检索结果-南通市图书馆

MiR-663a Inhibits Radiation-Induced Epithelium-to-Mesenchymal Transition by Targeting TGF-β1

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2022年第5期35卷 437-447页

作者： QU Pei SHAO zhi Ang WANG Bing HE jin Peng ZHANG Ya Nan WEI Wen Jun HUA Jun Rui ZHOU Heng LU Dong {2. Nan WANG Ju Fang Key Laboratory of Space Radiobiology of Gansu Province&Key Laboratory of Heavy Ion Radiation Biology and Medicine Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000GansuChina University of chinese academy of Sciences Beijing 100049China

Objective miR-663 a has been reported to be downregulated by X-ray irradiation and participates in radiation-induced bystander effect via TGF-β*** goal of this study was to explore the role of mi R-663 a during radiation-induced Epithelium-to-mesenchymal transition(EMT).Methods TGF-β1 or IR was used to induce *** mi R-663 a transfection,cell migration and cell morphological changes were detected and the expression levels of mi R-663 a,TGF-β1,and EMT-related factors were *** Enhancement of cell migration and promotion of mesenchymal changes induced by either TGF-β1 or radiation were suppressed by mi R-663 ***,both X-ray and carbon ion irradiation resulted in the upregulation of TGF-β1 and downregulation of mi R-663 a,while the silencing of TGF-β1 by mi R-663 a reversed the EMT process after *** Our findings demonstrate an EMT-suppressing effect by mi R-663 a via TGF-β1 in radiationinduced EMT.

关键词： Epithelium-to-mesenchymal transition(EMT) Ionizing Radiation TGF-β1 microRNA miR-663a

New hydrous phases in the Al_(2.O_(3)-SiO_(2.-H_(2.O system under the mantle transition zone conditions

在线全文

学校读者我要写书评

暂无评论

Science china Earth Sciences 2023年第4期66卷 730-737页

作者： Baoyun WANG jin LIU Suyu FU Pu XIAO Li LI Xing ding Wansheng XIAO College of Material and Chemical Engineering Tongren UniversityTongren 554300China Center for High Pressure Science and technology Advanced Research(HPSTAR) Beijing 100193China Department of Earth and Planetary Science the University of TokyoTokyo 1130033Japan State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Key Laboratory of Mineralogy and Metallogeny Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China

Hydrous minerals in the subducting slabs are potential water carriers into the deep mantle,and thus the synthesis of new hydrous phases is significant in our understanding of water circulation throughout the Earth’s *** this study,we report the two new hydrous phases,Al_(2.SiO_(6)H_(2.and Al_(5.5)Si_(4)O_(18)H_(3.5)(hereafter referred to simply as phases Psi and Phi,respectively),which are synthesized in the Al_(2.O_(3)-SiO_(2.-H_(2.O system at 15.5 GPa,1400℃and 17.5 GPa,1600℃ by using Sakura2.00-ton multi-anvil *** luminescence spectra of Cr3+show the phase Psi has characteristic peaks at 687,693 and705 nm,while phase Phi has characteristic peaks at 691,696 and 708 ***-crystal X-ray diffraction (SCXRD) refinements yield a monoclinic structure of both phases (space group P2.(1)) with ideal chemical formulae of Al_(2.SiO6H2.nd *** determined lattice parameters for phase Psi are a=9.4168±0.0016Å,b=4.3441±0.0007Å,c=9.4360±0.002.and β=119.72.±0.005°at ambient pressure and 300 K,while the phase Phi has a=7.2.49±0.0018Å,b=4.3144±0.001Å,c=8.052.±0.002.,and β=101.740±0.009°at ambient pressure and 2.0 *** microprobe analyses (EPMA) show the chemical compositions of phases Psi and Phi to be Al_(1.99)Si_(0.85)O_(6)H_(2.62.and Al_(5.58)Si_(2.81)O_(18)H_(8.03),respectively,which slightly deviate from the ideal formulae inferred from SCXRD *** may result from the disorder or substitution of Al and Si by H in the crystal structures under our synthesis *** study suggests that phases Psi and Phi are the two potential water carriers at the upper part of the mantle transitions zone,providing new insights into how deep water is stored in this region.

