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Efficient multi-level fault simulation of HW/SW systems for structural faults

Science China(Information Sciences) 2011年第9期54卷 1784-1796页

作者： BARANOWSKI Rafal di carlo stefano HATAMI Nadereh IMHOF Michael E. KOCHTE Michael A. PRINETTO Paolo WUNDERLICH Hans-Joachim ZOELLIN Christian G. University of Stuttgart Institute of Computer Architecture and Computer Engineering Politecnico di Torino Dipartimento di Automatica e Informatica

In recent technology nodes,reliability is increasingly considered a part of the standard design flow to be taken into account at all levels of embedded systems *** traditional fault simulation techniques based on low-level models at gate-and register transfer-level offer high accuracy,they are too inefficient to properly cope with the complexity of modern embedded ***,they do not allow for early exploration of design alternatives when a detailed model of the whole system is not yet available,which is highly required to increase the efficiency and quality of the design ***-level models that combine the simulation efficiency of high abstraction models with the accuracy of low-level models are therefore essential to efficiently evaluate the impact of physical defects on the *** paper proposes a methodology to efficiently implement concurrent multi-level fault simulation across gate-and transaction-level models in an integrated simulation *** leverages state-of-the-art techniques for efficient fault simulation of structural faults together with transaction-level *** combination of different models allows to accurately evaluate the impact of faults on the entire hardware/software system while keeping the computational effort ***,since only selected portions of the system require low-level models,early exploration of different design alternatives is efficiently *** results obtained from three case studies are presented to demonstrate the high accuracy of the proposed method when compared with a standard gate/RT mixed-level approach and the strong improvement of simulation time which is reduced by four orders of magnitude in average.

关键词： fault simulation multi-level transaction-level modeling

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FunMod: A Cytoscape Plugin for Identifying Functional Modules in Undirected Protein–Protein Networks

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Genomics,Proteomics & Bioinformatics 2014年第4期12卷 178-186页

作者： Massimo Natale Alfredo Benso stefano di carlo Elisa Ficarra Department of Control and Computer Engineering Politecnico di Torino

The characterization of the interacting behaviors of complex biological systems is a primary objective in protein–protein network analysis and computational biology. In this paper we present FunMod, an innovative Cytoscape version 2.8 plugin that is able to mine undirected protein–protein networks and to infer sub-networks of interacting proteins intimately correlated with relevant biological pathways. This plugin may enable the discovery of new pathways involved in diseases. In order to describe the role of each protein within the relevant biological pathways, FunMod computes and scores three topological features of the identified sub-networks. By integrating the results from biological pathway clustering and topological network analysis, FunMod proved to be useful for the data interpretation and the generation of new hypotheses in two case studies.

关键词： Systems biology Network analysis Pathway analysis Network modules Cytoscape Budd–Chiari syndrome

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Colorectal cancer and lymph nodes:The obsession with the number 12

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World Journal of Gastroenterology 2014年第8期20卷 1951-1960页

作者： Giovanni Li Destri Isidoro di carlo Roberto Scilletta Beniamino Scilletta stefano Puleo Department of Surgical Sciences Organ Transplantation and Advanced TechnologiesUniversity of Catania95123 CataniaItaly

Lymphadenectomy of colorectal cancer is a decisive factor for the prognostic and therapeutic staging of the patient. For over 15 years, we have asked ourselves if the minimum number of 12 examined lymph nodes (LNs) was sufficient for the prevention of understaging. The debate is certainly still open if we consider that a limit of 12 LNs is still not the gold standard mainly because the research methodology of the first studies has been criticized. Moreover many authors report that to date both in the United States and Europe the number “12” target is uncommon, not adequate, or accessible only in highly specialised centres. It should however be noted that both the pressing nature of the debate and the dissemination of guidelines have been responsible for a trend that has allowed for a general increase in the number of LNs examined. There are different variables that can affect the retrieval of LNs. Some, like the surgeon, the surgery, and the pathology exam, are without question modifiable; however, other both patient and disease-related variables are non-modifiable and pose the question of whether the minimum number of examined LNs must be individually assigned. The lymph nodal ratio, the sentinel LNs and the study of the biological aspects of the tumor could find valid application in this field in the near future.

关键词： Colorectal cancer Lymphadenectomy Lymph node count Lymph node ratio Staging

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Histologic evaluation of bone healing of adjacent alveolar sockets grafted with bovineand porcine-derived bone:a comparative case report in humans

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Regenerative Biomaterials 2017年第2期4卷 125-128页

作者： Renzo Guarnieri Patricia DeVilliers Maurizio Grande Luigi Vito Stefanelli stefano di carlo Giorgio Pompa Adjunct Professor Department of Dental and Maxillofacial SciencesSchool of DentistryUniversity La SapienzaRomeItaly Adjunct Assistant Professor of Pathology University of Alabama at BirminghamBirminghamALUSA Private Dental Implant Practice RomaItaly Assistant Professor Department of Dental and Maxillofacial SciencesSchool of DentistryUniversity La SapienzaRomeItaly Professor director Department of Dental and Maxillofacial SciencesSchool of DentistryUniversity La SapienzaRomeItaly.

To evaluate and compare histomorphometrically the bone response to two xenografts,one bovine and the other porcine,grafted in adjacent extraction sockets in a *** this case report,two adjacent maxillary premolars were extracted,and the sockets were filled with two different xenogeneic bone substitutes(first premolar with bovine bone,and second premolar with porcine bone)to counteract post-extraction volume *** 6 months bone core specimens were harvested during the placement of implants at the regenerated ***,for the bovine xenograft the percentage of newly formed bone(osteoid)was 26.85%,the percentage of the residual graft material was 17.2%and the percentage of connective tissue 48.73%,while for the porcine xenograft,newly formed bone(osteoid)represented 32.19%,residual graft material was 6.57%and non-mineralized connective tissue was 52.99%.Histological results indicated that both biomaterials assessed in this study as grafts for socket preservation technique are biocompatible and *** bone derived demonstrated to be less resorbable than porcine bone *** xenogenic biomaterials did not interfere with the normal bone reparative processes.

关键词： socket preservation bovine bone-derived porcine bone-derived histology

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Development of a prognostic scoring system for resectable hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第36期22卷 8194-8202页

作者： carlo Sposito stefano di Sandro Federica Brunero Vincenzo Buscemi carlo Battiston Andrea Lauterio Marco Bongini Luciano De Carlis Vincenzo Mazzaferro Gastrointestinal Surgery and Liver Transplantation Fondazione IRCCS Istituto Nazionale Tumori University of Milan General Surgery and Organ Transplants Ospedale Niguarda Ca’Granda20133 Milan Italy Clinical Trial Office and Biomedical Statistic Fondazione IRCCS Istituto Nazionale Tumori

AIM To develop a prognostic scoring system for overall survival(OS) of patients undergoing liver resection(LR) for hepatocellular carcinoma(HCC).METHODS Consecutive patients who underwent curative LR for HCC between 2000 and 2013 were identified. The series was randomly divided into a training and a validation set. A multivariable Cox model for OS was fitted to the training set. The beta coefficients derived from the Cox model were used to define a prognostic scoring system for OS. The survival stratification was then tested, and the prognostic scoring system was compared with the European Association for the Study of the Liver(EASL)/American Association for the Study of Liver diseases(AASLD) surgical criteria by means of Harrell's C *** A total of 917 patients were considered. Five variables independently correlated with post-LR survival: Model for End-stage Liver disease score, hepatitis C virus infection, number of nodules, largest diameter and vascular invasion. Three risk classes were identified, and OS for the three risk classes was significantly different both in the training(P ding to EASL/AASLD. Survival of patients in the low-risk class was not significantly different compared with surgical indication for EASL/AASLD guidelines(77.2 mo vs 82.5 mo respectively, P = 0.22). Comparison of Harrell's C statistics revealed no significant difference in predictive power between the two systems(-0.00999, P = 0.667).CONCLUSION This study established a new prognostic scoring system that may stratify HCC patients suitable for surgery, expanding surgical eligibility with respect to EASL/AASLD criteria with no harm on survival.

关键词： Hepatocellular carcinoma Liver resection Liver cirrhosis Prognosis Survival study

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FunMod： A Cytoscape Functional Modules in Networks Plugin for Identifying Undirected Protein-Protein

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Genomics, Proteomics & Bioinformatics 2014年第4期12卷 178-186页

作者： Massimo Natale Alfredo Benso stefano di carlo Elisa Ficarra Department of Control and Computer Engineering Politecnico di Torino Torino 10128 Italy

The characterization of the interacting behaviors of complex biological systems is a pri- mary objective in protein protein network analysis and computational biology. In this paper we present FunMod, an innovative Cytoscape version 2.8 plugin that is able to mine undirected pro- rein-protein networks and to infer sub-networks of interacting proteins intimately correlated with relevant biological pathways. This plugin may enable the discovery of new pathways involved in dis- eases. In order to describe the role of each protein within the relevant biological pathways, FunMod computes and scores three topological features of the identified sub-networks. By integrating the results from biological pathway clustering and topological network analysis, FunMod proved to be useful for the data interpretation and the generation of new hypotheses in two case studies.

关键词： Systems biology Network analysis Pathway analysis Network modules Cytoscape Budd Chiari syndrome

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Metal-Halide Perovskite Submicrometer-Thick Films for Ultra-Stable Self-Powered direct X-Ray Detectors

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Nano-Micro Letters 2024年第9期16卷 410-431页

作者： Marco Girolami Fabio Matteocci Sara Pettinato Valerio Serpente Eleonora Bolli Barbara Paci Amanda Generosi stefano Salvatori Aldo di carlo Daniele M.Trucchi CNR‑ISM Consiglio Nazionale delle RicercheIstituto di Struttura della MateriaSede Secondaria di MontelibrettiDiaTHEMA LabStrada Provinciale 35D900010 MontelibrettiRomeItaly CHOSE–Centre for Hybrid and Organic Solar Energy Department of Electronic EngineeringUniversity of Rome“Tor Vergata”Via del Politecnico 100133 RomeItaly Faculty of Engineering Universita degli Studi Niccolo CusanoVia don Carlo Gnocchi 300166 RomeItaly SpecXLab CNR‑ISMConsiglio Nazionale Delle RicercheIstituto di Struttura Della MateriaArea della Ricerca di Tor VergataVia del Fosso del Cavaliere 10000133 RomeItaly

Metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective ***-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin ***,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection *** it is shown that self-powered direct X-ray detectors,fabricated starting from a FAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent *** structural modification is observed after irradiation with a total ionizing dose of almost 200 Gy,revealing an unexpectedly high radiation hardness for a metal-halide perovskite thin *** addition,trap-assisted photoconductive gain enabled the device to achieve a record bulk sensitivity of 7.28 C Gy^(−1)cm^(−3)at 0 V,an unprecedented value in the field of thin-film-based photoconductors and photodiodes for“hard”***,prototypal validation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced.

关键词： Metal-halide perovskite thin films direct X-ray detectors Self-powered devices Operational stability Medical linear accelerator

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Valorisation of industrial hemp (Cannabis sativa L.) residues and cheese whey into volatile fatty acids for single cell protein production

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Environmental Science and Ecotechnology 2024年第5期21卷 369-380页

作者： carlo Moscariello Silvio Matassa Francesco Pirozzi Giovanni Esposito stefano Papirio Department of Civil Architectural and Environmental EngineeringUniversity of Napoli Federico IIvia Claudio 2180125NapoliItaly

The production of single cell protein(SCP)using lignocellulosic materials stands out as a promising route in the circular bioeconomy ***,multiple steps are necessary for lignocellulosics-to-SCP processes,involving chemical pretreatments and specific aerobic *** there are no studies that investigated the SCP production from lignocellulosics by using only biological processes and microbial biomass able to work both anaerobically and *** this view,the valorisation of industrial hemp(Cannabis sativa L.)biomass residues(HBRs),specifically hurds and a mix of leaves and inflorescences,combined with cheese whey(CW)was investigated through a semi-continuous acidogenic co-fermentation process(co-AF).The aim of this study was to maximise HBRs conversion into VFAs to be further used as carbon-rich substrates for SCP *** process conditions were tested by either removing CW or increasing the amount of HBRs in terms of VS(i.e.,two and four times)to evaluate the performance of the co-AF *** HBRs resulted in a proportional increase in VFA production up to 3115 mg HAc L^(-1),with experimental production nearly 40%higher than theoretical *** synergy between HBRs and CW was demonstrated,proving the latter as essential to improve the biodegradability of the *** produced VFAs were subsequently tested as substrates for SCP synthesis in batch aerobic tests.A biomass concentration of 2.43 g TSS L^(-1) was achieved with a C/N ratio of 5.0 and a pH of 9.0 after two days of aerobic fermentation,reaching a protein content of 42%(g protein per g TSS).These results demonstrate the overall feasibility of the VFA-mediated HBR-to-SCP valorisation process.

关键词： Hemp biomass residues Cheese whey Volatile fatty acids Acidogenic fermentation Single cell protein

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Testing cable system reliability after commissioning and during operation life:in medio stat virtus?

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High Voltage 2021年第1期6卷 34-41页

作者： Gian carlo Montanari Paolo Seri Riddhi Ghosh stefano Franchi Bononi Marco Albertini Center for Advanced Power Systems Florida State University2000 Levy Avenue FLUSA DEI University of BolognaViale del RisorgimentoBolognaItaly Prysmian S.p.A. Via ChieseMilanItaly

Quality control,commissioning and diagnostic tests on insulation systems of electrical apparatus are necessary to reduce the failure risk under operation,eliminate infant mortality failures and reduce the impact of ageing on insulation system *** study tries to establish a path which,based on the statistical-phenomenological modelling of the hazard rate,or bathtub curve,drives in the choice of test overvoltage and *** choice of the test voltage and its waveform should be made carefully to improve reliability(reduce failure hazard)in any section of the bathtub *** may require,however,different choices depending on the section which corresponds to the planned *** example,large overvoltages could be acceptable to remove the infant mortality to ensure the highest reliability of newly commissioned apparatus,but they can incept highly energetic,and,thus,fast degradation mechanisms on apparatus operating on the field for a period of time,that can worsen,rather than improving,the insulation system *** to partial discharge measurement during any overvoltage test seems to be the optimal solution to find the most appropriate overvoltage for any type of testing need,leveraging the Latin concept that‘in medio stat virtus’.

关键词： apparatus insulation operation

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diagnosis of ruptured superior mesenteric artery aneurysm mimicking a pancreatic mass

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World Journal of Gastroenterology 2010年第18期16卷 2298-2301页

作者： stefano Palmucci Letizia Antonella Mauro Pietro Milone Francesco di stefano Antonino Scolaro Antonio di Cataldo Giovanni carlo Ettorre Department DOGIRA Section of Radiological Sciences"Policlinico-Vittorio Emanuele" University Hospital division of Phlebologic Vascular Surgery Hospital "Garibaldi Nesima" Department of General and Colorectal Surgery "Policlinico-Vittorio Emanuele" University Hospital

Aneurysms and pseudoaneurysms of the superior mesenteric artery are potentially lethal and should be treated as urgently as *** a 52-year-old man with occasional epigastric pain,we accidentally discovered a superior mesenteric artery aneurysm that was ruptured with spontaneous tamponade in the uncinate process and in the head of the *** ruptured aneurysm had a heterogeneous appearance due to its thrombotic and hemorrhagic content,and it simulated a voluminous mass in the head and uncinate process of the pancreas,associated with mild dilatation of the main pancreatic *** advances in multidetector computed tomography and magnetic resonance imaging have enabled radiologists to develop a correct diagnosis of mesenteric aneurysms and pseudoaneurysms of the visceral branches of the abdominal aorta,and to differentiate this diagnosis from that of pancreatic or peripancreatic masses;angiography is currently used to confirm a diagnosis and to develop therapeutic treatments.

关键词： Superior mesenteric artery Magnetic resonance imaging Computed tomography Ruptured aneurysm

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