day under standard and cold stress *** showed that TLS can quantify the seasonal and circadian rhythm in structural traits at both plant and leaf levels.(1)Leaf inclination angle decreased significantly between the jointing stage and bell-mouthed *** azimuth was stable after the jointing stage.(2.Some individual-level structural rhythms(e.g.,azimuth and projected leaf area/PLA)were consistent with leaf-level structural rhythms.(3)The circadian rhythms of some traits(e.g.,PLA)were not consistent under standard and cold stress conditions.(4)Environmental factors showed better correlations with leaf traits under cold stress than standard *** was the most important factor that significantly correlated with all leaf traits except leaf *** study highlights the potential of time-series TLS in studying outdoor agricultural chronobiology.

关键词： crops heading traits

W波段InP DHBT宽带高功率压控振荡器（英文）

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红外与毫米波学报 2019年第1期38卷 27-31,43页

作者：王溪姚鸿飞苏永波丁武昌阿瑟夫丁芃童志航金智中国科学院微电子研究所高频高压器件与集成研发中心北京100029 中国科学院大学电子电气与通信工程学院北京100049

成功实现了一款具有高输出功率和宽频率调谐范围的基波压控振荡器.其制作工艺为0. 8μm InP DH-BT工艺,晶体管的最大fT和fmax分别为170和2.0 GHz.电路核心部分采用了为高频应用改进的平衡式考毕兹拓扑,在后面添加一级缓冲放大器来抑制... 详细信息

成功实现了一款具有高输出功率和宽频率调谐范围的基波压控振荡器.其制作工艺为0. 8μm InP DH-BT工艺,晶体管的最大fT和fmax分别为170和2.0 GHz.电路核心部分采用了为高频应用改进的平衡式考毕兹拓扑,在后面添加一级缓冲放大器来抑制负载牵引效应,并提升了输出功率. DHBT的反偏CB结作为变容二极管来实现频率调谐.芯片测试结果表明,压控振荡器的频率调谐范围为81～97. 3 GHz,相对带宽为18. 3%.在调谐频率范围内最大输出功率为10. 2.dBm,输出功率起伏在3. 5 dB以内.在该压控振荡器的最大调谐频率97. 3 GHz处相位噪声为-88 dBc/Hz@1MHz.

关键词：压控振荡器磷化铟双异质结晶体管宽调谐范围高输出功率

Preliminary experimental results by the prototype of Sanya Incoherent Scatter Radar

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Earth and Planetary Physics 2020年第6期4卷 579-587页

作者： XinAn Yue WeiXing Wan Han Xiao LingQi Zeng ChangHai Ke BaiQi Ning Feng ding BiQiang Zhao Lin jin Chen Li MingYuan Li JunYi Wang HongLian Hao Ning Zhang Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation academy for Earth Science Chinese Academy of SciencesBeijing 100029China beijing National Observatory of Space Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary sciences University of the Chinese Academy of SciencesBeijing 100049China Nanjing Research institute of Electronics {2. Nanjing 210039China

In the past decades,the Incoherent Scatter Radar(ISR)has been demonstrated to be one of the most powerful instruments for ionosphere *** institute of Geology and Geophysics at the chinese academy of sciences was founded to build a state-ofthe-art phased-array ISR at Sanya(18.3°N,109.6°E),a low-latitude station on Hainan Island,named the Sanya ISR(SYISR).As a first step,a prototype radar system consisting of eight subarrays(SYISR-8)was built to reduce the technical risk of producing the entire large *** this work,we have summarized the preliminary experimental results based on the *** amplitude and phase among 2.6 channels were first calibrated through an embedded internal monitoring *** mean oscillation of the amplitude and phase after calibration were about 1 dB and 5°,respectively,which met the basic *** beam directivity was confirmed by crossing screen of the International Space *** SYISR-8 was further used to detect the tropospheric wind profile and *** derived winds were evaluated by comparison with independent radiosonde and balloon-based GPS *** SYISR-8 was able to observe several typical meteor echoes,such as the meteor head echo,range-spread trail echo,and specular trail *** results confirmed the validity and reliability of the SYISR-8 system,thereby reducing the technical risk of producing the entire large array of the SYISR to some extent.

关键词： incoherent scatter radar SYISR ionosphere phased array beam direction tropospheric wind meteor

Damage produced on GaN surface by highly charged Krq+irradiation

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Nuclear Science and Techniques 2017年第12期28卷 220-225页

作者： Li-Qing Zhang Chong-Hong Zhang Chao-Liang Xu Heng-Qing Zhang Yi-Tao Yang jin-Yu Li Hui-Ping Liu Zhao-Nan ding Ting-Xing Yan institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of chinese academy of sciences Beijing 100049China

Surface morphology, compositions, microstructure and optical properties of GaN film irradiated by highly charged Kr^(q+)(q = 2., 15, 11) in two geometries to a fluence of 1×10^(15)kr^(q+)/cm^2.were studied using AFM,XPS, PL, Raman scattering and UV–visible *** AFM observation shows that the irradiated GaN area is a swollen terrace. The swelling rate increased with the charge state(potential energy). For the same charge state,the swelling rate of tilted incidence was greater than that for normal incidence. The XPS measurements reveal that N deficiency, Ga enrichment and Ga–O and Ga dangling bonds generated on the irradiated GaN surface increased with the charge state, and more N was lost for normal incidence than that for tilted incidence. The UV–Vis results show that the transmittance decreased with increasing charge state. For the same charge state, the transmittance for tilted incidence is higher than that for normal *** PL spectra present that, with increasing charge state,the YL band intensity decreased, with a blueshift in its peak position; while the NBE peak intensity increased firstand then reduced, and a blue luminescence band appeared.A rapid quenching of both the YL and the NEB for normal incidence was observed. Raman spectra display that screw dislocations perhaps were produced near the surface for normal incidence.

关键词： GaN Highly charged Krypton ion AFM XPS UV–Vis transmittance spectra PL Raman spectra