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Photonics Research 2020年第4期8卷 511-518页

作者： PING kwong CHENG CHUN YIN TANG XIN YU WANG LONG-HUI ZENG YUEN HONG TSANG Department of Applied Physics and Materials Research Center The Hong Kong Polytechnic UniversityHung HornKowloonHong KongChina

Stable Q-switched and mode-locked erbium-doped fiber lasers(EDFLs)are first demonstrated by using the novel layered palladium disulfide(PdS2),a new member of group 10 transition metal dichalcogenides(TMDs)-based saturable absorbers(SAs).Self-started Q-switched operation at 1567 nm was achieved with a threshold pump power of 50.6 *** modulation ranges of pulse duration and repetition rate were characterized as 12.6-4.5μs and 17.2-26.0 kHz,***,a mode-locked EDFL was also obtained with a pump power threshold of 106.4 *** achieved pulse duration is 803 fs,corresponding to a center wavelength of 1565.8 nm and4.48 nm 3 dB *** the best of our knowledge,the achieved pulse duration of the mode-locked EDFL in this work is the narrowest compared with all other group 10 TMD SA-based lasers.

关键词： Passively Q-switched femtosecond modelocked erbium-doped fiber laser a 2D palladium disulfide

Chinese-translated Behavioral Regulation in Exercise Questionnaire-2： Evidence from university students in the Mainland and Hong Kong of China

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Journal of Sport and Health Science 2015年第3期4卷 228-234页

作者： Jing Dong Liu Pak-kwong Chung Chun-Qing Zhang Gangyan Si Department of Physical Education Hong Kong Baptist University Hong Kong 999077 China Department of Health and Physical Education Hong Kong Institute of Education Hong Kong 999077 China

目的:本研究的目的是在中国大陆和中国香港的大学生人群中,进一步检验中译版《锻炼行为调节问卷-2》(C-BREQ-2)的相关心理测量学属性。方法:来自中国大陆(n=191)和中国香港(n=194)的大学生参加了本次研究,检验了C-BREQ-2的因素效度、区... 详细信息

目的:本研究的目的是在中国大陆和中国香港的大学生人群中,进一步检验中译版《锻炼行为调节问卷-2》(C-BREQ-2)的相关心理测量学属性。方法:来自中国大陆(n=191)和中国香港(n=194)的大学生参加了本次研究,检验了C-BREQ-2的因素效度、区别效度、法则效度、内部一致性信度以及测量恒等性。结果:验证性因素分析结果为18条目C-BREQ-2的5因素结构提供了支持。因素间相关程度的95%置信区间检验表明,C-BREQ-2各因素间虽具有相关性但属不同概念,这为区分效度提供了支持。C-BREQ-2的内部一致性信度达到可接受水平。不同行为调节因素间相关系数呈简单相关模式,为C-BREQ-2的法则效度提供了支持。不同行为调节变量与情感及行为变量间的相关结果符合理论假设,进一步对其法则效度提供了支持。多组验证性因素分析结果表明,在中国大陆和中国香港大学生中,C-BREQ-2测量模型的因子载荷和因子方差/协方差具有跨人群恒等性。结论:本研究为在中国大学生人群使用C-BREQ-2进一步提供了心理测量学证据,也使得以自我决定理论为基础的相关动机理论在中国人人群以及在锻炼和体力活动等领域的进一步研究与应用成为可能。

关键词：中国大陆大学生香港大学行为练习翻译香港中文大学中国内地

颅脑有限元模型演化规律及其生物力学研究进展

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医用生物力学 2014年第6期29卷 576-581,588页

作者：羊玢曹立波陈宁 Tse kwong Ming lee Heow Pueh 湖南大学汽车车身先进设计制造国家重点实验室长沙410082 南京林业大学汽车与交通工程学院南京210037 新加坡国立大学机械工程系新加坡117576

交通事故中头颈部损伤因其较高的致命性,已成为最严重的损伤类型。有限元模型在创伤性脑损伤生物力学机理研究中得到日益广泛应用。回顾头颈部有限元模型的生物力学研究历史和现状,并阐述车辆碰撞交通事故中人体颅脑典型交通伤演化规律... 详细信息

交通事故中头颈部损伤因其较高的致命性,已成为最严重的损伤类型。有限元模型在创伤性脑损伤生物力学机理研究中得到日益广泛应用。回顾头颈部有限元模型的生物力学研究历史和现状,并阐述车辆碰撞交通事故中人体颅脑典型交通伤演化规律和生物力学研究进展,探索头颈部损伤安全防护的方法,以期为车辆碰撞事故中人体颅脑损伤生物力学研究和相应的汽车安全防护装置研制提供理论依据。

关键词：有限元模型颅脑损伤生物力学演化规律损伤防护

Stress analysis of the TMSR graphite component under irradiation conditions

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Nuclear Science and Techniques 2018年第12期29卷 21-29页

作者： Xiong Yang Yan-Tao Gao Yang Zhong Dong Ding Derek-kwong-Lai Tsang Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China University of Chinese Academy of Science Beijing 100049China

TMSR uses nuclear graphite as a neutron moderator, a reflector, and the structural material, and utilizes molten salt as a coolant. When running normally, the graphite components are immersed in the molten ***, the nuclear graphite comes into direct contact with the molten salt, which infiltrates the open pores of the nuclear graphite. This infiltration may influence the stress analysis of the graphite component. In this study, a User Material subroutine was used to analyze the stress distribution of the graphite component, both with and without molten salt infiltration. Many influence factors were taken into consideration, such as the dose gradient, the shape of the permeation zone, and the permeation area. The results show that the dose gradient, shape, and area of the permeation zone all significantly influence the stress distribution. Furthermore, the results of the stress analysis indicate that for a regular graphite component with a square cross section, the peak maximum principal stress value occurs at the center of the cross section, and the symmetry of the maximum principal stress distributions was modified by quarter circle and half ellipse permeation zones.

关键词：石墨部件压力分析直接接触影响因素压力分布熔融浸透

Elderly patients over 80 years undergoing colorectal cancer resection: Development and validation of a predictive nomogram for survival

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 892-905页

作者： Aik Yong Chok Yun Zhao Hui Lionel Raphael Chen Ivan En-Howe Tan Desmond Han Wen Chew Yue Zhao Marianne Kit Har Au Emile John kwong Wei Tan Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Group Finance Analytics Singapore Health ServicesSingapore 168582Singapore Group Finance Singapore Health ServicesSingapore 168582Singapore Singhealth Community Hospitals Singapore 168582Singapore

BACKGROUND Surgery remains the primary treatment for localized colorectal cancer(CRC).Improving surgical decision-making for elderly CRC patients necessitates an accurate predictive *** To build a nomogram to predict the overall survival of elderly patients over 80 years undergoing CRC *** Two hundred and ninety-five elderly CRC patients over 80 years undergoing surgery at Singapore General Hospital between 2018 and 2021 were identified from the American College of Surgeons–National Surgical Quality Improvement Program(ACS-NSQIP)*** variables were selected using univariate Cox regression,and clinical feature selection was performed by the least absolute shrinkage and selection operator regression.A nomogram for 1-and 3-year overall survival was constructed based on 60%of the study cohort and tested on the remaining 40%.The performance of the nomogram was evaluated using the concordance index(C-index),area under the receiver operating characteristic curve(AUC),and calibration *** groups were stratified using the total risk points derived from the nomogram and the optimal cut-off *** curves were compared between the high-and low-risk *** Eight predictors:Age,Charlson comorbidity index,body mass index,serum albumin level,distant metastasis,emergency surgery,postoperative pneumonia,and postoperative myocardial infarction,were included in the *** AUC values for the 1-year survival were 0.843 and 0.826 for the training and validation cohorts,*** AUC values for the 3-year survival were 0.788 and 0.750 for the training and validation cohorts,respectively.C-index values of the training cohort(0.845)and validation cohort(0.793)suggested the excellent discriminative ability of the *** curves demonstrated a good consistency between the predictions and actual observations of overall survival in both training and validation cohorts.A significant difference in overall survival wa

关键词： Colorectal cancer Elderly Nomogram Overall survival Prognostic Risk stratification

A bio-instructive parylene-based conformal coating suppresses thrombosis and intimal hyperplasia of implantable vascular devices

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Bioactive Materials 2023年第10期28卷 467-479页

作者： Dake Hao Jonathan Lin Ruiwu Liu Christopher Pivetti Kaeli Yamashiro Linda M.Schutzman Junichiro Sageshima Mimmie kwong Nataliya Bahatyrevich Diana L.Farmer Misty D.Humphries Kit S.Lam Alyssa Panitch Aijun Wang Department of Surgery School of MedicineUniversity of California DavisSacramentoCA95817United States Institute for Pediatric Regenerative Medicine Shriners Hospitals for ChildrenSacramentoCA95817United States Department of Biochemistry and Molecular Medicine School of MedicineUniversity of California DavisSacramentoCA95817United States Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlant1GA30332United States Department of Biomedical Engineering University of California DavisDavisCA95616United States

