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Chemical synthesis of a synthetically useful L-galactosaminuronic acid building block

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Chinese Journal of Natural Medicines 2022年第5期20卷 387-392页

作者： QIN Chun-Jun HOU Hong-Li ding mei-ru QI Yi-Kuan TIAN Guang-Zong ZOU Xiao-Peng FU Jun-Jie HU Jing YIN Jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Wuxi School of Medicine Jiangnan UniversityWuxi 214122China

Most bacterial cell surface glycans are structurally unique, and have been considered as ideal target molecules for the developments of detection and diagnosis techniques, as well as vaccines. Chemical synthesis has been a promising approach to prepare well-defined oligosaccharides, facilitating the structure-activity relationship exploration and biomedical applications of bacterial glycans. L-Galactosaminuronic acid is a rare sugar that has been only found in cell surface glycans of gram-negative bacteria. Here, an orthogonally protected L-galactosaminuronic acid building block was designed and chemically synthesized. A synthetic strategy based on glycal addition and TEMPO/BAIB-mediated C6 oxidation served well for the transformation of commercial L-galactose to the corresponding L-galactosaminuronic acid. Notably, the C6 oxidation of the allyl glycoside was more efficient than that of the selenoglycoside. In addition, a balance between the formation of allyl glycoside and the recovery of selenoglycoside was essential to improve efficiency of the NIS/TfOH-catalyzed allylation. This synthetically useful L-galactosaminuronic acid building block will provide a basis for the syntheses of complex bacterial glycans.

关键词： L-galactosaminuronic acid Chemical synthesis Orthogonal protection Glycal addition C6 oxidation

运动锻炼操联合握拳训练对PICC置管者贵要静脉血流与血管内径的影响

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护理实践与研究 2020年第18期17卷 153-155页

作者：丁如梅上海长征医院上海市200003

目的探讨运动锻炼操联合握拳训练对经外周静脉置入中心静脉导管(PICC)置管者贵要静脉血流与血管内径的影响。方法选择2017年8月至2019年8月我院180例PICC置管者为研究对象,随机等分为对照组与观察组,对照组采用常规护理,观察组在对照组... 详细信息

目的探讨运动锻炼操联合握拳训练对经外周静脉置入中心静脉导管(PICC)置管者贵要静脉血流与血管内径的影响。方法选择2017年8月至2019年8月我院180例PICC置管者为研究对象,随机等分为对照组与观察组,对照组采用常规护理,观察组在对照组基础上进行运动锻炼操联合握拳训练。连续干预8周,采用多普勒超声诊断仪检测干预后贵要静脉血流速度与血管内径,记录PICC置管期间导管堵塞、非计划性拔管、上肢静脉血栓等不良事件发生率。结果观察组贵要静脉血流速度与血管内径明显高于对照组,差异具统计学意义(P<0.05);观察组导管堵塞、非计划性拔管、上肢静脉血栓等不良事件发生率明显低于对照组,差异具统计学意义(P<0.05)。结论运动锻炼操联合握拳训练有助于加快PICC置管者贵要静脉血流速度,增大血管内径,能够有效预防上肢静脉血栓、导管堵塞等PICC置管不良事件发生。

关键词：运动锻炼操握拳训练 PICC置管贵要静脉血流速度血管内径静脉血栓

综合护理干预对晚期不可切除胰腺癌化疗患者精神状态的影响

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护理实践与研究 2018年第11期15卷 88-90页

作者：范静丁如梅海军军医大学附属长征医院胰胆外科上海市200003

目的探讨综合护理干预对晚期不可切除胰腺癌化疗患者精神状态的影响。方法选取我院2014年1月至2017年12月肿瘤科接诊的117例胰腺癌患者作为研究对象,随机分为对照组57例和研究组60例,对照组给予常规护理,研究组实施综合护理干预。观察... 详细信息

