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Chemical Research in Chinese Universities 2007年第4期23卷 388-390页

作者： ding han-ming zhang da-wei li jiang kong ai-guo shan yong-kui Department of Chemistry East China Normal University Shanghai 200062 P. R. China

A new titanium-silicate material was synthesized with cubic cage-like tetramethylammonium octasilicate and TiCl4 ethanol solution as precursors. The product was characterized by FTIR, ^29Si NMR, UV-Vis, and XRD. Struc-tural and ingrediental analyses suggest that this material has a layered structure with cubic cage-like polyhedral oligo-silsesquioxane as building blocks and titanium as bridging atoms.

关键词： Polyhedral oligosilsesquioxane Synthesis Titanium-silicate material

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun lin Hou Huang Jin-Jie Yu Feng Su Tian jiang Shao-Yuan zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou wei-Feng Tang guo-Wen ding li-ming Wang li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

GmDRR1,a dirigent protein resistant to Phytophthora sojae in Glycine max (L.) Merr.

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Journal of Integrative Agriculture 2018年第6期17卷 1289-1298页

作者： CHEN Qing-shan YU guo-long ZOU Jia-nan WANG Jing QIU Hong-mei ZHU Rong-sheng ChanG Hui-lin jiang Hong-wei HU Zhen-bang li Chang-yu zhang Yan-jiao WANG Jin-hui WANG Xue-ding GAO shan liU Chun-yan QI Zhao-ming FU yong-fu XIN da-wei Key Laboratory of Soybean Biology Ministry of Education/College of AgricultureNortheast Agricultural University Key Laboratory of Soybean Biology (Beijing) Ministry of Agriculture/National Key Facility of Crop Gene Resource and Genetic Improvement/Institute of Crop SciencesChinese Academy of Agricultural Sciences

Soil-borne pathogen Phytophthora sojae is an oomycete that causes devastating damage to soybean yield. To mine original resistant genes in soybean is an effective and environmentally-friend approach controlling the disease. In this study, soybean proteins were extracted from the first trifoliolates infected by predominant P. sojae race 1 and analyzed by twodimensional gel electrophoresis. Nineteen differently-expressed protein spots were detected, and 10 of them were further applied for Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry Assay. One protein containing a dirigent （DIR） domain was identified and belonged to the DIR-b/d family. Therefore, it was named as GmDRR1 （Glycine max Disease Resistance Response 1）. Then, GmDRR1 gene was pathologically confirmed to be involved in the resistant to P. sojae in soybean. GmDRR1-GFP （green fluorescent protein） fusion proteins localized in the cell membrane. qRTPCR results showed GmDRR1 gene expressed differently in P. sojae resistant- and susceptible-soybean cultivars. By the promoter analysis, we found a haplotype H8 was existing in most resistant soybean varieties, while a haplotype H77 was existing in most susceptible soybean varieties. The H77 haplotype had seven SNPs （C to A, G to C, C to A, T to A, T to C, T to C, and T to A） and two single nucleotide insertions. The results supported that the expression difference of GmDRR1 genes between P. sojae resistant- and susceptible-soybean cultivars might depend on the GmDRR1 promoter SNPs. The results suggested that GmDRR1 was a dirigent protein involved in soybean resistant to P. sojae and paved a novel way for investigation of the molecular regulatory mechanism of the defense response to P. sojae in soybean.

关键词： dirigent domain GmDRR1 soybean Phytophthora sojae oomycete proteomics

Effects of AT1 receptor antagonist,Iosartan,on rat hepatic fibrosis induced by CCl_4

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World Journal of Gastroenterology 2000年第4期6卷 540-545页

作者： Hong shan wei ding guo li han ming Lu Yu Tao Zhan Zhi Rong Wang Xin Huang Jing zhang Ji lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,shanghai Second Medical University,shanghai 200092,China 上海第二医科大学上海

aiM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl;and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-dawley rats,weighing（180±20）g,wererandomized into five groups（control group,modelgroup,and three losartan treated groups）,inwhich all rats were given the subcutaneousinjection of 40% CCl4（every 3 days for 6 weeks）except for rats of control *** of losartan-treated groups were treated with losartan（20 mg/kg,10 mg/kg,5 mg/kg,daily gavage）,After 6weeks liver tissue and serum samples of all ratswere *** hyaluronic acid（HA）,procollagen typeⅢ（PCⅢ）were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver *** expression of AT1receptors,transforming growth factor-beta（TGF-β）,and alpha-smooth muscle actin（a-SMA）inliver tissue were determined byimmunohistochemical *** withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced（t=4.20,Pliver *** AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl4.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors.

