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Preclinical Efficacy of Nimotuzumab, an Anti-Egfr Monoclonal Antibody as a Single Agent Therapy in Human GBM u87mg Xenografts

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Journal of Cancer Therapy 2012年第4期3卷 245-255页

作者： Arlhee diaz Rances Blanco Margit Lemm Iduna Fichtner Kalet Leon Enrique Montero Center of Molecular Immunology Havana Cuba Max Delbrück Center for Molecular Medicine. Berlin Germany

Background: The poor prognosis of patients with high-grade glioma multiform (GBM) has led investigators to the search of new therapeutic strategies. Current treatment includes surgery when possible, radiotherapy and chemotherapy. Molecular-targeted therapies are in the process of clinical testing, and promising agents include monoclonal antibodies. Our study examined the antitumor activity of three different single therapies in nude mice bearing both subcutaneous and orthotopic brain xenografts of the U87MG human GBM cell line. Methods: Cell culture, Histology, Immunohistochemistry, Animal experiments, Statistical analysis. Results: Different groups of treatment included nimotuzumab, a humanized monoclonal antibody that inhibits the EGFR tyrosine kinase activity, or total body irradiation, or the chemotherapeutic agent temozolomide (TMZ). For the control group animals received saline solution instead of the antibody. For the subcutaneous model, only nimotuzumab or TMZ produced a significant delay in tumor growth. In the intracranial model, unlike TMZ, the systemic administration of the antibody did not reduce the tumor growth, despite both therapies inhibited the formation of microsatellites in the brain of mice. The antitumor activity of nimotuzumab was accompanied by a decrease in the microvessel density and the proliferative activity of tumor cells. TMZ only inhibited the tumor cell proliferation but not the formation of new tumor-associated microvessels in xenografts. For radiation therapy, neither antiproliferative nor antiangiogenic activity was found, in accordance with the lack of antitumor activity. Only nimotuzumab reduced the frequency of chemo and radioresistant CD133+ population. Conclusion: Our results illustrate the potential efficacy of nimotuzumab as a single agent against an EGFR-amplified human GBM, a tumor resistant to the therapy with all well-known forms of treatment.

关键词： CD133 Epidermal Growth Factor Receptor Glioblastoma Multiforme Nimotuzumab Radiation Temozolomide

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根据血清ckMB水平型式识别心肌梗塞的扩展

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吉林医学 1988年第6期 374-374页

作者： diaz CaslellanosMA 张密林

本文研究141名急性心梗患者,在入院的前5天进行监护。每8小时连续监测血清 ck和 ckMB 水平。ckMB 正常范围低于10u/L。ckMB 在最初峰值后再升高大于10u/L 定为不正常的 ckMB 再升高。据 ckMB 演变形式,将患者分为:A 组:表现为 ckMB 水... 详细信息

本文研究141名急性心梗患者,在入院的前5天进行监护。每8小时连续监测血清 ck和 ckMB 水平。ckMB 正常范围低于10u/L。ckMB 在最初峰值后再升高大于10u/L 定为不正常的 ckMB 再升高。据 ckMB 演变形式,将患者分为:A 组:表现为 ckMB 水平恢复至正常范围前再升高,B 组:表现为 ckMB水平恢复至正常范围后再升高;C 组:无

关键词： ckMB 血清

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Measurement of Ξcc++ production in pp collisions at s1/2=13 TeV

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Chinese Physics C 2020年第2期44卷 13-23页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves Jr S.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann J.J.Back S.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi V.Batozskaya B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin S.Belin V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim S.Benson S.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom M.S.Bieker S.Bifani P.Billoir A.Bizzeti M.Bjørn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk T.J.V.Bowcock C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calero diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani R.Cenci J.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs S.Coquereau G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska A.Crocombe M.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo J.Dalseno C.D' Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3UniversitéParis-SaclayOrsayFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly INFN Sezione di Padova PadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakówPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakówPoland Nationa

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4 详细信息

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4ck^-π^+ π^+decay relative to the prompt ∧^+c production cross-section is found to be(2.22±0.27±0.29)×10^-4,assuming the central value of the measured lifetime,where the first uncertainty is statistical and the second systematic.

关键词： doubly charmed baryons hadron production QCD

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