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Bronchoalveolar lavage fluid metagenomic next-generation sequencing assay for identifying pathogens in lung cancer patients

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BIOCELL 2024年第4期48卷 623-637页

作者： JIYU WANG HUIXIA LI deyuan zhou LIHONG BAI KEJING TANG Division of Pulmonary and Critical Care Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Institute of Pulmonary Diseases Sun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

Background:For patients with lung cancer,timely identiﬁcation of new lung lesions as infectious or non-infectious,and accurate identiﬁcation of pathogens is very important in improving OS of *** a new auxiliary examination,metagenomic next-generation sequencing(mNGS)is believed to be more accurate in diagnosing infectious diseases in patients without underlying diseases,compared with conventional microbial tests(CMTs).We designed this study toﬁnd out whether mNGS has better performance in distinguishing infectious and non-infectious diseases in lung cancer patients using bronchoalveolar lavageﬂuid(BALF).Materials and Methods:This study was a real-world retrospective review based on electronic medical records of lung cancer patients with bronchoalveolar lavage(BAL)and BALF commercial mNGS testing as part of clinical care from 1 April 2019 through 30 April 2022 at The First Afﬁliated Hospital of Sun Yat-sen University.164 patients were included in this *** were categorized into the pulmonary non-infectious disease(PNID)group(n=64)and the pulmonary infectious disease(PID)group(n=100)groups based onﬁnal ***:BALF mNGS increased the sensitivity rate by 60%compared to CMTs(81%vs.21%,p0.1).Among the patients with PID,bacteria were the most common cause of *** infections occurred in 32%of patients,and Pneumocystis Yersini was most *** with Tyrosine kinase inhibitors(TKIs)therapy possess longer overall survival(OS)than other anti-cancer agents,the difference between TKIs and immuno-checkpoint inhibitors(ICIs)was insigniﬁcant(median OS TKIs *** ***-angiogenic *** ***=76 vs.84 vs.61 vs.58 vs.60).Conclusions:our study indicates that BALF mNGS can add value by improving overall sensitivity in lung cancer patients with potential pulmonary infection,and was outstanding in identifying Pneumocystis *** could be able

关键词： Lung cancer Bronchoalveolar lavage fluid Metagenomic next-generation sequencing Infectious diseases

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基于嵌入式传感技术的混凝土结构概率损伤成像方法

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建筑结构学报 2024年第6期45卷 143-152页

作者：张明辉周德源何斌陈洪兵孔庆钊同济大学结构防灾减灾工程系上海200092 同济大学电子与信息工程学院上海200092 北京科技大学土木与资源工程学院北京100083 上海韧性城市与智能防灾工程技术研究中心上海200092

混凝土结构损伤的早期预警与精准量化是土木工程结构健康监测领域的热点。提出了一种基于嵌入式传感技术的混凝土结构概率损伤成像方法,通过对混凝土材料中骨料、砂浆基体以及界面过渡区的二维细观有限元建模,揭示了探测应力波在不均匀... 详细信息

混凝土结构损伤的早期预警与精准量化是土木工程结构健康监测领域的热点。提出了一种基于嵌入式传感技术的混凝土结构概率损伤成像方法,通过对混凝土材料中骨料、砂浆基体以及界面过渡区的二维细观有限元建模,揭示了探测应力波在不均匀性混凝土材料及损伤界面的传播机制。结合传感器阵列的损伤可视化机理,设计了一种嵌入式压电传感器阵列模块,为精准量化混凝土损伤,结合概率损伤成像方法,通过基线相减法和希尔伯特变换从探测信号中提取损伤散射波的传播时间信息,引入累积分布函数,实现对混凝土损伤区域的可视化重构。试验结果表明,嵌入式传感模块可实现对混凝土结构的三维损伤成像,且识别出损伤中心位置与真实损伤中心位置在二维投影面上的误差为1.0 cm,验证了该方法对混凝土损伤感知的有效性与准确性。相比于现有嵌入式稀疏分布传感器,多传感单元集成的阵列模块可明显提升对混凝土局部损伤的探知能力,同时降低传感器系统在服役期的运维成本。

关键词：结构健康监测混凝土结构细观有限元模型压电传感器嵌入式压电传感阵列模块概率损伤成像

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Study on the effect of the infill walls on the seismic performance of a reinforced concrete frame

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 507-517页

作者： Zhang Cuiqiang zhou Ying zhou deyuan Lu Xilin Research Institute of Structural Engineering and Disaster Reduction Tongji University Shanghai 200092 China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji University Shanghai 200092 China

Motivated by the seismic damage observed to reinforced concrete （RC） frame structures during the Wenchuan earthquake, the effect of infill walls on the seismic performance of a RC frame is studied in this paper. Infill walls, especially those made of masonry, offer some amount of stiffness and strength. Therefore, the effect of infill walls should be considered during the design of RC frames. In this study, an analysis of the recorded ground motion in the Wenehuan earthquake is performed. Then, a numerical model is developed to simulate the infill walls. Finally, nonlinear dynamic analysis is carried out on a RC frame with and without infill walls, respectively, by using CANNY software. Through a comparative analysis, the following conclusions can be drawn. The failure mode of the frame with infill walls is in accordance with the seismic damage failure pattern, which is strong beam and weak column mode. This indicates that the infill walls change the failure pattern of the frame, and it is necessary to consider them in the seismic design of the RC frame. The numerical model presented in this paper can effectively simulate the effect of infill walls on the RC frame.

关键词： infill walls RC frame structure strong column and weak beam strong beam and weak column nonlinear time history analysis

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Segment-wise learning control for trajectory tracking of robot manipulators under iteration-dependent periods

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Science China(Information Sciences) 2024年第3期67卷 155-166页

作者： Fan ZHANG deyuan MENG Kaiquan CAI The Seventh Research Division Beihang University School of Automation Science and Electrical Engineering Beihang University School of Electronics and Information Engineering Beihang University

This paper is concerned with the amplitude boundedness problem of adaptive iterative learning control(AILC) for robot manipulators operating with iteration-dependent periods. By introducing virtual memory slots for storing historical data, a practical AILC method is proposed to achieve the segmentwise learning. This method requires less memory storage for historical information of previous iterations,especially in comparison with that of the conventional AILC methods using point-wise learning *** is shown that not only the energy boundedness but also the amplitude boundedness of estimates and inputs of practical AILC can be guaranteed. Moreover, the practical AILC method can achieve the perfect tracking objective regardless of iteration-dependent periods when the robot manipulators have a persistent full learning property. In addition, a solution to the visual manipulator platform is provided and deployed based on Coppeliasim and Matlab, which helps to show the amplitude boundedness of learning results and the perfect tracking performances of the proposed practical AILC method for robot manipulators.

关键词： amplitude boundedness iteration-dependent period iterative learning control robot manipulator segment-wise virtual memory slot

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A Magnetic-Driven Multi-motion Robot with Position/Orientation Sensing Capability

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Research 2024年第1期2023卷 675-685页

作者： Liwen Zhang Song Zhao Xinzhao zhou Xueshan Jing Yu zhou Yan Wang Yantong Zhu Xiaolin Liu Zehui Zhao deyuan Zhang Lin Feng Huawei Chen School of Mechanical Engineering and Automation Beihang UniversityBeijingChina Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijingChina

Miniature magnetic-driven robots with multimode motions and high-precision pose sensing capacity(position and orientation)are greatly demanded in in situ manipulation in narrow opaque enclosed *** magnetic robots have been carried out,whereas their deformations normally remain in single mode,and the lack of the robot’s real-time status leads to its beyond-sight remagnetization and manipulation being *** function integration of pose sensing and multimode motion is still of ***,a multimotion thin-film robot is created in a novel multilayer structure with a magneticdriven layer covered by a heating-sensing conductive *** a heating-sensing layer not only can segmentally and on-demand heat the magnetic-driven layer for in situ magnetization reprogramming and multimode motions but also can precisely detect the robot’s pose(position and orientation)from its electrical-resistance effect by creating a small deformation under preset magnetic fields.

关键词： robot Robot motion

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High-efficiency ultrasonic assisted drilling of CFRP/Ti stacks under non-separation type and dry conditions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 275-291页

作者： Enze YING Zehua zhou Daxi GENG Zhenyu SHAO Zhefei SUN Yihang LIU Lianxing LIU Xinggang JIANG deyuan ZHANG School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Beijing Chenjing Electronics Company Limited Beijing 100015China Aerospace Times Feihong Technology Company Limited Beijing 100094China

In this study,to address the low efficiency for conventional ultrasonic-assisted drlling(UAD)of carbon fiber-reinforced plastic and titanium alloy(CFRP/Ti)stacks,feasibility experiments of non-separation UAD,in which continuous cutting between the tool and the workpiece occurs at a high feed rate,are carried *** experimental results indicate that,compared to conventional separation UAD,the non-separation UAD effectively reduces the cutting forces by 24.2%and 1.9%for CFRP stage and 22.1%and 2.6%for the Ti stage at the feed rates of 50 and 70μm/r,***,the non-separation UAD significantly improves hole quality,including higher hole diameter accuracy,lower hole surface roughness,and less hole *** addition,the non-separation UAD can decrease adhesive tool *** study demonstrates that,compared to conventional drilling(CD),the non-separation UAD can effectively improve drilling quality and tool life while maintaining high efficiency.

关键词： Carbon fiber-reinforced plastic and titanium alloy(CFRP/Ti)stacks Ultrasonic-assisted drlling(UAD) Cutting force Surface integrity Tool wear

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Energy mechanism of bolt supporting effect to fissured rock under static and dynamic loads in deep coal mines

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International Journal of Mining Science and Technology 2024年第3期34卷 371-384页

作者： deyuan Fan Xuesheng Liu Yunliang Tan Xuebin Li Shenglong Yang College of Energy and Mining Engineering Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of Mining Disaster Prevention and Control Shandong University of Science and TechnologyQingdao 266590China National Energy Group Ningxia Coal Industry Co. Ltd.Yinchuan 753001China

The stability control of fissured rock is difficult,especially under static and dynamic loads in deep coal *** this paper,the dynamic mechanical properties,strain rate evolution and energy dissipation of fissured and anchored rocks were respectively obtained by SHPB *** was found that bolt can provide supporting efficiency-improving effect for fissured rock against dynamic disturbance,and this effect increased quadratically with decrease in anchoring ***,the energy dissipation mechanism of anchored rock was obtained by slipping ***,bolt energy-absorbing mechanism by instantaneous tensile-shear deformation was expressed based on material mechanics,which was the larger the anchoring angle,the smaller the energy absorption,and the less the contribution to supporting efficiency *** this basis,the functional relationship between energy dissipation of anchored rock and energy absorption of bolt was *** the coal-gangue separation system of Longgu coal mine as an example,the optimal anchoring angle can be determined as 57.5°–67.5°.Field monitoring showed fissured rock with the optimal anchoring angle,can not only effectively control the deformation,but also fully exert the energy-absorbing and efficiency-improving effect of bolt *** study provides guidance to the stability control and supporting design for deep engineering under the same or similar conditions.

关键词： Static and dynamic loads Anchored rock Energy absorption Anchoring angle Engineering verification

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RIOK1 synergizes with TRIP13 by regulating the E2F-Rb signaling pathway to promote the proliferation of esophageal cancer cells

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Genes & Diseases 2024年第3期11卷 55-58页

作者： Chengyu Li deyuan Pan Wan Lin Danxia Deng Yingxin zhou Hui Zhao Feng Pan Liyan Xu Enmin Li Lin Long The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area Department of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology Institute of Oncologic PathologyShantou University Medical CollegeShantouGuangdong 515041China Institute of Basic Medical Science Cancer Research CenterShantou University Medical CollegeShantouGuangdong 515041China Clinical Research Center Shantou Central HospitalShantouGuangdong 515041China

Esophageal cancer is one of the leading causes of cancer death in the world,with approximately half of the new cases occurring in China every year.^(1)Esophageal squamous cell carcinoma(ESCC)is the main subtype,accounting for more than 90%,and the five-year survival rate is less than 10%.Using large-scale genome analysis,many driver mutations and key pathways associated with ESCC have been ***,these genomic signatures have not improved the clinical management of EscC patients,or established effective targeted therapy.^(2)Esophageal cancer still lacks representative molecular markers.

关键词： cancer esophageal Esophageal

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A Bionic Starfish Adsorption Crawling Soft Robot

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Journal of Bionic Engineering 2024年第1期21卷 149-165页

作者： Xiangang Huang Chenghao Zhang Wenqi Feng Xiangye Zhang deyuan Zhang Yanqiang Liu Institute of Bionic and Micro-Nano Systems School of Mechanical Engineering and AutomationBeihang UniversityBeijing 100191China

A variety of soft wall-climbing robots have been developed that can move in certain *** of these soft robots can only move on conventional surfaces and lack adaptability to complex *** the adaptability of soft robots on complex surfaces is still a challenging *** this end,we study the layered structure of the starfish tube foot and the valve flap structure in the water vascular system,and use an ultrasonic stress detector to study the stiffness distribution of the arm *** by the motion of the starfish,we present a bionic soft wall-climbing robot,which is driven by two groups of pneumatic feet and achieves body bending through active adaptation *** design the structure of the foot to flex to provide driving force,and there are suction cups at the end of the foot to provide *** soft foot has a simple structure design,adapts to a variety of surfaces,and does not damage the surface of the *** stiffness layers achieve stiffness changes by the principle of line *** Central Pattern Generator theory is introduced to coordinately control the multiple feet of the *** experiments,we verify the adaptability of the soft robot to curved *** research may provide a reference for the design and development of crawling soft robots on complex surfaces.

关键词： Starfish Tube foot Biomimetic robot Soft robot Climbing robot

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滑跑无人机起降过程动力学特性分析及性能底数评估

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动力学与控制学报 2023年第9期21卷 91-97页

作者：周德元李严彪田岳 32204部队渭南714200

在备战打仗大环境下,为了给装备试验考核提供技术参考,针对滑跑起降无人机起降阶段机身-起落架-地面之间复杂的动态特性,本文建立了飞机-起落架-跑道的系统动力学仿真模型及动力学方程,分别采用多尺度法和有限元分析法研究了其在不同气... 详细信息

在备战打仗大环境下,为了给装备试验考核提供技术参考,针对滑跑起降无人机起降阶段机身-起落架-地面之间复杂的动态特性,本文建立了飞机-起落架-跑道的系统动力学仿真模型及动力学方程,分别采用多尺度法和有限元分析法研究了其在不同气动载荷、重力以及作动筒载荷耦合作用下的系统动力学特性,并对可靠性和安全性进行了仿真分析.结果表明,不同降落速度对起落架-地面系统的动力学行为有较大的影响;起落架系统强度、刚度和安全特性满足相关指标.通过滑跑起降无人机动态安全特性以及在飞行作战中的极限疲劳寿命分析,为后续武器装备的考核以及性能底数评估提供了技术参考.

关键词：无人机起落架作用力动力学仿真可靠性疲劳寿命

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