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Mediating function of heart failure in the causal relationship between diastolic blood pressure and hypertensive renal disease with renal failure:a mediated Mendelian randomization study

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Frontiers of Nursing 2024年第3期11卷 285-294页

作者： Lei pang Zi-Jun ding Hong-Qiang Chai Fei Li Ming Wu Wei-Bing shuang Department of Urology The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)TaiyuanShanxi 030012China First Clinical Medical College of shanxi Medical University TaiyuanShanxi 030012China Department of Neonatology Shanxi Children’s HospitalTaiyuanShanxi 030013China Department of Urology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030012China

Objective:To study the causality relationship between diastolic blood pressure(DBp)and hypertensive renal disease with renal failure(HRDRF)and the mediating role of hear t failure(HF)in the causality relationship by network Mendelian randomization(MR).Methods:genome-wide analysis of DBp,HRDRF,and HF was downloaded from the public database(genome-Wide Analysis study[gWAs])and was used to analyze the results and to conduct mediated MR ***:Analysis showed that DBp was positively correlated with HRDRF(OR=1.0002,95%CI:1.0001–1.0003,p=1.8076e-05)and DBp was positively correlated with HF(OR=1.0295,95%CI:1.0221–1.0370,p=2.5292e-15).HF and HRDRF had a positive causal effect(OR=1.0001,95%CI:1.0000–1.0001,p=0.0152).Mediation analysis showed that the contribution ratio of HF to the combined effect of DBp and HRDRF was 24.69%.Conclusions:DBp can increase the risk of renal disease with renal failure,and HF may play an impor tant role in mediating this causal relationship.

关键词： atherosclerotic heart disease diastolic blood pressure heart arrhythmia heart failure hypertensive renal disease with renal failure Mendelian randomization

草黄口蘑多糖对s180荷瘤小鼠抗肿瘤活性分子机制研究

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食品与发酵工业 2024年第11期50卷 27-37页

作者：赵倪慧蒋琳张丁段江波丁祥侯怡铃西华师范大学生命科学学院西南野生动植物资源保护教育部重点实验室四川南充637009 西华师范大学环境科学与工程学院四川南充637009

多糖作为口蘑属真菌的主要功能成分之一,具有免疫调节、抗氧化及抗肿瘤等活性。为明确草黄口蘑多糖的结构特征及其对s180荷瘤小鼠抗肿瘤活性相关分子机制,该研究以草黄口蘑子实体经热水浸提法提取的草黄口蘑多糖[Tricholoma lascivum (F... 详细信息

多糖作为口蘑属真菌的主要功能成分之一,具有免疫调节、抗氧化及抗肿瘤等活性。为明确草黄口蘑多糖的结构特征及其对s180荷瘤小鼠抗肿瘤活性相关分子机制,该研究以草黄口蘑子实体经热水浸提法提取的草黄口蘑多糖[Tricholoma lascivum (Fr.)gillet polysaccharide,TLg-1]为实验材料,初步解析TLg-1结构,以s180荷瘤小鼠为模型检测体内抗肿瘤活性,并采用转录组测序技术对s180肿瘤组织总RNA进行测序分析。结果表明,TLg-1重均分子质量为13 442 Da,由木糖、甘露糖、葡萄糖和半乳糖4种单糖组成,其比例为1.57∶1.45∶2.84∶4.14。TLg-1可显著抑制荷瘤小鼠s180肿瘤的生长(pg-1能显著上调mt-Co1、prlr、Foxa1以及下调pitx2、Rplp1、Eef1a1及Lgals1等基因,影响s180肿瘤细胞的代谢途径,调控细胞周期并抑制上皮间质转化过程。基因本体富集分析表明,TLg-1可激活细胞因子介导的信号通路,引发细胞免疫。京都基因与基因组百科全书富集分析显示,在Jak-sTAT信号通路中的Il21、Il12rb2、Il12b、Il2ra、Il2rb、Il2rg、Il15ra和Ifng等基因显著上调,通过转换肿瘤相关巨噬细胞表型及分泌干扰素-γ等,增强小鼠抗肿瘤免疫应答。该研究结果为草黄口蘑多糖的开发和利用提供了一定的理论基础。

关键词：草黄口蘑多糖TLg-1 抗肿瘤 s180 转录组测序技术 Jak-sTAT信号通路

serum activin A as a prognostic biomarker for community acquired pneumonia

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World Journal of Clinical Cases 2024年第22期12卷 5016-5023页

