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Waiting for You Under the Camphor Tree

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China Book International 2024年第1期 108-110页

作者： ding dong People's Congress of Zhangjiagang City

This book is a collection of essays rich in local flavor and everyday life,both documentary and *** author,extracts what he has seen,heard,thought,and realized in his life journey,reflecting on the past and the present,empathizing with others,and deeply interpreting the history,authenticity,and culture of *** author presents the development and life history of the common people of Zhangjiagang from multiple levels,aspects,and angles.

关键词： everyday authentic interpreting

Winter extreme precipitation over the Tibetan Plateau influenced by Arctic sea ice on interdecadal timescale

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Advances in Climate Change Research 2024年第1期15卷 42-51页

作者： Qing-Quan LI Miao BI Song YANG Qing-Yuan WU Yi-Hui ding xin-Yong SHEN Xiao-Ting SUN Meng-Chu ZHAO China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China CMA Key Open Laboratory of Transforming Climate Resources to Economy Chongqing Institute of Meteorological SciencesChongqing 401147China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University Zhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate ***,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still *** this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1980 to *** found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after *** interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea *** the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake *** wave trains originating over the Barents-Kara Sea can be *** southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the *** HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the *** northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly *** HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the *** the SIC in the Barents-Kara Sea increases,the situation is *** above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.

关键词： Arctic sea ice Tibetan Plateau Winter extreme precipitation Rossby wave activity Interdecadal variation

DLX3(Q178R)mutation delays osteogenic differentiation via H19/miR-29c-3p/KDM5B axis in TDO-iPSCs-derived MSCs

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Genes & Diseases 2024年第4期11卷 49-52页

作者： Liying dong Na Zhao dongmei Wang Meng Wang Yixin Zhang Liangjie Sun Chong ding Yixiang Wang Zeyun Ma Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Department of Oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyBeijing 100081China National Engineering Laboratory for Digital and Material Technology of Stomatology Peking University School and Hospital of StomatologyBeijing 100081China Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of StomatologyBeijing 100081China The Second Clinical Division Peking University School and Hospital of StomatologyBeijing 100081China Department of VIP Service Peking University School and Hospital of StomatologyBeijing 100081China Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental MedicineBostonMA 02115USA Department of Prosthodontics Fudan UniversityShanghai 200001China Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological HospitalFudan UniversityShanghai 200001China

Tricho-dento-osseous(TDO)syndrome is a rare autosomal dominant disease resulting from distal-less homeobox 3(DLX3)mutation.1,2 Accumulative bone density in alveolar bone is a clinically favorable phenotype for TDO ***... 详细信息

关键词： patients clinically alveolar

Atomically precise Ru-O-Ru clusters for enhanced water dissociation in alkaline hydrogen evolution

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Nano Research 2024年第8期17卷 6993-7000页

作者： dong Liu Li Xu Sicheng Li Airong Xu Yuanhua Sun Tong Liu Mengyuan Liu Huijuan Wang Xiaokang Liu Tao Yao Tao ding Hefei National Research Center for Physical Sciences at the Microscale School of Nuclear Science and TechnologyKey Laboratory of Precision and Intelligent ChemistryNational Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230029China Experimental Center of Engineering and Materials Science University of Science and Technology of ChinaHefei 230026China

Atomic clusters typically exhibit distinctive electronic structures and physicochemical ***,as the size decreases,their ability to adsorb and dissociate water also diminishes,thereby affecting chemical reactions involving water *** the adsorption and dissociation capabilities of atomic clusters towards water molecules and elucidating the mechanisms underlying their performance enhancement have become important research ***,employing the carrier-anchored strategy,Ru-O-Ru atomic clusters were prepared and displayed excellent activity and durability in the hydrogen evolution ***,the Ru-O-Ru atomic clusters exhibited only 86 mV overpotential at 100 mA·cm−^(2)and superior membrane-electrode-assembly activity than commercial Ru/C *** radiation-based Fourier transform infrared spectroscopic measurements revealed that the modification of oxygen in Ru-O-Ru units promoted the reorientation of water molecules from a H-up orientation to H-down,therefore,enhanced the formation of strong hydrogen-bond network of interfacial water on the surface of Ru-O-Ru clusters,leading to enhanced adsorption and dissociation of water and accelerated Volmer *** findings provide a potential strategy and deep insights for the development of atomic clusters in electrocatalysts.

