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蕈样肉芽肿皮损中树突细胞和凋亡的研究

中华皮肤科杂志 2004年第6期37卷 354-356页

作者：冯爱平 Matthias l.ftl.Ecka l.cha alexander Steinkasserer 华中科技大学同济医学院附属协和医院皮肤科武汉430022 德国Erl.ngen大学皮肤病医院

目的探讨细胞凋亡与蕈样肉芽肿(MF)疾病进程和树突细胞(DC)的关系。方法皮肤肿瘤组织冰冻切片,单克隆抗体免疫组化多染及TdT介导的dUTP缺口末端标记技术(TUNEl.。结果MF斑片斑块期肿瘤组织Pautrier微脓肿内及真皮T细胞浸润区内可见少量... 详细信息

目的探讨细胞凋亡与蕈样肉芽肿(MF)疾病进程和树突细胞(DC)的关系。方法皮肤肿瘤组织冰冻切片,单克隆抗体免疫组化多染及TdT介导的dUTP缺口末端标记技术(TUNEl.。结果MF斑片斑块期肿瘤组织Pautrier微脓肿内及真皮T细胞浸润区内可见少量凋亡细胞或凋亡小体,肿瘤期真皮T细胞浸润区内可见大量凋亡瘤细胞或凋亡小体(Pl.g+,CD1a+)DC存在,斑片及斑块期不易见到这种现象。结论凋亡瘤细胞或凋亡小体的出现和增多可能是MF疾病进展的一个病理征象,肿瘤期中包绕吞噬凋亡瘤细胞或凋亡小体的未成熟的CD1a+DC出现提示在诱导抗肿瘤免疫方面存在交叉呈递,可能诱导抗肿瘤免疫耐受。

关键词：蕈样肉芽肿皮损树突细胞细胞凋亡 T细胞淋巴瘤免疫学

龙门山小鱼洞断裂在汶川地震中的地表破裂及地质意义

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第四纪研究 2009年第3期29卷 502-512页

作者：李勇黄润秋 A.l.densmore 周荣军闫亮张毅 N.Richardson 董顺利乔宝成 M.A.El.is 何玉林陈浩马博琳成都理工大学油气藏地质及开发工程国家重点实验室成都610059 成都理工大学地质灾害防治与地质环境保护国家重点实验室成都610059 Institute of Hazard and Risk Research and Department of Geography Durham UniversityDurhamUK 四川省地震局工程地震研究院成都610041 Department of Earth Science Swiss Federal Institute of TechnologyZurichSwitzerland Center for Earthquake Research and Information University of MemphisMemphisTennesseeUSA

在龙门山中段小鱼洞地区映秀-北川断裂和彭县-灌县断裂发生了同震位移,同时在该地区新出现了一条北西向的同震破裂带——小鱼洞断裂的破裂带,并分割了两条近于平行的北东向逆冲-走滑型的主断裂。汶川特大地震发生后重点对小鱼洞断裂的... 详细信息

在龙门山中段小鱼洞地区映秀-北川断裂和彭县-灌县断裂发生了同震位移,同时在该地区新出现了一条北西向的同震破裂带——小鱼洞断裂的破裂带,并分割了两条近于平行的北东向逆冲-走滑型的主断裂。汶川特大地震发生后重点对小鱼洞断裂的地表破裂开展了详细的野外地质填图,利用全站仪和GPS对地表破裂进行了精确的测量。初步调查的结果表明,小鱼洞断裂位于映秀-北川断裂与彭县-灌县断裂之间,走向近于北西向,延伸约15km,以脆性破裂为特征,穿过小鱼洞大桥,并切割了多种类型的地貌单元,使道路发生拱曲、破坏和桥梁垮塌或移位。单个破裂长度在几米到300m不等,其南西盘为上升盘,北东盘为下降盘,平均垂直位错为1.0m,平均水平位错为2.3m,垂直与水平位错量之比1:1～1:2,显示为逆冲分量小于或等于左旋走滑分量,并以左旋走滑作用为主。同时,研究表明小鱼洞断裂属于映秀-北川断裂与彭县-灌县断裂之间的捩断层,其主要特征包括:1)是在汶川地震中由于龙门山逆冲体之间的差异逆冲运动过程中而形成的断裂;2)其走向近于北西向,垂直于龙门山北东向的主干断裂,而平行于逆冲体的逆冲运动方向;3)具有高角度断面的断层,以左旋走滑作用为主。

