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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： desmond A.Nunez Ru C.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第09期 2513-2519页

作者： desmond A.Nunez Ru C.Guo Division of Otolaryngology-Head & Neck Surgery Department of SurgeryFaculty of MedicineThe University of British Columbia Division of Otolaryngology-Head & Neck Surgery Gordon & Leslie Diamond Health Care CentreVancouver General Hospital Faculty of Medicine-The University of British Columbia

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs) have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with "hearing loss," "hypoxamiRs," "hypoxia," "microRNAs," "ischemia," and "oxidative stress" text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC

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Advances of embedded resistive random access memory in industrial manufacturing and its potential applications

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International Journal of Extreme Manufacturing 2024年第3期6卷 175-214页

作者： Zijian Wang Yixian Song Guobin Zhang Qi Luo Kai Xu Dawei Gao Bin Yu desmond Loke Shuai Zhong Yishu Zhang College of Integrated Circuits Zhejiang UniversityHangzhouZhejiang 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China

Embedded memory,which heavily relies on the manufacturing process,has been widely adopted in various industrial *** the field of embedded memory continues to evolve,innovative strategies are emerging to enhance *** them,resistive random access memory(RRAM)has gained significant attention due to its numerousadvantages over traditional memory devices,including high speed(<1 ns),high density(4 F^(2)·n^(-1)),high scalability(~nm),and low power consumption(~pJ).This review focuses on the recent progress of embedded RRAM in industrial manufacturing and its *** provides a brief introduction to the concepts and advantages of RRAM,discusses the key factors that impact its industrial manufacturing,and presents the commercial progress driven by cutting-edge nanotechnology,which has been pursued by manysemiconductor ***,it highlights the adoption of embedded RRAM in emerging applications within the realm of the Internet of Things and future intelligent computing,with a particular emphasis on its role in neuromorphic ***,the review discusses thecurrent challenges and provides insights into the prospects of embedded RRAM in the era of big data and artificial intelligence.

关键词： embedded resistive random access memory industrial manufacturing intelligent computing advanced process node

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Hydrogeochemical Characterization of Groundwater from Fissured Aquifers in the Angovia Mine Operating Permit Area (Central-West Côte d’Ivoire)

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Journal of Water Resource and Protection 2024年第1期16卷 83-101页

作者： Kouadio Michel Yao Tanina Drissa Soro Tanoh Jean Jacques Koua Akaie Jean Fabrice Tchakray Yao Emile desmond Konan Brou Dibi Laboratory of Sciences and Technologies of Environment University Jean Lorougnon Guede Daloa C&ocircte d’Ivoire

The main objective of this study is to determine the hydrogeochemical specificities of the groundwater of the Angovia mine operating permit, located in the Yaouré mountains in the center-west of Côte d’Ivoire. To do so, descriptive and multivariate statistical analysis methods with the SOM (Self Organizing Maps) algorithm were applied to the physicochemical parameters of 17 boreholes using the calcite (ISC) and dolomite (ISD) saturation indices. The results obtained have shown that the groundwater in the Angovia mine operating permit area has an average temperature of 27.52°C (long rainy season) and 27.87°C (long dry season) and has an average pH of 7.09 ± 0.35 during the main rainy season and 7.32 ± 0.35 during the main dry season. They are mineralized with an average electrical conductivity of 505.98 ± 302.85 μS/cm during the long rainy season and with 450.33 ± 233.74 μS/cm as average during the long dry season. The main phenomena at the origin of groundwater mineralization are water residence time, oxidation-reduction and surface inflow. The study of the relative age of the water shows that the groundwater in the Angovia mine operating permit area is mainly undersaturated with respect to calcite and dolomite. They are therefore very old in the aquifer with a slow circulation speed during the long rainy season and the long dry season.

关键词： Hydrogeochemistry Mineralization Fissure Aquifers Operating Permits The Angovia Mine

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A risk assessment system for alien plant bio-invasion in Xiamen,China

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Journal of Environmental Sciences 2008年第8期20卷 989-997页

作者： desmond K.O'TOOLE Department of Biology and Chemistry City University of Hong Kong83 Tat Chee AveKowloonHong Kong SAR 999077China

Bio-invasion has caused serious ecosystem damage and enormous economic losses in China,and it has been the greatest factor to island bio-diversity ***,as an important seaport with a relatively high conservation value,is particularly vulnerable to bio-invasion for its typical island ecosystem as well as frequent human-made *** a result of field surveys,literature review, and consultation with experts,a list of 67 alien plants identified as major invaders(12 species)and emerging invade...

关键词： bio-invasion invasive species alien plants risk assessment

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Acacia mearnsii management in a South African National Parks：SWOT analysis using hot topics in biological invasion as a guide

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Journal of Mountain Science 2017年第1期14卷 205-218页

作者： Geoffrey MUKWADA desmond MANATSA Geography Department and Afromontane Research Unit University of Free State Phuthaditjhaba 9866 South Africa Bindura University of Science Bindura Zimbabwe

The assessment of the policy framework governing Invasive Alien Species(IAS) control is of critical importance in conservation. The undertaking of a SWOT analysis of such a framework is necessary because it enhances the efficacy of IAS control. The aim of this study is to carry out a SWOT analysis of the policy framework guiding the control of the spreading of Acacia mearnsii and other IAS in the Golden Gate Highlands National Park in South Africa,as well as the implementation of restorative measures in the park and adjacent communities in line with the recommendations of the Convention on Biodiversity. A comparative analysis of this framework and the hierarchical framework that was developed during the European Union Conference on Freshwater Invasives- Networking for Strategy in 2013 is undertaken. The results indicate the need to strengthen parkcommunity relations,upgrade existing legislation,and boost the technical capacity of South African national parks to identify,detect,monitor and predict IAS invasions,both within the parks and their surroundings. This knowledge is important for developing future policies on IAS control in South Africa.

