检索结果-南通市图书馆

A deep learning interatomic potential suitable for simulating radiation damage in bulk tungsten

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tungsten 2024年第2期6卷 304-322页

作者： Chang-Jie ding Ya-Wei Lei Xiao-Yang Wang Xiao-Lin Li Xiang-Yan Li Yan-Ge Zhang Yi-Chun Xu Chang-song Liu Xue-Bang Wu Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Science Island University of Science and Technology of ChinaHefei 230026China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China

So far, it has been a challenge for existing interatomic potentials to accurately describe a wide range of physical properties and maintain reasonable efficiency. In this work, we develop an interatomic potential for simulating radiation damage in body-centered cubic tungsten by employing deep potential, a neural network-based deep learning model for representing the potential energy surface. The resulting potential predicts a variety of physical properties consistent with first-principles calculations, including phonon spectrum, thermal expansion, generalized stacking fault energies, energetics of free surfaces, point defects, vacancy clusters, and prismatic dislocation loops. Specifically, we investigated the elasticity-related properties of prismatic dislocation loops, i.e., their dipole tensors, relaxation volumes, and elastic interaction energies. This potential is found to predict the maximal elastic interaction energy between two 1/2 loops better than previous potentials, with a relative error of only 7.6%. The predicted threshold displacement energies are in reasonable agreement with experimental results, with an average of 128 eV. The efficiency of the present potential is also comparable to the tabulated gaussian approximation potentials and modified embedded atom method potentials, meanwhile, can be further accelerated by graphical processing units. Extensive benchmark tests indicate that this potential has a relatively good balance between accuracy, transferability, and efficiency.

关键词： Machine learning Deep learning Interatomic potential Radiation damage Tungsten

在线全文

学校读者我要写书评

暂无评论

突发公共卫生事件中个人信息处理规则研究

科学决策 2022年第8期 124-135页

作者：宋丁博男西北工业大学公共政策与管理学院

突发公共卫生事件中对个人信息的处理有效推动了防控工作的开展,但个人信息侵权行为的频发暴露出我国个人信息保护制度与公共卫生法治体系的不健全。个人信息处理面临着分散立法、身份认定、范围界定、知情同意四个方面的现实困境。基... 详细信息

突发公共卫生事件中对个人信息的处理有效推动了防控工作的开展,但个人信息侵权行为的频发暴露出我国个人信息保护制度与公共卫生法治体系的不健全。个人信息处理面临着分散立法、身份认定、范围界定、知情同意四个方面的现实困境。基于突发公共卫生事件中个人信息的复合法益属性,尤其是公共利益属性的凸显,结合域外先进立法经验,提出突发公共卫生事件中个人信息处理的规范化路径,包括规范信息收集主体和收集手段、严格限定信息处理的防控目的、完善个人信息梯度保护体系、构建个人信息全程监管机制。

关键词：突发公共卫生事件大数据个人信息个人信息处理法律保护

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

数学严谨性分析

西北师范大学学报（自然科学版） 2022年第5期58卷 1-5页

作者：丁传松西北师范大学数学与统计学院甘肃兰州730070

数学是一门严谨的学科,其严谨性已为社会普遍认同,也为其他学科所效法;任何学科的严谨性总是相对的,有时代性,也与人们当时的认知能力有关,数学学科的严谨性更是如此;数学严谨性最大的挑战者是“无穷”,随着数学对“无穷”认识的深化,... 详细信息

数学是一门严谨的学科,其严谨性已为社会普遍认同,也为其他学科所效法;任何学科的严谨性总是相对的,有时代性,也与人们当时的认知能力有关,数学学科的严谨性更是如此;数学严谨性最大的挑战者是“无穷”,随着数学对“无穷”认识的深化,它的严谨性得到了极大提高;另一方面,不拘泥于严谨性、适当冲破严谨性,也是一种思路创新.

关键词：数学严谨性微积分自然哲学悖论发散级数

Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,opportunities and challenges

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2024年第3期11卷 400-429页

作者： Jia-Yi ding Min-Jiang Chen Ling-Feng Wu Gao-Feng Shu Shi-Ji Fang Zhao-Yu Li Xu-Ran Chu Xiao-Kun Li Zhou-Guang Wang Jian-song Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000ZhejiangChina Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina Department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany Pulmonary and Critical Care Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or *** such injuries are common to all human groups,they may at times represent a serious socioeconomic ***,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound *** a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell *** based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair *** addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix ***,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma *** the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound *** conclusion,MSCderived EV-based therapies have important application prospects in wound *** we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

关键词： Mesenchymal stem cell(MSC) Extracellular vesicles(EVs) Wound repair Engineered nanoparticles

Quantitative design of yield components to simulate yield formation for maize in China

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2020年第3期19卷 668-679页

作者： HOU Hai-peng MA Wei Mehmood Ali NOOR TANG Li-yuan LI Cong-feng ding Zai-song ZHAO Ming Institute of Crop Sciences Chinese Academy of Agricultural Sciences/Key Laboratory of Crop Physiology and EcologyMinistry of Agriculture and Rural AffairsBeijing 100081P.R.China Institute of Cotton Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050051P.R.China

Maize(Zea mays L.) stands prominently as one of the major cereal crops in China as well as in the rest of the ***,predicting the growth and yield of maize for large areas through yield components under high-yielding environments will help in understanding the process of yield formation and yield potential under different environmental *** accurate early assessment of yield requires accuracy in the formation process of yield components as *** order to formulate the quantitative design for high yields of maize in China,yield performance parameters of quantitative design for high grain yields were evaluated in this study,by utilizing the yield performance equation with normalization of planting *** density was evaluated by parameters including the maximum leaf area index and the maximum leaf area per *** showed that the variation of the maximum leaf area per plant with varying plant density conformed to the Reciprocal Model,which proved to have excellent prediction with root mean square error(RMSE) value of 5.95%.Yield model estimation depicted that the best optimal maximum leaf area per plant was 0.63 times the potential maximum leaf area per plant of *** performance parameters for different yield levels were quantitatively designed based on the yield performance *** validation of the yield performance model by simulating high yields of spring maize in the Inner Mongolia Autonomous Region and Jilin Province,China,and summer maize in Shandong Province,the yield performance equation showed excellent prediction with the satisfactory mean RMSE value(7.72%) of all the *** present study provides theoretical support for the formulation of quantitative design for sustainable high yield of maize in China,through consideration of planting density normalization in the yield prediction process,providing there is no water and nutrient limitation.

关键词： maize yield performance parameters high yield yield prediction process quantitative design

基于自适应调节的灰色滚动预测模型及对碳排放趋势预测

在线全文

学校读者我要写书评

暂无评论

控制与决策 2023年第12期38卷 3409-3417页

作者：徐宁秦邱皓王天宇丁松南京审计大学商学院南京211815 浙江财经大学经济学院杭州310018

利用有限数据预测发展趋势是数据建模领域广泛存在的问题,采用灰预测模型处理此类问题时会面临适应数据不规则波动特征的挑战性.在灰预测模型基础上提出适应数据特征的滚动建模方法,结合双参数的变权缓冲算子建立一种AGRM(1,1)模型,该... 详细信息

利用有限数据预测发展趋势是数据建模领域广泛存在的问题,采用灰预测模型处理此类问题时会面临适应数据不规则波动特征的挑战性.在灰预测模型基础上提出适应数据特征的滚动建模方法,结合双参数的变权缓冲算子建立一种AGRM(1,1)模型,该模型在数据的切片基础上使用优化的灰预测模型实现对不同增长系数的准确模拟,利用缓冲算子链对数据进行调整处理,最后设计以差分进化算法为基础的算子参数优化方法.所提出的模型改变了传统灰预测模型响应式形式单调的结构特点,实现对带有波动和振荡的序列的准确预测.在算例检验中,利用不同增长系数的检验数据验证了AGRM(1,1)模型同样具备无偏性,同时将模型应用于我国宏观范围碳排放数据的发展趋势预测,建模结果印证了该模型相对同类模型具有明显的精确度提升.

