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Mild synthesis of ultra-bright carbon dots with solvatochromism for rapid lipid droplet monitoring in varied physiological processes

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Regenerative Biomaterials 2024年第3期3卷 30-42页

作者： Borui Su dong Gao Nini xin Kai Wu Mei Yang Shichao Jiang Yusheng Zhang Jie ding Chengheng Wu Jing Sun Dan Wei Hongsong Fan Zhenzhen Guo National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan 610064China Institute of Regulatory Science for Medical Devices Sichuan UniversityChengduSichuan 610064China Department of Gastroenterology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610o72China

Lipid droplets(LDs)participating in various cellular activities and are increasingly being *** imaging provides powerful tool for dynamic tracking of LDs,however,most current LDs probes remain inconsistent performance such as low Photoluminescence Quantum Yield(PLQY),poor photostability and tedious washing ***,a novel yellow-emissive carbon dot(OT-cD)has been synthesized conveniently with high PLQY up to 90%.Besides,OT-CD exhibits remarkable amphiphilicity and solvatochromic property with lipid-water partition coefficient higher than 2,which is much higher than most LDs *** characters enable OT-CD high brightness,stable and wash-free LDs probing,and feasible for in vivo ***,detailed observation of LDs morphological and polarity variation dynamically in different cellular states were recorded,including ferroptosis and other diseases ***,fast whole imaging of zebrafish and identifed LD enrichment in injured liver indicate its further feasibility for in vivo *** contrast to the reported studies to date,this approach provides a versatile conventional synthesis system for high-performance LDs targeting probes,combing the advantages of easy and high-yield production,as well as robust brightness and stability for long-term imaging,facilitating investigations into organelle interactions and LD-associated diseases.

关键词： lipid droplet probe carbon dots fluorescence imaging wash-free dynamic monitoring

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The role of primary cilia in mechanical transmission of osteocyte based on a 3D finite element model

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Medicine in Novel Technology and Devices 2024年第1期21卷 31-38页

作者： Zhuang Han dong ding Yu-bo Fan xin-tong Wu Xiao Yang Lian-wen Sun Key Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The primary cilium,as a mechanical receptor of osteocytes,participates in the regulation of osteocyte ***,how the length of osteocyte primary cilia changes with fluid shear stress(FSS)are unclear,and how the mechanical transmission within osteocytes altered by primary cilia is not well understood ***,the ciliary length changes of osteocyte under 15dyn/cm2 of FSS were experimentally detected,and then 3D finite element models of osteocyte primary cilia containing the basal body and axoneme were *** results showed that(1)The ciliary length of the CON group,FSS 1h,and FSS 6h were 3.71±1.34μm,3.79±1.04μm,and 1.24±0.73μm respectively,indicating the different durations of FSS might lead to the adaptive changes of cilium *** calculations showed(2)when the ciliary length became shorter with the ciliary angle stayed the same,the deformation and stress of the cell membrane and membrane skeleton was ***,the deformation and stress of the cilia membrane,basal body,the rotation angles of basal body were decreased,and those of cytoplasm,cytoskeleton,actin cortex and nucleus were also decreased;(3)With the decrease of the ciliary angle,the deformation and stress of the cilia membrane,basal body,as well as the rotation angles of basal body were *** of the cytoplasm,cytoskeleton,actin cortex,and nucleus were also increased except the cell membrane and membrane *** calculation results suggested the length and angle of the primary cilia,the deformation and stress of intracellular structures in osteocyte were altered with ciliary basal body,indicated the connection between the basal body and cytoskeleton may be a key factor that affected the mechanical transport in osteocytes across the cell *** finally promoted the adaptive change of ciliary length under FSS.

关键词： Primary cilia Osteocyte model Finite element analysis Mechanotransduction

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Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis

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World Journal of Gastroenterology 2024年第10期30卷 1405-1419页

作者： Ye Tian xin Li Xu Wang Si-Ting Pei Hong-xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-dong ding Petersen Ping Zhang International School of Public Health and One Health Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Medical Laboratory Science and Technology College Harbin Medical University-Daqing CampusDaqing 163000Heilongjiang ProvinceChina Department of Laboratory Diagnosis Qiqihar Tuberculosis Control CenterQiqihar 161000Heilongjiang ProvinceChina Department of Public Health University of CopenhagenCopenhagen 1353Denmark Department of Public Health University of Southern DenmarkOdense 5000Denmark

BACKGROUND Ulcerative colitis is a chronic inflammatory disease of the colon with an unknown *** sphingomyelinase(alk-SMase)is specifically expressed by intestinal epithelial cells,and has been reported to play an anti-inflammatory ***,the underlying mechanism is still *** To explore the mechanism of alk-SMase anti-inflammatory effects on intestinal barrier function and oxidative stress in dextran sulfate sodium(DSS)-induced *** Mice were administered 3%DSS drinking water,and disease activity index was determined to evaluate the status of *** permeability was evaluated by gavage administration of fluorescein isothiocyanate dextran,and bacterial translocation was evaluated by measuring serum *** epithelial cell ultrastructure was observed by electron *** blotting and quantitative real-time reverse transcription-polymerase chain reaction were used to detect the expression of intestinal barrier proteins and mRNA,*** oxidant and antioxidant marker levels were analyzed using commercial kits to assess oxidative stress *** Compared to wild-type(WT)mice,inflammation and intestinal permeability in alk-SMase knockout(KO)mice were more severe beginning 4 d after DSS *** mRNA and protein levels of intestinal barrier proteins,including zonula occludens-1,occludin,claudin-3,claudin-5,claudin-8,mucin 2,and secretory immunoglobulin A,were significantly reduced on 4 d after DSS *** observations revealed progressive damage to the tight junctions of intestinal epithelial ***,by day 4,mitochondria appeared swollen and ***,compared to WT mice,serum malondialdehyde levels in KO mice were higher,and the antioxidant capacity was significantly *** expression of the transcription factor nuclear factor erythroid 2-related factor 2(Nrf2)in the colonic mucosal tissue of KO mice was significantly decr

关键词： Alkaline sphingomyelinase Intestinal mucosal barrier Antioxidant capacity Dextran sulfate sodium-induced colitis nuclear factor erythroid 2-related factor 2

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Characteristics of Controlled Bridge Circuit and Its Application in Magnetic Field Induction Measurement

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Tsinghua Science and Technology 2024年第4期29卷 1105-1117页

作者： Yanchu Li Qingqing ding Mingchen Yan Jiyao Wang Jun Xu xinzhou dong Department of Electrical Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Control and Simulation of Power System and Generation Equipments Tsinghua UniversityBeijing 100084China School of Electrical and Electronic Engineering North China Electric Power UniversityBeijing 100096China

The article designs a new type of bridge circuit with a controlled source—when the resistance on the bridge arm of the controlled source bridge circuit meets the bridge balance condition, and the bridge branch contains only one Current-Controlled Current Source (CCCS), a Voltage-Controlled Current Source (VCCS), a Current-Controlled Voltage Source (CCVS), or a Voltage-Controlled Voltage Source (VCVS), the circuit is called a controlled bridge circuit, which has the characteristics of bridge balance. Due to the relationship between the controlled source and the bridge arm, the sensitivity of the components on the bridge is higher mathematically and logically. When applied to measurement, engineering, automatic control, and other fields, the controlled bridge circuit has higher control ac-curacy. Mathematical derivation and simulation results prove the correctness of the bridge balance conclusion and the special properties of this bridge when applied to the measurement field.

关键词： bridge bircuit bridge circuit applications bridge balanced condition controlled bridge circuit magnetic field induction measurement

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Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： Xiaowan Fan Tao Zhang xin ding Yushuo Gu Qing Li Wei Jiang Kelong Fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of General Surgery Strategic Support Force Medical CenterBeijing 100101China Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

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Water modeling on fluid flow and mixing phenomena in a BOF steelmaking converter

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Journal of Iron and Steel Research International 2024年第3期31卷 595-607页

作者： xin-yu Cai Hao-jian Duan ding-han Li Anjun Xu Li-feng Zhang School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing 100083China School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

A 1∶8 physical water model was constructed to investigate the fluid flow and mixing phenomena in the basic oxygen furnace(BOF)*** particle image velocimetry was employed to measure the velocity distribution of the bath and the high-speed camera was applied to capture the cavity shape in the combined blowing BOF *** mixing time for varied operating conditions was measured by the stimulus-response *** cavity depth increased with the decrease in the lance height and the increase in the top gas flow rate while the bottom blowing gas had little influence on the cavity *** minimum cavity depth was obtained under the condition of a 69.8 m^(3)/h top gas flow rate,a 287.5 mm lance height and a 0.93 m^(3)/h bottom blowing gas flow rate,which was 161.2 *** mixing time decreased as the lance height decreased and the top blowing gas flow rate *** mixing time was first decreased and then increased with the increase in the bottom gas flow *** the condition of 69.8 m^(3)/h gas flow rate of top blowing,the 287.5 mm lance height and the 0.93 m^(3)/h gas flow rate of bottom blowing,the mixing time in the converter was 48.65 *** empirical formula between the stirring power and the mixing time in the converter was calculated.

关键词： Water model Fluid flow Particle image velocimetry Mixing time BOF converter

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Distributed Platooning Control of Automated Vehicles Subject to Replay Attacks Based on Proportional Integral Observers

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1954-1966页

作者： Meiling Xie Derui ding Xiaohua Ge Qing-Long Han Hongli dong Yan Song Department of Control Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia Artificial Intelligence Energy Research Institute Northeast Petroleum UniversityDaqing 163318the Heilongjiang Provincial Key Laboratory of Networking and Intelligent ControlNortheast Petroleum UniversityDaqing 163318 Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572024China

Secure platooning control plays an important role in enhancing the cooperative driving safety of automated vehicles subject to various security *** paper focuses on the distributed secure control issue of automated vehicles affected by replay attacks.A proportional-integral-observer(PIO)with predetermined forgetting parameters is first constructed to acquire the dynamical information of ***,a time-varying parameter and two positive scalars are employed to describe the temporal behavior of replay *** light of such a scheme and the common properties of Laplace matrices,the closed-loop system with PIO-based controllers is transformed into a switched and time-delayed ***,some sufficient conditions are derived to achieve the desired platooning performance by the view of the Lyapunov stability *** controller gains are analytically determined by resorting to the solution of certain matrix inequalities only dependent on maximum and minimum eigenvalues of communication ***,a simulation example is provided to illustrate the effectiveness of the proposed control strategy.

关键词： Automated vehicles platooning control proportional-integral-observers(PIOs) replay attacks time-delays

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Additive-free synthesis of S-substituted isothioureas via visible-light-induced four-component reaction ofα-diazoesters,aryl isothiocyanates,amines and cyclic ethers

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Chinese Chemical Letters 2024年第2期35卷 415-419页

作者： Yufen Lv Hongyu ding Jinmao You Wei Wei dong Yi Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufu 273165China College of Chemistry and Chemical Engineering Shaoxing UniversityShaoxing 312000China School of Pharmacy Southwest Medical UniversityLuzhou 646000China

An additive-free and environmentally friendly strategy has been realized for the construction of S-substituted isothioureas through visible-light-induced multicomponent reaction starting fromα-diazoesters,aryl isothiocyanates,amines and cyclic *** methodology features simple operation,mild reaction conditions,favorable functional group tolerance,easily available starting materials and high efficiency.

关键词： Visible-light Additive-free Four-component reaction S-Substituted isothioureas

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Nanostructured AlFeO_(3) thin films as a novel photoanode for photoelectrochemical water splitting

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Nano Research 2024年第3期17卷 1075-1085页

作者： xin Sun Min Wang Qi Geng Shuailin Chen Xiaojun Lv Xunlei ding Meicheng Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources School of New EnergyNorth China Electric Power UniversityBeijing 102206China School of Mathematics and Physics North China Electric Power UniversityBeijing 102206China

The earth-abundant and robust aluminum ferrite,AlFeO_(3)(AFO),is mainly studied in the context of ***,we demonstrate that AFO can be used as a stable solar absorber in photoelectrochemical cells for solar water splitting,exhibiting attractive *** is the first report on the photoelectrochemical activity of *** thin-film photoelectrodes prepared by solution-processing methods are composed of vertically oriented thin nanosheets,featuring the rhombohedral symmetry(R3c)and n-type *** as-prepared AFO photoanodes generate a photocurrent density of+0.78 mA·cm^(-2) at 1.23 V *** hydrogen electrode(RHE)with the photocurrent _(onset) potential(U_(onset))close to the flat band potential of 0.5 V *** in the presence of hole ***,the U_(onset) of AFO for solar water splitting coincides with the flat band potential as well,which is rare in n-type inorganic *** also report other properties of AFO associated with photoelectrochemical *** films exhibit a band gap energy of 2.31 eV and positive band edges with low ***,the carrier lifetimes in AFO films are up to millisecond timescales under the mediation of defect *** on the photoelectrochemical behavior and optoelectronic properties,we believe that AFO has great potential for application in photoelectrochemical cells.

关键词： AlFeO_(3) photoanode nanosheets photoelectrochemistry onset potential

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Effects of serum proteins on corrosion rates and product bioabsorbability of biodegradable metals

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Regenerative Biomaterials 2024年第1期3卷 132-148页

作者： Hongjie Zhang xin Li Zehua Qu Wanqian Zhang Qunsong Wang dinglingge Cao Yaoben Wang xin Wang Yang Wang Lin Yu Jiandong ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

Corrodible metals are the newest kind of biodegradable materials and raise a new problem of the corrosion ***,the removal of the precipitated products has been unclear and even largely ignored in ***,we find that albumin,an abundant macromolecule in serum,enhances the solubility of corrosion products of iron in blood mimetic Hank’s solution *** is universal for other main biodegradable metals such as magnesium,zinc and polyester-coated *** also influences corrosion rates in diverse trends in Hank’s solution and normal *** on quantitative study theoretically and experimentally,both the effects on corrosion rates and soluble fractions are interpreted by a unified mechanism,and the key factor leading to different corrosion behaviors in corrosion media is the interference of albumin to the Ca/P passivation layer on the metal *** work has illustrated that the interactions between metals and media macromolecules should be taken into consideration in the design of the next-generation metal-based biodegradable medical devices in the formulism of precision *** improved Hank’s solution in the presence of albumin and with a higher content of initial calcium salt is suggested to access biodegradable metals potentially for cardiovascular medical devices,where the content of calcium salt is calculated after consideration of chelating of calcium ions by albumin,resulting in the physiological concentration of free calcium ions.

关键词： biodegradable metal macromolecule albumin corrosion bioabsorbability iron polylactide magnesium zinc

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