关键词： hydrogen evolution in-situ Fourier transform infrared(FTIR) Ru catalysts electrocatalysis atomic clusters

A 12-month follow-up study of discharged patients with acute pancreatitis:An acute condition with prolonged sequela

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Chinese Medical Journal 2024年第2期137卷 250-252页

作者： Hanyue ding Jiayuan Dai Jiaye Lin Liang Gong Han Sun Kai Song Feng Xie dong Wu Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China School of Population Medicine and Public Health Peking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong Kong Special Administrative RegionChina Emergency Department Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonCanada Centre for Health Economics and Policy Analysis McMaster UniversityHamiltonCanada State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China Clinical Epidemiology Unit International Clinical Epidemiology NetworkBeijing 100730China

To the Editor:Acute pancreatitis(AP)is the most common gastrointestinal condition that leads to acute hospitalization.[1]The incidence of AP has increased in recent decades,with a current global incidence of 34/100,000,probably due to a rising trend of obesity and gallstone *** is associated with remarkable pain,reduced quality of life(QoL),and even death,thus posing a heavy socioeconomic *** addition,approximately 22%of AP patients experience recurrent AP(RAP)and 10%of AP patients progress to chronic pancreatitis.[2]Petrov and Yadav[3]have,therefore,argued that AP should not be considered as an acute and self-limiting *** and long-term care after AP have drawn widespread attention,which has improved patients’physical and mental health.

关键词： patients pancreatitis acute

Durable ruthenium oxide catalysts for water oxidation reaction

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Science China Chemistry 2024年

作者： Jixiang Jiao ding Chen Hongyu Zhao Ying dong Shichun Mu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

Water electrolysis is an important way for high-purity hydrogen production. However, the oxygen evolution reaction（OER）, as a key reaction, has a high energy barrier, and the associated catalyst is prone to failure. Therefore, efficient and stable OER catalysts are urgently required. Compared with commercial iridium oxide（IrO2）, ruthenium oxide（RuO2） has a lower price and higher catalytic activity for OER due to its location at the near-top of the volcano plot, but has lower structural stability. Thus, an in-depth understanding of the failure mechanism of RuO2is conducive to the reaction pathway design and structural modulation for obtaining higher stable RuO2catalysts. Here, we discuss recent advances in the enhancement of the stability of RuO2catalysts. First, we analyze in depth the three failure modes of RuO2, including the oxidation of Ru, the lattice oxygen evolution,and the catalyst exfoliation during the OER process. Second, to improve the durability of RuO2catalysts, five modification strategies, comprising defective engineering, strain engineering, phase engineering, interface engineering and microenvironmental engineering, are summarized, and corresponding enhancement mechanisms are also discussed. Finally, the challenges and possible solutions for further breakthroughs of RuO2catalysts are proposed, and the future research trends and prospects of RuO2catalysts are also envisioned. Undoubtedly, this work will contribute to the understanding and design of highly stable OER catalysts and beyond.

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New advances in the study of Tethyan Geodynamic System

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Science China Earth Sciences 2024年第3期67卷 874-878页

作者： Lin ding State Key Laboratory of Tibetan Plateau Earth System Science(LATPES) Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Tethyan Ocean was initially proposed by Austrian geologist Eduard Suess in 1893. The study of the Tethyan evolution by European geologists has led to the development of modern geology, but not to the establishment of plate tectonics theory(Trümpy, 2001). With the progress in various studies, the concept of Tethys has evolved from a Mesozoic ocean into three long-term evolving oceans:Proto-Tethys, Paleo-Tethys, and Neo-Tethys (Figure 1), and their life cycles cover the entire Phanerozoic era (Wu et al., 2020).

关键词： geology Mesozoic ocean

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Improvement for creep strength of a second-generation single crystal superalloy by design of heat treatments

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Rare Metals 2024年第1期43卷 342-350页

作者： Wan-Shun Xia xin-Bao Zhao Jia-Chen Xu Quan-Zhao Yue Qing-Qing ding Huan-Chang Duan Yue-Feng Gu Hong-Bin Bei Ze Zhang Institute of Superalloys Science and Technology School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Silicon and Advanced Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Design of heat treatments is related to the key technology for development of nickel-based single crystal superalloys(Ni-SXs). Based on the full understanding of the solidification characteristics, this work applies optimization design of heat treatments for a second-generation Ni-SX. Microstructure evolution and creep properties are compared in the material under conventional/standard(Std.) and optimized(Opt.) treatments. For the Std. sample,strong dendritic segregations determine inconsistent microstructure evolution in the dendritic(D) and interdendritic region(ID), while the latter serves as weak area to have the prior microcrack initiation, damaging overall performance of the alloy. The Opt. treatment applies higher homogenization temperature, leading to overall reduced segregations, while not inducing incipient melting. A lower temperature of first-step ageing is used to lower the size ofγ'particles. These help to form the more uniform microstructure in dendritic and interdendritic region and relieve the inconsistent microstructure evolution. The balanced local strength makes ID no longer as the weak area,thus restricting microcrack initiation. Great improvement of high temperature and low stress property is obtained by this progress, leading to the pronounced increase of creep rupture life under 1100 °C/140 MPa.

关键词： Single crystal superalloy Heat treatment Segregation Solidification Creep property

SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong ding Fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-Lu Hong Ming-Chen Wang Fang-Zhi Yan Kai ding Ya-Lu Cui Bai-Nan Zheng Jin ding Cheng Luo xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise