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Simulation-based Optimization of Supply Chain Network with Facility Location

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Simulation-based Optimization of Supply Chain Network with F...

作者： Nikola bogojevic 上海交通大学

学位级别：硕士

In the context of globalization and economic development,customer’s needs are *** whole market is changing from a static market ruled by big companies and manufacturers,to customer-driven market with increasingly high expectations and *** large-scale production has turned into horizontally integrated,small batch and multivariety production *** entity in such a process is trying to make use of its technologies and adapt to the changes providing additional *** the other hand,they will outsource non-core business activities,and try to utilize external resources,avoiding problems of long cycles and high risks of extensive *** succeed,strengthening cooperation and the relationship between suppliers,manufacturers,and sellers have become a *** these participants in the process create a complex supply chain network（SCN）.Traditional manual operations will gradually be replaced by machines and *** the same time,under globalization,the national barriers to science and technology will be broken,and the global procurement of equipment and materials will gradually make their costs converge globally,with the supply chain becoming gradually even more *** matter how the technology develops in the future,logistics and supply chain activities focusing on optimizing their networks by more cost-efficient facility locations,transportation,warehousing,loading,and unloading will always exist,and the cost of optimizing the supply chain will take a larger portion of overall cost due to diminishing presence of ***,the need for cutting costs and increasing efficiency to achieve better performance and increase the profit of supply chains and logistics will grow in its priority,and therefore,SCN planning will play even a bigger role in any *** on the SCN design in the automotive manufacturing industry is in a relatively early phase due to global change of the manufacturing ***

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SPEEDUP Code for Calculation of Transition Amplitudes via the Effective Action Approach

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Communications in Computational Physics 2012年第3期11卷 739-755页

作者： Antun Balaz Ivana Vidanovic Danica Stojiljkovic Dusan Vudragovic Aleksandar Belic Aleksandar bogojevic Scientific Computing Laboratory Institute of Physics BelgradeUniversity of BelgradePregrevica 11811080 BelgradeSerbia.

We present Path Integral Monte Carlo C code for calculation of quantum mechanical transition amplitudes for *** SPEEDUP C code is based on the use of higher-order short-time effective actions and implemented to themaximal order p=18 in the time of propagation(Monte Carlo time step),which substantially improves the convergence of discretized amplitudes to their exact continuum *** derivation of higher-order effective actions is implemented in SPEEDUP Mathematica codes,using the recursive Schrodinger equation *** addition to the general 1D quantum theory,developed Mathematica codes are capable of calculating effective actions for specific models,for general 2D and 3D potentials,as well as for a general many-body theory in arbitrary number of spatial dimensions.

关键词： Transition amplitude effective action path integrals Monte Carlo

Primary leiomyosarcoma of the thyroid gland with prior malignancy and radiotherapy:A case report and review of literature

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World Journal of Clinical Cases 2019年第4期7卷 473-481页

作者： Snezana Vujosevic Djordjije Krnjevic Milan bogojevic Ljiljana Vuckovic Aleksandar Filipovic Du?ko Dun?erovi? Jelena Sopta Endocrinology Clinical Center of Montenegro Internal Medicine Clinic Clinical Center of Montenegro Institute of Pathology Clinical Center of Montenegro Surgery Clinical Center of Montenegro Institute of Pathology University of Belgrade

BACKGROUND Leiomyosarcoma(LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors' knowledge, there currently exist only 28 known cases described in the literature(limited to English).CASE SUMMARY Herein a case is reported of a 60-year-old female patient who had an LMS of the thyroid, which was accompanied by periodic dysphonia and breathing disorder as well as the feeling of pressure in the chest and neck. At the time the disease was diagnosed, no metastases were detected. Prior to the diagnosis, the patient experienced a uterine adenocarcinoma that had been treated by surgical procedure and radiotherapy. For the LMS, a total thyroidectomy was performed,followed by radiotherapy. Since metastases were also discovered in the lungs,sternum, and femur, chemotherapy was administered as ***, the tumor cells in the thyroid indicated positively for alpha smooth muscle actin, calponin, and H-caldesmon, but were negative for CD34, p63, estrogen receptor, progesterone receptor, and Epstein-Barr *** Although the etiology of the LMS is as of yet unknown, prior malignancy and radiation should be considered as risk factors.

