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Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONg jia-huan QIN Meng-meng LIU Tian-shu ZHU Chun-chao gUO Wei-jian ding Hong-hua gUO Yuan-biao LIU Li-kun SONg jin-jie WU ji-ping CHENg Yue-lei ZENg Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AgC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AgC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AgC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(PgC in China,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

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手投式强光爆震弹发展现状研究

火力与指挥控制 2024年第3期49卷 1-6,18页

作者：季顶马永忠武警工程大学研究生大队西安710086 武警工程大学装备管理与保障学院西安710086

通过了解当前国内外强光爆震弹的发展现状,介绍几种国内外比较典型且具有代表性的强光爆震弹。通过对比、分析其相关参数和设计特点,结合部队基层单位使用实际,对当前爆震弹存在的短板进行归纳总结,并提出针对国内现役强光爆震弹的优化... 详细信息

通过了解当前国内外强光爆震弹的发展现状,介绍几种国内外比较典型且具有代表性的强光爆震弹。通过对比、分析其相关参数和设计特点,结合部队基层单位使用实际,对当前爆震弹存在的短板进行归纳总结,并提出针对国内现役强光爆震弹的优化设计思路,为下一步优化、研制新型强光爆震弹提供一定参考依据,进一步提高部队稳妥高效处置各类事件的能力。

关键词：非致命弹药强光爆震弹发展现状优化设计

看不见的底层:对低社会等级者的人际忽视及其理论解释

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心理科学进展 2024年第9期32卷 1539-1550页

作者：何佳妮杨洁纪婷婷丁毅南京师范大学心理学院南京210097 江苏省张家港市第八中学苏州215600

人际忽视是指在人际互动中,主体有意或无意对互动对象的视而不见,表现为在认知、情感和行为上缺少投入或较少有投入的状态,它本质上是一种隐性的人际贬低与排斥。人际忽视与社会等级有着重要联系,其中低社会等级者更容易受到人际忽视;... 详细信息

人际忽视是指在人际互动中,主体有意或无意对互动对象的视而不见,表现为在认知、情感和行为上缺少投入或较少有投入的状态,它本质上是一种隐性的人际贬低与排斥。人际忽视与社会等级有着重要联系,其中低社会等级者更容易受到人际忽视;社会文化机制、地位假说、目标可供性控制理论和交叉隐形理论可以作为解释这一现象的重要理论视角。未来研究需进一步完善对人际忽视的概念界定和测量,深化对低社会等级者人际忽视的理论研究,探究互动双方的社会等级在人际忽视中的交互作用,关注并干预人际忽视所导致的消极后果,以及在中国社会文化背景下探索人际忽视可能存在的独特效应。

关键词：人际忽视社会等级理论解释社会互动

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全自动电位滴定仪测定尿氟含量的方法研究

中华地方病学杂志 2024年第7期43卷 598-602页

作者：徐署东丁刚谢继安詹子悦张琪许娴李卫东安徽省疾病预防控制中心理化检验室合肥安徽省疾病预防控制中心办公室合肥安徽省疾病预防控制中心地方病与寄生虫病防治科合肥

目的建立尿氟含量全自动电位滴定仪测定方法(简称本方法)。方法采用全自动电位滴定仪测定人尿中氟化物含量;方法学分析本方法的线性范围、检测限、精密度和准确度(质控样品检测和实际样品加标回收实验)。采用本方法与国家卫生行业标准... 详细信息

目的建立尿氟含量全自动电位滴定仪测定方法(简称本方法)。方法采用全自动电位滴定仪测定人尿中氟化物含量;方法学分析本方法的线性范围、检测限、精密度和准确度(质控样品检测和实际样品加标回收实验)。采用本方法与国家卫生行业标准《尿中氟化物测定离子选择电极法》(WS/T 89-2015, 简称标准方法)检测实际尿样(n = 33), 并对结果进行对比分析。结果本方法尿氟含量标准曲线线性范围为0.1 ～ 10.0 mg/L;线性相关系数(r)值范围为0.999 6 ～ 0.999 9;最低尿氟质量浓度检出限为0.01 mg/L(取样量为10.0 ml);精密度实验显示, 相对标准偏差(RSD)范围为0.00% ～ 3.45%;质控样品测定结果均在公议值范围内;加标回收实验显示, 回收率范围为100.0% ～ 104.4%, 总平均回收率为102.1%;方法对比实验显示, 本方法与标准方法检测结果比较, 差异无统计学意义(t = - 0.90, P = 0.375)。结论成功建立本方法, 实现了取样后试剂加入、检测过程全自动化, 具有线性范围宽、检出限低、精密度好、准确性高等特点, 适合大批量尿样氟含量的快速自动化测定。