关键词： liver cirrhosis/drug therapy renin-angiotensin system angiotensin Ⅱ type 1 receptor antagonist losartan

Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography

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Asian Journal of Andrology 2016年第4期18卷 633-638页

作者： guo-Peng Yu Rong Na ding-wei Ye Jun Qi Fang liu Hai-Tao Chen Yi-Shuo Wu Gui-ming zhang Jie-lin Sun Yao Zhu li-Qun Huang shan-Cheng Ren De-Ke jiang S lilly Zheng Hao-Wenjiang Ying-Hao Sun Qiang ding Jianfeng Xu Fudan Institute of Urology Huashan Hospital Fudan University Shanghai China Department of Urology Huashan Hospital Fudan University Shanghai China Department of Urology Fudan University Shanghai Cancer Center and Department of Oncology Shanghai Medical College Fudan University Shanghai China Department of Urology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China State Key Laboratory of Genetic Engineering School of Life Salience Fudan University Shanghai China Center for Cancer Genomics Wake Forest School of Medicine Winston-Salem North Carolina USA Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai China Program for Personalized Cancer Care NorthShore University HealthSystem Evanston IL USA.

The [-2]proPSA （p2PSA） and its derivatives, the p2PSA-to-free PSA ratio （%p2PSA）, and the Prostate Health Index （PHI） have greatly improved discrimination between men with and without prostate cancer （PCa） in prostate biopsies. However, little is known about their performance in cases where a digital rectal examination （DRE） and transrectal ultrasonography （TRUS） are negative. A prospective cohort of 261 consecutive patients in China with negative DRE and TRUS were recruited and underwent prostate biopsies. A serum sample had collected before the biopsy was used to measure various PSA derivatives, including total prostate-specific antigen （tPSA）, free PSA, and p2PSA. For each patient, the free-to-total PSA ratio （%fPSA）, PSA density （PSAD）, p2PSA-to-free PSA ratio （%p2PSA）, and PHI were calculated. Discriminative performance was assessed using the area under the receiver operating characteristic curve （AUC） and the biopsy rate at 91% sensitivity. The AUC scores within the entire cohort with respect to age, tPSA, %fPSA, PSAD, p2PSA, %p2PSA, and PHI were 0.598, 0.751, 0.646, 0.789, 0.814, 0.808, and 0.853, respectively. PHI was the best predictor of prostate biopsy results, especially in patients with a tPSA of 10.1-20 ng ml-1. Compared with other markers, at a sensitivity of 91%, PHI was the most useful for determining which men did not need to undergo biopsy, thereby avoiding unnecessary procedures. The use of PHI could improve the accuracy of PCa detection by predicting prostate biopsy outcomes among men with a negative DRE and TRUS in China.

关键词： [-2]proPSA prostate cancer Prostate Health Index prostate-specific antigen receiver operating curve

SAPT:a synchrotron-based proton therapy facility in shanghai

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Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou zhang De-ming li li-Ren Shen Hai-Rong zhang Zhi-ling Chen han-Wen Du ming Gu Rui li De-Kang liu Yue-Hu Pu Jun-Feng Yu Jian-Feng Chen Chu Chen Chun-Long guo Hao guo Ge-Yang jiang Zhi-Qiang jiang lin Jin Wen-Jing li Xiu-Fang li Ye lin ming liu yong-Hao liu Ya-Juan liu ming Lv Qing-Ru Mi lian-Hua Ouyang wei-guo Shi hang Shu Qi-Sheng Tang Kun Wang Zhi-shan Wang Jun Wu Xiao-Bing Wu Jia-Qiang Xu Wen-Zhen Xu Chong-Xian Yin Cheng Yu Ren-Xian Yuan Qi-Bing Yuan Hai-Qun zhang Miao zhang Wen-Zhi zhang li-Ying Zhao wei-Min Zhou Shou-Xian Fang Xi-Dong Sun Zhen-Tang Zhao shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution

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National Science Review 2019年第5期6卷 982-992页

作者： Hao Wang Qingyuan Zhu Lufeng ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie guo Zhiwei Xiong Qinghong shan Fan Jia Peng Su Qian-Ru Yang Bing li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu jiang-Ning Zhou Fuqiang Xu Hua han Pak-ming Lau guo-Qiang Bi Hefei National Laboratory for Physical Sciences at the Microscale and School of Life SciencesUniversity of Science and Technology of China CAS Key Laboratory of Brain Function and Disease and School of Life Sciences University of Science and Technology of China Institute of Automation Chinese Academy of Sciences University of Chinese Academy of Sciences School of Information Science and Technology University of Science and Technology of China National Engineering Laboratory for Brain-inspired Intelligence Technology and Application University of Science and Technology of China Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences CAS Center for Excellence in Brain Science and Intelligence Technology

The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits, which is of fundamental importance for neuroscience ***, we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R) for high-throughput, high-quality brain *** synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion, the VISo R system effectively eliminates motion blur to obtain undistorted *** continuously imaging moving samples without stopping, the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours, at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation, imaging, 3D image reconstruction and *** approach is compatible with immunofluorescence methods, enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate *** this system, we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming *** results indicate the involvement of multiple subcortical areas in stress ***, neuronal activation in these areas exhibits striking individual variability among different animals, suggesting the necessity of sufficient cohort size for such studies.

关键词： fluorescence microscopy brain mapping tissue clearing immunostaining activity trace mapping

Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle

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Zoological Research 2022年第2期43卷 275-284页

作者： Chun-Long Yan Jun lin Yuan-Yuan Huang Qing-shan Gao Zheng-Yu Piao Shou-li Yuan li Chen Xue Ren Rong-Cai Ye Meng Dong han-lin zhang Hui-Qiao Zhou Xiao-Xiao jiang Wan-Zhu Jin Xu-ming Zhou Chang-guo Yan College of Agriculture Yanbian UniversityYanjiJilin 133000China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China North-East Cold Region Beef Cattle Science&Technology Innovation Ministry of Education Engineering Research Center Yanbian UniversityYanjiJilin 133000China Annoroad Gene Technology Co.Ltd Beijing 100176China

Environmental temperature serves as a major driver of adaptive changes in wild *** discover the mechanisms underpinning cold tolerance in domestic animals,we sequenced the genomes of 28 cattle from warm and cold areas across *** characterizing the population structure and demographic history,we identified two genetic clusters,i.e.,northern and southern groups,as well as a common historic population peak at 30 kilo years *** scan of cold-tolerant breeds determined potential candidate genes in the thermogenesis-related pathways that were under ***,functional analysis identified a substitution of PRDM16(p.P779 L)in northern cattle,which maintains brown adipocyte formation by boosting thermogenesis-related gene expression,indicating a vital role of this gene in cold *** findings provide a basis for genetic variation in domestic cattle shaped by environmental temperature and highlight the role of reverse mutation in livestock species.

关键词： Population genomics Cattle Cold tolerance PRDM16 Brown adipose tissue

dawson结构多金属含氧酸盐热解性质研究(英文)

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华东师范大学学报（自然科学版） 2008年第4期 78-87页

作者：孔爱国李疆赖克强张贵荣丁旵明单永奎华东师范大学化学系上海200062

用变温XRD,变温IR以及TG-DTA等方法,系统地研究了具有dawson结构的Y_m H_n P_2 M_(18)O_(62)·qH_2OOY=K^+,NH_4^+,Cu^(2+);M=Mo,W)的热解性质,获得了它们较为精确的热分解温度,对其热分解的判断方法提出了一些新的见解.结果表明.以钼... 详细信息

用变温XRD,变温IR以及TG-DTA等方法,系统地研究了具有dawson结构的Y_m H_n P_2 M_(18)O_(62)·qH_2OOY=K^+,NH_4^+,Cu^(2+);M=Mo,W)的热解性质,获得了它们较为精确的热分解温度,对其热分解的判断方法提出了一些新的见解.结果表明.以钼为配位原子的dawson结构钾盐,铵盐.铜盐分别在250℃,210℃,240℃发生了热重排,生成了具有Keggin结构的化合物.以钨为配位原子的钾盐在410℃也有相似的行为,但铵盐和铜盐却没有观察到类似的热重排现象,分别在400℃,450℃直接热分解为WO_3.这些结果显示,热重排现象的发生可能与相应的Keggin结构化合物的热稳定性有关.

关键词： dawson结构多金属含氧酸盐热解

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(ChanCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-liang li ming-Sheng Huang wei-Zhu Yang guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin ding Wen-Hui li Jin-Hua Huang wei Mu shan-Zhi Gu Jia-Ping li Hui Zhao Shu-wei Wen Yan-ming Lei Yu-Sheng Song Chun-Wang Yuan wei-Dong Wang ming Huang wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun han wei-Xin Ren Zai-ming Lu Wen-Ge Xing yong Fan Hai-Lan lin Zi-Shu zhang guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-wei Zhao ai-Bing Xu Jian Xu Qing-Hua Wu Huan-zhang Niu Jian Wang Feng dai Dui-Ping Feng Qing-Dong li Rong-Shu Shi Jia-Rui li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E liu Zheng Cai Po Yang Yang Zhao Xiao-li Zhu li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching