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Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons

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Journal of Molecular Cell Biology 2021年第5期13卷 335-346页

作者： Yu Wu Xinyou Lv Haiting Wang Kai Qian jinjun ding Jiejie Wang Shushan Hua Tiancheng Sun Yiting Zhou Lina Yu Shuang Qiu Department of Neurobiology Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Anesthesiology Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Biochemistry Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Orthopaedic Surgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China

Local signaling events at synapses or axon terminals are communicated to the nucleus to elicit transcriptional responses,and thereby translate information about the external environment into internal neuronal *** retrograde signaling is critical to dendritic growth,synapse development,and neuronal ***,we demonstrate that neuronal activity induces retrograde translocation and nuclear accumulation of endosomal adaptor *** the interaction of APPL1 with Importin ocl abolishes nuclear accumulation of APPL1,which in turn decreases the levels of histone *** further demonstrate that retrograde translocation of APPL1 is required for the regulation of gene transcription and then maintenance of hippocampal late-phase long-term ***,these results illustrate an APPLl-mediated pathway that contributes to the modulation of synaptic plasticity via coupling neuronal activity with chromatin remodeling.

关键词： APPL1 excitation-transcription coupling synaptic plasticity chromatin remodeling gene transcription

Examining the characteristics between time and distance gaps of secondary crashes

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Transportation Safety and Environment 2024年第1期6卷 116-131页

作者： Xinyuan Liu jinjun Tang Chen Yuan Fan Gao Xizhi ding Smart Transport Key Laboratory of Hunan Province School of Transport and Transportation EngineeringCentral South UniversityChangsha 410075China Department of Computer Science City University of Hong Kong999077Kowloon TongHong KongChina Department of Geography and Resource Management The Chinese University of Hong KongShatinNT 999077Hong KongChina

Understanding the characteristics of time and distance gaps between the primary(PC)and secondary crashes(SC)is crucial for preventing SC ccurrences and improving road *** previous studies have tried to analyse the variation of gaps,there is limited evidence in quantifying the relationships between different gaps and various influential *** study proposed a two-layer stacking framework to discuss the time and distance ***,the framework took random forests(RF),gradient boosting decision tree(GBDT)and eXtreme gradient boosting as the base classifiers in the first layer and applied logistic regression(LR)as a combiner in the second *** this basis,the local interpretable model-agnostic explanations(LIME)technology was used to interpret the output of the stacking model from both local and global *** SC dentification and feature selection,346 SCs and 22 crash-related factors were collected from California interstate *** results showed that the stacking model outperformed base models evaluated by accuracy,precision,and recall *** explanations based on LIME suggest that collision type,distance,speed and volume are the critical features that affect the time and distance *** volume can prolong queue length and increase the distance gap from the SCs to *** collision types,peak periods,workday,truck involved and tow away likely induce a long-distance ***,there is a shorter distance gap when secondary roads run in the same direction and are close to the primary *** speed is a significant factor resulting in a long-time gap,while the higher speed is correlated with a short-time *** results are expected to provide insights into how contributory features affect the time and distance gaps and help decision-makers develop accurate decisions to prevent SCs.

关键词： secondary crash(SC) time and distance gaps stacking framework local interpretable model-agnostic explanations(LIME)

PHASE EQUILIBRIA OF α_2(α)/γ IN Ti-Al-Nb TERNARY SYSTEM

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中国有色金属学会会刊：英文版 1997年第4期7卷 21-24页

作者： ding jinjun, Zhao Gang, Hao Shiming Department of Materials Science and Engineering School of Materials and Metallurgy, Northeastern University, Shenyang 110006

ＰＨＡＳＥＥＱＵＩＬＩＢＲＩＡＯＦα２（α）／γＩＮＴｉＡｌＮｂＴＥＲＮＡＲＹＳＹＳＴＥＭ①ＤｉｎｇＪｉｎｊｕｎ，ＺｈａｏＧａｎｇ，ＨａｏＳｈｉｍｉｎｇＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎ... 详细信息

ＰＨＡＳＥＥＱＵＩＬＩＢＲＩＡＯＦα２（α）／γＩＮＴｉＡｌＮｂＴＥＲＮＡＲＹＳＹＳＴＥＭ①ＤｉｎｇＪｉｎｊｕｎ，ＺｈａｏＧａｎｇ，ＨａｏＳｈｉｍｉｎｇＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒｉｎｇＳｃｈｏｏｌ...

关键词： Ti Al Nb ternary system diffusion couple α 2(α)/γ phase equilibria

Stoichiometric NbTiAl_3 (γ1 Phase) Alloy in Ti-Al-Nb Ternary System

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Journal of Materials Science & Technology 1996年第6期12卷 464-466页

作者： Jingxia CAO jinjun ding and Shiming HAO (Dept. of Materials Science and Technology, Northeastern University Shenyang 110006, China)(To whom correspondence should be addressed)Guoliang CHEN (Dept. of Materials Science and Technology University of Science Dept. of Materials Science and Technology Northeastern University Shenyang 110006 China Dept. of Materials Science and Technology University of Science and Technology Beijing Beijing 100083 China

The microstructure and phase constitution in stoichiometric NbTiAl3 (γ1 phase) alloy treated at 1000℃ were examined by metallography and X-ray diffraction. The alloy microstructure is mainly γ1 phase containing η second phase [(Ti,Nb)Al3] less than 1%. DTA analysis shows no phase transformation from room temperature to 1200℃. In the diffusion couple of NbTiAl3 with 7-TiAl compound, clear phase boundary and composition jump exist between γ1 and γ *** results further confirm the existence of γ1 single phase at 1000℃ in Ti-Al-Nb ternary system.

关键词： Ti Stoichiometric NbTiAl3 Alloy in Ti-Al-Nb Ternary System Phase

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晚清中国与万国邮联交往述略

历史档案 1998年第3期11卷 94-98页

作者：丁进军

1874年9月15日，世界上22个国家的邮政代表在瑞士首都伯尔尼召开会议，并于IO月9目共同签署《伯尔尼邮政公约》，正式成立了“邮政总联盟”（后改称“万国邮政联盟”）。其宗旨是：“以邮联总会名义，组成—个邮政领域，以便各国邮政间... 详细信息

1874年9月15日，世界上22个国家的邮政代表在瑞士首都伯尔尼召开会议，并于IO月9目共同签署《伯尔尼邮政公约》，正式成立了“邮政总联盟”（后改称“万国邮政联盟”）。其宗旨是：“以邮联总会名义，组成—个邮政领域，以便各国邮政间互换邮件”，“组织和改善国际邮政业务，?（共5页)

关键词：万国邮联邮政总办外务部中国邮政意大利清政府邮传部伍廷芳邮政公约总税务司

Regulation of AMPA receptor surface trafficking and synaptic scaling by Pb2+ exposure

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Regulation of AMPA receptor surface trafficking and synaptic...