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Intestinal flora: New perspective of type 2 diabetes

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World Journal of Clinical Cases 2024年第11期12卷 1996-1999页

作者： Yan Liu Jun Chang Li-ding bai Department of Gastroenterology Hospital of Integrated Chinese and Western MedicineTianjinTianjin 300100China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381China Academy of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300193China

Diabetes comprises a group of metabolic diseases characterized by hyperglycemia stemming from various *** diabetes management primarily focuses on blood glucose control,yet it is inherently progressive,necessitating increased reliance on exogenous blood glucose control methods over ***,there is an urgent need to explore novel intervention strategies addressing both diabetes and its *** human intestinal microbiota,often referred to as the"second genome",exhibits significant diversity and plays a pivotal role in insulin resistance,glucose and lipid metabolism,and inflammatory ***,Li and Guo have elucidated the involvement of intestinal flora in the pathogenesis of type 2 diabetes mellitus(T2DM)and proposed a novel therapeutic approach targeting intestinal *** advancement enhances our comprehension of the multifaceted and multi-target regulation of T2DM by intestinal microflora,thereby offering fresh avenues for understanding its pathogenesis and clinical *** letter briefly summarizes the role of intestinal flora in T2DM based on findings from animal experiments and clinical ***,it discusses the potential clinical applications and challenges associated with targeting intestinal flora as therapeutic interventions.

关键词： Microbial metabolites Intestinal flora Probiotics Insulin resistance Type 2 diabetes

TiO_2 nanotube arrays and TiO_2-nanotube-array based dye-sensitized solar cell

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Chinese Science Bulletin 2007年第12期52卷 1585-1589页

作者： LIU YanBiao ZHOU BaoXue XIONG BiTao bai ding LI LongHai School of Environmental Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

To substitute the non-regular nano-crystalline semiconductor for a novel kind of ordered microstructure is a very important aspect in the domain of dye-sensitized solar cell. One of the researching hot- spots is the highly-ordered TiO2 nanotube architecture. As a new type of titania nano-material, titania nanotube arrays have drawn extraordinary attention due to its distinctive morphology, notable photo-electrical and hydro-sensitive performance. At 100% sun the new kind of TiO2 nanotube arrays solar cell exhibits an overall conversion efficiency of 5.44%. This paper introduces the preparation methods of titania nanotube arrays, the existing problems and recent progress in titania nanotube arrays solar cell.

关键词：阳极氧化二氧化钛纳米管阵列太阳能电池纳米晶半导体

National Report on Space Medicine Progress in 2010—2012

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空间科学学报 2012年第5期32卷 693-703页

作者： LI Yinghui LIU Zhaoxia ding bai LIU Yue ZHANG Xiaoyou bai Yanqiang CHEN Shanguang China Astronaut Research and Training Center Beijing 100094

Accompanying the flourishing developments of China's manned spaceflight,space medicine has achieved great development during the past two years in *** this paper,scientific research of space medicine and its applicati... 详细信息

关键词： Space medicine Progress Spaceflight

ZBP1(DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling

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Bone Research 2020年第2期8卷 219-228页

作者： Xuefeng Zhao Liang Xie Zhiyong Wang Jiongke Wang Hao Xu Xianglong Han ding bai Peng Deng State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesChinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and ManagementWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041PR China Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduSichuan 610041PR China

The lineage specification of mesenchymal stem/stromal cells(MSCs) is tightly regulated by a wide range of factors. Recently, the versatile functions of ZBP1(also known as DAI or DLM-1) have been reported in the blood circulation and immune ***, the biological function of ZBP1 during the lineage specification of MSCs is still unknown. In the present study, we found that ZBP1 was upregulated during osteogenesis but downregulated during adipogenesis in mouse bone marrow-derived MSCs(m BMSCs). ZBP1 was highly expressed in osteoblasts but expressed at a relatively low level in marrow adipocytes. Knockdown of ZBP1 inhibited alkaline phosphataseactivity, extracellular matrix mineralization, and osteogenesis-related gene expression in vitro and reduced ectopic bone formation in vivo. Knockdown of ZBP1 also promoted adipogenesis in MSCs in vitro. Conversely, the overexpression of ZBP1 increased the osteogenesis but suppressed the adipogenesis of MSCs. When the expression of ZBP1 was rescued, the osteogenic capacity of ZBP1-depleted m BMSCs was restored at both the molecular and phenotypic ***, we demonstrated that ZBP1, a newly identified target of Wnt/β-catenin signaling, was required for β-catenin translocation into nuclei. Collectively, our results indicate that ZBP1 is a novel regulator of bone and fat transdifferentiation via Wnt/β-catenin signaling.

关键词： inhibited inhibiting versatile

Progress of Space Medicine Research in China

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空间科学学报 2020年第5期40卷 920-927页

作者： ding bai LIU Zhaoxia LÜKe LING Shukuan LIU Yue XU Zi LI Yinghui Astronaut Center of China Beijing 100094

With the approaching of the Chinese Space Station(CSS)era,the focus of space medicine applications and related research has shifted to addressing the astronauts’health support in long-duration spaceflights,including nutrition,countermeasure against the physiological effects of weightlessness,medical monitoring and support,psychology status,etc.,and accordingly the human experiments to simulate long-duration weightlessness have been carried ***,basic research has been put forward in the key areas,such as space bone loss,cardiovascular dysfunction and the molecular mechanisms underlying radiobiological ***,specific novel research fields,such as hypometabolism technology,were *** research projects in the field of space medicine experiment,as an important aspect of the Chinese Space Station’s application,have been officially approved and launched.

关键词： Space medicine Chinese Space Station Health risk

National Report on Space Medicine Progress in 2014-2016

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空间科学学报 2016年第5期36卷 781-787页

作者： LI Yinghui ZHANG Xiaoyou WAN Yumin ding bai LIU Zhaoxia LING Shukuan bai Yanqiang CHEN Shanguang State Key Lab of Space Medicine Fundamentals and Application China Astronaut Research and Training Center

The progress of China Spaceflight makes a great impetus for the development of space *** the developing of China Space Station,the national space medicine has attained great *** this paper,the basic research of Space ... 详细信息

关键词：航天医学中国航天医学发展基础研究空间站

National Report on Space Medicine Progress in 2012–2014

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空间科学学报 2014年第5期34卷 740-746页

作者： LI Yinghui ZHANG Xiaoyou WAN Yumin ding bai LIU Zhaoxia LING Shukuan bai Yanqiang CHEN Shanguang LIU Shujuan State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center

The application of manned spaceflight makes a great impetus on the development of space medicine. With the deep growth of Chinese manned space, our national space medicine has attained great achievements. In this pape... 详细信息

关键词： Spaceflight Space medicine Progress

Long-Term, Low-Level Microwave Radiation Impairs Learning and Memory via Synbindin: Molecular Basis and Underlying Mechanism

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Biomedical and Environmental Sciences 2022年第6期35卷 552-557页

作者： YANG Zhen Zhong WU Da Wei ding bai MA Hong Bo FEI Jin Xue CHENG Liang ZHAO Ya Li State Key Lab of Space Medicine Fundamentals and Application(SMFA) Astronaut Research and Training CenterBeijing 100094China

Human beings are usually exposed to microwaves originated from the equipment in industry,communication,military,and aerospace,which has led to interest in health effects of long-term low level microwave radiation exposure,particularly on the brain,one of the most sensitive organs to microwaves[1].Morris water maze,oxidative stress related typical markers of corticosteroids(CORT),malondialdehyde(MDA),catalase(CAT),superoxide dismutase(SOD)and total antioxidant capacity(TAOC),ultrastructure,dendritic spine growth and molecular signaling pathway are important indicators in the study of learning and memory effects[2].Among them,Synbindin(Sbdn),closely associated to dendritic spine growth,learning and memory,was found to be a remarkable microwave sensitive molecule in our previous work[3]..Additionally,it’s well known that both the CA1 and Dentate Gyrus(DG)regions of the hippocampus are involved in learning and memory,however studies on the effect of microwave on DG region were less,so,this paper further focused on DG region in the study of dendrite spine,ultrastructure of neurons and phospho-extracellular signal-regulated kinase(pERK)protein ***,Synbindin was focused on and the above indicators were integrated in this paper to study the influence and mechanism of long-term low-intensity 2,100 MHz microwave on learning and memory.

关键词： organs microwave originated

Expression analysis of a-smooth muscle actin and tenascin-C in the periodontal ligament under orthodontic loading or in vitro culture

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International Journal of Oral Science 2015年第4期7卷 232-241页

作者： Hui Xu ding bai L-Bruno Ruest Jian Q Feng Yong-Wen Guo Ye Tian Yan Jing Yao He Xiang-Long Han State Key Laboratory of Oral Diseases Department of OrthodonticsWest China Hospital of StomatologySichuan University Department of Biomedical Sciences Baylor College of DentistryTexas A&M University

α-smooth muscle actin （α-SMA） and tenascin-C are stress-induced phenotypic features of myofibroblasts. The expression levels of these two proteins closely correlate with the extracellular mechanical microenvironment. We investigated how the expression of α-SMA and tenascin-C was altered in the periodontal ligament （PDL） under orthodontic loading to indirectly reveal the intrinsic mechanical microenvironment in the PDL. In this study, we demonstrated the synergistic effects of transforming growth factor-β1 （TGF-β1） and mechanical tensile or compressive stress on myofibroblast differentiation from human periodontal ligament cells （hPDLCs）. The hPDLCs under higher tensile or compressive stress significantly increased their levels of α-SMA and tenascin-C compared with those under lower tensile or compressive stress. A similar trend was observed in the tension and compression areas of the PDL under continuous light or heavy orthodontic load in rats. During the time-course analysis of expression, we observed that an increase in α-SMA levels was matched by an increase in tenascin-C levels in the PDL under orthodontic load in vivo. The time-dependent variation of α-SMA and tenascin-C expression in the PDL may indicate the time-dependent variation of intrinsic stress under constant extrinsic loading.

关键词： α-smooth muscle actin mechanical load myofibroblast periodontal ligament tenascin-C transforming growthfactor-β1