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Effects of temperature and precipitation on drought trends in Xinjiang, china

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Journal of Arid Land 2024年第8期16卷 1098-1117页

作者： YANG Jianhua li Yaqian ZHOU lei zhang Zhenqing ZHOU Hongkui WU Jianjun Academy of Eco-civilization Development for Jing-Jin-Ji Megalopolis Tianjin Normal UniversityTianjin 300387China School of Geomatics and Urban Spatial Informatics Beijing University of Civil Engineering and ArchitectureBeijing 100044China Institute of Digital Agriculture Zhejiang Academy of Agricultural SciencesHangzhou 310021China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China

The characteristics of drought in Xinjiang Uygur Autonomous Region(Xinjiang),china have changed due to changes in the spatiotemporal patterns of temperature and precipitation,however,the effects of temperature and precipitation—the two most important factors influencing drought—have not yet been thoroughly explored in this *** this study,we first calculated the standard precipitation evapotranspiration index(SPEI)in Xinjiang from 1980 to 2020 based on the monthly precipitation and monthly average *** the spatiotemporal characteristics of temperature,precipitation,and drought in Xinjiang from 1980 to 2020 were analyzed using the Theil-sen median trend analysis method and Mann-Kendall test.A series of SPEI-based scenario-setting experiments by combining the observed and detrended climatic factors were utilized to quantify the effects of individual climatic factor(i.e.,temperature and precipitation).The results revealed that both temperature and precipitation had experienced increasing trends at most meteorological stations in Xinjiang from 1980 to 2020,especially the spring temperature and winter *** to the influence of temperature,trends of intensifying drought have been observed at spring,summer,autumn,and annual *** addition,the drought trends in southern Xinjiang were more notable than those in northern *** 1980 to 2020,temperature trends exacerbated drought trends,but precipitation trends alleviated drought trends in *** meteorological stations in Xinjiang exhibited temperature-dominated drought trend except in winter;in winter,most stations exhibited precipitation-dominated wetting *** findings of this study highlight the importance of the impact of temperature on drought in Xinjiang and deepen the understanding of the factors influencing drought.

关键词： standardized precipitation evapotranspiration index(SPEI) climate change drought characteristics trend analysis arid area temperature trend contribution analysis

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Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging

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Protein & Cell 2024年第8期15卷 612-632页

作者： Qinchao Hu Bin zhang Yaobin Jing Shuai Ma lei Hu jingyi li Yandong Zheng Zijuan Xin Jianmin Peng Si Wang Bin Cheng Jing Qu Weiqi zhang Guang-Hui liu Songlin Wang State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou 510060China Salivary Gland Disease Center and beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Laboratory of Oral Health and Beijing Stomatological HospitalCapital Medical UniversityBeijing 100050China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China university of Chinese Academy of sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuan Wu HospitalCapital Medical UniversityBeijing 100053China Intemational Center for Aging and Cancer Hainan Medical UniversityHaikou 571199China Aging Biomarker Consortium Beijing 100101China

Aging has a profound impact on the gingiva and significantly increases its susceptibility to periodontitis,a worldwide prevalent inflammatory ***,a systematic characterization and comprehensive understanding of the regulatory mechanism underlying gingival aging is still ***,we systematically dissected the phenotypic characteristics of gingiva during aging in primates and constructed the first single-nucleus transcriptomic landscape of gingival aging,by which a panel of cell type-specific signatures were *** cells were identified as the most affected cell types by aging in the *** analyses pinpointed the crucial role of YAP in epithelial self-renew and homeostasis,which declined during aging in epithelial cells,especially in basal *** decline of YAP activity during aging was confrmed in the human gingival tissues,and downregulation of YAP in human primary gingival keratinocytes recapitulated the major phenotypic defects observed in the aged primate gingiva while overexpression of YAP showed rejuvenation *** work provides an in-depth understanding of gingival aging and serves as a rich resource for developing novel strategies to combat aging-associated gingival diseases,with the ultimate goal of advancing periodontal health and promoting healthy aging.

关键词： single-nucleus RNA-sequencing primate gingiva aging YAP

Cloning and characterization of DcLEA1,a new member of carrot LEA gene family

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Progress in Natural Science:Materials International 2005年第3期 28-36页

作者： liu Yiming 1,2 ,diao Fengqiu 1 ,zhang lei 1 ,huaNG Meijuan 2 and WU Naihu 1ˇˇ (1.Institute of Genetics and Developmental Biology,Chinese Academy of sciences,beijing100080,china 2.college of life sciences,Peking university,beijing100871,china) Institute of Genetics and Developmental Biology，Chinese Academy of sciences，beijing 100080，china college of life sciences Peking University，Beijing 100871，China Institute of Genetics and Developmental Biology，Chinese Academy of sciences，beijing 100080，china college of life sciences Peking University，Beijing 100871，China

Using a modified cDNA representational difference analysis(RDA)method,a LEA gene fragment was isolated from the regulated carrot somatic embryo,which was used as the probe to screen the cDNA library of the regulated carrot somatic embryo and the genomic library constructed by the method of altering osmotic *** analysis showed that it is homologous to LEA gene family and designated as DcLEA1(GenBank number:AF308739),a new member of the carrot LEA gene *** transcription re-gion contains5′UTR,two exons,one intron and3′UTR region;its coding region is480bp long,coding for159amino acids and one stop *** hybridization indicated that DcLEA1gene was not expressed in the adult carrot but expressed at high levels in the regulated carrot somatic *** carrot somatic embryo which had been deregulated for12hours,the expression levels dropped rapid-ly;with the prolongation of deregulation,the radicle of carrot somatic embryo began to stretch,and the expression level of DcLEA1gene *** phenomenon is similar to the expression pattern of LEA gene in the course of dormancy and germination of the seed;thus suggesting that the sucrose regulation-deregulation system of the carrot somatic embryo can be used to mimic plant seed dormancy and ger-mination and can also be used to study the molecular mechanisms of these two biological processes.

关键词： carrot(Daucus carota L.) DcLEA1 development of radicle.

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-hua Wang Xiao-Tian zhang lei Tang Qi Wu Mu-Yan Cai Yuan-Fang li Xiu-Juan Qu Hong Qiu Yu-Jing zhang Jie-Er Ying Jun zhang ling-Yu Sun Rong-Bo lin Chang Wang Hao liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji Yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-lin Yuan Feng Bi Tian-Shu liu Han liang Yan-Qiao zhang Guo-Xin li Jun liang Bao-Rui liu lin Shen Jin li Rui-hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in china,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of china,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

Unveiling the secrets of gastrointestinal mucous adenocarcinoma survival after surgery with artificial intelligence:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2404-2418页

作者： Jie Song Xiang-Xiu Yan Fang-liang zhang Yong-Yi lei Zi-Yin Ke Fang li Kai zhang Yu-Qi He Wei li Chao li Yuan-Ming Pan Department of Gastroenterology Dongying People’s HospitalDongying Hospital of Shandong Provincial Hospital GroupDongying 257000Shandong ProvinceChina Gastrointestinal Surgery Department Suining Central HospitalSuining 629000Sichuan ProvinceChina Obstetrical Department Suining Central HospitalSuining 629000Sichuan ProvinceChina School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina Department of Pathology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China General Department Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Gastroenterology Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Thoracic Surgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Gastroenterology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

BACKGROUND Research on gastrointestinal mucosal adenocarcinoma(GMA)is limited and controversial,and there is no reference tool for predicting postoperative *** To investigate the prognosis of GMA and develop predictive *** From the Surveillance,Epidemiology,and End Results database,we collected clinical information on patients with *** random sampling,the patients were divided into the discovery(70%of the total,for model training),validation(20%,for model evaluation),and completely blind test cohorts(10%,for further model evaluation).The main assessment metric was the area under the receiver operating characteristic curve(AUC).All collected clinical features were used for Cox proportional hazard regression analysis to determine factors influencing GMA’s *** This model had an AUC of 0.7433[95% confidence intervals(95%CI):0.7424-0.7442]in the discovery cohort,0.7244(GMA:0.7234-0.7254)in the validation cohort,and 0.7388(95%CI:0.7378-0.7398)in the test *** packaged it into Windows software for doctors’use and uploaded *** gastric adenocarcinoma had the worst prognosis,and these were protective factors of GMA:Regional nodes examined[hazard ratio(HR):0.98,95%CI:0.97-0.98,P1]and chemotherapy(HR:0.62,95%CI:0.58-0.66,P1).CONCLUSION The deep learning-based tool developed can accurately predict the overall survival of patients with GMA *** surgery,chemotherapy,and adequate lymph node dissection during surgery can improve patient outcomes.

关键词： Deep learning Gastrointestinal mucous adenocarcinoma Overall survival Surgery Clinical tool

Roadmap for rechargeable batteries:present and beyond

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Science china Chemistry 2024年第1期67卷 13-42页

作者： sen Xin Xu zhang lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang huang Xinbo zhang Yu Su Yao Xiao Shu-lei Chou Shilin zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng lei Jianxiong Zhao Jiayi Wang Dong Su Yu-Guo Guo Qiang zhang Jun Chen li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China university of Chinese Academy of sciences.beijing 100049 China Institute of Advanced Battery Materials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing 100124China beijing Key Laboratory of Green Chemical Reaction Engineering and technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChangchun 130022China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide 5000Australia Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China college of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Division of Energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chem

Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate *** to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable *** efforts are made to developing the next-generation post-li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow *** the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a *** roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable *** computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research.

关键词： energy storage rechargeable batteries battery materials electrochemistry

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Real-world data on ALK rearrangement test in Chinese advanced non-small cell lung cancer(RATICAL):a nationwide multicenter retrospective study

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Cancer Communications 2024年第9期44卷 992-1004页

作者： lin li Wencai li ChunyanWu Yanfeng Xi lei Guo Yuan Ji lili Jiang Ji li Jingping Yun Gang Chen Yuan li Yueping liu DianbinMu Yuchen Han leina Sun Qingxin Xia Xiaodong Teng Nanying Che WeiWu Xueshan Qiu Chao liu Xiaochu Yan Daiqiang li Zhihong zhang ZheWang Yujun li ZhengWang lingchuan Guo Xiu Nie Jingshu Geng Jianhua Zhou Jianming Ying Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking UnionMedical CollegeBeijingP.R.China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Pathology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiP.R.China Department of Pathology Cancer Hospital Affiliated to Shanxi Medical UniversityShanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesTaiyuanShanxiP.R.China Department of Pathology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of Pathology West China Hospital of Sichuan UniversityChengduSichuanP.R.China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Pathology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Pathology Department of OncologyFudan University Cancer CenterShanghaiMedical College of Fudan UniversityShanghaiP.R.China Department of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China Department of Pathology Shandong Cancer HospitalJinanShandongP.R.China Department of Pathology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pathology Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Department of Pathology the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Cancer HospitalZhengzhouHenanP.R.China Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Department of Pathology Bei

Background:Anaplastic lymphoma kinase(ALK)test in advanced non-small cell lung cancer(NSCLC)can help physicians provide target therapies for patients harboring ALK gene *** study aimed to investigate the real-world test patterns and positive rates of ALK gene rearrangements in advanced ***:In this real-world study(ChiCTR2000030266),patientswith advanced NSCLC who underwent an ALK rearrangement test in 30 medical centers in china between October 1,2018 and December 31,2019 were retrospectively *** training was conducted before the study was *** controls were performed at participating centers using immunohistochemistry(IHC)-*** positive ALK gene rearrangement rate and consistency rate were *** associated clinicopathological characteristics of ALK gene rearrangement were investigated as ***:The overall ALK gene rearrangement rate was 6.7%in 23,689 patients with advanced NSCLC and 8.2%in 17,436 patients with advanced lung *** quality control analysis of IHC-VENTANA-D5F3 revealed an intrahospital consistency rate of 98.2%(879/895)and an inter-hospital consistency rate of 99.2%(646/651).IHC-VENTANA-D5F3 was used in 53.6%,real-time polymerase chain reaction(RT-PCR)in 25.4%,next-generation sequencing(NGS)in 18.3%,and fluorescence in-situ hybridization(FISH)in 15.9%in the adenocarcinoma *** specimens tested with multiple methods,the consistency rates confirmed by IHC-VENTANA-D5F3 were 98.0%(822/839)for FISH,98.7%(1,222/1,238)forNGS,and 91.3%(146/160)for *** overall ALK gene rearrangement rateswere higher in females,patients of≤35 years old,never smokers,tumor cellularity of>50,and metastatic specimens used for testing in the total NSCLC population and adenocarcinoma subgroup(all Plights the real-world variability and challenges of ALK test in advanced NSCLC,demonstrating a predominant use of IHCVENTANA-D5F3 with high co

关键词： anaplastic lymphoma kinase diagnosis gene fusion non-small cell lung cancer

Probing dark matter particles from evaporating primordial black holes via electron scattering in the CDEX-10 experiment

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Science china(Physics,Mechanics & Astronomy) 2024年第10期67卷 83-91页

作者： Zhenhua zhang litao Yang Qian Yue Kejun Kang Yuanjing li Haipeng An Greeshma C. Jianping Chang Yunhua Chen Jianping Cheng Wenhan Dai Zhi Deng Changhao Fang Xinping Geng Hui Gong Qiuju Guo Tao Guo Xuyuan Guo li He Shengming He Jinwei Hu Hanxiong huang Tuchen huang lin Jiang S.Karmakar Haubin li Hanyu li Jianmin li Jin li Qianyun li Renmingjie li Xueqian li Yulan li Yifan liang Bin liao FongKay lin ShinTed lin Jiaxuan liu Shukui liu Yandong liu Yu liu Yuanyuan liu Hao Ma Yucai Mao Qiyuan Nie Jinhua Ning Hui Pan Ningchun Qi Jie Ren Xichao Ruan Monoj Kumar Singh Tianxi Sun Changjian Tang Yang Tian Guangfu Wang Junzheng Wang li Wang Qing Wang Yufeng Wang Yunxiang Wang Henry Tsz-King Wong Shiyong Wu Yucheng Wu Haoyang Xing Rui Xu Yin Xu Tao Xue Yulu Yan Nan Yi Chunxu Yu Haijun Yu Jianfeng Yue Ming Zeng Zhi Zeng Bingtao zhang Fengshou zhang lei zhang Zhenyu zhang Jizhong Zhao Kangkang Zhao Minggang Zhao Jifang Zhou Zuying Zhou Jingjun Zhu CDEX Collaboration Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China college of Nuclear Science and technology Beijing Normal UniversityBeijing 100875China college of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Sino-French Institute of Nuclear and technology Sun Yet-sen UniversityZhuhai 519082China School of Physics Nankai UniversityTianjin 300071China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China 不详

Dark matter(DM)is a major constituent of the ***,no definite evidence of DM particles(denoted as“χ”)has been found in DM direct detection(DD)experiments to *** is a novel concept of detectingχfrom evaporating primordial black holes(PBHs).We search forχemitted from PBHs by investigating their interaction with target *** examined PBH masses range from 1×10^(15)to 7×10^(16)g under the current limits of PBH abundance *** 205.4 kg·day data obtained from the CDEX-10 experiment conducted in the china Jinping Underground Laboratory,we exclude theχ-electron(χ-e)elastic-scattering cross sectionσ_(χe)~5×10^(-29)cm^(2)forχwith a mass■keV from our *** the higher radiation background but lower energy threshold(160 eV),CDEX-10 fills a part of the gap in the previous ***(m_(χ),σ_(χe))can be determined in the future,DD experiments are expected to impose strong constraints on fPBHfor large MPBHs.

关键词： CDEX primordial black hole light dark matter particle dark matter-electron scattering high purity germanium detector

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Cloning and expression of DnaJ homolog in carrot somatic embryo

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Progress in Natural Science:Materials International 2003年第5期 32-38页

作者： YANG Zhipan, zhang lei, diao Fengqiu, huaNG Meijuan and WU Naihu ( 1. Institute of Genetics and Developmental Biology, Chinese Academy of sciences, beijing 100080, china 2. college of life sciences Peking university, beijing 100871, china) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100080 China college of life sciences Peking University Beijing 100871 China

As the co-chaperone of DnaK/Hsp70 protein, DnaJ/Hsp40 protein influences the synthesis and assembly of the protein complex by regulating ATPase activity of DnaK/Hsp70 protein. By employing the modified method of cDNA representational difference analysis, a homologous fragment of DnaJ was isolated from the deregulated carrot somatic embryos, and it was further used as the probe to screen the cDNA library of carrot somatic embryo deregulated for 12 h. As the result, DcJ1 gene, the homologous gene of DnaJ, was isolated from carrot. Sequence analysis showed that its coding region is 1257 bp, which codes 418 amino acids and comprises 3 highly-conserved characteristic domains. Southern blot analysis suggested that the DcJ1 gene seems to be a single copy in the genome, while Northern blot result indicated that DcJ1 expresses only in roots and its degree of expression changes obviously with the regulation-deregulation process. These results suggest that DcJ1 is correlated with the early development of carrot so

关键词： Dna J carrot somatic embryo express regulation heat shock protein.