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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-Gang shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Physiochemical Properties of Resistant Starch and Its Enhancement Approaches in Rice

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Rice science 2021年第1期28卷 31-42页

作者： ding yi Wang Maike shen yi Shu Xiaoli Wu Dianxing Song Wenjian State Key Laboratory of Rice Biology/Key Laboratory of the Ministry of Agriculture for the Nuclear Agricultural Sciences Zhejiang UniversityHangzhou 310058China Agricultural Technology Extension Center Zhejiang UniversityHangzhou 310058China

With changes in food preferences and life styles,more and more attentions have been focused on healthier ***,resistant starch(RS)which can resist digestion in the human intestine has been recognized and *** RS diet shows great benefit for the human health,and breeding high RS rice variety is a great target for realizing dietary *** provide guidance for RS improvement in rice,this review summarized the unique physiochemical properties of RS and the possible approaches,*** regulation,for enhancing RS content in rice,and proposed the potential ways to obtain rice variety with high RS content.

关键词： rice resistant starch starch modification physiochemical property

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Extraction of iron and aluminum from high-iron bauxite by ammonium sulfate roasting and water leaching

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Journal of Iron and Steel Research International 2019年第6期26卷 578-584页

作者： ding Tian Xiao-yi shen Yu-chun Zhai Penny Xiao Paul Webley School of Metallurgy Northeastern University Shenyang 110819 Liaoning China School of Material Science and Engineering Dalian Jiaotong University Dalian 11602& Liaoning China Liaoning Key Laboratory for Metallurgical Sensor and Technology Northeastern University Shenyang 110819 Liaoning China School of Resources and Materials Northeastern University at Qinhuangdao Qinhuangdao 066004 Hebei China Department of Chemical & Biomolecular Engineering University of Melbourne Melbourne 3010 VIC Australia

High iron content is one of the challenges in utilizing the refractory bauxites in China. An improved method for treating the high-iron bauxite by roasting with (NH4)2SO4 was proposed, which offers a possible alternative method for utilizing the high-iron bauxite. The influences of the roasting time, roasting temperature, material ratio, and ore particle size on the extraction ratios of Fe and Al were studied, and the orthogonal test was used to optimize the reaction conditions. The optimized reaction conditions were proposed as follows: roasting temperature of 450 °C, roasting time of 120 min, material ratio of (NH4)2SO4 to ore of 2.5:1.0, and ore particle size below 80 jim. The roasting mechanism and kinetic parameters including the apparent activation energy and reaction rate constant were investigated. The results showed that the control step of the roasting process was the internal diffusion on the product layer and the apparent activation energy was 19.22 kJ mol-1 in the reaction temperature range. The kinetic equation was obtained finally.

关键词： High-iron bauxite Ammonium sulfate Roasting Reaction process Kinetics

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Carbon isotopic composition and its implications on paleoclimate of the underground ancient forest ecosystem in Sihui,Guangdong

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Science China Earth Sciences 2009年第5期52卷 638-646页

作者： Ping ding ChengDe shen Ning Wang WeiXi yi KeXin Liu XingFang ding DongPo Fu Key Laboratory of Isotope Geochronology and Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of H

We present the carbon isotopic composition of the total organic carbon (TOC) and fine roots in the sedimentary profile from the underground ancient forest in Sihui to study the climatic and environmental changes from ... 详细信息

关键词： Holocene underground ancient forest Pearl River Delta fine root atmospheric CO2

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血卟啉衍生物对X线照射小鼠移植瘤(S180)的增敏作用

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军事医学科学院院刊 1985年第2期 109-114页

作者：陈定一沈孝恩卢明张建军军事医学科学院放射医学研究所军事医学科学院附属医院北京市肿瘤研究所军事医学科学院放射医学研究所进修人员

激光加血卟啉衍生物(Hematoporphyrin Derivative,HpD)对治疗表浅癌肿的效果已受到人们的重视,并已用于临床。但激光穿透组织的能力是呈负指数函数衰减的,即使用穿透力较强的6300A氦氖激光,其单束光穿透组织到达2cm深度时,光强也仅为原... 详细信息

激光加血卟啉衍生物(Hematoporphyrin Derivative,HpD)对治疗表浅癌肿的效果已受到人们的重视,并已用于临床。但激光穿透组织的能力是呈负指数函数衰减的,即使用穿透力较强的6300A氦氖激光,其单束光穿透组织到达2cm深度时,光强也仅为原来的万分之一。因此,激光加HpD对深部肿瘤的疗效很难达到同样的效果。1966年Cohen等曾报道血卟啉(Hematoporphyrin)加X-线治疗小鼠腿部移植瘤的研究结果,作者给小鼠腹腔注射不同剂量的血卟啉后3小时,在植瘤小腿部照射X-线2750伦,发现血卟啉量为0.05mg时,有增加疗效作用。但

关键词：小鼠周长小家鼠增敏作用移植瘤增敏效应治疗肿瘤

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Incorporating Domain Knowledge into Data Mining Process:An Ontology Based Framework

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 165-169页

作者： PAN ding shen Jun-yi ZHOU Mu-xin Department of Computer Science and Technology Xi＇an jiaotong University Xi＇an 710049 Shaanxi China Department of Computer Science and Engineering Shanghai Jiaotong University Shanghai 200240 China

With the explosive growth of data available, there is an urgent need to develop continuous data mining which reduces manual interaction evidently. A novel model for data mining is proposed in evolving environment. First, some valid mining task schedules are generated, and then au tonomous and local mining are executed periodically, finally, previous results are merged and refined. The framework based on the model creates a communication mechanism to in corporate domain knowledge into continuous process through ontology service. The local and merge mining are transparent to the end user and heterogeneous data ,source by ontology. Experiments suggest that the framework should be useful in guiding the continuous mining process.

关键词： continuous data mining domain knowledge ontology framework

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How to get high-efficiency lead chalcogenide quantum dot solar cells?

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Science China(Physics,Mechanics & Astronomy) 2023年第1期66卷 34-59页

作者： Chao ding Qing shen Faculty of Informatics and Engineering The University of Electro-CommunicationsTokyo 182-8585Japan

Lead chalcogenide colloidal quantum dots(CQDs)are regarded as attractive absorption materials for novel solar cells(SCs).The cost of lead chalcogenide CQD has been decreased to a commercialization target of$5/g due to the direct production of CQD ***,the photoelectric conversion efficiency(PCE)of lead chalcogenide CQDSCs is presently close to 14%,well below the commercialization target(20%),which is only 41%of the theoretical Shockley-Queisser limit *** this study,the different losses of open-circuit voltage(V_(oc)),fill factor(FF),and short circuit current density(J_(sc))for current CQDSCs are systematically discussed,as well as the percentage and likely causes of each *** the primary reasons for the CQDSCs’performance constraints are *** that,we focus on the CQDSCs interfaces(i.e.,CQD/CQD,CQD/HTL,and ETL/CQD)and explore viable ways to reduce device performance ***,based on the discussion above,we propose many enhancements to significantly solve numerous major obstacles impeding device performance to boost the PCE of CQDSCs for future commercialization significantly.

关键词： lead chalcogenide colloidal quantum dots solar cell interface engineering non-radiative carrier recombination charge carrier transport losses

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Enhancement in Energy Loss of MeV Silicon Clusters in C Films

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Chinese Physics Letters 2001年第4期18卷 525-527页

作者： shen yi-Xiong JIANG Dong-Xing LU Xi-Ting shen ding-Yu Department of Technical Physics and Institute of Heavy Ion Physics Peking UniversityBeijing 100871

Energy losses of 0.63-1.03MeV/atom Sin(n≤3)clusters in thin carbon films(2-12μg/cm^(2))have been measured by using a special experimental setup with Rutherford backscattering(RBS)*** experimental results show that for a given energy per atom,the energy loss of Si^(+)_(2) ions,as well as Si^(+)_(3) ions,is significantly larger than that of Si+*** is the first observation of energy loss enhancement in the measurements with RBS *** enhancement in energy loss(*** cluster effect)is evident when the effective thickness of the carbon target is thin enough,but not evident when it is *** effect will not be obvious until the energy of the projectile is over a certain limit for a special *** suggests that the cluster effect only occurs in the first layers of the target film,and that the energy of the projectile must be large enough for the effect to be seen.

关键词： technique. cluster evident

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Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression

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Signal Transduction and Targeted Therapy 2023年第2期8卷 692-704页

作者： Zonglong Hu Fan Wei yi Su Yafang Wang Yanyan shen Yanfen Fang Jian ding yi Chen Division of Anti-Tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing100049China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China

Histone deacetylase(HDAC)is a kind of protease that modifies histone to regulate gene expression,and is usually abnormally activated in *** approved pan-HDAC inhibitors have demonstrated clinical benefits for patients in some hematologic *** limited therapeutic success in breast cancer has been observed in clinical *** this study,we declare that pan-HDAC inhibitors targeting NEDD9-FAK pathway exacerbate breast cancer metastasis in preclinical models,which may severely impede their clinical ***9 is not an oncogene,however,it has been demonstrated recently that there are high level or activity changes of NEDD9 in a variety of cancer,including leukemia,colon cancer,and breast ***,pan-HDAC inhibitors enhance H3K9 acetylation at the nedd9 gene promoter via inhibition of HDAC4 activity,thus increase NEDD9 expression,and then activate FAK *** realization that pan-HDAC inhibitors can alter the natural history of breast cancer by increasing invasion warrants clinical *** addition,although NEDD9 has been reported to have a hand in breast cancer metastasis,it has not received much attention,and no therapeutic strategies have been ***,we demonstrate that FAK inhibitors can reverse breast cancer metastasis induced by upregulation of NEDD9 via pan-HDAC inhibitors,which may offer a potential combination therapy for breast cancer.

关键词： metastasis breast cancer

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A strategy for generating rice apomixis by gene editing

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Journal of Integrative Plant Biology 2019年第8期61卷 911-916页

作者： En Xie Yafei Li ding Tang Yanli Lv yi shen Zhukuan Cheng State Key Laboratory of Plant Genomics and Center for Plant Gene Research Institute of Genetics and Developmental Biologythe Chinese Academy of SciencesBeijing 100101China The University of Chinese Academy of Sciences Beijing 100049China

Apomixis is an asexual reproduction way of plants that can produce clonal offspring through *** this study,we introduced apomixis into rice(Oryza sativa)by mutating OsSPO11-1,OsREC8,OsOSD1,and OsMATL through a CRISPR/Cas9 *** quadruple mutant showed a transformation from meiosis to mitosis and produced clonal diploid *** mutated Osmatl,which gives rise to haploid induction in plants,the quadruple mutant is expected to be able to be produced apomictic diploid *** named this quadruple mutant as AOP(Apomictic Offspring Producer)for its ability to produce apomictic offspring.

关键词： asexual reproduction meiosis apomictic

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