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Vulnerable brain regions in adolescent major depressive disorder:A resting-state functional magnetic resonance imaging activation likelihood estimation meta-analysis

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World Journal of Psychiatry 2024年第3期14卷 456-466页

作者： Hui ding Qin Zhang Yan-Ping Shu Bin Tian Ji Peng yong-Zhe Hou gang Wu Li-Yun Lin Jia-Lin Li Department of Radiology The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina Department of Psychiatry of Women and Children The Second People's Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Zhijin County People's HospitalBijie 552100Guizhou ProvinceChina Medical Humanities College Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Adolescent major depressive disorder(MDD)is a significant mental health concern that often leads to recurrent depression in ***-state functional magnetic resonance imaging(rs-fMRI)offers unique insights into the neural mechanisms underlying this ***,despite previous research,the specific vulnerable brain regions affected in adolescent MDD patients have not been fully *** To identify consistent vulnerable brain regions in adolescent MDD patients using rs-fMRI and activation likelihood estimation(ALE)*** We performed a comprehensive literature search through July 12,2023,for studies investigating brain functional changes in adolescent MDD *** utilized regional homogeneity(ReHo),amplitude of low-frequency fluctuations(ALFF)and fractional ALFF(fALFF)*** compared the regions of aberrant spontaneous neural activity in adolescents with MDD vs healthy controls(HCs)using *** Ten studies(369 adolescent MDD patients and 313 HCs)were *** the ReHo and ALFF/fALFF data,the results revealed that the activity in the right cuneus and left precuneus was lower in the adolescent MDD patients than in the HCs(voxel size:648 mm3,Pding of the neuropathology of affected adolescents.

关键词： Major depressive disorder Resting-state functional magnetic resonance imaging Adolescent Activation likelihood estimation Meta-analysis

Oxidation behavior of low-grade vanadiferous titanomagnetite concentrate with high titanium

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Journal of Iron and Steel Research International 2024年第2期31卷 329-341页

作者： Jin-sheng Liu Zhen-xing Xing Gong-jin Cheng Xue-yong ding Xiang-xin Xue School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Liaoning Key Laboratory of Recycling Science for Metallurgical Resources Shenyang110819LiaoningChina Innovation Research Institute of Vanadium and Titanium Resource Industry Technology Northeastern UniversityShenyang110819LiaoningChina

In order to clarify the oxidation mechanisms and make better use of the low-grade vanadiferous titanomagnetite concentrate with high titanium(LVTC),the oxidation behavior of LVTC was *** results showed that oxidation degree was achieved within 90 min when temperature was not lower than 700°C,and the main phases of the oxidized LVTC consisted of Fe9TiO15,Fe2O3,CaSiTiO5 and a small amount of *** temperature is favorable to the formation of *** surface of LVTC gradually becomes rough,with fine particles of needle-like and granular shape appearing on the surface,which finally turn from laminar to creamy,spread out,and are interspersed with many tiny *** phase oxidation paths in LVTC were as follows:(1)Fe2.75Ti0.25O4→Fe9TiO15+Fe2O3;(2)Fe2.75Ti0.25O4→Fe2O3+FeTiO3→Fe2TiO5;(3)FeTiO3→Fe2O3+Fe2Ti3O9→*** is predominantly mesoporous whether oxidized or not,with the pores mainly distributed in the range of 2–40 nm,and the specific surface area of LVTC decreases significantly with increasing temperature.

关键词： Low-grade vanadiferous titanomagnetite concentrate Oxidation degree Phase transformation Micromorphology Oxidation path Pore structure

Remote sensing of air pollution incorporating integrated-path differential-absorption and coherent-Doppler lidar

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Defence Technology（防务技术） 2024年第1期31卷 594-601页

作者： Ze-hou Yang yong Chen Chun-li Chen yong-ke Zhang Ji-hui Dong Tao Peng Xiao-feng Li ding-fu Zhou School of Physics Beijing Institute of TechnologyBeijing 100081China Southwest Institute of Technical Physics Chengdu 610041SichuanChina School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

An innovative complex lidar system deployed on an airborne rotorcraft platform for remote sensing of atmospheric pollution is proposed and *** system incorporates integrated-path differential absorption lidar(DIAL) and coherent-doppler lidar(CDL) techniques using a dual tunable TEA CO_(2)laser in the 9—11 μm band and a 1.55 μm fiber *** combining the principles of differential absorption detection and pulsed coherent detection,the system enables agile and remote sensing of atmospheric *** static tests validate the system’s real-time detection capabilities,including the measurement of concentration-path-length product(CL),front distance,and path wind speed of air pollution plumes over long distances exceeding 4 *** experiments is conducted with the *** of the pollutant concentration and the wind field is carried out in an approximately 1 km slant range over scanning angle ranges from 45°to 65°,with a radial resolution of 30 m and10 *** test results demonstrate the system’s ability to spatially map atmospheric pollution plumes and predict their motion and dispersion patterns,thereby ensuring the protection of public safety.

关键词： Differential absorption LIDAR Coherent Doppler lidar Remoting sensing Atmospheric pollution

The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer

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Research 2024年第1期2023卷 119-130页

作者： ding ding Haitao Zhao Dali Wei Qinglai Yang Cai Yang Ruowen Wang Yumei Chen Lianghua Li Shuxian An Qian Xia gang Huang Jianjun Liu Zeyu Xiao Weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Center for Molecular Imaging Probes Cancer Research InstituteUniversity of South ChinaHengyangHunan 421001China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai200127China

Serving as targeting ligands,aptamers have shown promise in precision ***,the lack of knowledge of the biosafety and metabolism patterns in the human body largely impeded aptamers’clinical *** bridge this gap,here we report the first-in-human pharmacokinetics study of protein tyrosine kinase 7 targeted SGC8 aptamer via in vivo PET tracking of gallium-68(^(68)Ga)radiolabeled *** specificity and binding affinity of a radiolabeled aptamer,named ^(68)Ga[Ga]-NOTA-SGC8,were maintained as proven in *** preclinical biosafety and biodistribution evaluation confirmed that aptamers have no biotoxicity,potential mutation risks,or genotoxicity at high dosage(40 mg/kg).Based on this result,a first-in-human clinical trial was approved and carried out to evaluate the circulation and metabolism profiles,as well as biosafety,of the radiolabeled SGC8 aptamer in the human *** advantage of the cutting-edge total-body PET,the aptamers’distribution pattern in the human body was acquired in a dynamic fashion.

关键词： metabolism dosage Whole

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儿童卵巢扭转的MSCT表现

中国介入影像与治疗学 2015年第6期12卷 349-352页

作者：丁永刚蔡金华秦勇李伟平顶山市妇幼保健院放射科河南平顶山467000 重庆医科大学附属儿童医院放射科重庆400014

目的观察儿童卵巢扭转的MSCT表现。方法回顾性分析23例经手术或病理检查证实的儿童卵巢扭转MSCT资料,主要观察扭转后卵巢大小和形态、蒂扭转、子宫及附件周围血管异常改变。23例中,6例仅接受CT平扫,17例接受CT平扫及双期增强扫描。结果... 详细信息

目的观察儿童卵巢扭转的MSCT表现。方法回顾性分析23例经手术或病理检查证实的儿童卵巢扭转MSCT资料,主要观察扭转后卵巢大小和形态、蒂扭转、子宫及附件周围血管异常改变。23例中,6例仅接受CT平扫,17例接受CT平扫及双期增强扫描。结果 23例患儿中,原发性卵巢扭转4例,继发性卵巢扭转19例;发生于左侧9例,右侧14例。23例中,MSCT示15例卵巢体积增大且密度增高,12例增大的卵巢表面可见数量不等的增大滤泡。23例中,11例(11/23,47.83%)可见卵巢蒂扭转。CT增强扫描动脉期及门静脉期均见卵巢扭转侧子宫及附件周围血管增多、增粗、走行异常。15例子宫不同程度变形、移位;11例可见盆腔内少量积液。结论儿童卵巢扭转的MSCT表现具有一定特征性,MSCT检查有助于提高卵巢扭转的检出率。

关键词：卵巢扭转儿童体层摄影术,X线计算机诊断显像

多维地震动作用下摩擦摆基础隔震结构能量反应分析

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振动与冲击 2011年第5期30卷 241-244页

作者：王建强赵卓丁永刚李大望郑州大学土木工程学院郑州450001 河南工业大学土木建筑学院郑州450052 深圳大学土木工程学院深圳518060

对摩擦摆基础隔震结构进行了能量反应分析,研究了多维地震动、地震烈度和支座摩擦系数对结构能量反应的影响,表明水平双向地震动输入时结构总输入能量明显增大,隔震层滞回耗能比增大,上部结构变形耗能比减小;而竖向地震动的参与使结构... 详细信息

对摩擦摆基础隔震结构进行了能量反应分析,研究了多维地震动、地震烈度和支座摩擦系数对结构能量反应的影响,表明水平双向地震动输入时结构总输入能量明显增大,隔震层滞回耗能比增大,上部结构变形耗能比减小;而竖向地震动的参与使结构总输入能量略有增大,隔震层滞回耗能比减小,上部结构变形耗能比增大;随着地震动强度的提高,结构的总输入能量显著增大,隔震层滞回耗能比增大,上部结构变形耗能比减小;随着支座摩擦系数的增大,结构的总输入能量明显增大,隔震层滞回耗能比减小,上部结构的变形耗能比增大。

关键词：摩擦摆基础隔震结构多维地震动能量反应

Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review

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Neural Regeneration Research 2024年第3期19卷 563-570页

作者： Bo Han Weishi Liang yong Hai Duan Sun Hongtao ding Yihan Yang Peng Yin Department of Orthopedics Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina

Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal *** the increased degree and duration of distraction,spinal cord injuries become more serious in terms of their neurophysiology,histology,and *** few studies have been published on the specific characteristics of distraction spinal cord *** this study,we systematically review 22 related studies involving animal models of distraction spinal cord injury,focusing particularly on the neurophysiological,histological,and behavioral characteristics of this *** addition,we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord *** provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research,and provide reference guidelines for the clinical diagnosis and treatment of this disease.

关键词： animal models behavior distraction heterogeneity histology mechanism neurophysiology spinal cord injury systematic review tension

Strongly Coupled Ag/Sn-SnO_(2)Nanosheets Toward CO_(2)Electroreduction to Pure HCOOH Solutions at Ampere‑Level Current

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Nano-Micro Letters 2024年第3期16卷 212-226页

作者： Min Zhang Aihui Cao Yucui Xiang Chaogang Ban Guang Han Junjie ding Li‑yong Gan Xiaoyuan Zhou College of Physics and Center of Quantum Materials and Devices Chongqing UniversityChongqing 401331People’s Republic of China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences(CAS)Fuzhou 350002People’s Republic of China College of Materials Science and Engineering Chongqing UniversityChongqing 400044People’s Republic of China Institute of New Energy Storage Materials and Equipment Chongqing 401135People’s Republic of China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044People’s Republic of China

Electrocatalytic reduction of CO_(2) converts intermittent renewable electricity into value-added liquid products with an enticing prospect,but its practical application is hampered due to the lack of high-performance ***,we elaborately design and develop strongly coupled nanosheets composed of Ag nanoparticles and Sn-SnO_(2) grains,designated as Ag/Sn-SnO_(2) nanosheets(NSs),which possess optimized electronic structure,high electrical conductivity,and more accessible *** a result,such a catalyst exhibits unprecedented catalytic performance toward CO_(2)-to-formate conversion with near-unity faradaic efficiency(≥90%),ultrahigh partial current density(2,000 mA cm^(−2)),and superior long-term stability(200 mA cm^(−2),200 h),surpassing the reported catalysts of CO_(2) electroreduction to ***,in situ attenuated total reflection-infrared spectra combined with theoretical calculations revealed that electron-enriched Sn sites on Ag/Sn-SnO_(2)NSs not only promote the formation of*OCHO and alleviate the energy barriers of*OCHO to*HCOOH,but also impede the desorption of H*.Notably,the Ag/Sn-SnO_(2)NSs as the cathode in a membrane electrode assembly with porous solid electrolyte layer reactor can continuously produce~0.12 M pure HCOOH solution at 100 mA cm^(−2)over 200 *** work may inspire further development of advanced electrocatalysts and innovative device systems for promoting practical application of producing liquid fuels from CO_(2).

关键词： Electrochemical CO_(2)reduction Coupled Ag/Sn-SnO_(2)nanosheets Electronic structure Porous solid electrolyte Pure

Regulation of the quantum barrier and carrier transport toward high-efficiency quasi-2D Dion-Jacobson tin perovskite solar cells

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Journal of Energy Chemistry 2024年第8期95卷 200-207,I0005页

作者： Huanhuan Yao Chang Shi Tai Wu Shurong Wang Mingyu Yin Liming ding yong Hua Feng Hao School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Yunnan Key Laboratory for Micro/Nano Materials&Technology School of Materials and EnergyYunnan UniversityKunming 650091YunnanChina Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

Quasi-2D Dion-Jacobson(DJ)tin halide perovskite has attracted much attention due to its elimination of Van der Waals gap and enhanced environmental ***,the bulky organic spacers usually form a natural quantum well structure,which brings a large quantum barrier and poor film quality,further limiting the carrier transport and device ***,we designed three organic spacers with different chain lengths(ethylenediamine(EDA),1,3-propanediamine(PDA),and 1,4-butanediamine(BDA))to investigate the quantum barrier *** and experimental characterizations indicate that EDA with short chain can reduce the lattice distortion and dielectric confinement effect,which is beneficial to the effective dissociation of excitons and the inhibition of trap-free non-radiative *** addition,EDA cation shows strong interaction with the inorganic octahedron,realizing large aggregates in precursor solution and high-quality films with improved structural ***,femtosecond transient absorption proves that EDA cations can also weaken the formation of small n-phases with large quantum barrier to achieve effective carrier transport between different ***,the quasi-2D DJ(EDA)FA_(9)Sn_(10)I_(31)solar cells achieves a 7.07%power conversion efficiency with good environment ***,this work sheds light on the regulation of the quantum barrier and carrier transport through the chain length of organic spacer for qua si-2D DJ lead-free perovskites.

关键词： Chain lengths Organic spacers Quantum well Carrier transport Lattice distortion