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Evolving thoracic surgery: from open surgery to single port thoracoscopic surgery and future robotic

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Chinese Journal of Cancer Research 2013年第1期25卷 4-6页

作者： diego Gonzalez-Rivas Corua University Hospital (CHUAC) and Minimally Invasive Thoracic Surgery Unit (UCTMI) Corua Spain

Thoracic Surgery is a continuous evolving specialty. In the past, thoracic surgeons had to make large incisions in order to operate any pathology inside the chest. This often meant big, painful and ugly scars and long recovery times after surgery. But he history of thoracic surgery changed since the begining of video-assisted thoracoscoDic surgery （VATg3

关键词： from open surgery to single port thoracoscopic surgery and future robotic VATS Evolving thoracic surgery Figure

Recent advances in uniportal video-assisted thoracoscopic surgery

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Chinese Journal of Cancer Research 2015年第1期27卷 90-93页

作者： diego Gonzalez-Rivas Coru?a University Hospital (CHUAC) and Minimally Invasive Thoracic Surgery Unit (UCTMI)

Thanks to the recent improvements in video-assisted thoracoscopic techniques （VATS） and anesthetic procedures, a great deal of complex lung resections can be performed avoiding open surgery. The experience gained through VATS techniques, enhancement of the surgical instruments ,improvement of high definition cameras and avoidance of intubated general anesthesia have been the greatest advances to minimize the trauma to the patient. Uniportal VATS for major resections has become a revolution in the treatment of lung pathologies since initially described 4 years ago. The huge number of surgical videos posted on specialized websites, live surgery events and experimental courses has contributed to the rapid learning of uniportal major thoracoscopic surgery during the last years. The future of the thoracic surgery is based on evolution of surgical procedures and anesthetic techniques to try to reduce the trauma to the patient. Further development of new technologies probably will focus on sealing devices for all vessels and fissure, refined staplers and instruments, improvements in 3D systems or wireless cameras, and robotic surgery. As thoracoscopic techniques continue to evolve exponentially, we can see the emergence of new approaches in the anesthetical and the perioperative management of these patients. Advances in anesthesia include lobectomies performed without the employment of general anesthesia, through maintaining spontaneous ventilation, and with minimally sedated patients. Uniportal VATS resections under spontaneous ventilation probably represent the least invasive approach to operate lung cancer.

关键词： Uniportal surgery awake lobectomy single-port robotic non-intubated lung cancer

Crushed rocks stabilized with organosilane and lignosulfonate in pavement unbound layers:Repeated load triaxial tests

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Frontiers of Structural and Civil Engineering 2021年第2期15卷 412-424页

作者： diego Maria BARBIERI Inge HOFF Chun-Hsing HO Department of Civil and Environmental Engineering Norwegian University of Science and TechnologyTrondheimTrøndelag7491Norway Department of Civil and Environmental Engineering Northern Arizona UniversityFlagstaffAZ86011USA

The creation of the new“Ferry-Free Coastal Highway Route E39”in southwest Norway entails the production of a remarkable quantity of crushed *** resources could be beneficially employed as aggregates in the unbound courses of the highway itself or other road pavements present *** innovative stabilizing agents,organosilane and lignosulfonate,can significantly enhance the key properties,namely,resilient modulus and resistance against permanent deformation,of the aggregates that are excessively weak in their natural *** beneficial effect offered by the additives was thoroughly evaluated by performing repeated load triaxial *** study adopted the most common numerical models to describe these two key mechanical *** increase in the resilient modulus and reduction in the accumulated vertical permanent deformation show the beneficial impact of the ***,a finite element model was created to simulate the repeated load triaxial test by implementing nonlinear elastic and plastic constitutive relationships.