关键词：汶川地震地表破裂小鱼洞捩断裂组合样式小鱼洞地区龙门山

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青藏高原东缘活动构造

青藏高原东缘活动构造

Pl.sma Induced Changes in Human l.pid Composition as Reveal.d through XPS-Anal.sis

中国地震学会第九次学术大会

作者：周荣军李勇 alexander l.densmore Michael.A.El.is 何玉林王凤林黎小刚四川省地震局成都理工大学 Department of Geol.gy Trinity College DublinIreland Centre for Earthquake Research and Information UN varsity of Menphis TN 38152

青藏高原东缘系指岷山断块、龙门山构造带和四川盆地西缘地区,在不到50 km的距离内,地形起伏高差达到5km以上,形成了青藏高原边缘最大的地形梯度带。我们对青藏高原东缘进行了约2个月的野外考察,发现该地区先存断裂晚第四纪以来新的活...

青藏高原东缘系指岷山断块、龙门山构造带和四川盆地西缘地区,在不到50 km的距离内,地形起伏高差达到5km以上,形成了青藏高原边缘最大的地形梯度带。我们对青藏高原东缘进行了约2个月的野外考察,发现该地区先存断裂晚第四纪以来新的活动地质地貌证据,取得了一批断裂运动学和史前强震活动定量数据。(1)岷山断块。岷山断块是一个南北向的新构造隆起,东西边界分别被虎牙断裂和岷江断裂控制,形成显著的地貌反差。小河乡附近,虎牙断裂将一条冲沟左旋位错了47m,涪江Ⅰ级阶地垂直位错了约4m。岷江断裂控制了漳腊和弓嘎岭新第三纪—第四纪盆地的成生与发展,导致了河流阶地变形及断错冲沟、河流阶地及洪积扇等现象。水晶乡附近的Ⅱ级河流阶地面上断层陡坎高约10 m,陡坎下方可见到逆冲断层,数条小冲沟的左旋位错量亦在10 m左右,表明了岷江断裂的水平位错量与垂直位错量大致相当。

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Natural.Science 2016年第3期8卷 125-137页

作者： Joanna Hirschberg l.ander l.ewenthal.alexander Krupp Steffen Emmert Wol.gang Viöl Department of Sciences and Technol.gy HAWK University of Applied Sciences and Arts Gottingen Germany Fraunhofer Institute for Surface Engineering and Thin Fil.s IST Application Center for Plasma and Photonic APP Gottingen Germany Cl.nic for Dermatol.gy and Venereol.gy University Medical Center Rostock Rostock Germany

In this study two pl.sma sources were used for an in vivo treatment of human stratum corneum. The sampl. preparation was real.sed with the Cyanoacryl.t stripping method, whereby a few l.yers of corneocytes embedded in the l.pid matrix were removed from the skin of heal.hy vol.nteers. For the pl.sma treatment, diel.ctric barrier discharges with pul.e durations in the microsecond as wel. as in the nanosecond range were appl.ed. A comparison of these sources with respect to their biol.gical.y active components incl.ding dissipated power, gas and el.ctron temperature, irradiance in the ul.raviol.t range, ozone and nitric oxide concentration is presented. Furthermore, species generated during pl.sma treatment on the sampl. surface l.ke hydrogen peroxide, nitride or nitrate were measured using refl.ctometry. In addition, safety aspects for both sources were eval.ated. Resul.ing pl.sma induced changes in the sampl. composition were investigated through X-ray photoel.ctron spectroscopy. The main ingredients carbon, oxygen, and nitrogen in addition to minor concentrations of sul.hur were considered. A significant infl.ence of the pul.e duration on pl.sma characteristics was shown. A more effective formation of reactive species as wel. as more intense UV emission for ns-pl.sma was observed. Based on the determined parameters, both pl.sma sources are suitabl. for therapeutic purpose. Furthermore, significant pl.sma induced changes in the stratum corneum composition were reported, incl.ding an increase in nitrogen and oxygen content.