目的探讨综合护理干预对晚期不可切除胰腺癌化疗患者精神状态的影响。方法选取我院2014年1月至2017年12月肿瘤科接诊的117例胰腺癌患者作为研究对象,随机分为对照组57例和研究组60例,对照组给予常规护理,研究组实施综合护理干预。观察两组患者干预前后生活质量(SF-36)、精神状态(SCL-90)变化情况及护理满意度。结果两组患者干预后生活质量显著优于干预前,研究组干预后生活质量改善效果显著(P<0.05);研究组患者SCL-90评分指数显著优于对照组,两组患者干预后各项指标比较差异有统计学意义(P<0.05);研究组患者满意度显著高于对照组(P<0.05)。结论不可切除胰腺癌患者化疗期间实施综合护理干预,有效改善患者精神状态及生活质量,效果显著,具有进一步拓展运用价值。

关键词：综合护理干预不可切除胰腺癌精神状态生活质量

十全大补汤联合正念减压疗法对中晚期肺癌患者癌因性疲乏的影响

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护理实践与研究 2020年第16期17卷 148-150页

作者：王燕丁如梅上海长征医院上海市200070

目的探讨十全大补汤联合正念减压疗法对中晚期肺癌患者癌因性疲乏的影响,为临床治疗方案提供支持。方法采取目的抽样法,选择2017年5月至2019年5月我院收治的中晚期肺癌患者78例为研究对象,按照随机数字表法等分为对照组和观察组,对照组... 详细信息

目的探讨十全大补汤联合正念减压疗法对中晚期肺癌患者癌因性疲乏的影响,为临床治疗方案提供支持。方法采取目的抽样法,选择2017年5月至2019年5月我院收治的中晚期肺癌患者78例为研究对象,按照随机数字表法等分为对照组和观察组,对照组给予常规护理,观察组辅助十全大补汤联合正念减压疗法,两组均持续治疗8周。比较两组中医证候积分、癌因性疲乏评分。结果干预后,观察组中医证候积分明显低于对照组(P<0.05);观察组躯体感知疲乏、情感疲乏、认知疲乏、行为疲乏各维度评分均明显低于对照组(P<0.05)。结论十全大补汤联合正念减压疗法可有效改善中晚期肺癌患者中医症状及癌因性疲乏度,提高疗效,具有临床应用价值。

关键词：十全大补汤正念减压疗法中晚期肺癌癌因性疲乏

Vaccination against AGE-LDL attenuates atherosclerosis in diabetic apoE mice

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Vaccination against AGE-LDL attenuates atherosclerosis in di...

第十三次全国心血管病学术会议

作者： ZHU Lin,LIANG Chun,HE Zhi-qing,LI mei,ding ru,ZHEN Yi, FAN Ming,WU Zong-gui Department of Cardiology,Second Affiliated Hospital of Second Military Medical University,Shanghai 200003,China

Objective To investigate the immunoprotective effects of vaccination against AGE-LDL in atherosclerotic lesions and underlying immunoregulatory *** Male apoE deficient mice were maintained on a standard diet for 2 weeks then changed to high fat diet during the rest of the *** model was induced by intraperitoneal injection of streptozotocin at a dose of 40 mg/kg in citrate buffer for 5 days in such mice,and identified by randomly measured fast blood glucose. LDL was obtained by ultracentrifugation from healthy human volunteers’ serum and then incubated in glucose for gly-

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胰腺癌患者疼痛情况及护理需求调查

护理实践与研究 2019年第2期16卷 29-31页

作者：丁如梅王燕范静上海长征医院上海市200003

目的调查胰腺癌患者疼痛情况和调查护理需求,为胰腺癌患者癌痛及临床护理提供理论依据。方法本研究选取2016年1月至2018年1月我院治疗的200例胰腺癌患者作为研究对象,参照相关文献以及我院具体情况制作调查问卷,调查患者疼痛发生率、疼... 详细信息

目的调查胰腺癌患者疼痛情况和调查护理需求,为胰腺癌患者癌痛及临床护理提供理论依据。方法本研究选取2016年1月至2018年1月我院治疗的200例胰腺癌患者作为研究对象,参照相关文献以及我院具体情况制作调查问卷,调查患者疼痛发生率、疼痛部位、疼痛性质,采用美国疼痛协会患者结果问卷修订版(APS-POQ)调查疼痛等级,调查患者疼痛护理需求,包括无痛时、止痛治疗以及疼痛期间的护理需求评分。结果 200例胰腺癌患者以疼痛为主诉者共138例,疼痛发生率69. 00%,男女疼痛发生率差异无统计学意义(P> 0. 05);疼痛部位中主要为上腹疼痛,共78例,占56. 52%;疼痛性质中主要表现为隐痛80例,占57. 97%; APS-POQ疼痛分级中Ⅱ级疼痛比例最高,共53例,占38. 41%; TNM分期中Ⅳ期患者疼痛发生率为84. 21%,显著高于I期、Ⅱ期、Ⅲ期患者,差异具有统计学意义(P <0. 05);无痛时护理需求评分最高为疼痛原因及干预措施,止痛治疗护理需求评分最高为药物使用注意事项,疼痛时护理需求评分最高为保持环境安静。结论胰腺癌患者中疼痛发生率较高,主要表现为上腹痛、隐痛以及二级疼痛,TNM分期中Ⅳ期患者疼痛发生率高,男女性别比较无差异,护理需求以疼痛健康知识、止痛药物使用以及保证环境安静为主。

关键词：胰腺癌疼痛情况护理需求

溯源解决护理法在肾移植术后早期腹胀中的应用

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护理实践与研究 2017年第17期14卷 77-79页

作者：李晓静丁如梅上海长征医院肾移植科上海市200003

目的 :探讨溯源解决护理法在肾移植术后早期腹胀中的应用效果。方法:将溯源解决护理法应用前(2013年1月~2014年12月)收治于我院行肾移植的患者50例作为对照组,应用后(2015年1月~2016年12月)的肾移植患者50例作为试验组,对照组接受肾移... 详细信息

目的 :探讨溯源解决护理法在肾移植术后早期腹胀中的应用效果。方法:将溯源解决护理法应用前(2013年1月~2014年12月)收治于我院行肾移植的患者50例作为对照组,应用后(2015年1月~2016年12月)的肾移植患者50例作为试验组,对照组接受肾移植术后早期腹胀常规护理;试验组接受针对术后腹胀的溯源解决护理法干预,比较该护理模式应用前后各相关观察指标。结果:试验组肾移植术患者干预后腹胀发生率明显低于对照组,腹胀评分差值和患者护理满意度评分均明显高于对照组(P<0.05)。结论:溯源解决护理法,可降低肾移植患者术后腹胀发生率和腹胀程度,提高患者对护理服务的满意度。

关键词：溯源解决法肾移植腹胀护理

The relationshiop among plasma exosomes,level of myocardial enzymes and the degree of coronary artery disease in patients with acute myocardial infarction

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The relationshiop among plasma exosomes,level of myocardial ...

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

第十三次全国心血管病学术会议

作者： WANG Li-yan,ZHU Lin,LIANG Chun,HE Zhi-qing, LI mei,ding ru,ZHEN Yi,FAN Ming,WU Zong-gui *Department of Cardiology,Second Affiliated Hospital of Second Military Medical University.Shanghai 200003,China

Objective To investigate the correlation plasma exosomes,level of myocardial enzymes and the degree of coronary artery disease in patients with acute myocardial *** 93 patients receiving coronary angiography(CAG) were enrolled and categorized as Group N(n = 24,control group),Group AMI(n = 23,acute myocardial infarction),Group SA(n = 24,stable angina pectoris) and Group UA(n = 22,unstable angina pectoris).Plasma exosomes were separated from 40 ml blood using *** of the markers of exosomes by FACS with antibodies against CD11c,

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-ru He Fei ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors