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Silodosin is effective for treatment of LUTS in men wii BPH： a systematic review

Asian Journal of Andrology 2013年第1期15卷 121-128页

作者： hui ding Wan Du Zi-Zhen Hou Han-Zhang Wang Zhi-Ping Wang Institute of Urology Key Laboratory of Diseases of Urological System Gansu Province Gansu Nephro-Urological Clinical Center The Second Hospital of Lanzhou University Lanzhou China 0tolaryngological Department The Second Hospital of Lanzhou University Lanzhou China The Medical College of Shandong University Jinan China

The aim of this study was to systematically review the evidence on the efficacy and safety of silodosin treatments on lower urinary tract symptoms （LUTS） in men with benign prostatic hyperplasia （BPH） from randomized controlled trials. We searched PubMed （1966- December 2011）, Embase （1974-December 2011） and the Cochrane Library Database （2011, Issue 12）. The assessed outcome measures were the change from baseline for the International Prostate Symptom Score （IPSS）, quality of life （QoL） score, peak urine maximum flow rate （Qmax）, QoL related to urinary symptoms and adverse effects. Two authors independently assessed the study quality and extracted data. All data were analysed using RevMan 5.1. The meta-analysis included four randomized controlled trials with a total of 2504 patients. The study durations were each 12 weeks. At the follow-up end points, the pooled results showed that the change from baseline for the silodosin group was significantly higher than the placebo group for the IPSS, QoL score and Qmax（mean difference （MD）=-2.78, P〈O.O0001; MD=-O.42, P--O.O04; MD= 1.17, P〈***,respectively） and patients felt more satisfied with QoL related to urinary symptoms in the silodosin group than the placebo group. Ejaculation disorder was the most commonly reported adverse effect. The pooled results also showed that the silodosin group was superior to the 0.2 mg tamsulosin group with respect to the IPSS and QoL score （IPSS： MD=- 1.14, P=O.02; QoL score： MD=-0.26, P=O.02） and inferior to the 0.2 mg tamsulosin group with respect to Qmax （MD=-0.85, P=O.01）. In contrast, there was no significant difference in the incidence of ejaculation disorder and dizziness between the silodosin and 0.2 mg tamsulosin groups. The current meta-analysis suggested that silodosin is an effective therapy for LUTS in men with BPH and is not inferior to 0.2 mg tamsulosin.

关键词： benign prostatic hyperplasia (BPH) KMD-3213 lower urinary tract symptoms (LUTS) silodosin tamsulosin systematic review meta-analysis

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Amperometric Determination of lndole-3-acetic Acid Based on Platinum Nanowires and Carbon Nanotubes

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Chinese Chemical Letters 2006年第12期17卷 1585-1588页

作者： Ruo Zhong WANG Lang Tao XIAO Ming hui YANG Jun hui ding Feng Li QU Guo Li-SHEN Hunan Provincial Key Laboratory of Phytohormones and Growth Development Hunan Agricultural University Changsha 410028 Chemistry and Chemical Engineering College State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University Changsha 410082

Platinum nanowire （PtNW） can be grown by electrodeposition in polycarbonate membrane, with the average diameter of the nanowires about 250 nm. The PtNW and multiwalled carbon nanotubes （CNT） are then dispersed into chitosan （CHIT） solution. The resulting PtNW-CNT-CHIT material brings new capabilities for electrochemical devices by using the synergistic action of the electrocatalytic activity of PtNW and CNT. By dropping the PtNW-CNT-CHIT film onto the glassy carbon （GO） electrode surface, and after evaporation an amperometric sensor for the determination of indole-3-acetic acid （IAA） was developed. The oxidation current of IAA increased significantly at the PtNW-CNT-CHIT film coated GC electrode, in contrast to that at the CNT-CHIT modified GC. The linear response of the sensor is from 50 ng/ml to 50 μg/ml with a detection limit of 25 ng/mL.

关键词： Chitosan platinum nanowire glassy carbon indole-3-acetic acid.

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Microstructures of mechanically activated Ti-46at.%Al powders and spark plasma sintered ultrafine TiAl alloy

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Rare Metals 2007年第6期26卷 572-577页

作者： XIA Li ding hui Ruan Xuefong REN Yaoyao College of Power and Mechanical Engineering Wuhan University Wuhan 430072 China School of Physicals Wuhan University Wuhan 430072 China

Powder of Ti-46at.%Al was synthesized through mechanical activation （MA） for different milling times, and the 16 h MAed powder was sintered by using a spark plasma sintering （SPS） process at different sintering temperatures. The XRD profiles showed that the MAed Ti-46at,%Al powder for 12, 16, and 20 h contained initial α-Ti and Al phases, and that the SPSed TiAl alloys contained the gamma TiAl and α2-Ti3Al phases. The TEM showed two different types of regions in the 16 h MAed Ti-46at.%Al powder. One type consisted of only Al with a grain size about 80 nm, and the other type a mixture of Al and Ti with a grain size of 30 nm. According to the optical micrographs of MA-SPSed samples, the alloys sintered at higher temperatures showed a coarser microstructure. In the case of the 1473 Ksintering, typical duplex structures （（α2 ＋γ） lamella and γ phases） with interlamellar spacings of 50-400 nm and the grain size either less than 100 nm, or 1000 nm were observed.

关键词： metal materials titanium aluminides spark plasma sintering (SPS) mechanical activation (MA)

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Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1271-1286页

作者： Xiaojun Wang hui ding Zongyang Li Yaonan Peng hui Tan Changlong Wang Guodong Huang Weiping Li Guanghui Ma Wei Wei Shenzhen Key Laboratory of Neurosurgery Department of NeurosurgeryShenzhen Second People’s HospitalShenzhen University 1st Affiliated HospitalGuangdong 518035P.R.China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020P.R.China Department of Otolaryngology and Institute of Translational Medicine Shenzhen Second People’s Hospitalthe First Affiliated Hospital of Shenzhen University Health Science CenterShenzhenGuangdong 518110P.R.China Department of Neurosurgery Jinling HospitalJiangsuNanjing 210000P.R.China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049P.R.China

Glioblastoma multiforme(GBM)is a highly aggressive brain tumor with an extremely low survival *** and effective approaches for treatment are therefore urgently ***,we successfully developed M1-like macrophage-derived extracellular vesicles(M1EVs)that overcome multiple challenges via guidance from two macrophage-related observations in clinical specimens from GBM patients:enrichment of M2 macrophages in GBM;and origination of a majority of infiltrating macrophage from peripheral *** maximize the synergistic effect,we further functionalized the membranes of M1EVs with two hydrophobic agents(the chemical excitation source CPPO(C)and the photosensitizer Ce6(C))and loaded the hydrophilic hypoxiaactivated prodrug AQ4N(A)into the inner core of the *** intravenous injection,the inherent nature of M1-derived extracellular vesicles CCA-M1EVs allowed for blood-brain barrier penetration,and modulated the immunosuppressive tumor microenvironment via M2-to-M1 polarization,which increased hydrogen peroxide(H_(2)O_(2))***,the reaction between H_(2)O_(2) and CPPO produced chemical energy,which could be used for Ce6 activation to generate large amounts of reactive oxygen species to achieve chemiexcited photodynamic therapy(CDT).As this reaction consumed oxygen,the aggravation of tumor hypoxia also led to the conversion of non-toxic AQ4N into toxic AQ4 for ***,CCA-M1EVs achieved synergistic immunomodulation,CDT,and hypoxia-activated chemotherapy in GBM to exert a potent therapeutic ***,we demonstrated the excellent effect of CCA-M1EVs against GBM in cell-derived xenograft and patient-derived xenograft models,underscoring the strong potential of our highly flexible M1EVs system to support multi-modal therapies for difficult-to-treat GBM.

关键词： therapeutic chemotherapy synergistic

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Preparation and Characterization of Amorphous W–B–C Alloy and Solid Solutions of C in Tungsten Borides

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Acta Metallurgica Sinica(English Letters) 2018年第4期31卷 380-388页

作者： Hao Sun Suo-Zhu Bai Dan-Dan Yao Bin Yao Zhan-hui ding Yong-Feng Li State Key Lab of Superhard Materials and College of Physics Jilin UniversityChangchun 130023China Key Laboratory of Physics and Technology for Advanced Batteries(Ministry of Education) College of PhysicsJilinUniversityChangchun 130012China Chemistry and Chemical Engineering College Inner Mongolia University for the NationalitiesTongliao 028000China Liaoning Academy of Safety Science Shenyang 110004China

Mixtures of W and B13C2 powders were mechanically milled and subsequently annealed at 900-1200℃.It is found that amorphous W-B-C alloy formed as the mixtures were milled for 20.80 *** annealing the 80 h-milled mixtures at 900-950℃,solid solutions of C and/or B in tungsten[W（B,C）],C in tungsten boride[W2B（C）or WB（C）]formed by the crystallization of amorphous *** formation temperature of W2B（C）and WB（C）is lower than that of W2B and WB reported *** the 80 h-milled mixtures were annealed at 1200℃,W reacted with amorphous W-B-C completely to form WB and W2B5 or W2B5 instead of the solid solutions of C in tungsten borides,which is determined by the mole ratio of W to *** formation mechanisms of the W2B（C）and WB（C）solid solutions as well as phase transition rules of the mixtures at annealing temperature and mole ratio were also investigated using first-principle calculation.

关键词： Ball milling Annealing Tungsten borides Amorphous alloy

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Pachymic acid exerts antitumor activities by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 170-180页

作者： Hao Zhang Kun Zhu Xue-Feng Zhang Yi-hui ding Bing Zhu Wen Meng Qing-Song ding Fan Zhang Department of Emergency Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006ZhejiangChina Department of Cardiothoracic Surgery The Third Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161000HeilongjiangChina Department of Cardiothoracic Surgery The Affiliated Heilongjiang Provincial Hospital of Harbin Institute of TechnologyHarbin 150036HeilongjiangChina

Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying ***:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluorescence assays were carried out to measure the effects of various concentrations of pachymic acid on LUAD cell proliferation,metastasis,angiogenesis as well as ***,molecular docking technology was used to detect the potential targeted binding association between pachymic acid and protein tyrosine phosphatase 1B(PTP1B).Moreover,PTP1B was overexpressed in A549 cells to detect the specific mechanisms of pachymic ***:Pachymic acid suppressed LUAD cell viability,metastasis as well as angiogenesis while inducing cell *** also targeted PTP1B and lowered PTP1B ***,PTP1B overexpression reversed the effects of pachymic acid on metastasis,angiogenesis,and autophagy as well as the expression of Wnt3a andβ-catenin in LUAD ***:Pachymic acid inhibits metastasis and angiogenesis,and promotes autophagy in LUAD cells by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B.

关键词： Pachymic acid Lung adenocarcinoma Protein tyrosine phosphatase 1B Wnt/β-catenin signaling pathway Metastasis Angiogenesis Autophagy

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Genesis of the Weiquan Ag-Polymetallic Deposit in East Tianshan, China： Evidence from Zircon U-Pb Geochronology and C-H-O-S-Pb Isotope Systematics

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Acta Geologica Sinica(English Edition) 2018年第3期92卷 1100-1122页

作者： ding hui GE Wensheng DONG Lianhui ZHANG Liangliang CHEN Xiaodong LIU Yan NIE Junjie School of Earth Sciences and Resources China University of Geosciences Beijing 100083 China Xinjiang Bureau of Geology and Mineral Resources Uriimqi 830000 China The Sixth Exploration Institute of Geology and Mineral Resources of Shandong Province Weihai 264209Shandong China Chengdu University of Technology Chengdu 610059 China MCC Capital Engineering & Research Incorporation Limited (CERI) Beijing 100176 China No. 1 Geological Party Xinjiang Bureau of Geology and MineralResources Changji 831100 Xinjiang China

The Weiquan Ag-polymetallic deposit is located on the southern margin of the Central Asian Orogenic Belt and in the western segment of the Aqishan-Yamansu arc belt in East Tianshan,northwestern China. Its orebodies, controlled by faults, occur in the lower Carboniferous volcanosedimentary rocks of the Yamansu Formation as irregular veins and lenses. Four stages of mineralization have been recognized on the basis of mineral assemblages, ore fabrics, and crosscutting relationships among the ore veins. Stage I is the skarn stage(garnet + pyroxene), Stage Ⅱ is the retrograde alteration stage(epidote + chlorite + magnetite ± hematite 士 actinolite ± quartz),Stage Ⅲ is the sulfide stage(Ag and Bi minerals + pyrite + chalcopyrite + galena + sphalerite + quartz ± calcite ± tetrahedrite),and Stage IV is the carbonate stage(quartz + calcite ± pyrite). Skarnization,silicification, carbonatization,epidotization,chloritization, sericitization, and actinolitization are the principal types of hydrothermal alteration. LAICP-MS U-Pb dating yielded ages of 326.5±4.5 and 298.5±1.5 Ma for zircons from the tuff and diorite porphyry, respectively. Given that the tuff is wall rock and that the orebodies are cut by a late diorite porphyry dike, the ages of the tuff and the diorite porphyry provide lower and upper time limits on the age of ore formation. The δ13C values of the calcite samples range from-2.5‰ to 2.3‰, the δ18OH2 Oand δDVSMOWvalues of the sulfide stage(Stage Ⅲ) vary from 1.1‰ to 5.2‰ and-111.7‰ to-66.1‰, respectively,and the δ13C, δ18OH2 Oand δDV-SMOWvalues of calcite in one Stage IV sample are 1.5‰,-0.3‰, and-115.6‰, respectively. Carbon, hydrogen, and oxygen isotopic compositions indicate that the ore-forming fluids evolved gradually from magmatic to meteoric sources. The δ34SV-CDTvalues of the sulfides have a large range from-6.9‰ to 1.4‰, with an average of-2.2‰, indicating a magmatic source, possibly with sedimentary contributions. The206Pb/204Pb,207Pb/204Pb, and208Pb/204

