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心肌缺血再灌注损伤中心肌免疫细胞单细胞图谱绘制及具有心肌保护效应的Ym-1hi中性粒细胞的鉴定

Science Bulletin 2024年第7期69卷 949-967页

作者：董亚兰康真玉张子力张永强周海锋刘艳飞帅欣欣李君仪殷梁青青王埙埙马彦范恒 Feng Jiang 林志豪丁从珠金渊真 Alexey Sarapultsev 李芳菲张戈谢天尹长军程翔罗珊珊刘玥胡德胜 Department of Integrated Traditional chinese and Western Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210008China National Clinical Research Center for chinese Medicine Cardiology Xiyuan HospitalChinese Academy of Chinese Medical SciencesBeijing 100091China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of International Education Tianjin University of Traditional Chinese MedicineTianjin 300193China institute of Neuroscience School of MedicineXiamen UniversityXiamen 361102China School of Traditional chinese Medicine Xiamen University MalaysiaSepang 43900Malaysia School of Medical Biology South Ural State UniversityChelyabinsk 620049Russia Shum Yiu Foon Sum Bik Chuen Memorial Centre for Cancer and Inflammation Research(CCIR) School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China institute of Integrated Bioinfomedicine and Translational Science School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Division of Vascular Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China institute of Precision Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-UniversityMunich 80336Germany institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China china-Russia Medical Research Center for Stress Immunology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Myocardial ischemia–reperfusion injury(MIRI)is a major hindrance to the success of cardiac reperfusion *** increased neutrophil infiltration is a hallmark of MIRI,the subtypes and alterations of neutrophils in this process remain ***,we performed single-cell sequencing of cardiac CD45^(+)cells isolated from the murine myocardium subjected to MIRI at six-time *** identified diverse types of infiltrating immune cells and their dynamic changes during *** neutrophils showed the most immediate response and largest changes and featured with functionally heterogeneous subpopulations,including Ccl3^(hi)Neu and Ym-1^(hi)Neu,which were increased at 6 h and 1 d after reperfusion,***-1^(hi)Neu selectively expressed genes with protective effects and was,therefore,identified as a novel specific type of cardiac cell in the injured *** analysis indicated that neutrophils and their subtypes orchestrated subsequent immune responses in the cardiac tissues,especially instructing the response of *** abundance of Ym-1^(hi)Neu was closely correlated with the therapeutic efficacy of MIRI when neutrophils were specifically targeted by anti-Lymphocyte antigen 6 complex locus G6D(Ly6G)or anti-Intercellular cell adhesion molecule-1(ICAM-1)neutralizing *** addition,a neutrophil subtype with the same phenotype as Ym-1^(hi)Neu was detected in clinical samples and correlated with ***-1 inhibition exacerbated myocardial injury,whereas Ym-1 supplementation significantly ameliorated injury in MIRI mice,which was attributed to the tilt of Ym-1 on the polarization of macrophages toward the repair phenotype in myocardial ***,our findings reveal the antiinflammatory phenotype of Ym-1^(hi)Neu and highlight its critical role in myocardial protection during the early stages of MIRI.

关键词： Myocardial ischemia-reperfusion injury Neutrophil Ym-1 Cardiac immune response Single-cell sequencing

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机载折反式光学系统的无热化设计

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液晶与显示 2019年第1期34卷 39-46页

作者：廖劲峰丁亚林姚园中国科学院长春光学精密机械与物理研究所航空光学成像与测量重点实验室吉林长春130033 中国科学院大学北京100049

为了消除在实际飞行过程中温度变化对机载折反式光学系统成像质量的影响,对该系统的光学元件、机械结构等部分进行热分析,实现机载折反式光学系统的无热化设计。首先,根据透镜的光焦度公式推导透镜的光焦度温度函数,列出透镜组的消热差... 详细信息

为了消除在实际飞行过程中温度变化对机载折反式光学系统成像质量的影响,对该系统的光学元件、机械结构等部分进行热分析,实现机载折反式光学系统的无热化设计。首先,根据透镜的光焦度公式推导透镜的光焦度温度函数,列出透镜组的消热差方程。接着,在考虑支撑结构的影响时引入轴向放大率,以此表现折反式系统部分元件间隔变化对系统焦距影响大的特点。最后,结合前两者确定完整的消热差方程来指导无热化设计。仿真结果表明,工作在486～656nm波段,焦距为1 850mm的机载折反式可见光光学系统在0～40℃之间成像良好,调制传递函数下降不到0.1。