关键词： Thyroid Leiomyosarcoma Smooth muscle tumor Radiotherapy Thyroidectomy Case report

Noninvasive Fibrosis Assessment in Chronic Hepatitis C Infection: An Update

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1228-1238页

作者： Kristina Bojanic Mirta Sudaric bogojevic Sonja Vukadin Renata Sikora Gordana Ivanac Nikola Raguz Lucic Martina Smolic Ashraf ATabll George YWu Robert Smolic Faculty of Dental Medicine and Health Osijek Josip Juraj Strossmayer University of OsijekOsijekCroatia Faculty of Medicine Osijek Josip Juraj Strossmayer University of OsijekOsijekCroatia Health Center Osijek-Baranja County OsijekCroatia Department of Biology Josip Juraj Strossmayer University of OsijekOsijekCroatia University Hospital Dubrava ZagrebCroatia School of Medicine University of ZagrebZagrebCroatia Microbial Biotechnology Department Biotechnology Research InstituteNational Research CenterGizaEgypt Egypt Center for Research and Regenerative Medicine(ECRRM) CairoEgypt University of Connecticut Health Center FarmingtonCTUSA

Liver biopsy is historically the gold standard for liver fibrosis assessment of chronic hepatitis C ***,with the introduction and validation of noninvasive tests(NITs)to evaluate advanced fibrosis,and the direct-acting antiviral agents for treatment of chronic hepatitis C virus(HCV),the role of NITs have become even more *** is now need for longitudinal monitoring and elucidation of cutoff values for prediction of liver-related complication after sustained virological *** aim of this report is to provide a critical overview of the various NITs available for the assessment of liver fibrosis in HCV patients.

关键词： Hepatitis C virus Fibrosis Noninvasive serum fibrosis markers Transient elastography Shear wave elastography Magnetic resonance elastography Steatohepatitis

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry

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World Journal of Critical Care Medicine 2022年第2期11卷 102-111页

作者： Aysun Tekin Shahraz Qamar Romil Singh Vikas Bansal Mayank Sharma Allison M LeMahieu Andrew C Hanson Phillip J Schulte Marija bogojevic Neha Deo Simon Zec Diana J Valencia Morales Katherine A Belden Smith F Heavner Margit Kaufman Sreekanth Cheruku Valerie C Danesh Valerie M Banner-Goodspeed Catherine A St Hill Amy B Christie Syed A Khan Lynn Retford Karen Boman Vishakha KKumar John C O'Horo Juan Pablo Domecq Allan J Walkey Ognjen Gajic Rahul Kashyap Salim Surani TheSociety of Critical Care Medicine(SCCM)Discovery Viral Infection and Respiratory Illness Universal Study(VIRUS):COVID-Registry Investigator Group Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research Education Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmonary and Critical Care Medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinical Trials and Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix School of Medicine Mayo ClinicRochesterMN 55905United States Division of Infectious Diseases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma Health GreenvilleSC 29605United States Englewood Health EnglewoodNJ 07631United States Divisions of Cardiothoracic Anesthesiology and Critical Care Medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States Center for Applied Health Research Baylor Scott and White HealthDallasTX 75246United States Department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina Health MinneapolisMN 55407United States Department of Critical Care Atrium Health NavicentMaconGA 31201United States Division of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critical Care Medicine Mount ProspectIL 60056United States Division of Infectious Diseases Mayo ClinicRochesterMN 55905United States Division of Nephrology and Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmonary Center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Department of Pulmonary and Critical Care Medicine Texas A&M UniversityBryanTX 77807United States 不详

BACKGROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental *** studies previously suggested a link between climatological factors and COVID-19 fatality ***,individual-level impact of these factors has not been thoroughly evaluated *** To study the association of climatological factors related to patient location with unfavorable outcomes in *** In this observational analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital *** for baseline parameters and admission date,multivariable regression modeling was *** estimating equations were used to fit the *** Twenty-two thousand one hundred eight patients from over 20 countries were *** median age was 62(interquartile range:49-74)years,and 54%of the included patients were *** median age increased with increasing latitude as well as the frequency of ***,the percentage of comorbidities was lower in elevated *** within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 *** the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality wi

关键词： 28 d mortality Altitude COVID-19 Hospital-free days Latitude Outcomes