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A computational model to identify fertility-related proteins using sequence information

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Frontiers of Computer Science 2024年第1期18卷 229-237页

作者： Yan LIN Jiashu WANG Xiaowei LIU Xueqin XIE De WU Junjie ZHANG hui ding Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China School of Life Science and Technology and Center for Informational Biology University of Electronic Science and Technology of ChinaChengdu 610054China

Fertility is the most crucial step in the development process,which is controlled by many fertility-related proteins,including spermatogenesis-,oogenesis-and embryogenesis-related *** identification of fertility-related proteins can provide important clues for studying the role of these proteins in ***,in this study,we constructed a two-layer classifier to identify fertility-related *** this classifier,we first used the composition of amino acids(AA)and their physical and chemical properties to code these three fertility-related ***,the feature set is optimized by analysis of variance(ANOVA)and incremental feature selection(IFS)to obtain the optimal feature *** five-fold cross-validation(CV)and independent data tests,the performance of models constructed by different machine learning(ML)methods is evaluated and ***,based on support vector machine(SVM),we obtained a two-layer model to classify three fertility-related *** the independent test data set,the accuracy(ACC)and the area under the receiver operating characteristic curve(AUC)of the first layer classifier are 81.95%and 0.89,respectively,and them of the second layer classifier are 84.74%and 0.90,*** results show that the proposed model has stable performance and satisfactory prediction accuracy,and can become a powerful model to identify more fertility related proteins.

关键词： sfertility-related proteins machine1 learning sequence information feature selection

Perforation optimization of layer-penetration fracturing for commingling gas production in coal measure strata

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Petroleum Science 2022年第4期19卷 1718-1734页

作者： Bing Hou Zhuang Cui Ji-hui ding Feng-Shou Zhang Li Zhuang Derek Elsworth State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BejingBejing102249China MOE Key Laboratory of Petroleum Engineering in China University of Petroleum Beijing 102249China Department of Geophysics Stanford University397 Panama MallStanfordCA94305USA Department of Geotechnical Engineering Tongji UniversityShanghai200092China Korea Institute of Civil Engineering and Building Technology Goyang10223South Korea The Pennsylvania State University University ParkPA16802USA

Optimization of fracturing perforation is of great importance to the commingling gas production in coal measure *** this paper,a 3 D lattice algorithm hydraulic fracturing simulator was employed to study the effects of perforation position and length on hydraulic fracture propagation in coal measures of the Lin-Xing block,*** on field data,three lithologic combinations are simulated:1)a thick section of coal seam sandwiched by sandstones;2)a thin coal seam layer overlay by gas-bearing tight sandstone;3)two coal seams separated by a thin layer of *** simulation shows that perforation position and length in multi-layer reservoirs play a major role in hydraulic fracture *** maximum stimulated volume requires consideration of lithologic sequence,coal seam thickness,stress states,and rock *** improve the combined gas production in coal measure strata,it is possible to simultaneously stimulate multiple coal seams or adjacent gas-bearing *** these cases,perforation location and length also significantly impact fracture propagation,and therefore should be carefully *** simulation results using 3 D lattice algorithm are qualitatively consistent with laboratory physical simulation.3 D lattice models can be used to effectively simulate the fracture propagation through layers in coal measure *** numerical results provide guidance for perforation optimization in the hydraulic fracturing of coal measure strata.

关键词： Coal measure strata Combined production 3D lattice algorithm Perforation scheme optimization Fracture propagation

High-temperature modification and air-quenching granulation of steel slag

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Journal of Iron and Steel Research International 2022年第5期29卷 783-792页

作者： hui Wang Chao Liu Hong-wei Xing Jin-hu Wu Wen-long Lin Shuo Li Guo-hui ding Yu-zhu Zhang College of Metallurgy and Energy North China University of Science and TechnologyTangshan063200HebeiChina Steelmaking Operation Department Shougang Jingtang United Iron&Steel Co.Ltd.Tangshan063200HebeiChina

To solve the problem of difficult utilization of steel slag,the liquid steel slag was modified and the air-quenching granulation process was carried out to make steel slag into a value-added end product:air-quenching granulated steel *** granulated slag was tested to analyze the variation rule of slag properties under different modification *** on the phase diagram of CaO–Si_(2)O–FeO–MgO–Al2O3 slag system,the feasibility of blast furnace(BF)slag as modifier was *** the addition of BF slag was increased from 0%to 35%,following results were *** slag fluidity was improved,and the air-quenching temperature range was ***,the yield of air-quenched steel slag increased,while the granulation rate,the degree of sphericity,the compactness were ***,the air-quenching granulation process could substantially improve the stability and the amorphous content of steel *** maximum removal rate of free CaO was above 80%and the amorphous content was up to 95%.Taking the factors of yield and properties of granulated steel slag into full consideration,the optimum proportion of BF slag is around 15%.

关键词： Steel slag Modification Air-quenching granulation Free CaO Amorphous Property

Eupatoranolide, a New Sesquiterpene Lactone from Eupatorium adenophorum

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Chinese Chemical Letters 1999年第6期10卷 491-494页

作者： Zhi hui ding Jing Kai ding(Laboratory of phytochemistry, Kunming Institute of Botany, Academia Sinica. Kunming 650204) Acad Sinica Kunming Inst Bot Lab Phytochem Kunming 650204 Peoples R China

A new sesquiterpene lactone eupatoranolide was isolated from the flowers of Eupatorium adenophorum, its structure was elucidated as 2 beta-acetoxy-(7 alpha, 9 beta H)-3.6(11)-cadinadien-12(7)-olide by spectral analysis.

关键词： Eupatorium adenophorum cadinene sesquiterpene lactone eupatoranolide

YAGG:Ce transparent ceramics with high luminous efficiency for solid-state lighting application

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Journal of Advanced Ceramics 2019年第3期8卷 389-398页

作者： hui HUA Shaowei FENG Zhongyu OUYANG Hezhu SHAO Haiming QIN hui ding Qiping DU Zhijun ZHANG Jun JIANG Haochuan JIANG School of Materials Science and Engineering Shanghai UniversityShanghai200072China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo315201China School of Materials Science and Engineering Tianjin UniversityTianjin300072China

A series of Y2.985Al5–xGaxO12:0.015Ce(YAGG:Ce,x=0,1,2,3,4,5)transparent ceramics were prepared via a solid-state reaction ***-step sintering technique was proved to be an effective approach to prepare functional ceramics with high Ga concentration,and Y3Ga5O12(YGG)transparent ceramic was successfully prepared for the first *** to the variation of Al/Ga ratio,regulation of band structure and luminescence properties of YAGG:Ce transparent ceramics were effectively *** Ga substitutes Al sites,the tetrahedral site is more favorable compared to the octahedral site for Ga to occupy according to the first-principle calculation.A continuous blue shift of the emission from 565 to 515 nm was achieved as Ga was gradually introduced into Y3Al5O12:Ce *** quality green light was obtained by coupling the YAGG:Ce ceramics with commercial blue InGaN *** luminescence ceramics accomplished in this work can be quite prospective for high power LED application.

关键词： YAGG:Ce transparent ceramics two-step sintering Al/Ga ratio luminous efficiency green-emitting LEDs

An experimental study on effects of temperature gradient on microstructure of a 308L stainless steel manufactured by directed energy deposition

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Journal of Iron and Steel Research International 2024年第8期31卷 2031-2040页

作者： Ting Dai De-yu Gu Yu-wen Qiu Wei Guo hui ding Yi-wei Sun School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Metallic MaterialsSoutheast UniversityNanjing 211189JiangsuChina

The effect of spatial temperature gradient on the microstructural evolution of a 308L stainless steel during the directed energy deposition(DED)process was experimentally investigated.A novel cooling system was designed and incorporated to a DED system in order to control the temperature gradient along the deposition direction during *** deposition,the workpiece was placed on a lifting platform,and as the deposition process proceeded,the platform and workpiece were gradually lowered into cooling water so that the temperature gradient along the deposition direction could be controlled and maintained stable during the deposition *** microstructure characterization results indicated that a deposition strategy with higher G and G/R values(where G is temperature gradient and R is solidification rate)produced finer cellular grains that were better aligned with the deposition direction,while a deposition strategy with lower G and G/R values produced columnar grains with larger primary arm spacing and less aligned with the deposition direction.

关键词： Additive manufacturing Directed energy deposition Stainless steel Microstructure Temperature gradient

Adaptive fractional window increment of TCP in multihop ad hoc networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 820-827页

作者： Liang-hui ding Wen-jun ZHANG Xin-bing WANG Liang QIAN You-yun XU Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

We propose an adaptive fractional window increasing algorithm (AFW) to improve the performance of the fractional window increment (FeW) in (Nahm et al., 2005). AFW fully utilizes the bandwidth when the network is idle, and limits the op-erating window when the network is congested. We evaluate AFW and compare the total throughput of AFW with that of FeW in different scenarios over chain, grid, random topologies and with hybrid traffics. Extensive simulation through ns2 shows that AFW obtains 5% higher throughput than FeW, whose throughput is significantly higher than that of TCP-Newreno, with limited modi-fications.

关键词： TCP Multihop Adaptive fractional window increasing algorithm (AFW)

The Suspended Sediment Concentration Distribution in the Bohai Sea,Yellow Sea and East China Sea

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Journal of Ocean University of China 2013年第3期12卷 345-354页

作者： BIAN Changwei JIANG Wensheng Richard J.Greatbatch ding hui Physical Oceanography Laboratory Ocean University of China Helmholtz Centre for Ocean Research at Kiel University (GEOMAR)

The distribution of the suspended sediment concentration （SSC） in the Bohai Sea, Yellow Sea and East China Sea （BYECS） is studied based on the observed turbidity data and model simulation results. The observed turbidity results show that （i） the highest SSC is found in the coastal areas while in the outer shelf sea areas turbid water is much more difficult to observe, （ii） the surface layer SSC is much lower than the bottom layer SSC and （iii） the winter SSC is higher than the summer SSC. The Regional Ocean Modeling System （ROMS） is used to simulate the SSC distribution in the BYECS. A comparison between the modeled SSC and the observed SSC in the BYECS shows that the modeled SSC can reproduce the principal features of tlte SSC distribution in the BYECS. The dynamic mechanisms of the sediment erosion and transport processes are studied based on the modeled results. The horizontal distribution of the SSC in the BYECS is mainly determined by the current-wave induced bottom stress and the fine-grain sediment distribution. The current-induced bottom stress is much higher than the wave-induced bottom stress, which means the tidal currents play a more significant role in the sediment resuspension than the wind waves. The vertical mixing strength is studied based on the mixed layer depth and the turbulent kinetic energy distribution in the BYECS. The strong winter time vertical mixing, which is mainly caused by the strong wind stress and surface cooling, leads to high surface layer SSC in winter. High surface layer SSC in summer is restricted in the coastal areas.

关键词： ROMS model turbidity observation seasonal variation bottom stress vertical mixing

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丁慧根据“月经周期”论治女性黄褐斑

中华中医药杂志 2019年第10期34卷 4643-4645页

作者：邓梦琪林爽丁慧广州中医药大学针灸康复临床医学院

黄褐斑是女性常见的损美性疾病,不仅影响患者容貌,更给患者带来诸多精神、生活方面的烦恼和痛苦。丁慧教授从事中医美容临床工作多年,对治疗黄褐斑有着丰富的经验。其认为岭南地区女性黄褐斑的发生主要与'肝''脾'两脏有关,且女子以血为... 详细信息

黄褐斑是女性常见的损美性疾病,不仅影响患者容貌,更给患者带来诸多精神、生活方面的烦恼和痛苦。丁慧教授从事中医美容临床工作多年,对治疗黄褐斑有着丰富的经验。其认为岭南地区女性黄褐斑的发生主要与'肝''脾'两脏有关,且女子以血为本,黄褐斑的发病与月经有着密切关系。丁慧教授根据月经周期不同时期阴阳、气血的变化规律结合黄褐斑的病机特点进行分期治疗,针药结合,配以科学日常面部护理,其临床疗效显著。

关键词：丁慧女性黄褐斑月经周期针药结合