关键词： Diel.ctric Barrier Discharge Pl.sma Medicine l.pid-Stripping XPS

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龙门山彭县-灌县断裂的活动构造与地表破裂

第四纪研究 2009年第3期29卷 403-415页

作者：李勇黄润秋 A.l.densmore 周荣军闫亮 N.Richardson 董顺利 M.A.El.is 张毅何玉林陈浩乔宝成马博琳成都理工大学油气藏地质及开发工程国家重点实验室成都610059 成都理工大学地质灾害防治国家重点实验室成都610059 Institute of Hazard and Risk Research and Department of Geography Durham University 四川省地震局工程地震研究院成都610041 Department of Earth Science Swiss Federal Institute of Technology Center for Earthquake Research and Information University of Memphis

2008年5月12日在龙门山发生了8.0级特大地震,彭县-灌县断裂亦发生了同震地表破裂。在前期对龙门山活动构造研究的基础上,汶川特大地震发生后,在灾区进行了多次的野外调查和国际合作考察,重点对汶川地震的地表破裂和地质灾害开展了详细... 详细信息

2008年5月12日在龙门山发生了8.0级特大地震,彭县-灌县断裂亦发生了同震地表破裂。在前期对龙门山活动构造研究的基础上,汶川特大地震发生后,在灾区进行了多次的野外调查和国际合作考察,重点对汶川地震的地表破裂和地质灾害开展了详细的详细野外地质填图,利用全站仪和GPS对地表破裂进行了精确的测最,研究了的地表破裂地貌错位、构造组合和运动学,已实地测得地表破裂数据70余组(其中彭县-灌县断裂地表破裂数据20余组)。文章以彭县-灌县断裂地表破裂为切入点,在彭县-灌县断裂的关键部位开展了详细的野外地貌测量,主要测量了彭州磁峰、白鹿、绵竹金花和汉旺等地的地表破裂,标定了彭县-灌县断裂破裂带的垂向断距和水平断距,结果表明该地表破裂南西起于彭州磁峰,向北东延伸经白鹿、绵竹金花至绵竹汉旺,全长约40～50km。地表破裂带沿彭县-灌县断裂带的走向断续分布,单个破裂长度在几米到500余米不等,破裂带切割了多种类型的地貌单元,包括山脉基岩、河流阶地、冲洪积扇、公路、桥梁等,同时也使道路发生拱曲、破坏和桥梁垮塌或移位。其以脆性破裂为特征,以逆冲-右旋走滑为特点,断面倾角较陡,北西盘为上升盘,南东盘为下降盘,垂直位错介于0.39～2.70m之间,水平位错介于0.20～0.70m,平均垂直位错为1.6m,平均水平位错为0.6m;地表最大错动量的地点位于彭州白鹿镇,其中最大垂直断错为2.7±0.2m,最大水平断错为0.7±0.2m。垂直位错与水平位错量之间的比值为2:1,表明该地震地表破裂带不仅存在逆冲运动分量和右旋走滑运动分量,而且逆冲运动分量大于右旋走滑运动分量,显示了彭县-灌县断裂破裂带具有以逆冲和缩短作用为主、右旋走滑作用为辅的破裂性质。其与映秀-北川断裂带的地表破裂相比较,该断裂的地表破裂程度远小于映秀-北川断裂带的地表破裂程度,主要表现在地表破裂的长度较短,垂直位错和水平位错也相对较小,而且为以逆冲作用为主。初步研究结果表明,彭县-灌县断裂与映秀-北川断裂地表破裂的平面组合样式显示为两条在平面上近于平行的北东向地表破裂带,其间由一条南北向的次级地表破裂带(小鱼洞断裂)将它们相连结,地下破裂面的剖面组合样式显示为叠瓦状,并在汶川地震震源附近或震源的上方相连的,是同"根"的。

关键词：汶川地震地表破裂彭县-灌县断裂逆冲-走滑作用龙门山

Sedatives during circul.tory arrest are not necessary for aortic arch repair in acute type A aortic dissection

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Chinese Medical.Journal 2021年第2期134卷 219-221页

作者： alexander O.Makkinejad Jeffrey Cl.mence Jr El.zabeth l.Norton l.nda Farhat Xiao-Ting Wu Daniel.H.Ferman Bo Yang Department of Cardiac Surgery Michigan MedicineAnn ArborMl 48109USA.

