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Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance

Journal of Animal Science and Biotechnology 2024年第5期15卷 1820-1831页

作者： Aakilah S.hernandez Gabriel A.Zayas Eduardo E.Rodriguez Kaitlyn M.Sarlo Davila Fahad Rafiq Andrea N.Nunez Cristiane Goncalves Titto Raluca G.Mateescu Department of Animal Science North Carolina State UniversityRaleighNCUSA Department of Animal Sciences University of FloridaGainesvilleFLUSA. Ruminant Diseases and Immunology Research Unit National Animal Disease CentersUnited States Department of Agriculture1920 Dayton AvenueAmesIA 50010USA. Department of Animal Science Iowa StateAmesIAUSA School of Animal Sciences and Food Engineering University of Sao PauloAv Duque de Caxias Norte 225PirassunungaSao Paulo 13635‑900Brazil

Background Thermal stress in subtropical regions is a major limiting factor in beef cattle production systems with around$369 million being lost annually due to reduced *** stress causes numerous physiological and behavioral disturbances including reduced feed intake and decreased production *** utilize various physiological mechanisms such as sweating to regulate internal *** in these traits can help identify genetic variants that control sweat gland properties and subsequently allow for genetic selection of cattle with greater *** This study used 2,401 Brangus cattle from two commercial ranches in *** phenotypes that contribute to an animal's ability to manage heat stress were calculated from skin biopsies and included sweat gland area,sweat gland depth,and sweat gland *** animals were genotyped with the Bovine GGP F250K,and BLUPF90 software was used to estimate genetic parameters and for Genome Wide Association *** Sweat gland phenotypes heritability ranged from 0.17 to 0.42 indicating a moderate amount of the phenotypic variation is due to genetics,allowing producers the ability to select for favorable sweat gland properties.A weighted single-step GWAS using sliding 10 kb windows identified multiple quantitative trait loci(QTLs)explaining a significant amount of genetic *** located on BTA7 and BTA12 explained over 1.0%of genetic variance and overlap the ADGRV1 and CCDC168 genes,*** variants identified in this study are implicated in processes related to immune function and cellular proliferation which could be relevant to heat *** of Origin Alleles(BOA)were predicted using local ancestry in admixed populations(LAMP-LD),allowing for identification of markers'origin from either Brahman or Angus ancestry.A BOA GWAS was performed to identify regions inherited from particular ancestral breeds that might have a significant impact on sweat gland pheno

关键词： GWAS Heritability Skin Thermotolerance

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光学相干断层成像评估高血压性视网膜病变神经元损伤应用价值的研究

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中国全科医学 2024年第9期27卷 1082-1087页

作者：赵润泽孙小佳 Melba Marquez hernandez 窦国睿空军军医大学西京医院眼科、全军眼科研究所陕西省西安市710032 Lázaro#701 esq.a Belascoaín Centro HabanaLa HabanaCuba.Hospital Clínico Quirúrgico“Hermanos Ameijeiras”(HHA)Calle San 10400Cube

背景当前高血压的患病率呈逐年增长趋势,其眼部并发症高血压视网膜病也日益受到关注。然而目前对于高血压性视网膜病变中神经元损伤的研究尚少。目的本研究以光学相干断层成像检查为检查手段,探究其在高血压性视网膜病变中神经元损伤评... 详细信息