作者： Yu-Ting Wang Yan Liu guang-Hui Zhou Kan Liu Yan Fen Hui ding pulmonary and Critical Care Medicine Yixing People’s Hospital of Jiangsu UniversityYixing 214200Jiangsu ProvinceChina

BACKgROUND It is essential to develop new biomarker with effective prognostic roles because of the unclear clinical use of the current community-acquired pneumonia(CAp)*** To evaluate the association between serum activin A levels and prognosis in CAp *** A total of 168 CAp individuals grouped according to the severity and prognosis of illness condition,and 48 healthy individuals as the control group were enrolled in this *** concentrations of activin A were measured using enzymelinked *** interaction between activin A levels and etiologies of CAp was *** on the severity of CAp,110 patients(65.48%)were categorized into group-I,42(25%)cases were grouped into group-II,and 16(9.52%)cases were categorized into *** serum activin A levels were higher in patients with CAp than controls,but independent of ***,the scores of pneumonia severity Index(psI)and CURB-65 positively correlated with the increasing levels of serum activin A,and were at their highest peak in individuals in group-III(pg activin A with CURB-65 or psI was more effective in improving predictive property(pding to Cox proportional regression analysis,after adjusting clinical parameters,we confirmed that activin A showed a powerful predictive property for hospital mortality in CAp patients(psION Higher level of serum activin A was associated with poor prognosis of *** A can be used as a more valuable biomarker of prognosis in CAp patients.

关键词： Community-acquired pneumonia Activin A Etiology prognosis Etiology

预见性护理联合加速康复外科理念对腰椎术后患者腰椎功能及睡眠质量的影响

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世界睡眠医学杂志 2024年第2期11卷 417-419,422页

作者：查磊蔡英风福建厦门大学附属第一医院骨科厦门361000

目的:分析预见性护理联合加速康复外科理念在腰椎术后的效果。方法:选取2021年1月至2022年12月福建厦门大学附属第一医院骨科收治的腰椎手术患者100例作为研究对象,随机分为对照组和观察组,每组50例。对照组接受常规护理干预,而观察组... 详细信息

目的:分析预见性护理联合加速康复外科理念在腰椎术后的效果。方法:选取2021年1月至2022年12月福建厦门大学附属第一医院骨科收治的腰椎手术患者100例作为研究对象,随机分为对照组和观察组,每组50例。对照组接受常规护理干预,而观察组则接受预见性护理联合加速康复外科理念,观察比较2组的护理干预效果。结果:与术前比较,2组术后第7天的视觉模拟评分法(VAs)评分、匹兹堡睡眠质量指数(psQI)评分均明显降低,差异均有统计学意义(均pps评分、psQI评分均明显低于对照组(均ppp<0.05)。结论:为腰椎手术患者提供预见性护理联合加速康复外科理念,能缓解疼痛,改善腰椎功能,提高睡眠质量,减少并发症,值得推广。

关键词：预见性护理加速康复外科理念腰椎手术腰椎功能睡眠质量

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中国自然失业率变化趋势分析

财经论丛 2024年第9期 25-34页

作者：丁守海冀承徐政中国人民大学应用经济学院北京100872 中共江苏省委党校经济学教研部江苏南京210009

本文基于全国城镇调查失业率、居民消费价格指数等月度数据,构建包含以三角模型表达的菲利普斯曲线关系和自然失业率变动过程的状态空间模型,采用Kalman滤波方法估算自然失业率。研究发现,近年来中国自然失业率呈现向上攀升的趋势,从201... 详细信息

本文基于全国城镇调查失业率、居民消费价格指数等月度数据,构建包含以三角模型表达的菲利普斯曲线关系和自然失业率变动过程的状态空间模型,采用Kalman滤波方法估算自然失业率。研究发现,近年来中国自然失业率呈现向上攀升的趋势,从2018年1月的4.22%持续升至2024年2月的4.77%,且在2023年经济回升向好以来,自然失业率并没有回复到新冠疫情冲击前的水平,出现了失业回滞的现象;不同年龄段、不同户籍劳动者群体的自然失业率均呈不断向上攀升,但16~24岁青年劳动者、本地户籍群体的自然失业率上升幅度明显更大。面对现阶段中国出现的自然失业率向上攀升和失业回滞的现象,政府部门要加强总量就业刺激政策的力度,创造更多就业机会,消除妨碍充分就业的结构性和摩擦性因素,放宽青年群体劳动力规制的力度,增强劳动力市场自我修复能力。