关键词： Convention on biodiversity Geographic Information Systems Golden Gate Highlands National Park Invasive alien species MalutiDrakensberg Mountains Protected Areas Policy Framework SWOT

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Securing Recommender Systems Against Shilling Attacks Using Social-Based Clustering

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Journal of Computer Science & Technology 2013年第4期28卷 616-624页

作者：张响亮 Tak Man desmond Lee Georgios Pitsilis King Abdullah University of Science and Technology Faculty of Science Technology and Communication University of Luxembourg

Abstract Recommender systems （RS） have been found supportive and practical in e-commerce and been established as useful aiding services. Despite their great adoption in the user communities, RS are still vulnerable to unscrupulous producers who try to promote their products by shilling the systems. With the advent of social networks new sources of information have been made available which can potentially render RS more resistant to attacks. In this paper we explore the information provided in the form of social links with clustering for diminishing the impact of attacks. We propose two algorithms, CLUTR and WCLUTR, to combine clustering with ＂trust＂ among users. We demonstrate that CLuTR and WCLUTR enhance the robustness of RS by experimentally evaluating them on data from a public consumer recommender system ***.

关键词： shilling attack recommender system collaborative filtering social trust clustering

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Branch Retinal Vein Occlusion and Its Management

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眼科学报 1992年第1期8卷 40-44页

作者： desmond Archer Department of Ophthalmology Queen's University BelfastEye and Ear ClinicRoyal Victoria HospitalBelfastNorthern Ireland

The natural course of Branch Retinal Vein Occlusion is determined by the site and completeness of the occlusion, the integrity of arterial perfusion to the affected sector and the efficiency of the developing collateral circulation. Most patients with tributary vein occlusion have some capillary fall out and microvascular incompetence in the distribution of the affected retina and vision is significantly compromised in over 50% of patients who have either chronic macular oedema or ischemia involving the...

关键词： Branch retinal vein occlusion causes photoablation laser photocoagulation complication.

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Influence of Cavitation on Unsteady Vortical Flows in a Side Channel Pump

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Chinese Journal of Mechanical Engineering 2023年第1期36卷 171-189页

作者： Yefang Wang Fan Zhang Shouqi Yuan Ke Chen Feng Hong desmond a.pia. National Research Center of Pumps Jiangsu UniversityZhenjiang212013China College of Mechanical&Power Engineering China Three Gorges UniversityYichang443002China

Previous investigation on side channel pump mainly concentrates on parameter optimization and internal unsteady vortical ***,cavitation is prone to occur in a side channel pump,which is a challenging issue in promoting *** the present study,the cavitating flow is investigated numerically by the turbulence model of SAS combined with the Zwart cavitation *** vapors inside the side channel pump firstly occur in the impeller passage near the inlet and then spread gradually to the downstream passages with the decrease of ***,a strong adverse pressure gradient is presented at the end of the cavity closure region,which leads to cavity shedding from the *** small scaled vortices in each passage reduce significantly and gather into larger vortices due to the *** the three terms of vorticity transport equation with the vapor volume fraction and vorticity distributions,it is found that the stretching term is dominant and responsible for the vorticity production and evolution in cavitating *** addition,the magnitudes of the stretching term decrease once the cavitation occurs,while the values of dilatation are high in the cavity region and increase with the decreasing *** though the magnitude of the baroclinic torque term is smaller than vortex stretching and dilatation terms,it is important for the vorticity production along the cavity surface and near the cavity closure *** pressure fluctuations in the impeller and side channel tend to be stronger due to the *** primary frequency of monitor points in the impeller is 24.94 Hz and in the side channel is 598.05 *** are quite corresponding to the shaft frequency of 25 Hz(fshaft=1/n=25 Hz)and the blade frequency of 600 Hz(fblade=Z/n=600 Hz)*** study complements the investigation on cavitation in the side channel pump,which could provide the theoretical foundation for further optimization of performance.

关键词： Side channel pump Vortical flows Cavitation Vortex-cavitation interaction Pressure fluctuation

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GIS&Remote Sensing Based Morphometric Parameters and Topographic Changes of the Lower Orashi River in Niger Delta desmond

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Journal of Atmospheric Science Research 2022年第1期5卷 1-10页

作者： desmond Eteh Edirin Akpofure Solomon Otobo Department of Geology Niger Delta UniversityWilberforce IslandBayelsa StateNigeria

In watershed hydrology,the morphometric features of a river basin are vital to examine the lower Orashi River basin morphological and hydrological aspects,as well as its flood potential,based on their morphometric characteristics using remotely sensed SRTM data that was analyzed with ArcGIS *** areal,linear,and relief aspects of the Orashi River basin were examined as morphometric *** lower Orashi river basin,according to the findings,has a total size of 625.61 km2 and a perimeter of 307.98 km,with a 5th order river network based on Strahler categorization and a dendritic drainage *** of low drainage density,the drainage texture is very fine,the relief is low,and the slope is very *** ratio,circularity ratio,drainage density aspect ratio,form factor,and stream frequency values indicate that the basin is less elongated and would produce surface runoff for a longer period,while topographic changes show that the river is decreasing with depth in the land area at about the same elevation as a result of sand deposited due to lack of maintenance by dredging,which implies that the basin is morphometrically elevated and sensitive to erosion and *** understand geo-hydrological features and to plan and manage watersheds,morphometric analysis based on geographic information systems and remote sensing techniques is beneficial.

关键词： Morphometric analysis Topographic changes Hydrology Flood GIS

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