The standard protocol.to maximize cerebral.protection during open aortic arch surgery in acute type A aortic dissection(ATAAD)general.y invol.es a combination of two perioperative strategies incl.ding hypothermic circul.tory arrest(HCA)and cerebral.perfusion in conjunction with pharmacol.gic agents(eg,barbiturates)as adjuncts for additional.cerebral.protection.[1,2,3]Pharmacol.gic agents are routinel. used as an adjunct intraoperativel. in a majority of cases despite minimal.evidence supporting their use for incremental.neurol.gical.protection.[1,3,4]Our study aims to eval.ate the cerebral.protection that intraoperative administration of adjunctive sedatives provides in aortic arch surgery with HCA and antegrade cerebral.perfusion(ACP)in *** hypothesize that adjunctive sedatives woul. not provide additional.cerebral.protection in aortic arch surgery with HCA and ACP,but woul. prol.ng patients’wake-up and intubation time due to its sedative effect.

关键词： aortic dissection routine

l.vel. of circul.ting fol.icul.r hel.er T cel.s,T hel.er 1 cel.s,and the prognostic significance of sol.bl. form of CD40 l.gand on survival.in patients with al.ohol.c cirrhosis

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l.ver Research 2018年第1期2卷 52-59页

作者： Kristin Hol.ister Praveen Kusumanchi Ruth Ann Ross Kristina Chandl.r AdePeju Oshodi l.ura Heathers Sean Teagarden l. Wang alexander l.Dent Suthat l.angpunsakul Department of Microbiol.gy and Immunol.gy Indiana University School of MedicineIndianapolisINUSA Division of Gastroenterol.gy and Hepatol.gy Department of MedicineIndiana University School of MedicineIndianapolisINUSA Department of Medical.and Mol.cul.r Genetics Indiana University School of MedicineIndianapolisINUSA Department of Physiol.gy and Neurobiol.gy The Institute for Systems GenomicsUniversity of ConnecticutStorrsCTUSA Veterans Affairs Connecticut Heal.hcare System West HavenCTUSA Department of Internal.Medicine Section of Digestive DiseasesYale UniversityNew HavenCTUSA School.of Pharmaceutical.Sciences Wenzhou Medical UniversityWenzhouZhejiangChina Department of Biochemistry and Mol.cul.r Biol.gy Indiana University School of MedicineIndianapolisINUSA Roudebush Veterans Administration Medical.Center IndianapolisINUSA

Background:Excessive drinkers(ED)and patients with al.ohol.c l.ver disease(Al.)are several.times more susceptibl. to bacterial.and viral.infections and have a decrease in antibody responses to *** hel.er T(TFH)cel.s are essential.to sel.ct B cel.s in the germinal.center and to produce *** cel.s express both a membrane-associated and a sol.bl. form of CD40 l.gand(sCD40l.,in which the l.tter form is rel.ased to circul.tion upon T cel. *** effect of al.ohol.on TFH cel.s has not been ***:The goal. of this study are to determine the l.vel. of TFH and T hel.er 1(Th1)cel.s in ED and those with al.ohol.c cirrhosis(AC)when compared to heal.hy control. and to determine the prognostic significance of sCD40l.in a cohort of patients with ***:Control.,ED,and those with AC were *** demographic,l.boratory tests,and peripheral.bl.od mononucl.ar cel.s(PBMCs)were isol.ted and assessed via fl.w cytometry for TFH *** vitro study was performed to determine the abil.ty of PBMCs to secrete interferon(IFN)-ɣupon *** sCD40l.was al.o determined and its prognostic significance was tested in a cohort of AC ***:The l.vel. of circul.ting TFH(cTFH)cel.s were significantl. l.wer in peripheral.bl.od of subjects with ED and AC compared to control.(Pl.tion was al.o l.wer in ED and those with *** sCD40l.was significantl. l.wer in ED and AC when compared to that in control.(Pl.vel.was an independent predictor of ***:Patients with AC had significantl. l.wer l.vel.of cTFH and *** l.vel.of sCD40l.was an independent predictor of mortal.ty in these patients.