关键词： zircon U-Pb geochronology C-H-O-S-Pb isotopes skarn-type Ag-polymetallic deposit Weiquan East Tianshan China

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Esterification of levulinic acid into n-butyl levulinate catalyzed by sulfonic acid-functionalized lignin-montmorillonite complex

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Journal of Bioresources and Bioproducts 2020年第4期5卷 291-299页

作者： Wenguang Zhao hui ding Jie Zhu Xianxiang Liu Qiong Xu Dulin Yin National&Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China

In this study,sulfonic acid-functionalized lignin-montmorillonite complex(LMT-SO_(3)H)was pre-pared and employed as an efficient heterogeneous catalyst for the esterification of levulinic acid(LA)into n-butyl levulinate(BL).An intermediate pseudo-butyl levulinate(p-BL)was determined by distilled water treatment and nuclear magnetic resonance(NMR)analysis,and a possible mech-anism for the esterification of LA is *** effects of various process parameters were studied and the results showed that the LMT-SO_(3)H catalyst had the excellent catalytic perfor-mance for esterification of the *** optimum reaction conditions,the yield of BL was 99.3%and the conversion of LA was 99.8%.The LMT-SO_(3)H catalyst exhibited strong acidic sites and high stability even after seven cycles of ***,esterification of the LA with various alcohols over the LMT-SO_(3)H was further investigated.

关键词： Levulinic acid Solid sulfonic acid n-Butyl levulinate Esterification Heterogeneous catalysis

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Effects of geometrical characteristics on defect distributions in alloy components produced by selective laser melting

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China Foundry 2021年第4期18卷 369-378页

作者： Yao Cai Tao Lu Gui-dian Ma Wang Li Ye Pan hui ding School of Materials Science and Engineering Southeast UniversityJiangsu Key Laboratory of Advanced Metallic MaterialsNanjing 211189China Nanjing Cham lion Laser Technology Co. LtdNanjing 210039China

Selective laser melting(SLM)has been applied to manufacture various alloy components with excellent properties,but its further application is restricted by the intrinsic *** this work,the internal defect distributions in samples of three alloys(316L stainless steel,AlSi10Mg and Inconel 718)were investigated respectively,considering the effects of geometrical characteristics of the *** defects in the 316L stainless steel sample tend to be formed densely in the central part with large wall thickness,indicating a strong sensitivity to heat ***,the Inconel 718 sample shows a higher relative density with homogeneous defect distribution,indicating better formability for the SLM *** the AlSi10Mg sample,the defect density keeps increasing as the deposition goes ***,the defect density located at sample edges shows an abnormally high level comparing with the inner part,especially in the top sections of AlSi10Mg and Inconel 718 *** results are helpful for the geometrical design,the adjustment of building orientation and the further optimization of process parameters in the SLM process.

关键词： selective laser melting defect 316L stainless steel AlSi10Mg Inconel 718 geometrical characteristics formability

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Effect of H_2S concentration on the corrosion behavior of pipeline steel under the coexistence of H_2S and CO_2

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International Journal of Minerals,Metallurgy and Materials 2014年第4期21卷 388-394页

作者： Da-peng Li Lei Zhang Jian-wei Yang Min-xu Lu Jin-hui ding Ming-liang Liu Institute of Advanced Materials and Technology University of Science and Technology Beijing Shougang Research Institute of Technology

The effect of H2S concentration on H2S/CO2 corrosion of API-X60 steel was studied by scanning electron microscopy, a weight-loss method, potentiodynamic polarization tests, and the electrochemical impedance spectroscopy technique. It is found that the cor-rosion process of the steel in an environment where H2S and CO2 coexist at different H2S concentrations is related to the morphological structure and stability of the corrosion product film. With the addition of a small amount of H2S, the size of the anode reaction region is de-creased due to constant adsorption and separation of more FeS sediment or more FeHS＋ions on the surface of the steel. Meanwhile, the dou-ble-layer capacitance is diminished with increasing anion adsorption capacity. Therefore, the corrosion process is inhibited. The general cor-rosion rate of the steel rapidly decreases after the addition of a small amount of H2S under the coexistence of H2S and CO2. With a further increase in H2S concentration, certain parts of the corrosion product film become loose and even fall off. Thus, the protection provided by the corrosion product film worsens, and the corrosion rate tends to increase.

关键词： pipeline steel hydrogen sulfide carbon dioxide corrosion corrosion rate electrochemical properties

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