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Chinese Journal of Chemistry 2021年第8期39卷 2083-2087页

作者： Mengyu Niu Xiaoping Yang Yanan Ma Chengri Wang Wenxin Hao Dongliang Shi desmond Schipper College of Chemistry and Materials Engineering Wenzhou UniversityWenzhouZhejiang 325035China Department of Chemistry and Biochemistry The University of Texas at Austin1 University Station A5300AustinTexas78712United States

One near-infrared(NIR)luminescent octanuclear Zn(Ⅱ)-Yb(Ⅲ)complex[Zn_(6)Yb_(2)L_(4)(OAc)_(2)(DMF)EtOH](1)was obtained from a new multidentate Schiff base *** exhibits interesting luminescent sensing activity to antib... 详细信息

关键词： Zn(Ⅱ)-Yb(Ⅲ)complex Schiff base Near-infrared(NIR)luminescence Luminescent sensing Antibiotics

Elevated atmospheric CO_(2) impact on carbon and nitrogen transformations and microbial community in replicated wetland

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Ecological Processes 2020年第1期9卷 677-688页

作者： Dawei Jiang Lifei Chen Nan Xia Eyram Norgbey desmond Ato Koomson Williams Kweku Darkwah College of Horticulture Jilin Agricultural UniversityChangchun 130118China Jilin Tiandiren Landscape Architecture Design Engineering Co.Ltd. Changchun 130117China Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of EducationEnvironmental Engi neering DepartmentCollege of EnvironmentHohai University1 Xikang RoadGulou210098 NanjingChina

Background:Elevated atmospheric CO_(2) has direct and indirect influences on ecosystem *** impact of elevated atmospheric CO_(2) concentration on carbon and nitrogen transformations,together with the microbial community,was evaluated with water hyacinth(Eichhornia crassipes)in an open-top chamber replicated *** responses of nitrogen and carbon pools in water and wetland soil,and microbial community abundance were studied under ambient CO_(2) and elevated CO_(2)(ambient+200μL L^(−1)).Results:Total biomass for the whole plant under elevated CO_(2) increased by an average of 8%(p=0.022).Wetlands,with water hyacinth,showed a significant increase in total carbon and total organic carbon in water by 7%(p=0.001)and 21%(p=0.001),respectively,under elevated CO_(2) compared to that of ambient CO_(2).Increase in dissolved carbon in water correlates with the presence of wetland plants since the water hyacinth can directly exchange CO_(2) from the atmosphere to water by the upper epidermis of ***,the enrichment CO_(2) showed an increase in total carbon and total organic carbon concentration in wetland soil by 3%(p=0.344)and 6%(p=0.008),*** total nitrogen content in water increased by 26%(p=0.0001),while total nitrogen in wetland soil pool under CO_(2) enrichment decreased by 9%(p=0.011)due to increased soil microbial community abundance,extracted by phospholipid fatty acids,which was 25%larger in amount than that of the ambient ***:The study revealed that the elevated CO_(2) would affect the carbon and nitrogen transformations in wetland plant,water,and soil pool and increase soil microbial community abundance.

关键词： Elevated CO_(2) Carbon transformation Nitrogen transformation Microbial community abundance Phospholipid fatty acids Open-top chamber

Atezolizumab and bevacizumab as first line therapy in advanced hepatocellular carcinoma:Practical considerations in routine clinical practice

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World Journal of Hepatology 2021年第9期13卷 1132-1142页

作者： Ankit Jain Shivakumar Chitturi Geoffrey Peters desmond Yip Department of Medical Oncology The Canberra HospitalGarran 2605ACTAustralia ANU Medical School Australian National UniversityCanberra 0200ACTAustralia Gastroenterology and Hepatology Unit Canberra HospitalCanberra 2605ACTAustralia

Hepatocellular carcinoma(HCC)is the most common primary liver *** advanced HCC,sorafenib was considered the standard of care for more than ten *** the atezolizumab and bevacizumab combination has become standard of care for these patients without contraindications to either immune checkpoint inhibitors or antiangiogenic *** now review the practical aspects of the atezolizumab and bevacizumab combination,including current evidence,indications,contraindications,management of adverse events,sequencing of this combination,areas of current knowledge gaps and future areas of active clinical research of this combination for busy clinicians in clinical practice.

关键词： Hepatocellular carcinoma Atezolizumab Bevacizumab Immunotherapy Child Pugh cirrhosis Anti-angiogenic therapy

Spatial Distribution of Black Soot and Its Health Effects in Port Harcourt Metropolis, Nigeria

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Journal of Environmental & Earth Sciences 2022年第1期4卷 32-46页

作者： Miebaka Oriasi Eteh desmond Rowland Ayowei Alvin Harry University of Port Harcourt River StateNigeria Niger Delta University Wilberforce IslandAmassomaBayelsa StateNigeria University of Salford LondonUK

This research presents a novel approach to assessing the health implications of black soot using a MiniVol air *** MiniVol air sampler was used to collect PM from the ambient air at six monitoring sites in Port Harcourt,*** was conducted every day for seven days,for a period of 24 ***_(2.5) concentrations at Uniport Junction,GRA Junction,Slaughter Roundabout,Abuloma Jetty,Rumuomasi Roundabout,and New Road Borokiri were 38.6 g/m^(3),28.3 g/m^(3),93.7 g/m^(3),72.9 g/m^(3),30.6 g/m^(3),and 31.3 g/m^(3),***_(10) concentrations ranged from 71.2 g/m^(3) to 60.6 g/m^(3),with 103.3 g/m^(3),85.5 g/m^(3),40.1 g/m^(3),and 35.2 g/m^(3) being the *** level of PM_(2.5) and PM_(10) pollution in the ambient air was high across the six sampling sites,with mean PM_(2.5) and PM_(10) concentrations exceeding the WHO(2011)*** flame atomic absorption spectrometry(FAAS)technique was *** presence of heavy metals,such as mean metal concentrations of lead,cadmium,chromium,mercury,and nickel,ranged from 0.009 g/m^(3)-0.532 g/m^(3),0.002 g/m^(3)-0.544 g/m^(3),0.002 g/m^(3)-0.338 g/m^(3),0.001 g/m^(3),and 0.001 g/m^(3)-0.432 g/m^(3),across the six sampling *** GC-MS was used to determine the presence of PAHs in particulate *** results revealed a strong positive correlation between PM_(2.5) and PM_(10).The findings also revealed a positive relationship between the metals as well as between the metals and PAHs,resulting in asthma,lung cancer,breathing difficulties,and miscarriages among pregnant women,which have affected the health implications of the people living in the environment.

关键词： Black soot Port harcourt Air polluion WHO PM_(2.5) PM_(10) PAHs

Influence of pump noise on the health of fish in a large pumping station

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Journal of Hydrodynamics 2022年第3期34卷 522-531页

作者： Fan Zhang Lu-feng Zhu Xiao-tao Shi Ke Chen desmond a.pia. Shou-qi Yuan Jin-feng Zhang National Research Center of Pumps Jiangsu UniversityZhenjiang212013China Hubei International Science and Technology Cooperation Base of Fish Passage China Three Gorges UniversityYichang443002China

The axial flow pump,characteristic of a large flow,is widely used in pumping stations of hydraulic ***,the internal noise of the axial-flow pump of a high sound pressure level is notable,with a great influence on the fishing *** present,the studies of the impact of the noise on fish are mainly focused on the explosion,the offshore wind power plant,the ship and other fields,with little attention on the noise generated by the pumping *** paper applies the combination of the computational fluid dynamics and the Actran to study the sound pressure level distribution in the high-noise area inside the axial-flow pump and the noise distribution in the downstream areas of the pumping *** comparisons are made of the hearing threshold and the hearing damage threshold of fish,and it is revealed that the noise inside the axial-flow pump exceeds the hearing damage threshold of fish,which could lead to the hearing damage of over-pumped ***,the noises emitted from the pumping station to the downstream are beyond the fish hearing threshold and will also have a significant impact on the fish around the pumping *** study can provide a reference for studying the impact of the noise generated by various large-scale water transfer projects on fish.

关键词： Fish numerical analysis axial flow pump ACTRAN hearing impairment

Hepatocellular carcinoma in central Sydney :a 10yearreview of patients seen in a medical oncology department

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World Journal of Gastroenterology 1999年第6期5卷 483-487页

作者： desmond Yip 1, Michael Findlay 2, Michael Boyer 1 and Martin H. Tattersall 3 Royal Prince Alfred Hospital 澳大利亚 Wellington Cancer Centre 新西兰 University of Sydney 澳大利亚

AIM To report a single Australian oncology unit′s experience with the management of patients with hepatocellular carcinoma (HCC), in the context of a literature review of the current management issues. METHODS Retrospective case record review of 76 patients with diagnosis of HCC referred to the unit between 1984 and 1995. RESULTS Sixty three patients had adequate records for analysis. Thirty six (56%) were migrants with half from Southeast Asia. Twenty four patients had a documented viral aetiology. Nine (14%) of 51 patients with pathological confirmation of HCC had normal alpha fetoprotein levels. Median survival of the 20 patients managed palliatively was 5 weeks compared to 16 weeks for the cohort overall. Surgery in 16 patients rendered all initially disease free with a median survival of 88 weeks. Chemoembolisation induced tumor responses in 5 of the 11 patients so treated. Systemic chemotherapy and tamoxifen treatment caused tumor response in two of 12 and one of 25 respectively. CONCLUSION Prolonged survival of patients with HCC depends on early detection of small tumors suitable for surgical resection. Other active treatments are palliative in intent and have limited success. In addition to tumor response and survival duration, the toxicities of therapies and the overall quality of life of patients need to be considered as important outcomes. Viral hepatitis prevention and screening of individuals at risk are strategies that are important for HCC management in communities where the disease is endemic.

关键词： carcinoma, hepatocellular liver neoplasms survival/rate Australia

Taking Children’s Voices in Disaster Risk Reduction a Step Forward

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International Journal of Disaster Risk Science 2015年第3期6卷 267-281页

作者： Chipo Mudavanhu Siambalala Benard Manyena Andrew E.Collins Paradzayi Bongo Emmanuel Mavhura desmond Manatsa Department of Geography Faculty of ScienceBindura University of Science Education(BUSE) Humanitarian and Conflict Response Institute University of Manchester Disaster and Development Centre School of Applied SciencesNorthumbria University

Disaster risk reduction(DRR) continues to gain momentum globally and locally, but there is a notable void in the DRR literature on the role of children in communitylevel disaster risk management in Zimbabwe. Children are among the most vulnerable groups when disasters occur,yet their voices in disaster risk reduction are rarely *** a qualitative methodology, this article examines the extent to which children are involved in disaster risk reduction in Muzarabani District, Zimbabwe. Despite evidence of the potential positive impact that children can have on DRR, their involvement in risk reduction planning in Zimbabwe is negligible. To achieve greater resilience to disasters requires that children’s voices are heard and recognized as central to improved disaster risk reduction.

关键词： Children’s vulnerability Disaster risk reduction Flood hazard Zimbabwe

Genotypes and viral variants in chronic hepatitis B: A review of epidemiology and clinical relevance

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World Journal of Hepatology 2015年第3期7卷 289-303页

作者： Catherine MN Croagh Paul V desmond Sally J Bell Department of Gastroenterology St Vincent's Hospital

The Hepatitis B Virus(HBV) has a worldwide distribu-tion and is endemic in many populations. It is constantly evolving and 10 genotypic strains have been identified with varying prevalences in different geographic regions. Numerous stable mutations in the core gene and in the su-rface gene of the HBV have also been identified in untreated HBV populations. The genotypes and viral variants have been associated with certain clinical featu-res of HBV related liver disease and Hepatocellu-lar carcinoma. For example Genotype C is associated withlater hepatitis B e antigen(HBe Ag) seroconversion, and more advanced liver disease. Genotype A is associated with a greater risk of progression to chronicity in adu-lt acqu-ired HBV infections. Genotype D is particu-larly associated with the precore mu-tation and HBe Ag negative chronic hepatitis B(CHB). The genotypes prevalent in parts of West Africa, Central and Sou-th America, E, F and H respectively, are less well stu-died. Viral variants especially the Basal Core Promotor mutation is associated with increased risk of fibrosis and cancer of the liver. Althou-gh not cu-rrently part of rou-tine clinical care, evalu-ation of genotype and viral variants may provide u-sefu-l adju-nctive information in predicting risk abou-t liver related morbidity in patients with CHB.

关键词： Chronic hepatitis B Genotype Pre-core Basal core promotor Mutations

Lobe-specific modulation of B16MET melanoma lung metastases by nephrilin peptide

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 239-245页

作者： desmond D.Mascarenhas Puja Ravikumar Edward P.Amento Mayflower Organization for Research&Education SunnyvaleCA 94085USA Transporin Inc.SunnyvaleCA 94085USA Molecular Medicine Research Institute SunnyvaleCA 94085USA

Aim:Nephrilin peptide modulates systemic immune responses to trauma in contexts characterized by simultaneous inflammation and *** study explores the possibility that nephrilin peptide may modulate lung metastasis,which also occurs in an environment of concurrent inflammation and ***:B16MET melanoma cells were injected via the tail vein of mice and the development of lung metastases was recorded in animals treated with nephrilin peptide or vehicle by subcutaneous bolus injection daily for three *** a separate experiment,nephrilin was administered by subcutaneous bolus injection for seven days to study the biodistribution of peptide and possible changes to plasma cytokine ***:Nephrilin significantly suppressed B16MET lung *** was more effective in deep lobes with the poorest access to circulation:accessory>inferior>middle>*** a separate biodistribution study in mice,nephrilin showed similar biodistribution levels in kidney,liver,brain,and left lung,but significantly higher accumulation in the lobes of the right lung in a gradient that matched its effectiveness in suppressing metastases(accessory>inferior>middle).The latter environments were also characterized by significantly higher local concentrations of succinate,a proxy for lower levels of ***:Nephrilin accumulates preferentially in the deep lobes of the right lung in mice and inhibits B16MET right lung metastases in a lobe-specific manner.

关键词： Nephrilin melanoma metastases deep lung lobes anoxia oxidative stress immune modulation

Hydrogeochemical Characterization of Groundwater from Fissured Aquifers in the Angovia Mine Operating Permit Area (Central-West Côte d’Ivoire)

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