关键词：自然失业率劳动力市场向上攀升失业回滞

source and accumulation process of Jurassic biodegraded oil in the Eastern Junggar Basin,NW China

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petroleum science 2021年第4期18卷 1033-1046页

作者： Mao-guo Hou Ming zha Xiu-Jian ding He Yin Bao-Li Bian Hai-Lei Liu Zhong-Fa Jiang school of geosciences China University of PetroleumQingdaoShandong 266580China Research Institute of Exploration and Development Xinjiang Petroleum Administration BureauKaramay 834000China

Biodegradation usually obscures or even radically alters the original characteristics of oil *** mixing of oil from multiple sources makes each source difficult to *** the source of biodegraded oil from multiple sources has always been a hard nut to *** to this challenge,in this study-we carried out a comprehensive investigation of biodegradation impacts,oil-source correlation,and oil charging history to trace the source and reveal the mixing process of biodegraded oil in the Toutunhe Formation(J_(2)t)in the eastern Junggar Basin,NW *** oil of this area was biodegraded to different extent,consequently,many commonly used biomarker parameters(***/ph,pr/n C_(17))became less powerful for oil-source *** address this problem,the resistance of many biomarkers to biodegradation was analyzed,and those of high bio resistance were selected to generate a more reliable oil-source *** results revealed that biodegraded oil was a mixture of oil sourced from Lucaogou Formation(p_(2)l)and Xiaoquangou Formation(T_(2-3)xq).Core sample observation,microscopic fluorescent analysis and fluid inclusion analysis were combined to analyze comprehensively oil charging *** analysis of accumulation process exhibited that the existing oil in J_(2)t was a mixture originated from the p_(2)l and T_(2-3)xq source rocks in two separate charging stages when it underwent a complicated process of charging,biodegradation,recharging and mixing.

关键词： Biodegraded oil Mixed oil Oil-source correlation Oil accumulation process Junggar Basin

高压氧治疗联合早期综合康复护理对缺氧缺血性脑病患儿神经功能及血清IgF-1、IL-6、NsE水平的影响

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中华航海医学与高气压医学杂志 2024年第2期31卷 249-252页

作者：丁莉殷文博临沂市人民医院门急诊管理办公室临沂276000 临沂市人民医院神经外科临沂276000

目的探讨高压氧治疗联合早期综合康复护理对缺氧缺血性脑病(HIE)患儿神经功能及血清胰岛素样生长因子-1(IgF-1)、白细胞介素-6(IL-6)、神经元特异性烯醇化酶(NsE)水平的影响。方法选取2019年2月至2022年2月临沂市人民医院神经外科收治... 详细信息

目的探讨高压氧治疗联合早期综合康复护理对缺氧缺血性脑病(HIE)患儿神经功能及血清胰岛素样生长因子-1(IgF-1)、白细胞介素-6(IL-6)、神经元特异性烯醇化酶(NsE)水平的影响。方法选取2019年2月至2022年2月临沂市人民医院神经外科收治的62例HIE患儿为研究对象,按照随机数字表法分为观察组和对照组,每组31例。2组患儿均接受常规治疗及高压氧治疗,对照组予以常规护理,观察组则予以早期综合康复护理。比较2组患儿的主要症状恢复时间、干预前后新生儿神经行为测定量表(NBNA)评分及血清IgF-1、IL-6、NsE水平差异。结果观察组患儿的意识恢复时间、反射恢复时间、肌张力恢复时间、可吸吮恢复时间均明显短于对照组,差异有统计学意义(pgF-1、IL-6、NsE水平比较差异无统计学意义(p>0.05);干预后,2组患儿的NBNA评分及血清IgF-1水平均高于干预前,且观察组高于对照组,而血清IL-6、NsE水平均低于干预前,且观察组低于对照组,差异有统计学意义(pgF-1水平,降低血清IL-6、NsE水平。

关键词：高压氧早期综合康复护理缺氧缺血性脑病儿童胰岛素样生长因子⁃1 白细胞介素⁃6 神经元特异性烯醇化酶

Mixing planting proportions in a plantation affects functional traits and biomass allocation of Cunninghamia lanceolata and phoebe bournei seedlings

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Journal of Forestry Research 2022年第6期33卷 1793-1805页

作者： Meiqin zha Youzhi Han Xiangrong Cheng Forestry College Shanxi Agriculture UniversityTaigu 030801People’s Republic of China East China Coastal Forest Ecosystem Long-Term Research station Institute of Subtropical ForestryChinese Academy of ForestryHangzhou 311400People’s Republic of China

Functional traits of trees are significantly associated with their adaptation strategies and ***,the effects of species composition and mixing proportion on the functional traits of trees grown in mixed plantations have not been studied *** this study,planting experiments(duration about seven months)were used to study variations in functional traits and biomass allocation of C unninghamia lanceolata(Lamb.)Hook and phoebe bournei(Hemsley)Yang seedlings in five different mixes(0C:4p,1C:3p,1C:1p,3C:1p,and 4C:0p).Total leaf area per seedling increased in each species as its respective proportion in the mixture ***,the specific leaf area decreased for *** under low percent composition,and the specific leaf area for *** differed only marginally among the *** net photosynthetic rates of the two species were higher in the mixed plantings than in their corresponding monocultures,whereas the transpiration rate,stomatal conductance,and instantaneous water use efficiency were not different among the *** average root length and root surface area of *** and *** were higher in the mixed plantings than in their ***,root surface area of *** and both root length and surface area of *** increased significantly in the 1C:3p and 2C:2p mixed ***,stem,root,and total dry mass per seedling for *** decreased with its increasing percent composition in the mixed plantings,while these variables varied less for *** plasticity of biomass allocation was relatively low for both *** biomass per planting was higher in the mixed plantings than in the *** study indicates that species composition and mixing proportion can considerably affect the functional traits of *** and *** increase in productivity in the mixed plantings may be partially attributed to low rates of competition between the two species,an

关键词： Mixing proportion Tree species composition Functional traits Interspecific relationship Intraspecific relationship

正常体质指数血液透析患者腰围身高比与肌少症性肥胖的相关性

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中华医学杂志 2024年第12期104卷 931-937页

作者：兰琴田茂露袁静佟小雅龙昌柱查艳遵义医科大学研究生院，遵义563000 贵州省人民医院肾内科国家卫生健康委员会肺脏免疫性疾病诊治重点实验室，贵阳550002

目的探讨正常体质指数维持性血液透析(MHD)患者腰围身高比(WHtR)与肌少症性肥胖(sO)的关系。方法多中心横断面研究。2021年6月1日至8月30日,在贵州省20家血液透析中心对正常体质指数成年MHD患者进行调查。通过基于生物电阻抗谱的身体成... 详细信息

目的探讨正常体质指数维持性血液透析(MHD)患者腰围身高比(WHtR)与肌少症性肥胖(sO)的关系。方法多中心横断面研究。2021年6月1日至8月30日,在贵州省20家血液透析中心对正常体质指数成年MHD患者进行调查。通过基于生物电阻抗谱的身体成分监测仪评估人体成分,根据WHtR四分位数将患者分为Q1~Q4四组。通过多因素logistic回归模型、分层分析、交互分析及受试者工作特征(ROC)曲线分析评估正常体质指数血液透析患者WHtR与sO的相关性。结果共纳入2207例MHD患者,男1341例,女866例,年龄[M(Q_(1),Q_(3))]为57(44,68)岁。随着WHtR四分位数增加,sO的患病率也随之升高,Q1、Q2、Q3、Q4组患者sO患病率分别为8.6%(46/533)、22.5%(141/628)、35.4%(215/608)和44.3%(194/438)。多因素logistic回归分析结果显示,在校正年龄、性别、透析时间、体质指数、生化指标和各类疾病史后,与Q1组患者相比,Q2~Q4组MHD患者的sO发生风险分别增加了1.54倍(OR=2.54,95%CI:1.69~3.83,pppsO的关联中具有交互作用(均psO的关联在不同的亚组中稳定存在,但在男性、年龄较大、无糖尿病史的患者中更为明显(均psO的ROC曲线下面积(AUC)为0.73(95%CI:0.70~0.75),cut-off值为0.49,灵敏度72.7%,特异度60.3%;在女性患者中WHtR识别sO的AUC为0.68(95%CI:0.65~0.71),cut-off值为0.51,灵敏度70.1%,特异度57.8%。结论WHtR可作为一种简便的指标评估正常体质指数MHD患者的sO患病风险。

关键词：血液透析肌少症性肥胖腰围身高比