关键词： organosilane lignosulfonate crushed rocks pavement unbound layers repeated load triaxial test finite element analysis

Mercury uptake and effects on growth in Jatropha curcas

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Journal of Environmental Sciences 2016年第10期28卷 120-125页

作者： Jose Marrugo-Negrete Jose Durango-hernandez Jose Pinedo-hernandez German Enamorado-Montes Sergi Diez University of Cordoba Faculty of Basic Sciences Department of Chemistry Water Applied and Environmental Chemistry Group Monteria Colombia Environmental Chemistry Department Institute of Environmental Assessment and Water Research ID█A-CSIC E-08034 Barcelona Spain

The use of metal-accumulating plants for the phytoremediation of contaminated soils is gaining more attention. Mercury （Hg）-contaminated soils from historical gold mines represent a potential risk to human health and the environment. Therefore, Jatropha curcas plant, that has shown its tolerance to these environments, is a species of particular interest to implement phytoremediation techniques in gold mining sites. In this work, the behavior of J. curcas was assessed in different hydroponic cultures fortified with Hg at concentrations of 5, 10, 20, 40, and 80μg Hg/mL （T5, T10, T20, T40 and T80, respectively）. After exposure, plant growth, net photosynthesis, leaf area, and Hg accumulation were determined and variables such as net Hg uptake, effective Hg accumulation, translocation and bioaccumu- lation factors were calculated. Accumulation of Hg in root and leaf tissues increased with respect to the Hg concentrations in the hydroponic culture, with statistically significant differences （p 〈 0.05） among treatments. Moreover, Hg concentration in roots was 7 and 12-fold higher in average than in plant leaves and shoots, respectively. Many effects were found in the development of plants, especially related with loss of biomass and leaf area, with significant growth inhibition related to control values （〉50% with treatment T5）. Moreover, percentage of inhibition was even higher （〉60%） with same treatment for net photosynthesis. Finally, it should be highlighted that for T40 and T80 treatments, plant growth and photosynthesis were almost completely depleted （88%-95%）.

关键词： Jatropha curcasPhytoextractionMercuryHydroponicGrowth inhibition

A microfluidic approach for development of hybrid collagen-chitosan extracellular matrix-like membranes for on-chip cell cultures

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Journal of Materials Science & Technology 2021年第4期63卷 54-61页

作者： Erica Rosella Nan Jia diego Mantovani Jesse Greener Laboratory Department of ChemistryLaval UniversityQuébecQCCanada Laboratory of Biomaterials and Bioengineering CRC-1Dept.Min-Met-Materials Eng&CHU de QuebecResearch CenterLaval UniversityQuébecQCCanada CHU de Quebec Research Centre Laval University10 rue de l’EspinayQuébecQC G1L 3L5Canada

To advance organ-on-a-chip development and other areas befitting from physiologically-relevant biomembranes,a microfluidic platform is presented for synthesis of biomembranes during gelation and investigation into their role as extracellular matrix *** this work,high-throughput studies of collagen,chitosan,and collagen-chitosan hybrid biomembranes were carried out to characterize and compare key properties as a function of the applied hydrodynamic conditions during ***,depending on the biopolymer material used,varying flow conditions during biomembrane gelation caused width,uniformity,and swelling ratio to be differently affected and ***,cell viability studies of seeded fibroblasts were conducted,thus showing the potential for biological applications.

关键词： matrix swelling showing

On the Present and the Past of Pandemics

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Chinese Medicine and Culture 2023年第3期6卷 280-289页

作者： diego Armus Department of History Swarthmore CollegeSwarthmore 19081USA

During the COVID-19 pandemic,a multitude of narratives saturated the print,audiovisual,and electronic ***,uninformed,apocalyptic and voluntarist approaches *** notes-written during the pandemic and delivered in the conference series-address the proliferation of such discourses,emphasizing a series of ***,the widespread ignorance about the history of ***,the inability to deal with the uncertainties that reign during pandemic times,as well as the announcements that this extraordinary health/sanitary event would produce a profound watershed in all walks of life and in all corners of the ***,and against the general assertion that“one learns from the past to understand the present,”these notes seek to point out how the present can illuminate the study of the past-or,more personally,what I think I have learned as a historian in the times of the COVID-19 pandemic.

关键词： COVID-19 Epidemics Historiography History

Microscale study of frictional properties of graphene in ultra high vacuum

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Friction 2015年第2期3卷 161-169页

作者： diego MARCHETTO Tim FESER Martin DIENWIEBEL Fraunhofer-Institute for Mechanics of Materials Microtribology CenterμTCWöhlerstr.1179108 FreiburgGermany Karlsruhe Institute of Technology Institute for Applied Materials-Computational Materials Science IAM-CMSKaiserstr.1276131 KarlsruheGermany

We report on the frictional properties of epitaxial graphene on SiC in ultra high *** have been performed using a microtribometer in the load regime of 0.5 to 1 *** observed that a ruby sphere sliding against graphene results in very low friction coefficients ranging from 0.02 to *** friction and also the stability of the graphene layer is higher than that under similar conditions in ambient *** friction shows a load *** it was found that graphene masks the frictional anisotropy which was observed on the SiC surface.

关键词： graphene SiC friction vacuum microtribology anisotropy

DUSM： A Method for Requirements Specification and Refinement Based on Disciplined Use Cases and Screen Mockups

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Journal of Computer Science & Technology 2018年第5期33卷 918-939页

作者： Gianna Reggio Maurizio Leotta Filippo Ricca diego Clerissi Department of Informatics Bioengineering Robotics and Systems Engineering (DIBRIS) University of Genova Genova 16146 Italy

In this work, we present DUSM （Disciplined Use Cases with Screen Mockups）, a novel method for describing and refining requirements specifications based on disciplined use cases and screen mockups. Disciplined use cases are characterized by a quite stringent template to prevent common mistakes, and to increase the quality of the specifications. Use cases descriptions are formulated in a structured natural language, which allows to reach a good level of precision, avoiding the need for further notations and complex models. Screen mockups are precisely associated with the steps of the use cases scenarios and they present the corresponding GUIs （graphical user interfaces） as seen by the human actors before/after the steps executions, improving the comprehension and the expression of the non-functional requirements on the user interface. DUSM has been proposed and fine-tuned during several editions of a software engineering course at the University of Genova. Then, by means of a series of case studies and experiments, we validated the method and evaluated： 1） its effectiveness in improving the comprehension and, in general, the quality of the produced requirements specification, and 2） its applicability in the industry, where the method has been found useful and not particularly onerous.

关键词： requirements specification use case screen mockup empirical validation graphical user interface (GUI) user interface requirements

Hepatotoxicity Induced by Biological Agents: Clinical Features and Current Controversies

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 486-495页

作者： Nelia hernandez Fernando Bessone Hospital de Clinicas Universidad de la RepublicaMontevideoUruguay Hospital Provincial del Centenario University of Rosario School of MedicineRosarioArgentina

Novel biological agents including cytokines and recombinant fusion proteins are increasingly prescribed for cancer,rheumatologic,autoimmune,and inflammatory diseases,and are currently being evaluated in hepatocellular carcinoma(HCC).They are classified by their mechanism of action and include tumor necrosis factor-alpha(TNF-α)antagonists,T cell mediated antitumor inhibitors,interleukin receptor antagonists,and immune checkpoint inhibitors(ICIs).Some ICIs cause frequent hepatotoxicity with a variable clinical,biochemical,and serological presentation,especially in patients receiving another immunomodulatory *** of the cases of liver damage induced by biological agents spontaneously regress after drug withdrawal,but the others require steroid ***,there are no widely accepted recommendation for the use of corticosteroids in these patients,even though international cancer societies have their own *** drug-induced autoimmune hepatitis(DIAIH)from classic AIH is challenging for pathologists,but liver biopsy is valuable,particularly in cases with unclear clinical ***,novel histological patterns have been described in liver damage induced by these agents(i.e.,endothelitis,ring granuloma and secundary sclerosing cholangitis associated with lymphocytic infiltration of cytotoxic CD8+T cells).Here,we describe the clinical and biochemical characteristics of patients with hepatotoxicity induced by TNF-αantagonists and *** issues involved in the administration of corticosteroid therapy,and hepatitis B virus(HBV)reactivation induced by immunosuppressive therapy are also discussed.

关键词： Hepatotoxicity Checkpoint inhibitors Biologics Autoimmune hepatitis Drug-induced liver injury