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Chinese Journal of Natural Medicines 2024年第2期22卷 112-126页

作者： REN Boxue LI Yang di lei CHENG Ranran LIU Lijuan LI Hongmei LI Yi TANG Zhangrui YAN Yongming LU Tao FU Rong CHENG Yongxian WU Zhaoqiu State Key Laboratory of Natural Medicines Department of PharmacologySchool of PharmacyChina Pharmaceutical UniversityNanjing 211198China Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhen 518060China

The tumor suppressor protein p53 is central to cancer biology,with its pathway reactivation emerging as a promising therapeutic strategy in *** study introduced LZ22,a novel compound that selectively inhibits the growth,migration,and metastasis of tumor cells expressing wild-type p53,demonstrating ineffectiveness in cells devoid of p53 or those expressing mutant ***22’s mechanism of action involves a high-affinity interaction with the histidine-96 pocket of the MDM2 *** interaction disrupted the MDM2-p53 binding,consequently stabilizing p53 by shielding it from proteasomal ***22 impeded cell cycle progression and diminished cell proliferation by reinstating the p53-dependent suppression of the CDK2/Rb signaling ***,LZ22 alleviated the p53-dependent repression of Snail transcription factor expression and its consequent EMT,effectively reducing tumor cell migration and distal ***,LZ22 administration in tumor-bearing mice did not manifest notable side *** findings position LZ22 as a structurally unique reactivator of p53,offering therapeutic promise for the management of human cancers with wild-type TP53.

关键词： LZ22 Wild-type p53 p53 Reactivator Snail-driven EMT Tumor growth and metastasis

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网络视角下航空公司竞争态势及影响因素研究

复杂系统与复杂性科学 2024年第1期21卷 66-73,84页

作者：汪瑜雷迪于娇娇温国兵中国民用航空飞行学院经济与管理学院四川广汉618307

为剖析疫情时期中国国内主要客运航空公司竞争格局和竞争优势的影响因素,利用TOPSIS-熵值法和修正Huff模型量化航空公司在航线上的竞争优势强度,构建基于优势强度的航空公司-航线赋权二分网络,从网络的视角对航空公司竞争优势市场划分... 详细信息

为剖析疫情时期中国国内主要客运航空公司竞争格局和竞争优势的影响因素,利用TOPSIS-熵值法和修正Huff模型量化航空公司在航线上的竞争优势强度,构建基于优势强度的航空公司-航线赋权二分网络,从网络的视角对航空公司竞争优势市场划分及其静态特征进行研究,利用Tobit回归模型剖析竞争优势的影响因素。研究表明:在疫情时期航空公司多市场接触程度较低,三大航空公司竞争优势明显,其优势在城市分布上差异巨大,主要集中在其基地城市。HU、3U等航空公司在市场竞争中优势不明显,更多表现为竞争且主要围绕沿海二线城市展开;航空公司竞争优势受到多因素共同制约,疫情时期收益更多表示成本控制的能力,低成本航空公司9C相较HU、3C等航空公司更具优势。

关键词：竞争态势航空公司-航线赋权二分网络 TOPSIS-熵值法修正Huff模型社团 Tobit模型

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回归热的研究进展

中国兽医科学 2024年第1期54卷 109-114页

作者：雷迪刘倩陈润秋方仁东王鸿志西南大学动物医学院动物健康与动物性食品安全国际合作联合实验室重庆400715 国家生猪技术创新中心重庆协同创新研究院重庆402460

回归热(RF)是一种全球范围内被忽视的人畜共患的自然疫源性疾病。由于非特异性临床症状、诊断技术不完善、抗生素的广泛使用等因素,该病对我国公共卫生安全的威胁未得到足够的重视。伴随抗生素的临床应用管理,全球化背景下的人口流动,... 详细信息

回归热(RF)是一种全球范围内被忽视的人畜共患的自然疫源性疾病。由于非特异性临床症状、诊断技术不完善、抗生素的广泛使用等因素,该病对我国公共卫生安全的威胁未得到足够的重视。伴随抗生素的临床应用管理,全球化背景下的人口流动,回归热可能呈现新的流行趋势。为提高医护人员、科研人员对回归热的认识,本文对回归热的致病性、流行病学、诊断监测技术等进行了系统综述,以期为有效提升回归热防控水平提供有价值的参考。

关键词：回归热疏螺旋体致病性诊断监测防制

MestReNova软件在二维核磁共振谱图教学中的应用

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广州化工 2024年第10期52卷 139-140,143页

作者：邸磊李自然童婧李宁安徽医科大学药学院安徽合肥230032

二维核磁共振谱(two dimensional NMR spectoscopy, 2D-NMR)是近代核磁共振技术发展最快的领域之一,方便了科研工作者鉴定复杂有机化合物的结构。本文以化合物Scabrol B为例,介绍MestReNova软件在《波谱解析》课程中2D-NMR谱图讲解时的... 详细信息

二维核磁共振谱(two dimensional NMR spectoscopy, 2D-NMR)是近代核磁共振技术发展最快的领域之一,方便了科研工作者鉴定复杂有机化合物的结构。本文以化合物Scabrol B为例,介绍MestReNova软件在《波谱解析》课程中2D-NMR谱图讲解时的使用方法。通过软件的介入,在教学过程中使复杂的2D-NMR谱图变得直观、易懂,易于培养学生分析、解决问题的能力。引入MestReNova软件的教学方式提供了一种理论结合实际应用的知行合一教学模式,加深了学生对知识点的理解和掌握,提升了《波谱解析》教学质量。

关键词： MestReNova 波谱解析软件应用二维核磁共振谱图教学

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可支持协议扩展的语义解析网关研究

制造业自动化 2024年第6期46卷 29-35页

作者：卢耀鹏王美林邸江磊广东工业大学信息工程学院广东广州510006

物联网设备之间通过不同的通信协议进行数据传输与信息交互。针对设备异构通信协议相互理解问题,深入研究了多工业协议解析技术,研究并实现了一种可支持协议扩展的语义解析网关。网关定义了多种工业协议解析脚本、开发了词法分析和语法... 详细信息

物联网设备之间通过不同的通信协议进行数据传输与信息交互。针对设备异构通信协议相互理解问题,深入研究了多工业协议解析技术,研究并实现了一种可支持协议扩展的语义解析网关。网关定义了多种工业协议解析脚本、开发了词法分析和语法分析程序、生成对应的协议解析指令集和实现了解析脚本执行程序和解析数据输出,建立了整体的语义解析系统。网关通过定义不同协议的解析脚本对不同协议的数据报文进行语义解析,析出的语义数据可以直接被设备或者云端应用,从而实现了更加灵活的数据传输和信息交互。网关通过扩展解析脚本来支持对协议扩展,不需要针对每种协议单独设计解析程序,极大地减少了协议解析程序开发的难度和工作量,更符合当前及未来物联网发展的趋势。通过对网关性能进行可靠性和实时性测试实验,验证了网关对工业协议解析转换稳定可靠及时。

关键词：工业智能网关协议解析语义解析物联网

Recent progress of cobalt-based electrocatalysts for water splitting: Electron modulation, surface reconstitution, and applications

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Nano Research 2024年第4期17卷 2234-2269页

作者： Zhijian Liang di Shen lei Wang Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

Electrocatalytic water splitting is an essential and effective means to produce green hydrogen energy structures,so it is necessary to develop non-precious metal catalysts to replace precious ***-based catalysts present effective alternatives due to the diverse valence states,adjustable electronic structures,and plentiful *** this review,the catalytic mechanisms of hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)for electrocatalytic water splitting are ***,the synthesis strategies of various cobalt-based catalysts are systematically summarized,followed by the relationships between the structure and performance ***,the effects of d-band center and spin regulation for cobalt-based catalysts are also ***,the dynamic electronic and structural devolution of cobalt-based catalysts are elucidated by combining a series of in-situ ***,we highlight the challenges and future developed directions of cobalt-based catalysts for electrocatalytic water splitting.

关键词： cobalt-based electrocatalysts water splitting electron modulation surface reconfiguration

鄂尔多斯盆地铁边城地区长2油层组剩余油模拟

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科学技术与工程 2024年第5期24卷 1799-1807页

作者：张晓明吴勤博邹焰王皓立韩明郭龙飞狄晓磊屈乐中国石油长庆油田分公司第八采油厂西安710069 西安市致密油(页岩油)重点实验室(西安石油大学) 西安710065

为了实现油田增储上产及老井挖潜的目标,提升剩余油资源开发潜力,通过岩心、薄片、电镜、物性、模拟方法系统的研究了鄂尔多斯盆地西北部姬塬油田铁边城地区长2段主力油层的剩余油分布特征。研究显示,长2_(1)^(3-2)和长2_(1)^(3-3)小层... 详细信息

为了实现油田增储上产及老井挖潜的目标,提升剩余油资源开发潜力,通过岩心、薄片、电镜、物性、模拟方法系统的研究了鄂尔多斯盆地西北部姬塬油田铁边城地区长2段主力油层的剩余油分布特征。研究显示,长2_(1)^(3-2)和长2_(1)^(3-3)小层为主力产油层,平均厚度分别为12.2 m及11.1 m。目的层砂岩储层的孔隙度通常介于12%~18%,渗透率则通常低于8 mD。根据相控原则,建立了主力产层的物理属性模型及流体模型;进而,开展了剩余油分布数值模拟研究。通过基于实测产水及产油量约束的历史生产曲线拟合,获得了剩余油的纵横向分布结果。研究显示,剩余油分布受砂体边界、物性差异及注采关系的影响。剩余油整体上成片分布;但是,受油藏物性差异的影响,注水多呈不均匀受效,因而造成局部剩余油富集。剩余油主要分布在砂体边界处,这些区域无井网控制,因而水驱程度低,剩余油分布较多。受长期注采的影响,井间会形成高渗区,这些其余类似高速通道,会发生快速水淹,其周边则形成剩余油滞留区。可见,剩余油富集明显受微相、物性、注水及井网因素的控制。

关键词：鄂尔多斯盆地长2段三维模型数值模拟剩余油

Molecular engineering binuclear copper catalysts for selective CO_(2) reduction to C_(2) products

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Journal of Energy Chemistry 2024年第6期93卷 166-173,I0005页

作者： Qi Zhao Kai lei Bao Yu Xia Rachel Crespo-Otero Devis di Tommaso Department of Chemistry School of Physical and Chemical SciencesQueen Mary University of LondonLondonE14NSUK Key Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education) Hubei Key Laboratory of Material Chemistry and Service FailureState Key Laboratory of Materials Processing and Die&Mould TechnologySchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074HubeiChina Department of Chemistry University College LondonLondonWC1H 0AJUK digital Environment Research Institute Queen Mary University of LondonEmpire HouseLondon E11HHUK

Molecular copper catalysts serve as exemplary models for correlating the structure-reaction-mechanism relationship in the electrochemical CO_(2) reduction(eCO_(2)R),owing to their adaptable environments surrounding the copper metal *** investigation,employing density functional theory calculations,focuses on a novel family of binuclear Cu molecular *** modulation of their coordination configuration through the introduction of organic groups aims to assess their efficacy in converting CO_(2) to C_(2)*** findings highlight the crucial role of chemical valence state in shaping the characteristics of binuclear Cu catalysts,consequently influencing the eCO_(2)R behaviour,Notably,the Cu(Ⅱ)Cu(Ⅱ)macrocycle catalyst exhibits enhanced suppression of the hydrogen evolution reaction(HER),facilitating proton trans fer and the eCO_(2)R *** rthermore,we explo re the impact of diverse electro n-withdrawing and electron-donating groups coordinated to the macrocycle(R=-F,-H,and-OCH_3)on the electron distribution in the molecular *** placement of-OCH_3 groups in the macrocycles leads to a favourable oxidation state of the Cu centres and subsequent C-C coupling to form C_(2) *** research provides fundamental insights into the design and optimization of binuclear Cu molecular catalysts for the electrochemical conversion of CO_(2) to value-added C_(2) products.

关键词： Molecular catalyst design Selective CO_(2)reduction C_(2)products Density functional theory calculations

Apple SINA11-JAZ2 module is involved in jasmonate signaling response

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Journal of Integrative Plant Biology 2024年第7期66卷 1270-1273页

作者： di Ai lei Zhao Chun-Xiang You Yuepeng Han Jian-Ping An State Key Laboratory of Plant diversity and Specialty Crops CAS Key Laboratory of Plant Germplasm Enhancement and Specialty AgricultureWuhan Botanical Garden of Chinese Academy of SciencesWuhan 430074China Hubei Hongshan Laboratory Wuhan 430070China University of Chinese Academy of Sciences Beijing 100049China Apple Technology Innovation Center of Shandong Province College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-An 271018China

Jasmonic acid(JA)is an important phytolipid hormone involved in regulating many processes of plant growth and development,and plays a key role in plant resistance to biotic and abiotic *** the first discovery of methy... 详细信息

关键词： nat Apple involv

Stigma-Specific Comparative Proteomic Analysis Reveals the distyly Response to Self-Incompatibility in Plumbago auriculata Lam

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 681-697页

作者： di Hu Shouli Yi di Lin Suping Gao Ting lei Wenji Li Tingdan Xu Songlin Jiang School of Fine Arts and Calligraphy Sichuan Normal UniversityChengdu610000China Sichuan Certification and Accreditation Association Chengdu610000China College of Landscape Architecture Sichuan Agricultural UniversityChengdu610000China School of Design Chongqing Industry Polytechnic CollegeChongqing401120China

In plants,heteromorphic self-incompatibility(HetSI)is a strategy for avoiding self-pollination and promoting outcrossing,and during this process,numerous protein-protein interaction events occur between the pistil and *** studies in Primula and Fagopyrum that focused on HetSI systems have provided interesting insights;however,the molecular mechanism underlying HetSI remains largely *** this study,we profiled the proteome of Plumbago auriculata stigmas before and after self-incompatible(SI)and self-compatible(SC)*** analyses were conducted by 4D-diA(Four-dimensional data independent acquisition),a promising technology that increases the sensitivity and reduces the spectral complexity of proteomic analysis by adding a fourth dimension,ion *** results revealed 33387 peptides and 5311 proteins in all *** pathways in which the differentially expressed proteins(DEPs)identified in the P×P(Pin style self-pollinated with pin pollen)***(Pin style)and T×T(Thrum style self-pollinated with thrum pollen)***(Thrum style)comparisons were significantly enriched were biosynthesis of secondary metabolites and pentose and glucuronate *** the P×T(Pin style cross-pollinated with thrum pollen)*** and T×P(Thrum style cross-pollinated with pin pollen)*** comparison,the top three pathways were biosynthesis of secondary metabolites,pentose and glucuronate interconversions,and phenylpropanoid *** phenylpropanoid biosynthesis,cutin,suberine and wax biosynthesis,and flavonoid biosynthesis pathways were enriched in the P×T vs.P×P comparison,and starch and sucrose metabolism,glycerophospholipid metabolism,and alpha-linolenic acid metabolism were abundant in the T×T vs.T×P *** enriched pathways between PS and TS were the biosynthesis of secondary metabolites,phenylpropanoid biosynthesis,and pentose and glucuronate ***-incompatibility protein S1(SI S1),Mitogen-activated protein ki

关键词： Heteromorphic self-incompatibility Plumbago auriculata proteomics 4D-diA