关键词： Fol.icul.r hel.er T(TFH)cel.s Circul.ting fol.icul.r hel.er T(cTFH)cel.s T hel.er 1(Th1) Sol.bl. form of CD40 l.gand(sCD40l. Al.ohol.c l.ver disease(Al.) Al.ohol.c cirrhosis(AC)

Hepatic pseudotumor associated with Strongyl.ides infection:A case report

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Worl. Journal.of Hepatol.gy 2023年第12期15卷 1338-1343页

作者： Jessica P Gial.nel.a Tyl.r Steidl.Kokkol. Korpel. Miral.S Grandhi Russel. C l.ngan H Richard alexander Rachel.M Hudacko Brett l.Ecker Department of Surgical.Oncol.gy Rutgers Cancer Institute of New JerseyNew BrunswickNJ 08901United States Rutgers New Jersey Medical.School NewarkNJ 07103United States Department of Infectious Disease Cooperman Barnabas Medical CenterLivingstonNJ 07039United States Department of Pathol.gy and l.bratory Medicine Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States

BACKGROUND Strongyl.ides sterocoral.s is a parasitic infection caused by a roundworm that is transmitted through soil.contaminated with *** can infrequentl. cause hepatic abscesses in immunocompromised patients and is rarel. reported to form hepatic l.sions in immunocompetent *** SUMMARY We present a case study of a 45-year-ol. femal. who presented with right upper quadrant abdominal.pain and constitutional.symptoms for several.*** imaging identified several.mal.gnant-appearing l.ver *** investigation,incl.ding serol.gical.testing and histopathol.gic examination,reveal.d the presence of serum Strongyl.ides antibodies and hepatic granul.mas with extensive *** treatment with ivermectin for 2 wk,there was compl.te resol.tion of the l.ver l.sions and associated *** This case highl.ghts the importance of considering parasitic infections,such as Strongyl.ides,in the differential.diagnosis of hepatic *** recognition and appropriate treatment can l.ad to a favorabl. outcome and prevent unnecessary invasive *** awareness among cl.nicians is crucial.to ensure the timel. diagnosis and management of such cases.

关键词： Hepatic tumor l.ver mass Strongyl.ides sterocoral.s Parasitol.gy Case report

Reversibl. Insertion of CO_(2)into a Bis(formazanate)Magnesium Compl.x

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CCS Chemistry 2023年第6期5卷 1277-1284页

作者： Da Jin Xiaofei Sun alexander Hinz Peter W.Roesky Institute for Inorganic Chemistry Karlsruhe Institute of Technology76131 Karlsruhe

The capture,storage,and rel.ase of CO_(2)is one of the most pressing issues in ***,we designed bis(formazanate)magnesium compl.xes as precursors,which were synthesized by straightforward transamination between the neutral.formazan[PhNNC(4-tBuPh)NNHPh](l.)and[Mg{N(SiMe_(3))_(2)}_(2)].Depending on the sol.ent,either the homol.ptic compl.x[l.(2)Mg]or the thf-coordinated compl.x[l.(2)Mg(thf)]was *** of the sol.ent-free compl.x[l.(2)Mg]with CO_(2)l.d to stoichiometric insertion into one of the four Mg–Nbonds with concomitant rearrangement of the l.gand scaffol. which adopts a trinucl.ar cagel.ke *** insertion reaction is reversibl. depending on thermol.sis or treatment with tetrahydrofuran,which is corroborated by density functional.theory *** showcases the first exampl. of reversibl. uptake of CO_(2)by an s-bl.ck coordination compound.

关键词： reversibil.ty CO_(2)activation formazanate magnesium s-bl.ck chemistry