背景当前高血压的患病率呈逐年增长趋势,其眼部并发症高血压视网膜病也日益受到关注。然而目前对于高血压性视网膜病变中神经元损伤的研究尚少。目的本研究以光学相干断层成像检查为检查手段,探究其在高血压性视网膜病变中神经元损伤评估中的应用和重要价值。方法纳入2019年3月—2020年7月于Hospital Clínico Quirúrgico“Hermanos Ameijeiras”(HHA医院)就诊的102例高血压患者为研究对象,同时纳入45名健康受试者,监测24 h动态血压,取24 h舒张压和收缩压的平均动脉血压值,测量眼压,计算眼灌注压。检测视盘区视网膜神经纤维(RNFL)厚度和黄斑区神经节细胞复合层(GCC)厚度。依据血压控制情况将患者分为血压控制组(n=51)和血压未控制组(n=51),45名健康受试者为对照组。采用Pearson相关性分析或Spearman秩相关分析探究血压、眼灌注压、视网膜病变与GCC厚度和血压、眼灌注压与视网膜病变的相关性,采用R 3.5.3软件进行中介作用分析。结果3组研究对象人种、收缩压、舒张压、平均动脉压、眼压、眼灌注压、视网膜病变比较,差异有统计学意义(P<0.05)。血压未控制组平均RNFL厚度低于对照组(P<0.05),血压控制组、血压未控制组GCC平均厚度低于对照组,血压未控制组GCC最小值低于对照组(P<0.05)。相关性分析结果显示,GCC平均厚度、上方GCC厚度、颞下方CCG厚度与收缩压、舒张压、眼灌注压、视网膜病变呈负相关(P<0.05),颞上方GCC厚度与收缩压、舒张压、眼灌注压呈负相关(P<0.05),下方GCC厚度与舒张压呈负相关(P<0.05),视网膜病变与收缩压、舒张压、眼灌注压呈正相关(P<0.05)。中介效应结果显示,“收缩压→GCC平均厚度→高血压性视网膜病变”效应显著,收缩压与GCC平均厚度呈正相关,GCC平均厚度与高血压性视网膜病变呈正相关(P<0.05)。收缩压对高血压性视网膜病变发生风险具有直接影响(β=0.013,95%CI=0.007~0.020,P<0.001),GCC平均厚度部分介导了收缩压对高血压性视网膜病变发生风险的影响(β=0.117,95%CI=0.014~0.360,P=0.04),中介效应占总效应的11.7%。结论光学相干断层成像检查是一种无创的眼科检查方法,可优于普通眼底检查提前发现高血压性视网膜神经元受损情况,对高血压导致视神经受损的不可逆盲和高血压靶器官受损进行早期预防和预警。

关键词：高血压性视网膜病变高血压光学相干断层成像术神经纤维中介分析

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Cardiac evaluation of renal transplant candidates with heart failure

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World Journal of Transplantation 2024年第4期14卷 44-49页

作者： Amer Ashaab Belal Alfonso hernandez Santos Jr Amir Kazory Department of Medicine Division of NephrologyUniversity of Florida College of MedicineGainesvilleFL 32610United States Division of Nephrology Hypertension and Renal TransplantationUniversity of FloridaGainesvilleFL 32608United States

Patients with advanced kidney disease are at elevated risk of developing heart failure and appropriate risk stratification is important to permit them to receive kidney *** American Heart Association and American College of Cardiology joint statement provides guidance on risk stratification for the major cause of heart failure for these patients in its recommendations for coronary heart *** we provide an overview of the available literature on risk strati-fication for nonischemic heart failure and functional heart disease states such as pulmonary *** of these options for optimizing these patients be-fore transplant include optimizing their volume status,often with more agg-ressive *** transplantation remains the treatment of choice for patients with advanced kidney disease and cardiac disease,the correction of the azotemic substances with kidney transplantation has been associated with imp-roved survival than remaining on dialysis *** findings in the studies reviewed here are expected to help clinicians refine current strategies for evalua-ting potential kidney transplant recipients.

关键词： Kidney transplantation Preoperative evaluation Clinical practice guidelines Heart failure Pulmonary hypertension

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Chemically robust superhydrophobic surfaces with a self‐replenishing nanoscale liquid coating

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Droplet 2024年第1期3卷 136-148页

作者： Xiaoteng Zhou Pranav Sudersan diego Diaz Benjamin Leibauer Chirag Hinduja Fahimeh Darvish Pravash Bista Lukas Hauer Manfred Wagner Werner Steffen Jie Liu Michael Kappl Hans‐Jürgen Butt Max Planck Institute for Polymer Research MainzGermany Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijingChina School of Chemical Sciences University of Chinese Academy of SciencesBeijingChina

Due to poor chemical robustness,superhydrophobic surfaces become susceptible to failure,especially in a highly oxidative *** ensure the longterm efficacy of these surfaces,a more stable and environmentally friendly coating is required to replace the conventional salinization ***,soottemplated surfaces with re‐entrant nanostructures are precoated with polydimethylsiloxane(PDMS)*** additional nanometer‐thick lubricant layer of PDMS was then applied to increase chemical *** surface is superhydrophobic with a nanoscale liquid *** the lubricant layer is thin,ridge formation is suppressed,which leads to low drop sliding friction and fast drop *** introducing a bottom“reservoir”of a free lubricant as an oil source for self‐replenishing to the upper layer,the superhydrophobic surface becomes more stable and heals spontaneously in response to alkali erosion and O2 plasma *** design also leads to a higher icing delay time and faster removal of impacting cooled water drops than for uncoated surfaces,preventing icing at low temperatures.

关键词： coating friction liquid

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Portal vein arterialization in 25 liver transplant recipients:A Latin American single-center experience

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World Journal of Transplantation 2024年第2期14卷 135-147页

作者： Nicolas Andres Cortes-Mejia Diana Fernanda Bejarano-Ramirez Juan Jose Guerra-Londono diego Rymel Trivino-Alvarez Raquel Tabares-Mesa Alonso Vera-Torres Division of Anesthesiology Critical Care Medicineand Pain MedicineThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Transplant and Hepatobiliary Surgery Department Fundacion Santa Fe de BogotaBogota 110111Colombia General Surgery Department Fundacion Santa Fe de BogotaBogota 110111Colombia

BACKGROUND Portal vein arterialization(PVA)has been used in liver transplantation(LT)to maximize oxygen delivery when arterial circulation is compromised or has been used as an alternative reperfusion technique for complex portal vein thrombosis(PVT).The effect of PVA on portal perfusion and primary graft dysfunction(PGD)has not been *** patients receiving PVA and LT at the Fundacion Santa Fe de Bogota between 2011 and 2022 were *** account for the time-sensitive effects of graft perfusion,patients were classified into two groups:prereperfusion(pre-PVA),if the arterioportal anastomosis was performed before graft revascularization,and postreperfusion(post-PVA),if PVA was performed *** pre-PVA rationale contemplated poor portal hemodynamics,severe vascular steal,or ***-PVA was considered if graft hypoperfusion became *** interventions were attempted before PVA.

关键词： Liver transplantation Portal vein arterialization Arteriovenous anastomoses Portal hypertension Portal vein thrombosis Spontaneous portosystemic shunts Vascular steal phenomenon Primary graft dysfunction Early allograft dysfunction

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Pembrolizumab autoimmune related diabetes:Moving forward,keep learning

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World Journal of Clinical Oncology 2024年第5期15卷 576-579页

作者： Jose Angel Garcia diego Alcaraz Esther Holgado Felipe Couñago Department of Medical Oncology GenesisCare Spain-San Francisco de Asis University HospitalMadrid 28002Spain Department of Chief of Medical Oncology GenesisCare Spain-San Francisco de Asis University HospitalMadrid 28002Spain Department of Chief of Radiation Oncology GenesisCare-Vithas La Milagrosa HospitalMadrid 28010Spain

Immune checkpoint inhibitors(and more specifically programmed cell death 1/programmed cell death ligand 1 inhibitors as Pembrolizumab)initiated a revolution in the field of melanoma and have now expanded to several tumor subtypes and in increasingly broader clinical contexts,including the adjuvant and neoadjuvant setting,with potentially curable patients and prolonged *** side effects related to these drugs include a wide spectrum of manifestations,with endocrinological adverse events being some of the most ***-induced type 1 diabetes mellitus is an infrequent but potentially serious and not clearly reversible side effect that possesses characteristic clinical features and has high morbidity and mortality,with a chronic impact on quality of *** etiopathogenesis of this phenomenom needs to be further investigated and a collaborative effort through the involvement of oncologists and other medical specialists is necessary for the correct identification and management of patients at risk.

关键词： Immune checkpoints Pembrolizumab Immunotherapy Side effects Endocrine system Diabetes mellitus

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Olympic Games and 24-hour movement behaviors:A match worth making

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Journal of Sport and Health Science 2024年第6期13卷 728-731页

作者： Mark S.Tremblay Nicholas Kuzik Markus J.Duncan diego Augusto Santos Silva CHEO Research Institute OttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Federal University of Santa Catarina FlorianopolisSanta Catarina 88040-900Brazil

*** The Olympic motto,"Faster,Higher,Stronger-Together",represents the pursuit of athletic excellence,united as a global community."Excellence,respect and friendship"are the Olympic *** the motto and values are multifaceted and holistic in nature,and all-encompassing in their reach while recognizing no single entity rises above the ***,these foundational statements anchor the Olympic movement in its quest to build a better world through sport.

关键词： movement Together pursuit

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Rainfall Sensitivity to Microphysics and Planetary Boundary Layer Parameterizations in Convection-Permitting Simulations over Northwestern South America

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Journal of Meteorological Research 2024年第4期38卷 805-825页

作者： K.Santiago hernandez Sebastian GOMEZ-RIOS Juan J.HENAO Vanessa ROBLEDO Alvaro RAMiREZ-CARDONA Angela M.RENDON Geolimna Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Grupo de Ingenieria y Gestion Ambiental(GIGA) Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Division of Atmospheric Sciences Desert Research InstituteRenoNV 89512USA

Convection-permitting modeling allows us to understand mechanisms that influence rainfall in specific ***,microphysics parameterization(MP) and planetary boundary layer(PBL) schemes remain an important source of uncertainty,affecting rainfall intensity,occurrence,duration,and ***,we study the sensitivity of rainfall to three MP [Weather Research and Forecasting(WRF) Single-Moment 6-class(WSM6),Thompson,and Morrison] and two PBL [the Yonsei University(YSU) and Mellor–Yamada Nakanishi Niino(MYNN)] schemes with a convection-permitting resolution(4 km) over northwestern South America(NWSA).Simulations were performed by using the WRF model and the results were evaluated against soundings,rain gauges,and satellite data,considering the spatio-temporal variability of rainfall over diverse regions prone to deep convection in *** and PBL schemes largely influenced simulated rainfall,with better results for the less computationally expensive WSM6 MP and YSU PBL *** rain gauges and satellite estimates,simulations with Morrison MP overestimated rainfall,especially westward of the Andes,whereas the MYNN PBL underestimated precipitation in the Amazon–Savannas *** found that the uncertainty in the rainfall representation is highly dependent on the region,with a higher influence of MP in the Colombian Pacific and PBL in the Amazon–Savannas *** analyzing rainfall-related processes,the selection of both MP and PBL parameterizations exerted a large influence on the simulated lower tropospheric moisture flux and moisture *** schemes significantly influenced the downward shortwave radiation,with MYNN simulating a greater amount of low clouds,which decreased the radiation ***,latent heat fluxes were greater for YSU,favoring moist convection and *** schemes had a marked impact on vertical ***,Morrison MP showed stronger convection and higher precipitation rates,which is assoc

关键词： sensitivity microphysics planetary boundary layer(PBL) Weather Research and Forecasting(WRF) processes

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High-repetition-rate source of nanosecond duration kA-current pulses driven by relativistic laser pulses

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High Power Laser Science and Engineering 2024年第3期12卷 106-115页

作者： Michael Ehret Jakub Cikhardt Philip Wykeham Bradford Iuliana-Mariana Vladisavlevici Tomas Burian diego de Luis Jose Luis Henares Rubén Hernández Martín Jon Imanol Apiñaniz Roberto Lera JoséAntonio Pérez-Hernández João Jorge Santos Giancarlo Gatti Centro de Láseres Pulsados(CLPU) VillamayorSpain Czech Technical University in Prague Faculty of Electrical EngineeringPragueCzech Republic Univ.Bordeaux-CNRS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance Department of Radiation and Chemical Physics FZU-Institute of Physics of the Czech Academy of SciencesPragueCzech Republic

We report the first high-repetition-rate generation and simultaneous characterization of nanosecond-scale return currents of kA-magnitude issued by the polarization of a target irradiated with a PW-class high-repetition-rate titanium:sapphire laser system at relativistic *** present experimental results obtained with the VEGA-3 laser at intensities from5×10^(18)to 1.3×10^(20)W cm^(-2).A non-invasive inductive return-current monitor is adopted to measure the derivative of return currents of the order of kA ns-1and analysis methodology is developed to derive return *** compare the current for copper,aluminium and Kapton targets at different laser *** data show the stable production of current peaks and clear prospects for the tailoring of the pulse shape,which is promising for future applications in highenergy-density science,for example,electromagnetic interference stress tests,high-voltage pulse response measurements and charged particle beam *** compare the target discharge of the order of hundreds of nC with theoretical predictions and a good agreement is found.

关键词： current pulses electromagnetic pulse application high-power laser relativistic laser plasma

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Towards precision 24-hour movement behavior recommendations—The next new paradigm?

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Journal of Sport and Health Science 2024年第6期13卷 743-748页

作者： Mark S.Tremblay Markus J.Duncan Nicholas Kuzik diego Augusto Santos Silva Valerie Carson CHEO Research Institute OttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Federal University of Santa Catarina Santa Catarina 88040900Brazil Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmontonAB T6G 2H9Canada

*** The importance of physical activity(PA)for health is unequivocal.^(1)Accordingly,population-based recommendations for exercise,and more recently public health guidelines for PA,have been developed and released by authoritative groups for many decades.^(2)Such guidelines emerged with leadership from the exercise physiology discipline and were rooted in,and loyal to,the importance of moderate-to-vigorous intensity PA(MVPA)or exercise.

关键词： movement behavior exercise

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