检索结果-南通市图书馆

Biomedical and Environmental Sciences 2023年第2期36卷 206-212页

作者： HONG Shan ding chun jie ZHOU Qiang SUN Yun Zhe ZHANG Miao LI Ning DONG Xin Wen GUAN Yi ZHANG Lin TIAN Lin Qiang CAO Jia YAO Wu REN Wen jie YAO San Qiao School of Public Health Xinxiang Medical UniversityXinxiang 453003HenanChina Department of Nephrology Xinxiang Second People’s HospitalXinxiang 453003HenanChina School of Public Health North China University ofScience and TechnologyTangshan 063210HebeiChina Clinical Medical Research Center for Women and ChildrenDiseases Maternal and Child Health Care Hospital of Shandong ProvinceShandong UniversityJinan 250001ShandongChina Institute of Trauma and Orthopedics Xinxiang Medical UniversityXinxiang 453003HenanChina ToxicologyResearch Institute PLA Army Medical UniversityChongqing 400038China School of Public Health ZhengzhouUniversityZhengzhou 450000HenanChina

Gas explosion injury is a compound injury caused by a shock wave,high-temperature flame,or toxic gas directly or indirectly acting on the human body,resulting in multiple organ *** a hyperaerated tissue,the lung is the primary organ that experiences an early *** pathological manifestations of gas-explosion-induced acute lung injury(ALI)include pulmonary tissue edema.

关键词： lung Lung acute

在线全文

学校读者我要写书评

暂无评论

考虑损失厌恶零售商的混合渠道库存决策问题

计算机集成制造系统 2014年第5期20卷 1199-1210页

作者：刘咏梅丁纯洁廖攀中南大学商学院湖南长沙410083

针对零售商损失厌恶行为往往导致其决策偏离最优的现象,从顾客渠道偏好和零售商损失厌恶因素角度研究混合渠道的库存决策。基于渠道偏好构建了风险中性制造商和损失厌恶零售商的混合渠道库存决策模型,探讨了独立库存和零售商集中库存下... 详细信息

针对零售商损失厌恶行为往往导致其决策偏离最优的现象,从顾客渠道偏好和零售商损失厌恶因素角度研究混合渠道的库存决策。基于渠道偏好构建了风险中性制造商和损失厌恶零售商的混合渠道库存决策模型,探讨了独立库存和零售商集中库存下制造商和零售商的最优库存策略,并通过数值模拟分析需求不确定性、损失厌恶及决策方式等因素对库存策略的影响。研究表明,独立库存模式下的集中决策是分散决策的Pareto改进,零售商集中库存模式下的集中决策提高了制造商和供应链的利润,却降低了零售商收益;损失厌恶零售商的订货量随需求不确定性增大,呈现先增后减趋势;对于零售商和供应链,零售商集中库存模式占优,面临损失厌恶零售商,制造商倾向于选择独立库存模式以维护自身利益。数值分析进一步表明,当制造商能提供合理利润共享契约并适当调节库存水平时,零售商集中库存模式将比独立库存模式更能协调具有损失厌恶零售商的混合渠道。

关键词：混合渠道供应链库存决策损失厌恶

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 152-167页

作者： jie Bai Jian Hui Jia Yu Wang chun Cheng Yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian ding chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

浅析不可译性在《红楼梦》谐音双关修辞英译中的部分表现

在线全文

学校读者我要写书评

暂无评论

黑龙江教育学院学报 2011年第3期30卷 111-112页

作者：丁纯洁浙江师范大学外国语学院浙江金华321004

《红楼梦》是一部中国语言和文化的百科全书,其中谐音双关修辞格的大量运用是小说的一大特色。从音效和释义两个层面分析《红楼梦》中地名、人名以及诗词中谐音双关修辞的英译,通过表格量化对比,最后论证了不可译性在《红楼梦》谐音双... 详细信息

《红楼梦》是一部中国语言和文化的百科全书,其中谐音双关修辞格的大量运用是小说的一大特色。从音效和释义两个层面分析《红楼梦》中地名、人名以及诗词中谐音双关修辞的英译,通过表格量化对比,最后论证了不可译性在《红楼梦》谐音双关修辞英译中的部分表现。

关键词：不可译性《红楼梦》谐音双关

基于DEA-Malmquist的中国塑料制品产业效率分析

在线全文

学校读者我要写书评

暂无评论

塑料科技 2020年第4期48卷 112-115页

作者：李磊丁春杰封家璇中国矿业大学管理学院江苏徐州221116 周口职业技术学院河南周口466000

采用DEA-Malmquist函数对中国塑料制品产业的效率和全要素生产率指数演变进行研究,研究结果发现,中国塑料制品产业的效率呈波动上升的趋势,综合效率、规模效率上升趋势明显,纯技术效率有待优化;全要素生产率指数可划分为波动上升阶段和... 详细信息

采用DEA-Malmquist函数对中国塑料制品产业的效率和全要素生产率指数演变进行研究,研究结果发现,中国塑料制品产业的效率呈波动上升的趋势,综合效率、规模效率上升趋势明显,纯技术效率有待优化;全要素生产率指数可划分为波动上升阶段和波动下降阶段,技术进步指数在全要素生产率中贡献较大。

关键词：塑料制品产业效率 DEA-Malmquist

参芪扶正注射液对晚期非小细胞肺癌化疗患者免疫功能的影响

在线全文

学校读者我要写书评

暂无评论

西部中医药 2012年第1期25卷 7-9页

作者：丁春杰杨磊甘肃中医学院甘肃兰州730020 甘肃省肿瘤医院呼吸内科

目的:观察参芪扶正注射液对晚期非小细胞肺癌(non-small-cell lung cancer,NSCLC)化疗患者细胞免疫功能的影响。方法:将70例初治晚期非小细胞肺癌患者随机分成2组,治疗组在化疗的同时给予参芪扶正注射液250 mL/d,静脉滴注,连用10天;对... 详细信息

目的:观察参芪扶正注射液对晚期非小细胞肺癌(non-small-cell lung cancer,NSCLC)化疗患者细胞免疫功能的影响。方法:将70例初治晚期非小细胞肺癌患者随机分成2组,治疗组在化疗的同时给予参芪扶正注射液250 mL/d,静脉滴注,连用10天;对照组单用化疗。2组化疗方案、对症及支持治疗方法均相同,均以21天为1个周期,共化疗4个周期。观察2组化疗前后CD3+、CD4+、CD4+/CD8+、NK细胞的变化。结果:治疗组治疗后NK细胞与治疗前相比升高(P<0.05),对照组治疗后CD3+、CD4+、CD4+/CD8+、NK细胞较治疗前明显降低(P<0.05)。结论:参芪扶正注射液配合化疗治疗晚期非小细胞肺癌,能提高患者机体的免疫功能。

关键词：晚期非小细胞肺癌参芪扶正注射液细胞免疫

在线全文

学校读者我要写书评

暂无评论

σ—代数族的条件独立性

新乡师范学院学报(自然科学版) 1985年第2期 22-31页

作者：钟计春丁承杰新乡师范学院数学系

条件独立性是通常独立性的一般化,马尔可夫性可看成是一种条件独立性,在概率论的专著中只引出定义和极少量的结果,[1][5]中较详细地论证了条件独立性的等价命题及其一系列的性质。本文在[1][5]的基础上进一步得到一些性质,并就[1]中提... 详细信息

条件独立性是通常独立性的一般化,马尔可夫性可看成是一种条件独立性,在概率论的专著中只引出定义和极少量的结果,[1][5]中较详细地论证了条件独立性的等价命题及其一系列的性质。本文在[1][5]的基础上进一步得到一些性质,并就[1]中提出的问题,我们得到了最小分裂σ-代数的充要条件及其等价命题和若干充分条件,并推广到无穷多个σ一代数上得到相应的结果。

关键词：代数族条件独立 AZ 定理独立性

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-jie Zhu Xiao-Jia Yang Qian-Ru He Fei ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

丙种球蛋白联合阿奇霉素对重症支原体肺炎患儿血气指标及凝血状态和氧化应激的影响

在线全文

学校读者我要写书评

暂无评论

医药论坛杂志 2023年第15期44卷 84-88页

作者：丁春杰曹甦曹丽娜焦作市第二人民医院儿科河南焦作454000 中国人民解放军第988医院儿科河南焦作454003

目的探讨丙种球蛋白联合阿奇霉素对重症支原体肺炎(severe mycoplasma pneumonia, SMPP)患儿血气指标、凝血状态和氧化应激水平的影响。方法将2020年9月-2023年2月焦作市第二人民医院儿科收治的116例SMPP患儿随机分为常规组(58例)和... 详细信息

目的探讨丙种球蛋白联合阿奇霉素对重症支原体肺炎(severe mycoplasma pneumonia, SMPP)患儿血气指标、凝血状态和氧化应激水平的影响。方法将2020年9月-2023年2月焦作市第二人民医院儿科收治的116例SMPP患儿随机分为常规组(58例)和球蛋白组(58例),常规组患儿静脉滴注阿奇霉素,球蛋白组患儿在常规组基础上联合静脉滴注丙种球蛋白;对比两组患儿临床疗效(有效率和症状改善时间)、免疫功能(CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)水平)、血气指标[动脉血氧饱和度(SaO_(2))、动脉二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))]、血清炎症介质[肿瘤坏死因子-α(TNF-α)、半乳糖凝集素-3(Gal-3)]、凝血指标[D-二聚体(D-D)、纤维蛋白原(Fbg)]、血清氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]和肺部感染评分(CPIS)、儿童生存质量普适性核心量表(PedsQL)评分。结果球蛋白组患儿治疗总有效率(87.93%)明显高于常规组(72.41%),且症状(体温恢复、咳嗽缓解和啰音消失)改善时间较常规组明显缩短(P<0.05)。与治疗前比较,治疗后两组中CD4^(+)、CD4^(+)/CD8^(+)、SaO_(2)、PaO_(2)、SOD水平和PedsQL评分显著升高,而CD8^(+)、PaCO_(2)、TNF-α、Gal-3、D-D、Fbg、MDA水平和CPIS评分显著降低(P<0.05),且球蛋白组变化幅度大于常规组(P<0.05)。结论丙种球蛋白联合阿奇霉素治疗SMPP患儿疗效良好,可有效提高患儿的免疫功能,改善血气指标和凝血状态,减轻肺部感染和氧化应激损伤。

关键词：重症支原体肺炎丙种球蛋白阿奇霉素血气指标凝血状态氧化应激