关键词：氟尿全自动电位测定方法研究

Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo Xueying Zheng Wei Bao Sheng Nie Yu ding Tong Yue Yilun Zhou Ying Hu Hua Li Qiongqiong Yang Qijun Wan Bicheng Liu Hong Xu guisen Li gang Xu Chunbo Chen Huafeng Liu Yongjun Shi Yan Zha Yaozhong Kong guobin Su Ying Tang Mengchun gong Linong ji Fan Fan Hou jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

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智慧公路毫米波雷达感知精度分析与验证

中国公路学报 2024年第1期37卷 205-214页

作者：赵聪师钰鹏丁德隆暨育雄杜豫川同济大学道路与交通工程教育部重点实验室上海201804

毫米波雷达是当前智慧公路中路侧感知系统的重要组成部分,在交通流运行态势感知与智能管控、车路协同与自动驾驶中广泛应用。然而,车辆与毫米波雷达之间的相对位置、相对姿态的变化会对雷达信号回波及点云分布产生影响,导致雷达对车辆... 详细信息

毫米波雷达是当前智慧公路中路侧感知系统的重要组成部分,在交通流运行态势感知与智能管控、车路协同与自动驾驶中广泛应用。然而,车辆与毫米波雷达之间的相对位置、相对姿态的变化会对雷达信号回波及点云分布产生影响,导致雷达对车辆的感知结果出现偏差,进而影响交通系统的管控决策。分析毫米波雷达感知精度的空间特征,对于指导毫米波雷达在智慧公路中的应用至关重要。为此,基于毫米波雷达的感知原理,综合考虑毫米波雷达信号处理与点云数据处理2个阶段中的感知误差来源,通过数值仿真与实测试验相结合的方式对目标在不同位置与姿态下毫米波雷达的感知精度特征进行分析与验证。研究表明:雷达纵向感知精度主要受到与车辆相对位置的影响,当车辆与雷达纵向距离小于30 m或大于200 m时,车辆位置感知结果会向车头或车尾方向显著偏移,相应产生的纵向感知误差通常超过0.5 m;雷达横向感知精度主要受到车辆横向位置及相对姿态的影响,当车辆横向位置偏离雷达中心光束超过5 m或车辆行驶的航向角超过40°时,车辆位置感知结果会向车身侧向偏移,相应产生的横向感知误差通常超过0.5 m。得到的影响因素分析结果,可进一步为智慧公路场景中毫米波雷达感知数据的应用与感知设备的部署提供建议。

关键词：交通工程感知精度数值仿真毫米波雷达智慧公路路侧感知

Creation and annihilation of artificial magnetic skyrmions with the electric field

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Chinese Physics B 2024年第3期33卷 132-137页

作者：程军孙亮张一可吉同舟曹荣幸缪冰锋赵永刚丁海峰 National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China Department of Physics State Key Laboratory of Low-Dimensional Quantum PhysicsTsinghua UniversityBeijing 100084China Frontier Science Center for Quantum Information Tsinghua UniversityBeijing 100084China College of Electrical Energy and Power EngineeringYangzhou UniversityYangzhou 225127China

Recent theory and experiments show that artificial magnetic skyrmions can be stabilized at room temperature without the need for the external magnetic field,casting strong potentials for the device *** this work,we study the electric field manipulation of artificial magnetic skyrmions imprinted by Co disks on CoPt multilayers utilizing the micromagnetic *** find that the reversible annihilation and creation of skyrmions can be realized with the electric field via the strain mediated magnetoelastic *** addition,we also demonstrate controllable manipulation of individual skyrmion,which opens a new platform for constructing magnetic field-free and low-energy dissipation skyrmion based media.

关键词： skyrmions magnetic anisotropy micromagnetic simulations

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电生理技术治疗慢性前列腺炎的临床疗效观察

中华男科学杂志 2024年第7期30卷 611-615页

作者：王松胡建新汪珊彭超蔡季丁敏贵州医科大学附属医院织金医院泌尿男科贵州省人民医院泌尿外科

目的:观察电生理技术治疗慢性前列腺炎的临床效果。方法:选取2022年1月至2023年4月就诊于我院和贵州省人民医院(合作治疗组)符合纳入标准的40例慢性前列腺炎/慢性骨盆疼痛综合征(CP/CPPS)患者，随机分为对照组(n=20)和治疗组(n=20),治... 详细信息

目的:观察电生理技术治疗慢性前列腺炎的临床效果。方法:选取2022年1月至2023年4月就诊于我院和贵州省人民医院(合作治疗组)符合纳入标准的40例慢性前列腺炎/慢性骨盆疼痛综合征(CP/CPPS)患者，随机分为对照组(n=20)和治疗组(n=20),治疗组采用低频神经肌肉电刺激联合药物治疗，对照组采取单纯药物治疗，对比分析治疗前后患者前列腺炎症症状评分(NIH-CPSI)、国际前列腺症状评分(IPSS)改善情况。结果:共完成并随访37例患者(治疗组退出1例，因对电极片过敏；对照组有2例丢失随访),两组患者基线资料比较，无显著差异(P>0.05);两组患者治疗前后NIH-CPSI评分和IPSS评分比较，差异具有统计学意义(P<0.05);比较两组患者治疗后IPSS评分，治疗组降低(15.84±0.92)分，对照组(7.17±0.40)分，两组比较，差异具有统计学意义(t=4.792,P<0.05);比较两组患者治疗后NIH-CPSI评分，治疗组平均降低(17.47±0.92)分，对照组(10.56±0.49)分，两组比较，差异具有统计学意义(t=6.654,P<0.05)。结论:电生理联合药物治疗效果明显优于单纯药物治疗，电生理治疗慢性前列腺炎临床疗效确切，值得推广应用。

关键词：慢性前列腺炎/慢性盆腔疼痛综合征电生理慢性前列腺症状评分国际前列腺症状评分

基于改进布谷鸟搜索算法的矿震震源定位方法研究

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地球物理学进展 2024年第3期39卷 1070-1080页

作者：马技刘彩霞丁琳琳辽宁大学信息学院沈阳110036

矿震震源定位精度对于矿山监测十分重要,为进一步加快算法的收敛速度,提升算法的稳定性,提高定位的准确度,提出一种基于改进布谷鸟搜索算法的震源定位算法(ICS).该算法首先利用差值绝对值得到目标函数,然后在布谷鸟搜索算法的基础上,通... 详细信息

矿震震源定位精度对于矿山监测十分重要,为进一步加快算法的收敛速度,提升算法的稳定性,提高定位的准确度,提出一种基于改进布谷鸟搜索算法的震源定位算法(ICS).该算法首先利用差值绝对值得到目标函数,然后在布谷鸟搜索算法的基础上,通过引入基于自适应度调节的步长比例因子和动态变化的发现概率,以改进选取鸟巢位置的方式,最后使用改进布谷鸟搜索算法对目标函数寻优求解.通过模拟实验比较可得,当速度在±1%、±3%和±5%的范围内浮动时,ICS算法的定位精度均高于原始布谷鸟搜索算法(CS)、海鸥优化算法(SOA)、灰狼优化算法(gWO)和非线性最小二乘法(NLS),相同情况下,ICS算法比原始CS算法的收敛速度提升52%.通过对内蒙古某煤矿的微震事件进行定位分析,ICS算法的定位误差由原始CS算法的40.1 m下降为23.3 m,定位精度提高了42%.验证了ICS算法具有更高的准确性和更快的收敛性.

关键词：矿震差值绝对值布谷鸟搜索算法自适应调节步长动态变化概率定位

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