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精细化护理结合临床护理路径对心血管疾病介入手术患者的应用效果

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国际医药卫生导报 2024年第3期30卷 515-519页

作者：贾晓辉丁鑫鑫潘亚娟河南省人民医院心脏中心、阜外华中心血管病医院郑州大学华中阜外医院介入手术室郑州451464

目的探究精细化护理结合临床护理路径对心血管疾病介入手术患者的应用效果。方法选取2021年2月至2022年2月在阜外华中心血管病医院行介入手术的心血管疾病患者85例作为研究对象,根据患者入住病房分组,入住A病房的为对照组(43例),入住B... 详细信息

目的探究精细化护理结合临床护理路径对心血管疾病介入手术患者的应用效果。方法选取2021年2月至2022年2月在阜外华中心血管病医院行介入手术的心血管疾病患者85例作为研究对象,根据患者入住病房分组,入住A病房的为对照组(43例),入住B病房的为研究组(42例)。对照组男性25例,女性18例,年龄40~75(58.47±6.49)岁,予以常规护理干预;研究组男性28例,女性14例,年龄为40~73(57.62±6.40)岁,在常规护理基础上增加精细化护理结合临床护理路径干预。比较两组干预效果、心理状态及术后并发症发生情况。统计学方法采用t检验和χ^(2)检验。结果研究组护理满意度高于对照组[95.24%(40/42)比74.42%(32/43)],住院时间短于对照组[(9.58±1.92)d比(12.31±2.46)d],差异均有统计学意义(χ^(2)=5.59、t=5.70,均P<0.05)。干预后,研究组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于对照组[(39.47±4.39)分比(42.15±4.68)分、(40.35±4.48)分比(43.56±4.84)分],差异均有统计学意义(t=2.72、3.17,均P<0.05)。研究组术后并发症发生率低于对照组[2.38%(1/42)比18.60%(8/43)],差异有统计学意义(χ^(2)=4.32,P<0.05)。结论对心血管疾病介入手术患者应用精细化护理结合临床护理路径可改善患者心理状态,减少术后并发症,临床护理效果较好。

关键词：心血管疾病介入手术临床护理路径精细化护理心理状态

中青年慢性心力衰竭患者死亡焦虑现状及其影响因素分析

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中华现代护理杂志 2024年第18期30卷 2423-2427页

作者：贾晓辉丁鑫鑫薛明孟令娟潘亚娟于雷河南省人民医院心脏中心阜外华中心血管病医院郑州大学华中阜外医院介入手术室郑州451464

目的探讨中青年慢性心力衰竭(CHF)患者死亡焦虑现状及其影响因素。方法采取便利抽样法,选择阜外华中心血管病医院2021年1月—2023年2月诊治的176例中青年CHF患者作为研究对象。采用一般资料调查表、医学应对方式问卷(MCMQ)、死亡焦虑量... 详细信息

目的探讨中青年慢性心力衰竭(CHF)患者死亡焦虑现状及其影响因素。方法采取便利抽样法,选择阜外华中心血管病医院2021年1月—2023年2月诊治的176例中青年CHF患者作为研究对象。采用一般资料调查表、医学应对方式问卷(MCMQ)、死亡焦虑量表对患者进行调查。结果本研究共发放问卷176份,回收有效问卷170份,问卷有效回收率为96.59%。170例中青年CHF患者中低死亡焦虑患者136例,高死亡焦虑患者34例。多重线性回归分析结果显示,教育水平、家庭人均月收入、病程、心功能分级、体育锻炼情况、应对方式(屈服)是中青年慢性心力衰竭患者死亡焦虑的影响因素(P<0.05)。结论中青年CHF患者的死亡焦虑主要与患者的教育水平、家庭人均月收入、病程、心功能分级、体育锻炼情况、应对方式(屈服)有关,临床应加强对上述因素的评估,并及时给予针对性的心理干预。

关键词：慢性心力衰竭中青年死亡焦虑影响因素

Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model

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Acta Pharmaceutica Sinica B 2020年第1期10卷 123-135页

作者： Xiaoyu Fan xinxin ding Qing-Yu Zhang Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA Wadsworth Center New York State Department of HealthSchool of Public HealthUniversity at AlbanyAlbanyNY 12201USA

We examined the impact of gut inflammation on the expression of cytochrome P450(P450)and other biotransformation genes in male mice using a dextran sulfate sodium(DSS)-induced colitis *** P450 isoforms,including CYPIA,CYP2B,CYP2C,and CYP3A,were downregulated,accompanied by decreases in microsomal metabolism of diclofenac and nifedipine,in the liver and small *** impact of the colitis on in vivo clearance of oral drugs varied for four different drugs tested:a small decrease for nifedipine,a relatively large decrease for lovastatin,but no change for pravastatin,and a large decrease in the absorption of cyclosporine *** further assess the scope of influence of gut inflammation on gene expression,we performed genome-wide expression analysis using RNA-seq,which showed down-regulation of many CYPs,non-CYP phase-Ⅰenzymes,phase-Ⅱenzymes and transporters,and up-regulation of many other members of these gene families,in both liver and intestine of adult C57BL/6 mice,by DSS-induced ***,our results indicate that gut inflammation suppresses the expression of many P450s and other biotransformation genes in the intestine and liver,and alters the pharmacokinetics for some but not all drugs,potentially affecting therapeutic efficacy or causing adverse effects in a drug-specific fashion.

关键词： Cytochrome P450 CYP Colitis Intestine Inflammatory bowel disease Drug metabolism Pharmacokinetics Gene expression

An update on the role of intestinal cytochrome P450 enzymes in drug disposition

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Acta Pharmaceutica Sinica B 2016年第5期6卷 374-383页

作者： Fang Xie xinxin ding Qing-Yu Zhang Bioimaging Glaxo Smith KlineKing of Prussia College of Nanoscale Science SUNY Polytechnic Institute Wadsworth Center New York State Department of Health

Oral administration is the most commonly used route for drug *** cytochrome P450(CYP)-mediated metabolism can eliminate a large proportion of some orally administered drugs before they reach systemic circulation,while leaving the passage of other drugs unimpeded.A better understanding of the ability of intestinal P450 enzymes to metabolize various clinical drugs in both humans and preclinical animal species,including the identification of the CYP enzymes expressed,their regulation,and the relative importance of intestinal metabolism compared to hepatic metabolism,is important for improving bioavailability of current drugs and new drugs in ***,we briefly review the expression of drug-metabolizing P450 enzymes in the small intestine of humans and several preclinical animal species,and provide an update of the various factors or events that regulate intestinal P450 expression,including a cross talk between the liver and the *** further compare various clinical and preclinical approaches for assessing the impact of intestinal drug metabolism on bioavailability,and discuss the utility of the intestinal epithelium–specific NADPH-cytochrome P450 reductasenull(IECN) mouse as a useful model for studying in vivo roles of intestinal P450 in the disposition of orally administered drugs.

关键词： Cytochrome P450 Intestine Bioavailability Drug disposition Drug metabolism

Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2751-2777页

作者： Yurong Lai Xiaoyan Chu Li Di Wei Gao Yingying Guo Xingrong Liu Chuang Lu Jialin Mao Hong Shen Huaping Tang Cindy Q.Xia Lei Zhang xinxin ding Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA Department of Pharmacokinetics Pharmacodynamics and Drug MetabolismMerck&Co.Inc.KenilworthNJ 07033USA Pharmacokinetics Dynamics and MetabolismPﬁzer Worldwide Research and DevelopmentGrotonCT 06340USA Eli Lilly and Company IndianapolisIN 46221USA Drug Metabolism and Pharmacokinetics BiogenCambridgeMA 02142USA Drug Metabolism and Pharmacokinetics Accent TherapeuticsInc.LexingtonMA 02421USA Department of Drug Metabolism and Pharmacokinetics GenentechA Member of the Roche GroupSouth San FranciscoCA 94080USA Drug Metabolism and Pharmacokinetics Department Bristol-Myers Squibb CompanyPrincetonNJ 08540USA Bioanalysis and Biomarkers Glaxo Smith KlineKing of the PrussiaPA 19406USA Department of Drug Metabolism and Pharmacokinetics Takeda Pharmaceuticals International Co.CambridgeMA 02139USA Ofﬁce of Research and Standards Ofﬁce of Generic DrugsCDERFDASilver SpringMD 20993USA Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA Current afﬁliation:Translational Medicine EMD Serono Research&Development InstituteInc.BillericaMA 01821USA Current afﬁliation:Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA

Drug metabolism and pharmacokinetics(DMPK) is an important branch of pharmaceutical *** nature of ADME(absorption,distribution,metabolism,excretion) and PK(pharmacokinetics) inquiries during drug discovery and development has evolved in recent years from being largely descriptive to seeking a more quantitative and mechanistic understanding of the fate of drug candidates in biological *** progress has been made in the past decade,not only in the characterization of physiochemical properties of drugs that influence their ADME,target organ exposure,and toxicity,but also in the identification of design principles that can minimize drug-drug interaction(DDI) potentials and reduce the *** importance of membrane transporters in drug disposition,efficacy,and safety,as well as the interplay with metabolic processes,has been increasingly *** increases in investments on new modalities beyond traditional small and large molecule drugs,such as peptides,oligonucleotides,and antibody-drug conjugates,necessitated further innovations in bioanalytical and experimental tools for the characterization of their ADME *** this review,we highlight some of the most notable advances in the last decade,and provide future perspectives on potential major breakthroughs and innovations in the translation of DMPK science in various stages of drug discovery and development.

关键词： Drug discovery and development New drug application Biologics license application Pharmacokinetics ADME New modalities Model-informed drug development Micro-physiological systems

The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3820-3835页

作者： Yisheng He Jiang Ma Xiaoyu Fan Liang ding xinxin ding Qing-Yu Zhang Ge Lin School of Biomedical Sciences Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Pharmacology&Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA

Pyrrolizidine alkaloids(PAs) are the most common phytotoxins with documented human *** require metabolic activation by cytochromes P450 to generate toxic intermediates which bind to proteins and form protein adducts,thereby causing *** study investigated the role of the gut-liver axis in PA intoxication and the underlying *** exposed mice to retrorsine(RTS),a representative PA,and for the first time found RTS-induced intestinal epithelium damage and disruption to intestinal barrier *** mice with tissue-selective ablation of P450 activity,we found that hepatic P450 s,but not intestinal P450 s,were essential for PA ***,in RTS-exposed,bile duct-cannulated rats,we found the liver-derived reactive PA metabolites were transported by bile into the intestine to exert *** impact of gut-derived pathogenic factors in RTS-induced hepatotoxicity was further studied in mice with dextran sulfate sodium(DSS)-induced chronic *** treatment increased the hepatic endotoxin level and depleted hepatic reduced glutathione,thereby suppressing the PA detoxification *** to RTS-exposed normal mice,the colitic mice displayed more severe RTS-induced hepatic vasculature damage,fibrosis,and ***,our findings provide the first mode-of-action evidence of PA-induced enterotoxicity and highlight the importance of gut barrier function in PA-induced liver injury.

关键词： Pyrrolizidine alkaloid Cytochrome P450 Inflammatory bowel disease Intestinal injury Liver injury Gut-liver axis

A Polysaccharide-based Hydrogel and PLGA Microspheres for Sustained P24 Peptide Delivery: An In vitro and In vivo Study Based on Osteogenic Capability

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Chemical Research in Chinese Universities 2019年第5期35卷 908-915页

作者： CAI Qing QIAO Chunyan NING Jun ding xinxin WANG Haoyang ZHOU Yanmin Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School of StomotologyJilin UniversityChangchun 130021P.R.China The First Hospital of Jilin University Changchun 130021P.R.China

A bone morphogenetic protein-2(BMP-2) derived synthetic oligopeptide, S [PO4]KIPKASSVPTELSAISTLYLDDD(P24), has shown great potential for facilitating bone regeneration. However, P24 cannot be directly used onto bone defects, while a continuous sustained delivery of P24 may lead to a better formation of bone tissue. Based on this issue, we have developed a sustained delivery system incorporating P24-loaded poly(lactide-co-glycolide)(PLGA) microspheres and nano-hydroxyapatite(n-HA) into the composite hydrogel. The P24-contained compound material was characterized with NMR, FTIR and SEM to demonstrate the fomiation of compound structure containing P24, PLGA and n-HA. A continuous drug release of P24 was observed for over 60 d that evidently enhanced the efficiency in promoting the proliferation of MC3T3-E1 cells and the secrete of alkaline phosphatase(ALP) in vitro. Moreover, the osteoinduction eflect of the hydrogel system with P24 peptide niicrospheres was demonstrated in vivo and manifested by the result of immunohistochemistry. This novel injectable composite hydrogel is expected to be applied to improving the bone defect treatment in bone tissue engineering.

关键词： BMP-2 derived peptide Hydrogel PLGA microsphere Osteogenesis Tissue engineering

Preferential expression of cytochrome CYP CYP2R1 but not CYP1B1 in human cord blood hematopoietic stem and progenitor cells

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Acta Pharmaceutica Sinica B 2014年第6期4卷 464-469页

作者： Shuoqi Xu Zhihua Ren Yanan Wang xinxin ding Yongping Jiang Biopharmaceutical R&D Center Chinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou 215126China Biopharmagen Corp. Suzhou 215126China Department of Clinical Laboratory Suzhou Municipal Affiliated Hospital of Nanjing Medical UniversitySuzhou 215002China

Cytochrome P450(CYP)enzymes metabolize numerous endogenous substrates,such as retinoids,androgens,estrogens and vitamin D,that can modulate important cellular processes,including proliferation,differentiation and *** aim of this study is to characterize the expression of CYP genes in CD34+human cord blood hematopoietic stem and early progenitor cells(CBHSPCs)as a first step toward assessment of the potential biological functions of CYP enzymes in regulating the expansion or differentiation of these ***34+CBHSPCs were purified from umbilical cord blood via antibody affinity *** of CD34+CBHSPCs was assessed using fluorescence-activated cell *** was isolated from purified CD34+CBHSPCs and total mononuclear cells(MNCs)for RNA-PCR analysis of CYP *** human CYPs were detected in the initial screening with qualitative RT-PCR in CD34+*** quantitative RNA-PCR analysis of the detected CYP transcripts yielded evidence for preferential expression of CYP2R1 in CD34+CBHSPCs relative to MNCs;and for greater expression of CYP1B1 in MNCs relative to CD34+*** findings provide the basis for further studies on possible functions of CYP2R1 and CYP1B1 in CBHSPCs'proliferation and/or differentiation and their potential utility as targets for drugs designed to modulate CD34+CBHSPC expansion or differentiation.

关键词： Cytochrome P450 CYP2R1 CYP1B1 CD34+ Hematopoietic stem cells Gene expression

CO_(2)/C_(2)H_(4)耦合制备丙烯酸及其衍生物的研究进展

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有机化学 2022年第4期42卷 965-977页

作者：朱有财丁欣欣孙莉刘振华东理工大学化工学院上海200237

二氧化碳(CO_(2))不仅仅是一种温室气体,更是一种重要的、有效的碳一资源,其来源丰富、无毒、无污染、不易燃烧,可用于生产有机化学品、材料、糖类等.由于CO_(2)分子中的碳处于最高氧化态,且其分子具有热力学和动力学惰性,因此人们不断... 详细信息

二氧化碳(CO_(2))不仅仅是一种温室气体,更是一种重要的、有效的碳一资源,其来源丰富、无毒、无污染、不易燃烧,可用于生产有机化学品、材料、糖类等.由于CO_(2)分子中的碳处于最高氧化态,且其分子具有热力学和动力学惰性,因此人们不断探索新型反应途径,以及新型的催化体系来有效资源化利用CO_(2).近年来,利用各种不饱和烃类,在过渡金属催化剂协助下催化CO_(2)与烯烃生成不饱和羧酸及其衍生物引起了极大关注.其中,催化CO_(2)/C_(2)H_(4)耦合反应制备丙烯酸及其衍生物因其原子经济性而备受瞩目.以镍系催化体系为主的过渡金属催化CO_(2)/C_(2)H_(4)偶联反应是CO_(2)化学转化与高值利用非常重要的研究热点之一.综述了近年来CO_(2)/C_(2)H_(4)偶联反应的最新进展,对相应的催化反应机理进行了评述.从多个角度对各位学者的研究进行分析比较,并对各研究方向进行了展望.

关键词：二氧化碳丙烯酸耦合反应反应机理