Implantable vascular devices are widely used in clinical treatments for various vascular diseases. However, current approved clinical implantable vascular devices generally have high failure rates primarily due to their surface lacking inherent functional endothelium. Here, inspired by the pathological mechanisms of vascular device failure and physiological functions of native endothelium, we developed a new generation of bioactive parylene (poly(p-xylylene))-based conformal coating to address these challenges of the vascular devices. This coating used a polyethylene glycol (PEG) linker to introduce an endothelial progenitor cell (EPC) specific binding ligand LXW7 (cGRGDdvc) onto the vascular devices for preventing platelet adhesion and selectively capturing endogenous EPCs. Also, we confirmed the long-term stability and function of this coating in human serum. Using two vascular disease-related large animal models, a porcine carotid artery interposition model and a porcine carotid artery-jugular vein arteriovenous graft model, we demonstrated that this coating enabled rapid generation of self-renewable “living” endothelium on the blood contacting surface of the expanded polytetrafluoroethylene (ePTFE) grafts after implantation. We expect this easy-to-apply conformal coating will present a promising avenue to engineer surface properties of “off-the-shelf” implantable vascular devices for long-lasting performance in the clinical settings.

关键词： Parylene coating Integrin ligand Thrombosis Intimal hyperplasia Implantable vascular devices

Putative Nitrogen Sensing Systems in Higher Plants

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Journal of Integrative Plant Biology 2006年第8期48卷 873-888页

作者： Hon-Ming Lam Ying Ann Chiao Man-Wah Li Yuk-kwong Yung Sang Ji Department of Biology Chinese University of Hong Kong Shatin Hong Kong Molecular Biotechnology Program Chinese University of Hong Kong Shatin Hong Kong

Nitrogen （N） metabolism is essential for the biosynthesis of vital biomolecules. N status thus exerts profound effects on plant growth and development, and must be closely monitored. In bacteria and fungi, a few sophisticated N sensing systems have been extensively studied. In animals, the ability to receive amino acid signals has evolved to become an integral part of the nervous coordination system. In this review, we will summarize recent developments in the search for putative N sensing systems in higher plants based on homologous systems in bacteria, fungi, and animals. Apparently, although plants have separated and diversified from other organisms during the evolution process, striking similarities can be found in their N sensing systems compared with those of their counterparts; however, our understanding of these systems is still incomplete. Significant modifications of the N sensing systems （including cross-talk with other signal transduction pathways） in higher plants may be a strategy of adaptation to their unique mode of life.

关键词： general amino acid control glutamate receptors His-Asp phosphorelay nitrogen metabolism nitrogen sensing PII, signal transduction.

Theoretical Calculations on the Second-order Nonlinear Optical Property of Chiral Bis-corroles

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Chinese Journal of Structural Chemistry 2007年第8期26卷 955-961页

作者： YING Xiao DENG Qin LIAO Shi-Jun HU Xi-Ming LIU Hai-Yang CHANG Chi-kwong Department of Applied Physics South China University of Technology Guangzhou 510641 China Department of Applied Chemistry South China University of Technology Guangzhou 510641 China Department of Chemistry The Hongkong University of Science and Technology Hongkong China

The second-order nonlinear optical （NLO） properties of 5,10,15-triphenylcorrole （TPC）, 5,10,15,20-tetraphenylporphyrin （TPP） and L-amino acid bridged bis-corroles 1,2,3 and 4 have been calculated by using TDHF/PM3 method based on the RHF/6-31G （TPC and TPP） or semiempirical PM3 （1, 2, 3, 4） optimized geometries. Calculation results showed TPC and TPP have C1 and D2h symmetry, respectively when N-H protons are localized on the nitrogen atoms. TPC is the second-order NLO active chromophore due to the cancellation of centrosymmetrical structure and its first hyperpolarizability β increases to 11.524×10^-30 esu. Under electrical dipole approximation, βvalues of bis-corroles 1, 2, 3 and 4 vary from 9.831×10^-30 to 14.221×10^-30 esu, and no much improvement in the first hyperpolarizability was observed as compared to TPC ***, β values of bis-corroles 1, 2, 3 and 4 are improved by about 4 times as compared to their bis-porphyrin counterparts. The analysis of β components indicates that β of this kind of bis-corroles is mainly contributed from its radial component βr. With the variation of amino acid side chains, βHRS, β,βxyz, βr and βa of bis-corroles change remarkably. Chiral L-amino acid bridged bis-corroles 2, 3 and 4 have a right-handed helix structure, and their chiral component βxyz matches βxyz ∝ r^2 ζ/L^4 （helix parameters）, showing the second-order chiral NLO response of these bis-corroles could be described by one-electron helical model theory. It was found that the radial component βr of chiral helix bis-corroles also matches βr ∝ r^2 ζ/L^4.

关键词： corrole amino acid chiral bis-corrole the second-order NLO TDHF/PM3

Towards a Theoretical Framework of Autonomous Systems Underpinned by Intelligence and Systems Sciences

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IEEE/CAA Journal of Automatica Sinica 2021年第1期8卷 52-63页

作者： Yingxu Wang Ming Hou Konstantinos NPlataniotis Sam kwong Henry Leung Edward Tunstel Imre JRudas Ljiljana Trajkovic International Institute of Cognitive Informatics and Cognitive Computing Department of Electrical and Computer EngineeringSchulich School of Engineering and Hotchkiss Brain InstituteUniversity of CalgaryCalgary T2N 1N4Canada Toronto Research Centre Defence Research&Development CanadaToronto M3K 2C9Canada Department of Electrical&Computer Engineering University of TorontoToronto M5S3G4Canada Department of Computer Science City University of Hong KongHong KongChina Department of Electrical and Computer Engineering Schulich School of EngineeringUniversity of CalgaryCalgary T2N 1N4Canada Autonomous&Intelligent Systems Department United Technologies Research CenterCT 06108 USA University Research&Innovation Center(EKIK) Óbuda UniversityBudapest H-1034Hungary School of Engineering Science Simon Fraser UniversityBurnaby V5A 1S6Canada

Autonomous systems are an emerging AI technology functioning without human intervention underpinned by the latest advances in intelligence,cognition,computer,and systems *** paper explores the intelligent and mathematical foundations of autonomous *** focuses on structural and behavioral properties that constitute the intelligent power of autonomous *** explains how system intelligence aggregates from reflexive,imperative,adaptive intelligence to autonomous and cognitive intelligence.A hierarchical intelligence model(HIM)is introduced to elaborate the evolution of human and system intelligence as an inductive *** properties of system autonomy are formally analyzed towards a wide range of applications in computational intelligence and systems *** paradigms of autonomous systems including brain-inspired systems,cognitive robots,and autonomous knowledge learning systems are *** in autonomous systems will pave a way towards highly intelligent machines for augmenting human capabilities.

关键词： Autonomous systems(AS) cognitive systems computational intelligence engineering paradigms intelligence science intelligent mathematics

The efficacy and effectiveness of machine learning for weaning in mechanically ventilated patients at the intensive care unit: a systematic review

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Bio-Design and Manufacturing 2019年第1期2卷 31-40页

作者： Man Ting kwong Glen Wright Colopy Anika M.Weber Ari Ercole Jeroen H.M.Bergmann Department of Engineering Science University of OxfordParks Road. Oxford OXI 3PJ. UK snap40 Inc.125 Princess Street Edinburgh EH2 4AD UK CRUK/MRC Oxford Institute for Radiation Oncology.Roosevelt Drive Oxford OX3 7DQ. UK Division of Anaesthesia Addenbrooke's Hospital University of Cambridge Hills Road Cambridge CB2 0QQ. UK

Weani ng from mechanical ventilation in the in tensive care unit (ICU) is a complex clinical problem and relevant for future organ engineering. Prolonged mechanical ventilation (MV) leads to a range of medical complications that increases length of stay and costs as well as contributes to morbidity and even mortality and long-term quality of life. The need to reduce MV is both clinical and economical. Artificial intelligence or machine learning (ML) methods are promising opportunities to positively influence patient outcomes. ML methods have been proposed to enhance clinical decisions processes by using the large amount of digital information generated in the ICU setting. There is a particular interest in empirical methods (such as ML) to improve management of "difficult-to-wean" patients, due to the associated costs and adverse events associated with this population. A systematic literature search was performed using the OVID, IEEEXplore, PubMed, and Web of Science databases. All publications that included (1) the application of ML to weaning from MV in the ICU and (2) a clinical outcome measurement were reviewed. A checklist to assess the study quality of medical ML publications was modified to suit the critical assessment of ML in MV weaning literature. The systematic search identified nine studies that used ML for weaning management from MV in critical care. The weaning management application areas included (1) prediction of successful spontaneous breathing trials (SBTs),(2) prediction of successful extubation,(3) prediction of arterial blood gases, and (4) ventilator setting and oxygenation-adjustment advisory systems. Seven of the nine studies scored seven out of eight on the quality index. The remaining two of the nine studies scored one out of eight on the quality index. This scoring may, in part, be explained by the publications' focus on technical novelty, and therefore focusing on issues most important to a technical audience, instead of issues most impor

关键词： Artificial intelligence Patient-centred medicine Clinical trial Critical care Data science