关键词： New hydrous phases Mantle transition zone Al_(2.O_(3)-SiO_(2.-H_(2.O system Al_(2.SiO_(6)H_(2. Al_(5.5)Si_(4)O_(18)H_(3.5)

Rapid Internal Control Reference Recombinase-Aided Amplification Assays for EBV and CMV Detection

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2021年第8期34卷 650-655页

作者： GAO Yuan TIE Yan Qing ZHAO Lin Qing TAN He ding Nan ding Ya Xin GUO Qi ZHANG Rui Qing WANG {2. Rong CHEN Zi Wei FAN Guo Hao SHEN Xin Xin FENG zhi Shan MA Xue Jun Hebei Medical University Shijiazhuang 050031HebeiChina NHC Key Laboratory of Medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Hebei General Hospital Shijiazhuang 050070HebeiChina Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijing 100020China The Third Xiangya Hospital of Central South University Changsha 410013HunanChina Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan 430071Hubei China

Epstein-Barr virus(EBV)and cytomegalovirus(CMV),two of the most prevalent human herpesviruses,cause a wide spectrum of diseases and symptoms and are associated with serious health *** this study,we developed an internal control reference recombinase-aided amplification(ICR-RAA)assay for the rapid detection of EBV and CMV within 30 *** assay had a sensitivity of 5 and 1 copies/test for EBV and CMV,respectively,with no cross reaction with other *** comparison with those of the commercial quantitative polymerase chain reaction(qPCR),the sensitivity of the EBV and CMV ICR-RAAs using extracted DNA was 93.33%and 84.84%,respectively;the specificity was 98.75%and 100.00%,respectively;and the Kappa values were 0.930 and 0.892.P2.2.%and 80.00%,respectively;the specificity was 100.00%。

关键词： specificity Internal EBV

Molecular Oxygen Abundance in Galactic Massive Star Formation Regions Based on SWAS Observations

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第9期24卷 83-98页

作者： Bing-Ru Wang Di Li Paul F.Goldsmith jingwen Wu Chao-Wei Tsai Donghui Quan Xia Zhang Junzhi Wang Gary J.Melnick jin-Zeng Li Gary A.Fuller jinjin Xie National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Tsinghua University Beijing 100084China University of chinese academy of Sciences Beijing 100049China Research Center for Astronomical computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Center for Astrophysics Harvard&Smithsonian60 Garden StreetMS 66CambridgeMA 02138USA Jodrell Bank Center for Astrophysics Department of Physics&AstronomyUniversity of ManchesterOxford RoadManchesterM139PLUK I.Physikalisches Institut University of CologneZülpicher Str.7750937 KölnGermany

Molecular oxygen abundance is a key parameter in understanding the chemical network of the interstellar *** estimate the molecular oxygen column density and abundance for a sample of Galactic massive star formation regions based on observations from the Submillimiter Wave Astronomy Satellite(SWAS)*** obtained an averaged O_(2.spectrum based on this sample using the(SWAS)survey data(O_(2.,487.2.9 GHz,N=3-1,J=3-2..No emission or absorption feature is seen around the supposed central velocity with a total integration time of t_(total)=8.67×10^(3)hr and an rms noise per channel of 1.45 m *** a kinetic temperature T_(kin)=30 K,we derive the 3σupper limit of the O_(2.column density to be 3.3×10^(15)cm^(-2.,close to the lowest values reported in Galactic massive star formation regions in previous *** corresponding O_(2.abundance upper limit is6.7×10^(-8),lower than all previous results based on SWAS observations and is close to the lowest reported value in massive star formation *** a galactic scale,our statistical results confirm a generally low O_(2.abundance for Galactic massive star formation *** abundance is also lower than results reported in extragalactic sources.

关键词： ISM:molecules galaxies:abundances ISM:lines and bands Galaxy:abundances

Responses of soil microbial communities and functions associated with organic carbon mineralization to nitrogen addition in a Tibetan grassland

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2020年第2期30卷 214-225页

作者： Ruyi LUO Jiafa LUO Jianling FAN Deyan LIU jin-Sheng HE Nazia PERVEEN Weixin ding State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of chinese academy of Sciences Beijing 10049China AgResearch Limited Ruakura Research CentreHamilton 3240New Zealand Department of Ecology College of Urban and Environmental SciencesKey Laboratory for Earth Surface Processes of the Ministry of EducationPeking UniversityBeijing 100871China

Alpine grasslands with a high soil organic carbon(SOC)storage on the Tibetan Plateau are experiencing rapid climate warming and anthropogenic nitrogen(N)deposition;this is expected to substantially increase the soil N availability,which may impact carbon(C)***,little is known regarding how N enrichment influences soil microbial communities and functions relative to C cycling in this *** conducted a 4-year field experiment on an alpine grassland to evaluate the effects of four different rates of N addition(0,2.,50,and 100 kg N ha^-1 year^-1)on the abundance and community structure(phospholipid fatty acids,PLFAs)of microbes,enzyme activities,and community level physiological profiles(CLPP)in *** found that N addition increased the microbial biomass C(MBC)and N(MBN),along with an increased abundance of bacterial PLFAs,especially Gram-negative bacterial PLFAs,with a decreasing ratio of Gram-positive to Gram-negative *** N addition also stimulated the growth of fungi,especially arbuscular mycorrhizal fungi,reducing the ratio of fungi to *** functional diversity and activity of enzymes involved in C cycling(β-1,4-glucosidase and phenol oxidase)and N cycling(β-1,4-N-acetyl-glucosaminidase and leucine aminopeptidase)increased after N addition,resulting in a loss of SOC.A meta-analysis showed that the soil C/N ratio was a key factor in the response of oxidase activity to N amendment,suggesting that the responses of soil microbial functions,which are linked to C turnover relative to N input,primarily depended upon the soil C/N ***,our findings highlight that N addition has a positive influence on microbial communities and their associated functions,which may reduce soil C storage in alpine grasslands under global change scenarios.

关键词： alpine grassland C cycling C turnover community level physiological profiles(CLPP) enzyme activity microbial community composition microbial function N input

Two-step gate-recess process combining selective wet-etching and digital wet-etching for InAIAs/InGaAs InP-based HEMTs

在线全文

学校读者我要写书评

暂无评论

Frontiers of Information technology & Electronic Engineering 2017年第8期18卷 1180-1185页

作者： Ying-hui ZHONG Shu-xiang SUN Wen-bin WONG Hai-li WANG Xiao-ming LIU zhi-yong DUAN Peng ding zhi jin School of Physics and Engineering Zhengzhou University Zhengzhou 450001 China institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China

A two-step gate-recess process combining high selective wet-etching and non-selective digital wet-etching techniques has been proposed for InAlAs/InGaAs InP-based high electron mobility transistors （HEMTs）. High etching-selectivity ratio of InGaAs to InA1As material larger than 100 is achieved by using mixture solution of succinic acid and hydrogen peroxide （H2.2.. Selective wet-etching is validated in the gate-recess process of InA1As/InGaAs InP-based HEMTs, which proceeds and auto- matically stops at the InA1As barrier layer. The non-selective digital wet-etching process is developed using a separately controlled oxidation/de-oxidation technique, and during each digital etching cycle 1.2.nm InAIAs material is removed. The two-step gate-recess etching technique has been successfully incorporated into device fabrication. Digital wet-etching is repeated for two cycles with about 3 nm InAIAs barrier layer being etched off. InP-based HEMTs have demonstrated superior extrinsic trans- conductance and RF characteristics to devices fabricated during only the selective gate-recess etching process because of the smaller gate to channel distance.

关键词： High electron mobility transistors (HEMTs) Gate-recess Digital wet-etching Selective wet-etching

不同谷子品种富硒能力及外源硒协同增效作用的研究

在线全文

学校读者我要写书评

暂无评论

中国土壤与肥料 2024年第4期 206-213页

作者：黄子鹏魏丹迟凤琴姚磊丁建莉李艳金梁何义利李沛东北农业大学资源与环境学院黑龙江哈尔滨150030 北京市农林科学院植物营养与资源环境研究所北京100097 黑龙江省黑土保护利用研究院黑龙江哈尔滨150086 北京市农林科学院农业生物技术研究所北京100097

为了实现缺硒带谷子高效富硒生产的目标,研究京郊谷子在缺硒土壤(褐土,硒含量0.2.6 mg/kg)吸收土壤硒的能力和喷施外源硒及增效制剂对硒的吸收效率。以“京谷2.”“京谷3号”“京谷4号”谷子为试验材料,设置4个硒水平(0、11.2.、15.00... 详细信息

为了实现缺硒带谷子高效富硒生产的目标,研究京郊谷子在缺硒土壤(褐土,硒含量0.2.6 mg/kg)吸收土壤硒的能力和喷施外源硒及增效制剂对硒的吸收效率。以“京谷2.”“京谷3号”“京谷4号”谷子为试验材料,设置4个硒水平(0、11.2.、15.00、2..50 g/hm^(2.)和2.增效剂(18.75 L/hm^(2.腐植酸和0.19 L/hm^(2.有机硅),采用田间随机区组试验,研究施用外源硒(Na_(2.SeO_(3))条件下,谷子品种与富硒的交互作用和增效制剂对富硒能力的提升。通过测定谷子籽粒硒含量、籽粒硒利用效率和强化指数,比较不同增效剂与硒协同作用对谷子富硒能力提升效率的影响,为生产中优化高附加值富硒农产品生产提供参考。结果表明:CK处理中,“京谷2.”籽粒硒含量、籽粒硒生物富集指数最高,筛选“京谷2.”为土壤硒富集能力强品种,Se处理中,“京谷4号”籽粒硒含量、硒利用效率、强化指数均最高,筛选“京谷4号”为外源硒富集能力强品种;腐植酸和有机硅增效剂与硒协同作用比较,喷施腐植酸增效剂显著提高谷子籽粒硒含量、硒利用效率和强化指数,其提高谷子富硒效率效果明显;喷施腐植酸增效剂条件下,“京谷4号”籽粒硒含量比Se2.理增加30.37%,“京谷2.”“京谷3号”籽粒硒含量比Se3处理增加41.50%、16.81%。缺硒土壤生产富硒谷子,品种选择“京谷4号”,选择腐植酸增效剂及15.00 g/hm^(2.Na_(2.SeO_(3),其中“京谷2.”“京谷3号”,喷施腐植酸增效剂可减少1/3亚硒酸钠用量,达到增加籽粒硒含量的目的。

关键词：谷子叶面施硒增效剂籽粒硒含量籽粒品质

Distribution of δ^(18)O in surface snow along a transect from Zhongshan Station to Dome A,East Antarctica

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

chinese Science Bulletin 2010年第24期55卷 2709-2714页

作者： ding MingHu XIAO CunDe jin Bo REN JiaWen QIN DaHe SUN WeiZhen Division of Cenozoic Geology and Environment Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China State Key Laboratory of Cryospheric Sciences Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Graduate University of chinese academy of Sciences Beijing 100049 China chinese Arctic and Antarctic Administration Beijing 100860 China

Surface snow samples were collected during the 14th(1997/1998)and 2.th(2.07/2.08)chinese National Antarctica Research Expeditions along a transect from Zhongshan Station to Dome *** stable oxygen isotope ratios of these samples were measured to investigate their relationships with temperature and geographical parameters(latitude,longitude,altitude and distance to the coast).The results reveal a strong positive correlation(R=0.945)betweenδ18O and mean annual temperature,with a gradient of 0.84‰°C-1,which is a little higher than that in Terre Adelie *** analyses also show that theδ18O of surface snow is strongly correlated with distance to the coast(R=0.942.,latitude(R=0.942.,and altitude(R=0.941).But no significant correlation was found betweenδ18O and longitude in study *** should be the most important factor influencing the δ18O distribution because of distinctive ***δ18O-altitude and T-altitude gradients along this transect are determined to be-1.1‰/100 m and 1.31°C/100 m,respectively.

关键词：东南极洲中山站断面积雪地表冰穹海拔高度同位素比值

Investigation of weak interlayer coupling in 2. layered GeS_(2. from theory to experiment

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第2期15卷 1013-1019页

作者： Hui-Juan Yan Zongbao Li Shun-Chang Liu Xia Wang Xing Zhang ding-Jiang Xue jin-Song Hu beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Laboratory of Molecular Nanostructure and NanotechnologyInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Material and Chemical Engineering Institute of Cultural and Technological Industry Innovation ofTongrenTongren UniversityTongren 554300China University of chinese academy of Sciences Beijing 100049China

Interlayer coupling as a unique feature for two-dimensional(2.)materials may influence their thickness-dependent physical properties,especially the bandgap due to quantum confinement ***-studied 2. materials usually possess strong interlayer coupling such as most of transition metal dichalcogenides(TMDs),PtS_(2. and so ***,2. materials with weak interlayer coupling are rarely referred that mainly focus on ReS_(2.,as well as its counterpart ReSe_(2..Here we report a new member of weak interlayer coupling 2. materials,germanium disulfide(GeS_(2.).The interlayer interaction in GeS_(2. is investigated from theory to *** density functional theory calculations,we find that this extraordinarily weak interlayer coupling in GeS_(2. originates from the weak hybridization of interlayer S ***-dependent Raman spectra of GeS_(2. flakes exhibit that the Raman peaks remain unchanged when increasing the thickness;and a small first-order temperature coefficient of-0.00857 cm^(-1)·K^(-1) is obtained from the temperature-dependent Raman *** experimental results further confirm the weak interlayer coupling in GeS_(2..

关键词： interlayer coupling two-dimensional GeS_(2. temperature coefficient