关键词：灰色预测 GM(1,1) 缓冲算子差分进化算法滚动建模

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

高超声速进气道内粉末燃料喷注及流动控制特性研究

在线全文

学校读者我要写书评

暂无评论

推进技术 2022年第12期43卷 381-389页

作者：丁宋毅孙波卓长飞代春良南京理工大学机械工程学院江苏南京210094

为了提高进气道性能以及金属粉末燃料的掺混效率,本文将粉末燃料的喷注提前到高超声速进气道内完成。以铝粉作为喷注燃料,氮气作为流化气,基于连续相-离散相(CFD-DPM)耦合模型,采用数值模拟的方法重点研究了在进气道内喷注粉末燃料对进... 详细信息

为了提高进气道性能以及金属粉末燃料的掺混效率,本文将粉末燃料的喷注提前到高超声速进气道内完成。以铝粉作为喷注燃料,氮气作为流化气,基于连续相-离散相(CFD-DPM)耦合模型,采用数值模拟的方法重点研究了在进气道内喷注粉末燃料对进气道性能和颗粒掺混度的影响。结果表明:在超额定状态下通过在外压段喷注粉末燃料进行波系控制,可以用比气体射流控制更低的喷注压力实现激波贴口的效果,在来流马赫数Ma_(0)=6时,与气体射流控制相比,两个喷嘴的入口总压分别降低了17.9%和31.8%。与常规定几何进气道相比,经过粉末燃料喷注后进气道的综合性能有了显著的提高,低马赫数下流量系数提高24%以上,总压恢复系数也明显提高,并且实现了粉末燃料与氧气的充分掺混。

关键词：高超声速进气道金属粉末燃料波系控制喷注掺混

Factors affecting thrombolysis in myocardial infarction myocardial perfusion frame count： insights of myocardial tissue-level reperfusion from a novel index for assessing myocardial perfusion

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第6期124卷 873-878页

作者： PU Jun SHAN Pei-ren ding song QIAO Zhi-qin JIANG Li-sheng song Wei DU Yong-ping SHEN Jie-yan SHEN Lin-hong JIN Shu-xuan HE Ben Department of Cardiology Shanghai Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Cardiology First Affiliated Hospital of Wenzhou Medical College Wenzhou Zhejiang 325000 China

Background Myocardial tissue-level perfusion failure is associated with adverse outcomes following ST-elevation myocardial infarction （STEMI） despite successful epicardial recanalization. We have developed a new quantitative index-thrombolysis in myocardial infarction （TIMI） myocardial perfusion frame count （TMPFC）-for assessing myocardial tissue level perfusion. However, factors affecting this novel index of myocardial perfusion are currently *** A total of 255 consecutive STEMI patients undergoing primary angioplasty were enrolled. Myocardial tissue level perfusion was assessed by TMPFC, which measures the filling and clearance of contrast in the myocardium using cine-angiographic frame counting. We differentiate three groups with two cut off values for TMPFC： a TMPFC of 90frames was the upper boundary of the 95% confidence interval （CI） for the TMPFC observed in normal arteries, and a TMPFC of 130 was the 75th percentile of *** STEMI patients with TMPFC 〉130 frames （68 patients, 26.7%） had higher clinical and angiographic risk factor profiles as well as a higher 30-day MACE rate compared with those with TMPFC ≤90 frames and those with TMPFC 〉90and ≤130 frames. Multivariable analysis identified that the independent predictors of TMPFC 〉130 frames were age ≥75years （OR 2.08, 95% CI 1.21 to 3.58, P=0.007）, diabetes （OR 1.37, 95% CI 1.01 to 1.86, P=0.042）, Killip class ≥2 （OR1.52, 95% CI 1.05 to 2.21, P=0.027）, and prolonged pain-to-balloon time （OR 1.73, 95% CI 1.07 to 2.79, P=0.013）.TMPFC 〉130 frames was identified as the strongest independent predictor of 30-day major adverse cardiac event （MACE）（OR 2.77, 95% CI 1.21 to 6.31, P=0.008）, along with age ≥75 years （OR 2.19, 95% CI 1.11 to 4.33, P=0.016）,female gender （OR 1.67, 95% CI 1.03 to 2.70, P=0.038）, and Killip class ≥2 （OR 1.83, 95% CI 1.07 to 3.14, P=0.021）.Conclusions STEMI patients with poor myocardial perfusion assessed by TMPFC had higher risk factor *** age, diabetes,

关键词： myocardial infarction perfusion angioplasty outcome