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Polycyclic aromatic hydrocarbon biodegradation and extracellular enzyme secretion in agitated and stationary cultures of Phanerochaete chrysosporium

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Journal of Environmental Sciences 2008年第1期20卷 88-93页

作者： ding juan CONG Jun ZHOU juan GAO Shixiang State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University Nanjing 210093 China School of the Energy and Environment Southeast University Nanjing 210096 China

The extracellular enzyme secretion and biodegradation of polycyclic aromatic hydrocarbons （PAHs） were studied in agitated and shallow stationary liquid cultures of Phanerochaete chrysosporium. Veratryl alcohol and Tween80 were added to cultures as lignin peroxidase （LIP） and manganese peroxidase （MnP） inducer, respectively. Shallow stationary cultures were suitable for the production of enzyme, whereas agitated cultures enhanced overall biodegradation by facilitating interphase mass transfer of PAHs into aqueous phases. The use of a LiP stimulator, veratryl alcohol, did not increase PAH degradation but significantly enhanced LiP activity. In contrast, Tween80 increased both MnP secretion and PAH degradation in shallow stationary cultures. On the other hand, high PAH degradation was observed in agitated cultures in the absence of detectable LiP and MnP activities. The results suggested that extracellular peroxidase activities are not directly related to the PAH degradation, and the increased solubility rather than enzyme activity may be more important in the promotion of PAH degradation.

关键词： lignin peroxidase (LIP) manganese peroxidase (MnP) Phanerochaete chrysosporium polycyclic aromatic hydrocarbons (PAHs) solubilization

Nested Group Testing Procedure

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Communications in Mathematics and Statistics 2023年第4期11卷 663-693页

作者： Wenjun Xiong juan ding Wei Zhang Aiyi Liu Qizhai Li School of Mathematics and Statistics Guangxi Normal UniversityGuilin 541004People’s Republic of China Department of Information and Computing Science College of SciencesHohai UniversityNanjing 210098People’s Republic of China LSC NCMISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190People’s Republic of China Biostatisics and Bioinformatics Branch Eunice Kennedy Shriver National Institute of Child HealthBethesda 20817USA University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

We investigated the false-negative,true-negative,false-positive,and true-positive predictive values from a general group testing procedure for a heterogeneous *** show that its false(true)-negative predictive value of a specimen is larger(smaller),and the false(true)-positive predictive value is smaller(larger)than that from individual testing procedure,where the former is in *** we propose a nested group testing procedure,and show that it can keep the sterling characteristics and also improve the false-negative predictive values for a specimen,not larger than that from individual *** characteristics are studied from both theoretical and numerical points of *** nested group testing procedure is better than individual testing on both false-positive and false-negative predictive values,while retains the efficiency as a basic characteristic of a group testing *** to Dorfman’s,Halving and Sterrett procedures are *** from extensive simulation studies and an application to malaria infection in microscopy-negative Malawian women exemplify the findings.

关键词： Group testing Negative predictive value Positive predictive value Retest

N-methyl-D-aspartate receptor subunit 1 regulates neurogenesis in the hippocampal dentate gyrus of schizophrenia-like mice

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Neural Regeneration Research 2019年第12期14卷 2112-2117页

作者： juan ding Chun Zhang Yi-Wei Zhang Quan-Rui Ma Yin-Ming Liu Tao Sun juan Liu Ningxia Key Laboratory of Cerebrocranial Diseases Institute of Basic Medical Sciences School of Basic Medical Sciences Ningxia Medical University

N-methyl-D-aspartate receptor hypofunction is the basis of pathophysiology in schizophrenia. Blocking the N-methyl-D-aspartate receptor impairs learning and memory abilities and induces pathological changes in the brain. Previous studies have paid little attention to the role of the N-methyl-D-aspartate receptor subunit 1 (NR1) in neurogenesis in the hippocampus of schizophrenia. A mouse model of schizophrenia was established by intraperitoneal injection of 0.6 mg/kg MK-801, once a day, for 14 days. In N-methyl-D-aspartate-treated mice, N-methyl-D-aspartate was administered by intracerebroventricular injection in schizophrenia mice on day 15. The number of NR1-, Ki67- or BrdU-immunoreactive cells in the dentate gyrus was measured by immunofluorescence staining. Our data showed the number of NR1-immunoreactive cells increased along with the decreasing numbers of BrdU- and Ki67-immunoreactive cells in the schizophrenia groups compared with the control group. N-methyl-D-aspartate could reverse the above changes. These results indicated that NR1 can regulate neurogenesis in the hippocampal dentate gyrus of schizophrenia mice, supporting NR1 as a promising therapeutic target in the treatment of schizophrenia. This study was approved by the Experimental Animal Ethics Committee of the Ningxia Medical University, China (approval No. 2014-014) on March 6, 2014.

关键词： nerve regeneration schizophrenia MK-801 N-methyl-D-aspartate neurogenesis N-methyl-D-aspartate receptor N-methyl-Daspartate receptor subunit 1 BrdU Ki67 hippocampal dentate gyrus hippocampal neurogenesis neural regeneration

Missense mutation in DYNC1H1 gene caused psychomotor developmental delay and muscle weakness:A case report

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World Journal of Clinical Cases 2021年第30期9卷 9302-9309页

作者： Feng-juan ding Gui-Zhen Lyu Victor Wei Zhang Hua Jin Prenatal Diagnosis Center Jinan Maternal and Child Health HospitalJinan 250001Shandong ProvinceChina AmCare Genomics lab(Guangzhou) Guangzhou 510300Guangdong ProvinceChina Department of Human and Molecular Genetics Baylor College of MedicineHoustonTX 77001United States

BACKGROUND The DYNC1H1 gene encodes a part of the dynamic protein,and the protein mutations may further affect the growth and development of neurons,resulting in degeneration of anterior horn cells of the spinal cord,and a variety of clinical phenotypes finally resulting in axonal Charcot-Marie-Tooth disease type 20(CMT20),mental retardation 13(MRD13)and spinal muscular atrophy with lower extremity predominant 1(SMA-LED).The incidence of the disease is low,and it is difficult to diagnose,especially in ***,we report a case of DYNC1H1 gene mutation and review the related literature to improve the pediatrician’s understanding of DYNC1H1 gene-related disease to make an early correct diagnosis and provide better services for *** SUMMARY A 4-mo-old Chinese female child with adducted thumbs,high arch feet,and epileptic seizure presented slow response,delayed development,and low limb muscle *** showed abnormal waves,a large number of multifocal sharp waves,sharp slow waves,and multiple spasms with a series of ***-throughput sequencing and Sanger sequencing identified a heterozygous mutation,c.5885 G>A(p.R1962H),in the DYNC1H1 gene(NM 001376)of the proband,which was not identified in her *** with the clinical manifestations and pedigree of this family,this mutation is likely pathogenic based on the American Academy of Medical Genetics and Genomics *** child was followed when she was 1 year and 2 mo *** magnetic resonance imaging result was consistent with the findings of white matter myelinated dysplasia and congenital giant *** extensive neurogenic damage to the extremities was considered,as the results of electromyography showed that the motor conduction velocity and sensory conduction of the nerves of the extremities were not abnormal,and the degree of fit of the children with severe contraction was *** present,the child is 80 cm in length and 9 kg in weight,with slender limbs and

关键词： DYNC1H1 Mental retardation Muscle weakness Medical exome sequencing Case report

Three-dimensional P-wave Velocity Structure Modelling of the Middle and Lower Reaches of the Yangtze River Metallogenic Belt: Crustal Architecture and Metallogenic Implications

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Acta Geologica Sinica(English Edition) 2020年第6期94卷 1808-1821页

作者： CHEN Anguo LÜ Qingtian ZHOU Taofa DU Jianguo ding juan YAN Jiayong LU Zhitang School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China Geological Survey of Anhui Province Hefei 230001China Chinese Deep Exploration Center(SinoProbe Center) Chinese Academy of Geological SciencesBeijing 100037China Anhui Earthquake Agency Hefei 230031China

In this study,we compiled and analyzed 69310 P-wave travel-time data from 6639 earthquake *** events(M≥2.0)occurred from 1980 s to June 2019 and were recorded at 319 seismic stations(Chinese Earthquake Networks Center)in the study *** adopted the double-difference seismic tomographic method(tomo DD)to invert the 3-D P-wave velocity structure and constrain the crust-upper mantle architecture of the Middle and Lower Reaches of the Yangtze River Metallogenic Belt(MLYB).A 1-D initial model extracted from wide-angle seismic profiles was used in the seismic tomography,which greatly reduced the inversion *** results indicate that reliable velocity structure of th e uppermost mantle can be obtained when Pn is involved in the *** results show that:(1)the pattern of the uppermost mantle velocity structure corresponds well with the geological partitioning:a nearly E-W-trending low-velocity zone is present beneath the Dabie Orogen,in contrast to the mainly NE-trending low-velocity anomalies beneath the Jiangnan *** suggest the presence of thickened lower crust beneath the orogens in the study *** contrast,the Yangtze and Cathaysia blocks are characterized by relatively high-velocity anomalies;(2)both the ultra-high-pressure(UHP)metamorphic rocks in the Dabie Orogen and the low-pressure metamorphic rocks in the Zhangbaling dome are characterized by high-velocity *** upper crust in the Dabie Orogen is characterized by a low-velocity belt,sandwiched between two high velocity zones in a horizontal direction,with discontinuous low-velocity layers in the middle *** keel of the Dabie Orogen is mainly preserved beneath its northern *** infer that the lower crustal delamination may have mainly occurred in the southern Dabie Orogen,which caused the mantle upwelling responsible for the formation of the granitic magmas emplaced in the middle crust as the low-velocity layers observed *** deep-level compression

关键词： 3D P-wave velocity structure double-difference seismic tomography crust-upper mantle Dabie Orogen Middle and Lower Reaches of the Yangtze River Metallogenic Belt

Achieving Total Enteroscopy by Consecutive Bidirectional Doubleballoon Enteroscopy Procedures

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Current Medical Science 2022年第1期42卷 144-149页

作者： Liang ZHAO An-ning YIN Fei LIAO Yi-juan ding Hong-gang YU Department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhan 430060China

Objective:To investigate the feasibility and safety of achieving total enteroscopy by consecutive bidirectional double-balloon enteroscopy(DBE)***:The demographic data,indication,initial insertion route,examination time for each insertion and the entire procedure,total enteroscopy rate,diagnostic yield and adverse events of patients who attempted to achieve total enteroscopy by consecutive bidirectional DBE procedures from January 2014 to December 2019 were retrospectively analyzed.

关键词： double-balloon enteroscopy feasibility safety total enteroscopy

Impact of failure mode and effects analysis-based emergency management on the effectiveness of craniocerebral injury treatment

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World Journal of Clinical Cases 2022年第2期10卷 554-562页

作者： Xiao-Lan Shao Ya-Zhou Wang Xiong-Hui Chen Wen-juan ding Department of Emergency Surgery Ward 48 First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Craniocerebral injuries encompass brain injuries,skull fractures,cranial soft tissue injuries,and similar ***,the incidence of craniocerebral injuries has increased dramatically due to the increased numbers of traffic accidents and aerial work injuries,threatening the physical and mental health of *** To investigate the impact of failure modes and effects analysis(FMEA)-based emergency management on craniocerebral injury treatment *** Eighty-four patients with craniocerebral injuries,treated at our hospital from November 2019 to March 2021,were selected and assigned,using the random number table method,to study(n=42)and control(n=42)*** in the control group received conventional management while those in the study group received FMEA theory-based emergency management,based on the control ***-and post-interventions,details regarding the emergency situation;levels of inflammatory stress indicators[Interleukin-6(IL-6),C-reactive protein(CRP),and procalcitonin(PCT)];incidence of complications;prognoses;and satisfaction regarding patient care were evaluated for both *** For the study group,the assessed parameters[pre-hospital emergency response time(9.13±2.37 min),time to receive a consultation(2.39±0.44 min),time needed to report imaging findings(1.15±4.44 min),and test reporting time(32.19±6.23 min)]were shorter than those for the control group(12.78±4.06 min,3.58±0.71 min,33.49±5.51 min,50.41±11.45 min,respectively;P0.05);post-intervention serum indicator levels were lower in both groups than pre-intervention ***,serum levels of IL-6(17.35±5.33 pg/mL),CRP(2.27±0.56 mg/L),and PCT(0.22±0.07 ng/mL)were low

关键词： Craniocerebral injury Failure modes and effects analysis theory Emergency management Treatment effect

Endoscopic treatment for acute appendicitis with coexistent acute pancreatitis: Two case reports

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World Journal of Clinical Cases 2021年第1期9卷 245-251页

作者： Zhi-Qiang Du Wen-juan ding Fei Wang Xiang-Rong Zhou Tian-Ming Chen Department of Gastroenterology Jianyang People’s Hospital of Sichuan ProvinceJianyang 641400Sichuan ProvinceChina

BACKGROUND Appendectomy is the procedure of choice for the treatment of acute ***,surgery may not be appropriate for patients with coexisting severe illness or comorbidities such as acute pancreatitis(AP).Endoscopic retrograde appendicitis treatment(ERAT)may be a novel alternative to surgery for treating such patients where existing medical therapies have *** SUMMARY We report 2 cases of moderately severe AP who developed acute uncomplicated appendicitis during their hospital stay and did not respond to traditional medical *** patient had moderately severe AP due to hyperlipidemia,while the other patient had a gallstone induced by moderately severe *** patient was fit to undergo an appendectomy procedure because of the concurrent ***,the alternative and minimally invasive ERAT was *** written informed consent was collected from the patients,the ERAT procedure was *** patients exhibited fast postoperative recovery after ERAT with minimal surgical *** ERAT is a safe and effective minimally invasive endoscopic procedure for acute appendicitis in patients with coexistent AP.

关键词： Endoscopic retrograde appendicitis treatment Acute pancreatitis Acute appendicitis Minimally invasive endoscopic procedure Safety and effectiveness Case report

Survey:Reemployment of Laid-Off Women

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China Population Today 2000年第1期17卷 11-17页

作者： ding juan