关键词：无热化设计折反式光学系统轴向放大率可见光波段

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铁路桥梁建设泥浆废水处理-机制砂生产组合工艺碳排放核算及综合评估

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铁路节能环保与安全卫生 2024年第1期14卷 1-9页

作者：周岩梅赵一帆郭逸涵史建国强燕郑美娜王锦丁国玉吕向茹张洁瑜北京交通大学环境学院北京100044 北京交通大学水中典型污染物控制与水质保障北京市重点实验室北京100044 西安建筑科技大学环境与市政工程学院陕西西安710200 中国铁道科学研究院集团有限公司节能环保劳卫研究所北京100081

桥梁建设过程中产生的泥浆废水由于高悬浮物(SS)和高pH值较难处理达标,钻孔桩基产生的钻渣可用来生产砂石骨料,但需要大量的水资源。本研究设计了8种近零排放泥浆废水处理与砂石骨料生产组合工艺,基于生命周期理论,构建组合工艺碳排放... 详细信息

桥梁建设过程中产生的泥浆废水由于高悬浮物(SS)和高pH值较难处理达标,钻孔桩基产生的钻渣可用来生产砂石骨料,但需要大量的水资源。本研究设计了8种近零排放泥浆废水处理与砂石骨料生产组合工艺,基于生命周期理论,构建组合工艺碳排放核算模型和综合评估方法。案例分析结果表明:化学混凝-pH值调节-棒磨机制砂生产组合工艺生命周期碳排放量最大,为2 974.29 tCO_(2e),机械分离-立轴式冲击破碎机制砂生产组合工艺碳排放量最小,约为1 038.75 tCO_(2e)。应用熵权-优劣解距离法(熵权-TOPSIS法)综合评估8种组合工艺,发现机械分离-pH值调节-棒磨机制砂生产组合工艺与最优工艺贴近度最高。该研究结果支持铁路桥梁建造泥浆废水处理和钻渣综合利用组合工艺设计。

关键词：泥浆废水机制砂生命周期碳排放综合评估

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CsPb(I_(x)Br_(1-x))_(3) solar cells

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Science Bulletin 2019年第20期64卷 1532-1539页

作者： Xue Jia Chuantian Zuo Shuxia Tao Kuan Sun Yixin Zhao Shangfeng Yang Ming Cheng Mingkui Wang Yongbo Yuan Junliang Yang Feng Gao Guichuan Xing Zhanhua Wei Lijun Zhang Hin-Lap Yip Mingzhen Liu Qing Shen Longwei Yin Liyuan Han Shengzhong Liu Lianzhou Wang jingshan Luo Hairen Tan zhiwen jin Liming ding Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing100190China University of chinese academy of sciences Beijing100049China CSIRO Manufacturing Bag10Clayton SouthVictoria3169Australia Center for Computational Energy Research Department of Applied PhysicsEindhoven University of Technology5600MB EindhovenThe Netherlands MOE Key Laboratory of Low-grade Energy Utilization Technologies and Systems Chongqing UniversityChongqing400044China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China Department of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China institute for Energy Research Jiangsu UniversityZhenjiang212013China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China School of Physics and Electronics Central South UniversityChangsha410083China Department of Physics Chemistry and BiologyLinkoping UniversitySE-58183 LinkopingSweden institute of Applied Physics and Materials Engineering University of MacaoMacao999078China College of Materials Science&Engineering Huaqiao UniversityXiamen361021China College of Materials Science and Engineering Jilin UniversityChangchun130012China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou510640China Center for Applied Chemistry School of Materials and EnergyUniversity of Electronic Science and Technology of ChinaChengdu611731China Faculty of Informatics and Engineering The University of Electro-CommunicationsTokyo182-8585Japan School of Materials Science and Engineering Shandong UniversityJinan250061China State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Normal UniversityXi’an710119China

Owing to its nice performance, low cost, and simple solution-processing, organic-inorganic hybrid perovskite solar cell(PSC) becomes a promising candidate for next-generation high-efficiency solar *** power conversion efficiency(PCE) has boosted from 3.8% to 25.2% over the past ten years. Despite the rapid progress in PCE, the device stability is a key issue that impedes the commercialization of PSCs. Recently, all-inorganic cesium lead halide perovskites have attracted much attention due to their better stability compared with their organic-inorganic counterpart. In this progress report, we summarize the properties of CsPb(IxBr1-x)3 and their applications in solar cells. The current challenges and corresponding solutions are discussed. Finally, we share our perspectives on CsPb(IxBr1-x)3 solar cells and outline possible directions to further improve the device performance.

关键词： Perovskite solar cells Cesium lead halide perovskites Power conversion efficiency Stability

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Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network

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Protein & Cell 2021年第7期12卷 557-577页

作者： Yu-Kun Xia Yi-Rong Zeng Meng-Li Zhang Peng Liu Fang Liu Hao Zhang Chen-Xi He Yi-Ping Sun jin-Ye Zhang Cheng Zhang Lei Song Chen ding Yu-Jie Tang Zhen Yang Chen Yang Pu Wang Kun-Liang Guan Yue Xiong Dan Ye Huashan Hospital Fudan Universityand Molecular and Cell Biology LabInstitutes of Biomedical Sciencesand the Shanghai Key Laboratory of Medical Epigeneticsand the Key Laboratory of Metabolism and MolecularMinistry of EducationShanghai 200032China The International Co-Laboratory of Medical Epigenetics and Metabolism Ministry of Science and TechnologyShanghai 200032China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200032China Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education Department of PathophysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Synthetic Biology Institute of Plant Physiology and EcologyShanghai 200032China institutes for Biological sciences Chinese Academy of SciencesShanghai 200032China State Key Laboratory of Proteomics Beijing Proteome Research CenterBeijing Institute of Radiation MedicineBeijing 102206China National Center for Protein sciences(The PHOENIX Center Beijing)Beijing 102206China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life SciencesInstitutes of Biomedical SciencesFudan UniversityShanghai 200032China Department of Pharmacology and Moores Cancer Center University of California San DiegoLa JollaCAUSA Lineberger Comprehensive Cancer Center Department of Biochemistry and BiophysicsUniversity of North CarolinaChapel HillNCUSA Department of General Surgery Huashan HospitalFudan UniversityShanghai 200032China

Additional sex combs-like 1(ASXL1)interacts with BRCA1-associated protein 1(BAP1)deubiquitinase to oppose the polycomb repressive complex 1(PRC1)-mediated histone H2A *** BAP1 mutations are found in a spectrum of human malignancies,while ASXL1 mutations recurrently occur in myeloid neoplasm and are associated with poor *** all ASXL1 mutations are heterozygous frameshift or nonsense mutations in the middle or to a less extent the C-terminal region,resulting in the production of C-terminally truncated mutant ASXL1 *** ASXL1 regulates specific target genes and how the C-terminal truncation of ASXL1 promotes leukemogen-esis are ***,we report that ASXL1 interacts with forkhead transcription factors FOXK1 and FOXK2 to regulate a subset of FOXK1/K2 target *** show that the C-terminally truncated mutant ASXL1 proteins are expressed at much higher levels than the wild-type protein in ASXL1 heterozygous leukemia cells,and lose the ability to interact with FOXK1/*** deletion of the mutant allele eliminates the expression of C-termi-nally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1,thereby restoring the expression of BAP1-ASXL1-FOXK1/K2 target genes,particularly those involved in glucose metabolism,oxygen sensing,and JAK-STAT3 signaling *** addition to FOXK1/K2,we also identify other DNA-bind-ing transcription regulators including transcription factors(TFs)which interact with wild-type ASXL1,but not C-terminally truncated *** results suggest that ASXL1 mutations result in neomorphic alleles that contribute to leukemogenesis at least in part through dominantly inhibiting the wild-type ASXL1 from interacting with BAP1 and thereby impairing the function of ASXL1-BAP1-TF in regulating target genes and leukemia cell growth.

