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Chinese Journal of Natural Medicines 2024年第2期22卷 112-126页

作者： REN Boxue LI Yang di lei CHENG Ranran LIU Lijuan LI Hongmei LI Yi TANG Zhangrui YAN Yongming LU Tao FU Rong CHENG Yongxian WU Zhaoqiu State Key Laboratory of Natural Medicines Department of PharmacologySchool of PharmacyChina Pharmaceutical UniversityNanjing 211198China Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhen 518060China

The tumor suppressor protein p53 is central to cancer biology,with its pathway reactivation emerging as a promising therapeutic strategy in *** study introduced LZ22,a novel compound that selectively inhibits the growth,migration,and metastasis of tumor cells expressing wild-type p53,demonstrating ineffectiveness in cells devoid of p53 or those expressing mutant ***22’s mechanism of action involves a high-affinity interaction with the histidine-96 pocket of the MDM2 *** interaction disrupted the MDM2-p53 binding,consequently stabilizing p53 by shielding it from proteasomal ***22 impeded cell cycle progression and diminished cell proliferation by reinstating the p53-dependent suppression of the CDK2/Rb signaling ***,LZ22 alleviated the p53-dependent repression of Snail transcription factor expression and its consequent EMT,effectively reducing tumor cell migration and distal ***,LZ22 administration in tumor-bearing mice did not manifest notable side *** findings position LZ22 as a structurally unique reactivator of p53,offering therapeutic promise for the management of human cancers with wild-type TP53.

关键词： LZ22 Wild-type p53 p53 Reactivator Snail-driven EMT Tumor growth and metastasis

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网络视角下航空公司竞争态势及影响因素研究

复杂系统与复杂性科学 2024年第1期21卷 66-73,84页

作者：汪瑜雷迪于娇娇温国兵中国民用航空飞行学院经济与管理学院四川广汉618307

为剖析疫情时期中国国内主要客运航空公司竞争格局和竞争优势的影响因素,利用TOPSIS-熵值法和修正Huff模型量化航空公司在航线上的竞争优势强度,构建基于优势强度的航空公司-航线赋权二分网络,从网络的视角对航空公司竞争优势市场划分... 详细信息

为剖析疫情时期中国国内主要客运航空公司竞争格局和竞争优势的影响因素,利用TOPSIS-熵值法和修正Huff模型量化航空公司在航线上的竞争优势强度,构建基于优势强度的航空公司-航线赋权二分网络,从网络的视角对航空公司竞争优势市场划分及其静态特征进行研究,利用Tobit回归模型剖析竞争优势的影响因素。研究表明:在疫情时期航空公司多市场接触程度较低,三大航空公司竞争优势明显,其优势在城市分布上差异巨大,主要集中在其基地城市。HU、3U等航空公司在市场竞争中优势不明显,更多表现为竞争且主要围绕沿海二线城市展开;航空公司竞争优势受到多因素共同制约,疫情时期收益更多表示成本控制的能力,低成本航空公司9C相较HU、3C等航空公司更具优势。

关键词：竞争态势航空公司-航线赋权二分网络 TOPSIS-熵值法修正Huff模型社团 Tobit模型

Preparation and evaluation of aminopropyl-functionalized manganese-loaded SBA-15 for copper removal from aqueous solution

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Journal of Environmental Sciences 2015年第2期27卷 118-127页

作者： di lei Qianwen Zheng Yili Wang Hongjie Wang College of Environmental Science and Engineering Beijing Forestry University

A novel material, aminopropyl-functionalized manganese-loaded SBA-15（NH2-Mn-SBA-15）, was synthesized by bonding 3-aminopropyl trimethoxysilane（APTMS） onto manganeseloaded SBA-15（Mn-SBA-15） and used as a Cu2＋adsorbent in aqueous solution. Fourier transform infrared spectroscopy（FT-IR）, X-ray diffraction spectra（XRD）, N2adsorption/desorption isotherms, high resolution field emission scanning electron microscopy（FESEM）and X-ray photoelectron spectroscopy（XPS） were used to characterize the *** ordered mesoporous structure of SBA-15 was remained after modification. The manganese oxides were mainly loaded on the internal surface of the pore channels while the aminopropyl groups were mainly anchored on the external surface of SBA-15. The adsorption of Cu2＋on NH2-Mn-SBA-15 was fitted well by the Langmuir equation and the maximum adsorption capacity of NH2-Mn-SBA-15 for Cu2＋was over two times higher than that of Mn-SBA-15 under the same conditions. The Elovich equation gave a good fit for the adsorption process of Cu2＋by NH2-Mn-SBA-15 and Mn-SBA-15. Both the loaded manganese oxides and the anchored aminopropyl groups were found to contribute to the uptake of Cu2＋. The NH2-Mn-SBA-15 showed high selectivity for copper ions. Consecutive adsorption–desorption experiments showed that the NH2-Mn-SBA-15 could be regenerated by acid treatment without altering its properties.

关键词： Copper SBA-15 Manganese oxides Aminopropyl groups Adsorption

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回归热的研究进展

中国兽医科学 2024年第1期54卷 109-114页

作者：雷迪刘倩陈润秋方仁东王鸿志西南大学动物医学院动物健康与动物性食品安全国际合作联合实验室重庆400715 国家生猪技术创新中心重庆协同创新研究院重庆402460

回归热(RF)是一种全球范围内被忽视的人畜共患的自然疫源性疾病。由于非特异性临床症状、诊断技术不完善、抗生素的广泛使用等因素,该病对我国公共卫生安全的威胁未得到足够的重视。伴随抗生素的临床应用管理,全球化背景下的人口流动,... 详细信息

回归热(RF)是一种全球范围内被忽视的人畜共患的自然疫源性疾病。由于非特异性临床症状、诊断技术不完善、抗生素的广泛使用等因素,该病对我国公共卫生安全的威胁未得到足够的重视。伴随抗生素的临床应用管理,全球化背景下的人口流动,回归热可能呈现新的流行趋势。为提高医护人员、科研人员对回归热的认识,本文对回归热的致病性、流行病学、诊断监测技术等进行了系统综述,以期为有效提升回归热防控水平提供有价值的参考。

关键词：回归热疏螺旋体致病性诊断监测防制

MestReNova软件在二维核磁共振谱图教学中的应用

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广州化工 2024年第10期52卷 139-140,143页

作者：邸磊李自然童婧李宁安徽医科大学药学院安徽合肥230032

二维核磁共振谱(two dimensional NMR spectoscopy, 2D-NMR)是近代核磁共振技术发展最快的领域之一,方便了科研工作者鉴定复杂有机化合物的结构。本文以化合物Scabrol B为例,介绍MestReNova软件在《波谱解析》课程中2D-NMR谱图讲解时的... 详细信息

二维核磁共振谱(two dimensional NMR spectoscopy, 2D-NMR)是近代核磁共振技术发展最快的领域之一,方便了科研工作者鉴定复杂有机化合物的结构。本文以化合物Scabrol B为例,介绍MestReNova软件在《波谱解析》课程中2D-NMR谱图讲解时的使用方法。通过软件的介入,在教学过程中使复杂的2D-NMR谱图变得直观、易懂,易于培养学生分析、解决问题的能力。引入MestReNova软件的教学方式提供了一种理论结合实际应用的知行合一教学模式,加深了学生对知识点的理解和掌握,提升了《波谱解析》教学质量。

关键词： MestReNova 波谱解析软件应用二维核磁共振谱图教学

Downward surface shortwave radiation over the subtropical Asia-Pacific region simulated by CMIP5 models

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Atmospheric and Oceanic Science Letters 2017年第2期10卷 130-137页

作者： WANG lei-di LV Da-Ren College of Agriculture South China Agricultural University Guangzhou China Plateau Atmosphere and Environment Key Laboratory of Sichuan Province Chengdu University of Information Technology Chengdu China Key Laboratory of Middle Atmosphere and Global Environmental Observation Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China

The downward surface shortwave radiation （DSSR） over the subtropical Asia-Pacific region simulated by the historical experiments of 15 CMIPS models is evaluated in this *** simulated DSSR is compared against two satellite observational datasets, and the possible causes for the DSSR bias of the models are further investigated by dividing the subtropical Asia-Pacific region into five areas. Most of the CMIP5 models underestimate DSSR over the oceans, but overestimate DSSR over land. Aside from the Mediterranean-West Asia （MWA） and Central Asia （CA） areas, both the biases in annual and seasonal mean DSSR are well explained by the bias in surface shortwave cloud radiative forcing （CRF）, with an overestimation of the CRF effect over the subtropical North Pacific but an underestimation over other land regions. The effect of cloud plays a dominant role over the subtropical Asia-Pacific region, with relatively weaker influences over MWA and CA in boreal summer and fall.

关键词： CMIPS surface shortwave radiation cloud radiative forcing

Removal of Pb(Ⅱ) from aqueous solution by hydrous manganese dioxide:Adsorption behavior and mechanism

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Journal of Environmental Sciences 2013年第3期25卷 479-486页

作者： Meng Xu Hongjie Wang di lei Dan Qu Yujia Zhai Yili Wang College of Environmental Science and Engineering Beijing Forestry University Beijing Key Lab for Source Control Technology of Water Pollution

Hydrous manganese dioxide （HMO） synthesized by redox of potassium permanganate and hydrogen peroxide was used as an adsorbent for Pb（Ⅱ） *** specific surface area,pore volume and BJH pore diameter of the HMO were 79.31m2/g,0.07cm3/g and 3.38 nm,*** adsorption equilibrium at 298K could be well described by the Langmuir isotherm equation with q max value of 352.55mg/*** negative values of G and the positive values of H and S indicated the adsorption process was spontaneous and *** pseudo second-order equation could best fit the adsorption *** value of the calculated activation energy for Pb（Ⅱ） adsorption onto the HMO was 38.23 kJ/*** uptake of Pb（Ⅱ） by HMO was correlated with increasing surface hydroxyl group content and the main adsorbed speciation was PbOH＋.The final chemical state of Pb（Ⅱ） on the surface of HMO was similar to *** was a promising candidate for Pb（Ⅱ） removal from aqueous solution.

关键词： adsorption mechanism heavy metal manganese dioxide

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可支持协议扩展的语义解析网关研究

制造业自动化 2024年第6期46卷 29-35页

作者：卢耀鹏王美林邸江磊广东工业大学信息工程学院广东广州510006

物联网设备之间通过不同的通信协议进行数据传输与信息交互。针对设备异构通信协议相互理解问题,深入研究了多工业协议解析技术,研究并实现了一种可支持协议扩展的语义解析网关。网关定义了多种工业协议解析脚本、开发了词法分析和语法... 详细信息

物联网设备之间通过不同的通信协议进行数据传输与信息交互。针对设备异构通信协议相互理解问题,深入研究了多工业协议解析技术,研究并实现了一种可支持协议扩展的语义解析网关。网关定义了多种工业协议解析脚本、开发了词法分析和语法分析程序、生成对应的协议解析指令集和实现了解析脚本执行程序和解析数据输出,建立了整体的语义解析系统。网关通过定义不同协议的解析脚本对不同协议的数据报文进行语义解析,析出的语义数据可以直接被设备或者云端应用,从而实现了更加灵活的数据传输和信息交互。网关通过扩展解析脚本来支持对协议扩展,不需要针对每种协议单独设计解析程序,极大地减少了协议解析程序开发的难度和工作量,更符合当前及未来物联网发展的趋势。通过对网关性能进行可靠性和实时性测试实验,验证了网关对工业协议解析转换稳定可靠及时。

关键词：工业智能网关协议解析语义解析物联网

Observation and Simulation of Abnormal Transmittance over Yangbajing,Tibet

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Atmospheric and Oceanic Science Letters 2014年第3期7卷 190-197页

作者： WANG lei-di Lü Da-Ren HUO Juan Key Laboratory of Middle Atmosphere and Global Environmental Observation (LAGEO) Institute of Atmospheric PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences

Defining abnormal transmittance as the case where the magnitude of the shortwave flux transmittance is greater than 1.0,the authors used surface solar irradiance and all-sky images obtained at the Yangbajing site in Tibet to analyze the reasons for the occurrence of abnormal shortwave flux *** on the International Intercomparision of Three-dimensional Radiation Code(I3RC) Monte Carlo community model of three-dimensional radiative transfer,the authors also performed simulations at a nonabsorbing wavelength and an absorbing wavelength through a stratocumulus and a cumulus *** results showed the detection of abnormal transmittance on more than half the days,and the maximum transmittance was *** probability of the occurrence of abnormal transmittance appeared to be largest in summer,and on a daily basis was mainly at about noon local *** transmittance mainly appeared when clear sky and clouds co-existed,especially at the edges of broken clouds and nearby regions with clear-sky *** flux transmittance decreased as the solar zenith angle increased.

关键词： three-dimensional cloudsshortwave flux transmittanceMonte Carlo modelTibet

Recent progress of cobalt-based electrocatalysts for water splitting: Electron modulation, surface reconstitution, and applications

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Nano Research 2024年第4期17卷 2234-2269页

作者： Zhijian Liang di Shen lei Wang Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

Electrocatalytic water splitting is an essential and effective means to produce green hydrogen energy structures,so it is necessary to develop non-precious metal catalysts to replace precious ***-based catalysts present effective alternatives due to the diverse valence states,adjustable electronic structures,and plentiful *** this review,the catalytic mechanisms of hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)for electrocatalytic water splitting are ***,the synthesis strategies of various cobalt-based catalysts are systematically summarized,followed by the relationships between the structure and performance ***,the effects of d-band center and spin regulation for cobalt-based catalysts are also ***,the dynamic electronic and structural devolution of cobalt-based catalysts are elucidated by combining a series of in-situ ***,we highlight the challenges and future developed directions of cobalt-based catalysts for electrocatalytic water splitting.

关键词： cobalt-based electrocatalysts water splitting electron modulation surface reconfiguration