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Cloning and characterization of DcLEA1,a new member of carrot LEA gene family

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Progress in Natural Science:Materials International 2005年第3期 28-36页

作者： liu Yiming 1,2 ,diao Fengqiu 1 ,zhang lei 1 ,huaNG Meijuan 2 and WU Naihu 1ˇˇ (1.Institute of Genetics and Developmental Biology,Chinese Academy of sciences,beijing100080,china 2.college of life sciences,Peking university,beijing100871,china) Institute of Genetics and Developmental Biology，Chinese Academy of sciences，beijing 100080，china college of life sciences Peking University，Beijing 100871，China Institute of Genetics and Developmental Biology，Chinese Academy of sciences，beijing 100080，china college of life sciences Peking University，Beijing 100871，China

Using a modified cDNA representational difference analysis(RDA)method,a LEA gene fragment was isolated from the regulated carrot somatic embryo,which was used as the probe to screen the cDNA library of the regulated carrot somatic embryo and the genomic library constructed by the method of altering osmotic *** analysis showed that it is homologous to LEA gene family and designated as DcLEA1(GenBank number:AF308739),a new member of the carrot LEA gene *** transcription re-gion contains5′UTR,two exons,one intron and3′UTR region;its coding region is480bp long,coding for159amino acids and one stop *** hybridization indicated that DcLEA1gene was not expressed in the adult carrot but expressed at high levels in the regulated carrot somatic *** carrot somatic embryo which had been deregulated for12hours,the expression levels dropped rapid-ly;with the prolongation of deregulation,the radicle of carrot somatic embryo began to stretch,and the expression level of DcLEA1gene *** phenomenon is similar to the expression pattern of LEA gene in the course of dormancy and germination of the seed;thus suggesting that the sucrose regulation-deregulation system of the carrot somatic embryo can be used to mimic plant seed dormancy and ger-mination and can also be used to study the molecular mechanisms of these two biological processes.

关键词： carrot(Daucus carota L.) DcLEA1 development of radicle.

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-hua Wang Xiao-Tian zhang lei Tang Qi Wu Mu-Yan Cai Yuan-Fang li Xiu-Juan Qu Hong Qiu Yu-Jing zhang Jie-Er Ying Jun zhang ling-Yu Sun Rong-Bo lin Chang Wang Hao liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji Yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-lin Yuan Feng Bi Tian-Shu liu Han liang Yan-Qiao zhang Guo-Xin li Jun liang Bao-Rui liu lin Shen Jin li Rui-hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in china,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of china,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

Real-world data on ALK rearrangement test in Chinese advanced non-small cell lung cancer(RATICAL):a nationwide multicenter retrospective study

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Cancer Communications 2024年第9期44卷 992-1004页

作者： lin li Wencai li ChunyanWu Yanfeng Xi lei Guo Yuan Ji lili Jiang Ji li Jingping Yun Gang Chen Yuan li Yueping liu DianbinMu Yuchen Han leina Sun Qingxin Xia Xiaodong Teng Nanying Che WeiWu Xueshan Qiu Chao liu Xiaochu Yan Daiqiang li Zhihong zhang ZheWang Yujun li ZhengWang lingchuan Guo Xiu Nie Jingshu Geng Jianhua Zhou Jianming Ying Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking UnionMedical CollegeBeijingP.R.China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Pathology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiP.R.China Department of Pathology Cancer Hospital Affiliated to Shanxi Medical UniversityShanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesTaiyuanShanxiP.R.China Department of Pathology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of Pathology West China Hospital of Sichuan UniversityChengduSichuanP.R.China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Pathology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Pathology Department of OncologyFudan University Cancer CenterShanghaiMedical College of Fudan UniversityShanghaiP.R.China Department of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China Department of Pathology Shandong Cancer HospitalJinanShandongP.R.China Department of Pathology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pathology Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Department of Pathology the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Cancer HospitalZhengzhouHenanP.R.China Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Department of Pathology Bei

Background:Anaplastic lymphoma kinase(ALK)test in advanced non-small cell lung cancer(NSCLC)can help physicians provide target therapies for patients harboring ALK gene *** study aimed to investigate the real-world test patterns and positive rates of ALK gene rearrangements in advanced ***:In this real-world study(ChiCTR2000030266),patientswith advanced NSCLC who underwent an ALK rearrangement test in 30 medical centers in china between October 1,2018 and December 31,2019 were retrospectively *** training was conducted before the study was *** controls were performed at participating centers using immunohistochemistry(IHC)-*** positive ALK gene rearrangement rate and consistency rate were *** associated clinicopathological characteristics of ALK gene rearrangement were investigated as ***:The overall ALK gene rearrangement rate was 6.7%in 23,689 patients with advanced NSCLC and 8.2%in 17,436 patients with advanced lung *** quality control analysis of IHC-VENTANA-D5F3 revealed an intrahospital consistency rate of 98.2%(879/895)and an inter-hospital consistency rate of 99.2%(646/651).IHC-VENTANA-D5F3 was used in 53.6%,real-time polymerase chain reaction(RT-PCR)in 25.4%,next-generation sequencing(NGS)in 18.3%,and fluorescence in-situ hybridization(FISH)in 15.9%in the adenocarcinoma *** specimens tested with multiple methods,the consistency rates confirmed by IHC-VENTANA-D5F3 were 98.0%(822/839)for FISH,98.7%(1,222/1,238)forNGS,and 91.3%(146/160)for *** overall ALK gene rearrangement rateswere higher in females,patients of≤35 years old,never smokers,tumor cellularity of>50,and metastatic specimens used for testing in the total NSCLC population and adenocarcinoma subgroup(all Plights the real-world variability and challenges of ALK test in advanced NSCLC,demonstrating a predominant use of IHCVENTANA-D5F3 with high co

关键词： anaplastic lymphoma kinase diagnosis gene fusion non-small cell lung cancer

Probing dark matter particles from evaporating primordial black holes via electron scattering in the CDEX-10 experiment

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Science china(Physics,Mechanics & Astronomy) 2024年第10期67卷 83-91页

作者： Zhenhua zhang litao Yang Qian Yue Kejun Kang Yuanjing li Haipeng An Greeshma C. Jianping Chang Yunhua Chen Jianping Cheng Wenhan Dai Zhi Deng Changhao Fang Xinping Geng Hui Gong Qiuju Guo Tao Guo Xuyuan Guo li He Shengming He Jinwei Hu Hanxiong huang Tuchen huang lin Jiang S.Karmakar Haubin li Hanyu li Jianmin li Jin li Qianyun li Renmingjie li Xueqian li Yulan li Yifan liang Bin liao FongKay lin ShinTed lin Jiaxuan liu Shukui liu Yandong liu Yu liu Yuanyuan liu Hao Ma Yucai Mao Qiyuan Nie Jinhua Ning Hui Pan Ningchun Qi Jie Ren Xichao Ruan Monoj Kumar Singh Tianxi Sun Changjian Tang Yang Tian Guangfu Wang Junzheng Wang li Wang Qing Wang Yufeng Wang Yunxiang Wang Henry Tsz-King Wong Shiyong Wu Yucheng Wu Haoyang Xing Rui Xu Yin Xu Tao Xue Yulu Yan Nan Yi Chunxu Yu Haijun Yu Jianfeng Yue Ming Zeng Zhi Zeng Bingtao zhang Fengshou zhang lei zhang Zhenyu zhang Jizhong Zhao Kangkang Zhao Minggang Zhao Jifang Zhou Zuying Zhou Jingjun Zhu CDEX Collaboration Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China college of Nuclear Science and technology Beijing Normal UniversityBeijing 100875China college of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Sino-French Institute of Nuclear and technology Sun Yet-sen UniversityZhuhai 519082China School of Physics Nankai UniversityTianjin 300071China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China 不详

Dark matter(DM)is a major constituent of the ***,no definite evidence of DM particles(denoted as“χ”)has been found in DM direct detection(DD)experiments to *** is a novel concept of detectingχfrom evaporating primordial black holes(PBHs).We search forχemitted from PBHs by investigating their interaction with target *** examined PBH masses range from 1×10^(15)to 7×10^(16)g under the current limits of PBH abundance *** 205.4 kg·day data obtained from the CDEX-10 experiment conducted in the china Jinping Underground Laboratory,we exclude theχ-electron(χ-e)elastic-scattering cross sectionσ_(χe)~5×10^(-29)cm^(2)forχwith a mass■keV from our *** the higher radiation background but lower energy threshold(160 eV),CDEX-10 fills a part of the gap in the previous ***(m_(χ),σ_(χe))can be determined in the future,DD experiments are expected to impose strong constraints on fPBHfor large MPBHs.

关键词： CDEX primordial black hole light dark matter particle dark matter-electron scattering high purity germanium detector

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Cloning and expression of DnaJ homolog in carrot somatic embryo

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Progress in Natural Science:Materials International 2003年第5期 32-38页

作者： YANG Zhipan, zhang lei, diao Fengqiu, huaNG Meijuan and WU Naihu ( 1. Institute of Genetics and Developmental Biology, Chinese Academy of sciences, beijing 100080, china 2. college of life sciences Peking university, beijing 100871, china) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100080 China college of life sciences Peking University Beijing 100871 China

As the co-chaperone of DnaK/Hsp70 protein, DnaJ/Hsp40 protein influences the synthesis and assembly of the protein complex by regulating ATPase activity of DnaK/Hsp70 protein. By employing the modified method of cDNA representational difference analysis, a homologous fragment of DnaJ was isolated from the deregulated carrot somatic embryos, and it was further used as the probe to screen the cDNA library of carrot somatic embryo deregulated for 12 h. As the result, DcJ1 gene, the homologous gene of DnaJ, was isolated from carrot. Sequence analysis showed that its coding region is 1257 bp, which codes 418 amino acids and comprises 3 highly-conserved characteristic domains. Southern blot analysis suggested that the DcJ1 gene seems to be a single copy in the genome, while Northern blot result indicated that DcJ1 expresses only in roots and its degree of expression changes obviously with the regulation-deregulation process. These results suggest that DcJ1 is correlated with the early development of carrot so

关键词： Dna J carrot somatic embryo express regulation heat shock protein.

The passivation role of the Si based film on the crystallinesillicon substrate

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The passivation role of the Si based film on the crystalline...

基于特征优选和机器学习的塔里木盆地东缘绿洲土壤镉元素含量预测及健康风险评价

第二届晶体硅太阳电池及材料科学与技术国际研讨会

作者： zhangyan12 Zhao lei1 diao hongweit Zeng xiangboa Zhou chunlan1 Wang wenjing1 Guo bei2 zhang bing2 li hongyuan2 Institute of electrician Chinese Academy of sciences HaiDian District beijing 100083 china School of Material Science and Engineering Hebei university of technology Tianjin 300130 china. Institute of Semiconductors Chinese Academy of sciences HaiDian District beijing 100083 china.

＜正＞Combination of characteristics of both crystalline and thin film Si,the amorphous /crystalline silicon heterojunction solar cells have attracted a growing amount of attention because of its low-temperature processes,high efficiency,and low cost *** solar cells were considered as interfacial *** the photo-carrier generation occurs mostly in the c-Si, it is known that the interface recombination between c-Si/a-Si:H,the surface passivation of the crystalline silicon substrate is a critical *** amorphous silicon film on texturised c-Si heterojunction solar cells with 20.1% efficiency developed by Sanyo were achieved by insert a thin hydrogenated amorphous silicon（a-Si:H） buffer *** goal of the paper is to research the the passivation role of the si based film on the crystalline silicon *** Deposite a series of thin film silicon layers on polished crystalline silicon substrate by *** influence of RF power,substrate temperature,hydrogen dilution and gas pressure have been systematically investigated on the properties of Si based *** the construction of the Si based films by laman spectrum and test the minority carrier lifetime by *** is found that the minority carrier lifetime of the silicon substrate became much better than *** shows that the Si based films play an important role on the passivation of the silicon substrate。And the passivation is related to the microstructure of the si based film,the best passivation role can be achieved by Complete amorphous si based *** also showed in this paper about the direction to make better si based films by PECVD.

关键词： PECVD passivation thin film

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环境科学 2024年第8期45卷 4802-4811页

作者：刘靖宇李若怡梁永春刘磊尹芳唐塑何林森张毅长安大学地球科学与资源学院西安710054 中国地质调查局乌鲁木齐自然资源综合调查中心乌鲁木齐830057 中国自然资源航空物探遥感中心北京100083 长安大学土地工程学院西安710054 中国地质调查局西安矿产资源调查中心西安710100

土壤重金属污染对粮食安全、人类健康和土壤生态系统均造成重大威胁.基于塔里木盆地东缘典型绿洲区获取的644个土壤样品,运用多元线性回归(LR)、神经网络(BP)、随机森林(RF)、支持向量机(SVM)和基于径向基函数神经网络(RBF)方法构建土... 详细信息

土壤重金属污染对粮食安全、人类健康和土壤生态系统均造成重大威胁.基于塔里木盆地东缘典型绿洲区获取的644个土壤样品,运用多元线性回归(LR)、神经网络(BP)、随机森林(RF)、支持向量机(SVM)和基于径向基函数神经网络(RBF)方法构建土壤重金属预测模型,利用最优预测结果分析重金属污染的空间分布特征与健康风险.结果表明:①研究区ω(Cd)均值为0.14 mg·kg^(-1),是新疆土壤背景值的1.17倍,是区内土壤重金属污染的主要因子;区内成人和儿童Cd元素致癌风险系数均小于10~(-4),对人类无明显的长期健康风险影响.②对比5种反演模型的预测精度,RF模型验证集R^(2)值为0.7637,在5种模型中最大;且其RMSE、MAE和MBE值在5种模型中最小,土壤Cd元素实测值与RF模型的预测值拟合效果最佳.同时,基于RF模型的研究区土壤Cd含量空间分布预测结果与实测样点插值结果具有较好的一致性.③在土壤Cd元素健康风险预测中,RF模型对成人与儿童的反演精度均优于其他4种模型,预测结果较好;LR模型验证集预测值变化幅度大,预测结果较差.综上,RF模型具有较好的泛化能力和抗过拟合能力,为研究区土壤Cd含量预测和健康风险评价的最优模型.

关键词：镉(Cd) 含量预测健康风险评价机器学习特征优选

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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao zhang Jun-Zheng Wang li-Tao Yang Qian Yue Ke-Jun Kang Yuan-Jing li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo li He Sheng-Ming He Jin-Wei Hu Han-Xiong huang Tu-Chen huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin li Jian-Min li Jin li Qian-Yun li Ren-Ming-Jie li Xue-Qian li Yu-Lan li Yi-Fan liang Bin liao Fong-Kay lin Shin-Ted lin Jia-Xuan liu Shu-Kui liu Yan-Dong liu Yu liu Yuan-Yuan liu Zhong-Zhi liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang li Wang Qing Wang Yu-Feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-Yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou zhang lei zhang Zhen-hua zhang Zhen-Yu zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 college of Nuclear Science and technology Beijing Normal UniversityBeijing 100875 college of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the china Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

The spectrum of rare monogenic diseases in patients with premature coronary artery disease

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Chinese Medical Journal 2024年第10期137卷 1246-1248页

作者： Yaqun Teng Tian Du Siqin Feng Ran Tian Yaping liu Jian Guo lei Wang Zhiyu zhang Xiaodong Luan Shan He Shengsheng Zhuang Yifei Wang Shuyuan zhang Shi Chen Zhenyu liu Shuyang zhang Department of Cardiology State Key Laboratory of Complex Severe and Rare diseasePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Internal Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Basic Medical sciences Tsinghua University School of MedicineBeijing 100084China Department of Breast Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China McKusick-zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Tsinghua university-Peking university Joint Center for life sciences Beijing 100084China Department of Cardiology Beijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 102218China Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Research Center for Behavior Medicine in Growth and DevelopmentBeijing 100730China

To the Editor:The global burden of premature coronary artery disease(CAD)is increasing among the young *** CAD generally refers to the occurrence of obstructive coronary atherothrombotic lesions in men and women aged1]The incidence of CAD in the younger population has remained stable or has increased,despite the declining incidence in older *** with premature CAD have a poor long-term prognosis,experiencing a high rate of recurrent ischemic events,rapid progression to multivessel disease,and frequent premature death.[1]Thus,it is crucial to identify the underlying causes of premature CAD that are distinct from those of age-related CAD and improve patient outcomes through precise diagnosis and treatment.

关键词： premature younger precise

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