关键词： ASXL1 BAP1 FOXK1/K2 leukemia epigenetics

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非掺杂型Si/SiGe异质结外延与表征

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物理学报 2024年第11期73卷 297-304页

作者：耿鑫张结印卢文龙明铭刘方泽符彬啸褚逸昕颜谋回王保传张新定郭国平张建军华南师范大学物理学院广州510631 松山湖材料实验室半导体异质材料与器件中心东莞523830 中国科学技术大学中国科学院量子信息重点实验室合肥230026 中国科学院物理研究所纳米物理与器件重点实验室北京100190 上海大学理学院上海200444

以自旋为编码单元的硅基半导体量子计算与传统微电子工艺兼容,易拓展且可以同位素纯化提高退相干时间,因而备受关注.本研究工作通过分子束外延生长了高质量非掺杂型Si/SiGe异质结并测试了二维电子气迁移率.球差电镜观察到原子级尖锐界面... 详细信息

以自旋为编码单元的硅基半导体量子计算与传统微电子工艺兼容,易拓展且可以同位素纯化提高退相干时间,因而备受关注.本研究工作通过分子束外延生长了高质量非掺杂型Si/SiGe异质结并测试了二维电子气迁移率.球差电镜观察到原子级尖锐界面,原子力显微镜表征显示其表面均方根粗糙度仅为0.44 nm,低温下迁移率达到20.21×10^(4)cm^(2)·V^(–1)·s^(–1).不同栅压下载流子浓度和迁移率的幂指数为1.026,材料丁格比值在7—12之间,表明载流子主要受到背景杂质散射和半导体/氧化物的界面散射.

关键词： Si/SiGe异质结二维电子气霍尔迁移率硅基量子计算

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尺寸可控的球型DNA纳米颗粒构筑策略及其应用

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高分子学报 2023年第3期54卷 336-345页

作者：成佳峰袁伟丁雨樵魏旭南郁志勇徐立进董原辰中国人民大学化学系北京100872 中国科学院化学研究所北京100190 中国科学院大学北京100049

为探究球型DNA纳米颗粒的尺寸对细胞摄取的影响,提出了一种新型构筑策略,制备了一系列尺寸精准可控的球型DNA纳米颗粒,并进一步揭示了球型DNA纳米颗粒的尺寸与MCF-7细胞内化效率的关系;此外,该策略还可以与框架诱导策略相结合,构筑尺寸... 详细信息

为探究球型DNA纳米颗粒的尺寸对细胞摄取的影响,提出了一种新型构筑策略,制备了一系列尺寸精准可控的球型DNA纳米颗粒,并进一步揭示了球型DNA纳米颗粒的尺寸与MCF-7细胞内化效率的关系;此外,该策略还可以与框架诱导策略相结合,构筑尺寸可控的磷脂囊泡.该结果为构建新型高效的DNA纳米颗粒载药系统提供了理论参考,为特定尺寸的药物载体设计和开发拓展了思路.

关键词：尺寸可控球型DNA纳米颗粒 DNA自组装框架诱导组装

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Influence of Human Activities on Wintertime Haze-Related Meteorological Conditions over the jing–jin–Ji Region

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Engineering 2021年第8期7卷 1185-1192页

作者： Ying Xu Yanju Liu Zhenyu Han Botao Zhou Yihui ding Jie Wuc Tongfei Tian Rouke Li jing Wang National Climate Center China Meteorological AdministrationBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Geography and Environmental Engineering Gannan Normal UniversityGanzhou 341000China Camford Royal School Beijing 100093China Climate and Environment Modeling Lab Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China

This work analyzes and discusses the influence of human activities on the meteorological conditions related to winter haze events in beijing,Tianjin,and Hebei(i.e.,the jing-jin-Ji region)during 1961-2016,using the results of two numerical simulation experiments based on the Community Atmosphere Model version 5.1.1(http://***/models/cesm1.0/cam/docs/ug5_1_1/***)used in the international Climate Variability and Predictability Programme(CLIVAR)Climate of the 20th Century Detection and Attribution Project(C20C+D&A).The results show that,under the influence of human activities,the changes in dynamical and thermal meteorological conditions related to winter haze events in the jing–jin–Ji region are conducive to the formation and accumulation of haze,and prevent the diffusion of *** dynamical conditions mainly include the obvious weakening of the East Asian winter monsoon(EAWM)and the enhancement of the near-surface anomalous southerly *** thermal conditions include the obvious increase in surface temperature,and the enhancement of water vapor transport and near-surface *** relative contribution of dynamical and thermal conditions to the variation of haze days in the jing-jin-Ji region is analyzed using statistical *** results show that the contribution of human activities to the increase of haze days in the jing-jin-Ji region is greater than that of natural forcing for the study *** be specific,the dynamical meteorological factors contribute more to the haze days than the thermal meteorological *** contribution of thermal meteorological factors is basically the same in both scenarios.

关键词： Meteorological conditions Human activities Haze jing-jin-Ji region

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Preoperative prediction of lymph node metastasis using deep learning-based features

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Visual computing for Industry,Biomedicine,and Art 2022年第1期5卷 88-98页

作者： Renee Cattell Jia Ying Lan Lei Jie ding Shenglan Chen Mario Serrano Sosa Chuan Huang Department of Biomedical Engineering Stony Brook UniversityNY 11794 Stony BrookUSA Department of Radiation Oncology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Program in Public Health Stony Brook MedicineStony BrookNY 11794USA Department of Medicine Northside Hospital GwinnettGA 30046 LawrencevilleUSA Department of Radiation Oncology Medical College of WisconsinMilwaukeeWI 53226USA institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Department of Radiology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794US

Lymph node involvement increases the risk of breast cancer *** accurate non-invasive assessment of nodal involvement is valuable in cancer staging,surgical risk,and cost *** has been proposed to pre-operatively predict sentinel lymph node(SLN)status;however,radiomic models are known to be sensitive to acquisition *** purpose of this study was to develop a prediction model for preoperative prediction of SLN metastasis using deep learning-based(DLB)features and compare its predictive performance to state-of-the-art ***,this study aimed to compare the generalizability of radiomics vs DLB features in an independent test set with dissimilar *** contrast-enhancement images from 198 patients(67 positive SLNs)were used in this *** these subjects,163 had an in-plane resolution of 0.7×0.7 mm^(2),which were randomly divided into a training set(approximately 67%)and a validation set(approximately 33%).The remaining 35 subjects with a different in-plane resolution(0.78×0.78 mm^(2))were treated as independent testing set for *** methods were employed:(1)conventional radiomics(CR),and(2)DLB features which replaced hand-curated features with pre-trained VGG-16 *** threshold determined using the training set was applied to the independent validation and testing *** feature reduction,feature selection,model creation procedures were used for both *** the validation set(same resolution as training),the DLB model outperformed the CR model(accuracy 83%vs 80%).Furthermore,in the independent testing set of the dissimilar resolution,the DLB model performed markedly better than the CR model(accuracy 77%vs 71%).The predictive performance of the DLB model outperformed the CR model for this *** interestingly,these improvements were seen particularly in the independent testing set of dissimilar *** could indicate that DLB features can ultimately result in a mor

关键词： Deep learning Radiomics Prediction model Lymph node metastasis Breast cancer

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1982—2015年中国气候变化和人类活动对植被NDVI变化的影响

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地理学报 2020年第5期75卷 961-974页

作者：金凯王飞韩剑桥史尚渝丁文斌西北农林科技大学水土保持研究所杨凌712100 青岛农业大学资源与环境学院青岛266109 中国科学院水利部水土保持研究所杨凌712100 中国科学院大学北京100049 中国科学院地理科学与资源研究所北京100101

基于中国603个气象站的地表气温和降水观测资料以及GIMMS NDVI3g数据,采用变化趋势分析和多元回归残差分析等方法研究了1982—2015年中国植被NDVI变化特征及其主要驱动因素(即气候变化和人类活动)的相应贡献。结果表明:①1982—2015年... 详细信息

基于中国603个气象站的地表气温和降水观测资料以及GIMMS NDVI3g数据,采用变化趋势分析和多元回归残差分析等方法研究了1982—2015年中国植被NDVI变化特征及其主要驱动因素(即气候变化和人类活动)的相应贡献。结果表明:①1982—2015年中国植被恢复明显,在选择的32个省级行政区中,山西、陕西和重庆的生长季NDVI增加最快,仅上海生长季NDVI呈减小趋势。②气候变化和人类活动的共同作用是中国植被NDVI呈现整体快速增加和巨大空间差异的主要原因,其中气候变化对各省生长季NDVI变化的影响在-0.01×10^-3~1.05×10^-3a^-1之间,而人类活动的影响在-0.32×10^-3~1.77×10^-3a^-1之间。③气候变化和人类活动分别对中国近34年来植被NDVI的增加贡献了40%和60%;人类活动贡献率超过80%的区域主要集中在黄土高原中部、华北平原以及中国东北和西南等地;人类活动贡献率大于50%的省份有22个,其中贡献率最大的3个地区为上海、黑龙江和云南。研究结果建议应更加重视人类活动在植被恢复中的作用。

关键词：植被变化气候变化人类活动 NDVI 残差分析中国

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