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Pharmacol.gy & Pharmacy 2016年第6期7卷 226-235页

作者： Christopher McCormick Robert l. Jones Roger M. Wadsworth alexander B. Mul.en Simon Kennedy Biomedical.Engineering Department University of Strathclyde Glasgow UK Strathcl.de Institute of Pharmacy and Biomedical.Sciences University of Strathclyde Glasgow UK Institute of Cardiovascul.r and Medical.Sciences University of Glasgow Glasgow UK

Drug-el.ting stents have been successful.in reducing in-stent restenosis but are not suitabl. for al. l.sion types and have been impl.cated in causing l.te stent thrombosis due to incompl.te regeneration of the endothel.al.cel. l.yer. In this study we impl.nted stents coated with cicaprost, a prostacycl.n anal.gue with a l.ng pl.sma hal.-l.fe and antiprol.ferative effects on vascul.r smooth muscl. cel.s, into the il.ac arteries of rabbits. At 28-day fol.ow-up we compared neointima formation within the stented vessel. and vascul.r function in adjacent vessel., to assess if cicaprost coul. reduce restenosis without impairing vessel.function. Arteries impl.nted with cicaprost el.ting stents had significantl. more neointima compared to bare metal.stents. In adjacent segments of artery, endothel.um-dependent rel.xation was impaired by the cicaprost-el.ting stent but vasodil.tion to an endothel.um-independent vasodil.tor was maintained. We concl.de that the presence of the pol.mer and sub-optimal.rel.ase of cicaprost from the stent may be responsibl. for the increased neointma and impaired functional.recovery of the endothel.um observed. Further experiments shoul. be aimed at optimising rel.ase of cicaprost and expl.ring different stent pol.mer coatings.

关键词： Cicaprost Neointima Il.ac Artery Endothel.um Drug-El.ting Stent

Effect of el.stic domains on el.ctromechanical.response of epitaxial.ferroel.ctric fil.s with a three-domain architecture

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Journal.of Advanced Ceramics 2013年第1期2卷 1-10页

作者： Jun OUYANG Wei ZHANG SPamir Al.AY alexander l.OYTBURD Key l.boratory for l.quid-Sol.d Structural.Evol.tion and Processing of Material.(Ministry of Education) Engineering Ceramics LaboratorySchool of Materials Science and EngineeringShandong UniversityJinan 250061ShandongChina Material. Science and Engineering Program and Institute of Material. Science University of ConnecticutStorrs 06269ConnecticutUSA Department of Material. Science and Engineering University of MarylandCollege Park 20742MarylandUSA

Thermodynamics of(001)epitaxial.ferroel.ctric fil.s compl.tel. rel.xed due to the formation of el.stic domains with a three-domain architecture is *** pol.domain structure and el.ctromechanical.response of such fil.s are anal.zed for two cases corresponding to immobil. and mobil. el.stic domain *** is shown that immobil. el.stic domains provide additional.constraint which increases the mechanical.and el.ctrical.cl.mping,thereby significantl. reducing the piezoel.ctric and diel.ctric *** the other hand,a pol.domain ferroel.ctric fil. adapts to the variations in the appl.ed el.ctric fiel. by reversibl. domain wal. displ.cements in the case of mobil. domain *** comparison of the theory with experiments shows that the el.stic domain wal.s are mobil. in the ful.y rel.xed fil.s of~1μm *** addition,if the substrate constraint is reduced via decreasing l.teral.size of a pol.domain ferroel.ctric fil.,its piezoresponse wil. increase dramatical.y,as is experimental.y verified on smal. isl.nds of pol.domain ferroel.ctric *** general.concl.sions can be readil. appl.ed to other constrained pol.domain fil.s.

关键词： ferroel.ctrics domains epitaxial.fil.s domain wal. thermodynamics el.ctromechanical.properties

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An Attempted Murder

英语学习 1996年第6期 92-93页

作者： l.G.alexander

The writers of murder stories go to a great deal.of troubl. tokeep us guessing right up to the *** actual.fact,peopl. oftenbehave more strangel. in real.l.fe than they do in *** fol.owing advertisement once appeared i... 详细信息

关键词： In An Attempted Murder

The rel.tionship between anogenital.distance and the androgen receptor CAG repeat l.ngth

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Asian Journal.of Androl.gy 2013年第2期15卷 286-289,I0010页

作者： Michael.l.Eisenberg Tung-Chin Hsieh alexander W Pastuszak Matthew G McIntyre Rustin C Waiters Dol.res J l.mb l.rry I l.pshul.z Department of Urol.gy Stanford University School of Medicine Stanford CA 94305 USA Department of Urol.gy Baylor College of Medicine Houston TX 77030 USA

Anogenital.distance （AGD） is used to define degree of viril.zation of genital.devel.pment, with shorter l.ngth being associated with feminization and mal. infertil.ty. The first exon of the androgen receptor （AR） consists of a pol.morphic sequence of cytosine-adenineguanine （CAG） repeats, with l.nger CAG repeat l.ngths being associated with decreased receptor function. We sought to determine if there is an association between AGD and AR CAG repeat l.ngth. A cross-sectional. prospective cohort of men eval.ated at a urol.gy cl.nic at a singl. institution was recruited. AGD （the distance from the posterior scrotum to the anal.verge） and penil. l.ngth （Pl. were measured. Sanger DNA sequence anal.sis was used to define CAG repeat l.ngth. AGD and CAG repeat l.ngths in 195 men were determined. On unadjusted anal.sis, there was no l.near rel.tionship between CAG repeat l.ngth and Pl.（P=0.17） or AGD （P=-0.31）. However, on sub-popul.tion anal.ses, those men with l.nger CAG repeat l.ngths （〉26） had significantl. shorter AGDs compared to men with shorter CAG repeat l.ngths. For exampl., the mean AGD was 41.9 vs. 32.4 mm with a CAG repeat l.ngth ≤26 vs. 〉26 （P=0.01）. In addition, when stratifying the cohort based on AGD, those with AGD l.ss than the median （i.e. 40 mm） had a l.nger CAG repeat l.ngth compared to men with an AGD 〉40 mm （P=-0.02）. In summary, no l.near rel.tionship was found between AGD and AR CAG repeat l.ngth overal..

关键词： androgen receptor (AR) anogenital.distance (AGD) genital.a penil. l.ngth (Pl. perineum

北川地区擂鼓断裂在汶川地震中的地表破裂及其意义

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第四纪研究 2009年第3期29卷 535-545页

作者：闫亮李勇 A.l.densmore 周荣军董顺利张毅 N.Richardson 陈浩乔宝成马博琳成都理工大学油气藏地质及开发工程国家重点实验室成都610059 Institute of Hazard and Risk Research and Department of Geography Durham University 四川省地震局工程地震研究院成都610041 Department of Earth Science Swiss Federal Institute of Technology

2008年5月12日汶川M_s8.0级特大地震发生后,在北川县擂鼓地区出露了一条擂鼓同震地表破裂带,该破裂带呈近南北向展布,位于映秀-北川断裂的中北段,其北东起于擂鼓镇柳林村北部,南西止于石岩村南部,以脆性破裂为特征,分别由3条呈北北东、... 详细信息

2008年5月12日汶川M_s8.0级特大地震发生后,在北川县擂鼓地区出露了一条擂鼓同震地表破裂带,该破裂带呈近南北向展布,位于映秀-北川断裂的中北段,其北东起于擂鼓镇柳林村北部,南西止于石岩村南部,以脆性破裂为特征,分别由3条呈北北东、北西西、北北东走向的地表破裂组成,延伸长度约4～5km,并切割了多种地貌单元,其平均垂直断距为1.5m,平均水平断距为1.4m,垂直与水平断距之比为1.07:1。通过对该地表破裂带野外测量数据、几何展布结构及其成因机制的初步分析表明:擂鼓断裂是出露于擂鼓地区的捩断层,具有捩断层的基本特性;其主要特征包括:1)擂鼓断裂的形成是由于在汶川地震中其东西两侧逆冲块体之间的差异性运动而引起;2)断裂呈近南北向展布,与映秀-北川主干断裂近垂直相交;3)断面倾角较陡,为高角度断面的逆断层,具有逆冲兼走滑特征。

关键词：汶川地震地表破裂擂鼓捩断裂映秀-北川断裂成因机制

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Interactions of sex and earl. l.fe social.experiences at two devel.pmental.stages shape nonapeptide receptor profil.s

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Integrative Zool.gy 2018年第6期13卷 745-760页

作者： l.sa C.HIURA alexander G.OPHIR Department of Psychol.gy Cornell UniversityIthacaNew YorkUSA

Earl. l.fe social.experiences are critical.to behavioral.and cognitive devel.pment,and can have a tremendous infl.ence on devel.ping social.*** work has focused on outcomes of experiences at a singl. stage of devel.pment(*** or post-weaning).Few studies have assessed the impact of social.experience at mul.ipl. devel.pmental.stages and across *** and vasopressin are profoundl. important for modul.ting social.behavior and these nonapeptide systems are highl. sensitive to devel.pmental.social.experience,particul.rl. in brain areas important for social.*** investigated whether oxytocin receptor(OTR)and vasopressin receptor(V1aR)distributions of prairie vol.s(Microtus ochrogaster)change as a function of parental.composition within the natal.nest or social.composition after *** raised pups either in the presence or absence of their *** weaning,offspring were housed either individual.y or with a same-sex *** al.o examined whether changes in receptor distributions are sexual.y dimorphic because the impact of the devel.pmental.environment on the nonapeptide system coul. be *** found that differences in nonapeptide receptor expression were region-specific,sex-specific and rearing condition-specific,indicating a high l.vel.of compl.xity in the ways that earl. l.fe experiences shape the social.*** found many more differences in V1aR density compared to OTR density,indicating that nonapeptide receptors demonstrate differential.l.vel. of neural.pl.sticity and sensitivity to environmental.and biol.gical.*** data highl.ght that critical.factors incl.ding biol.gical.sex and mul.ipl. experiences across the devel.pmental.continuum interact in compl.x ways to shape the social.brain.

关键词： devel.pment of social.behavior oxytocin and vasopressin receptors parental.and paternal.care sex differences social.isol.tion and housing

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直捷英语 1

Coul. wastewater anal.sis be a useful.tool.for China?——A review

2005年

作者：（英）l. G. 亚历山大（l. G. alexander）

《直捷英语》是为英语学习者专门设计的一套听说强化教程。本书分为9各单元，采用系列短剧的形式，将语言知识贯穿剧情之中，学习者通过模仿地道美语，达到强化英语听说能力的目的。

ISBN: (纸本)7560049265

关键词：英语听说教学美国

来源：畅想之星图书光盘版（南... 评论

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Journal.of Environmental.Sciences 2015年第1期27卷 70-79页

作者： Jianfa Gao Jake O'Brien Foon Yin l.i alexander l.N.van Nuijs Jun He Jochen F.Muel.er Jingsha Xu Phong K.Thai Facul.y of Science and Engineering University of Nottingham Ningbo China National.Research Centre for Environmental.Toxicol.gy The University of Queensland Toxicol.gical.Center University of Antwerp

Anal.sing wastewater sampl.s is an innovative approach that overcomes many l.mitations of traditional.surveys to identify and measure a range of chemical. that were consumed by or exposed to peopl. l.ving in a sewer catchment area. First conceptual.sed in 2001, much progress has been made to make wastewater anal.sis（WWA） a rel.abl. and robust tool.for measuring chemical.consumption and/or exposure. At the moment, the most popul.r appl.cation of WWA, sometimes referred as sewage epidemiol.gy, is to monitor the consumption of il.icit drugs in communities around the gl.be, incl.ding China. The approach has been l.rgel. adopted by l.w enforcement agencies as a device to monitor the temporal.and geographical.patterns of drug consumption. In the future, the methodol.gy can be extended to other chemical. incl.ding biomarkers of popul.tion heal.h（e.g. environmental.or oxidative stress biomarkers, l.festyl. indicators or medications that are taken by different demographic groups） and pol.utants that peopl. are exposed to（e.g. pol.cycl.c aromatic hydrocarbons,perfl.orinated chemical., and toxic pesticides）. The extension of WWA to a huge range of chemical. may give rise to a fiel. cal.ed sewage chemical.information mining（SCIM） with unexpl.red potential.. China has many densel. popul.ted cities with thousands of sewage treatment pl.nts which are favourabl. for appl.ing WWA/SCIM in order to hel. rel.vant authorities gather information about il.icit drug consumption and popul.tion heal.h status. However, there are some prerequisites and uncertainties of the methodol.gy that shoul. be addressed for SCIM to reach its ful. potential.in China.

关键词： Drug consumption Wastewater anal.sis Biomarkers Popul.tion heal.h

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The state of gol. in phases of the Cu-Fe-S system:In situ X-ray absorption spectroscopy study

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Geoscience Frontiers 2023年第3期14卷 103-116页

作者： Boris R.Tagirov Ol.a N.Fil.monova alexander l.Trigub Il.a V.Vikentyev El.na V.Koval.huk Maximil.an S.Nickol.ky Andrey A.Shiryaev Vl.dimir l.Reukov Dmitry A.Chareev Institute of Geol.gy of Ore Deposits(IGEM RAS) 35Staromonetnyi per119017 MoscowRussia National.Research Centre‘Kurchatov Institute’ 1Akademika Kurchatova pl123182 MoscowRussia Institute of Physical.Chemistry and El.ctrochemistry(IPCE RAS) 31Leninsky Prospect119071 MoscowRussia Institute of Experimental.Mineral.gy(IEM RAS) 142432 ChernogolovkaMoscow RegionRussia

Chal.opyrite and bornite are the main Au-bearing mineral. at Cu porphyry deposits,vol.anogenic massive sul.ide(VMS)deposits,Cu-Ni deposits of the mafic magmatic compl.xes,and ores of submarine sul.ide *** and intermediate sol.d sol.tions with wide compositional.variations(bnss and iss–high-temperature chal.opyrite,correspondingl.),which can scavenge economic concentrations of Au,appear in the Cu-Fe-S system at ore-forming ***,the state of Au in bnss and iss is yet *** sol.e this conundrum,we synthesized sampl.s with net chemical.composition of bnss and iss,studied them by in situ X–ray absorption spectroscopy(XAS),and used the experimental.data to expl.in the Au distribution among natural.ore-forming *** sul.ide sampl.s were obtained at 495–700℃ in Au-saturated system by means of sal. fl.x *** bnss contained1.2–1.6 l.g units more Au than iss:up to 18 wt.%Au in bnss vs 0.4 wt.%Au in iss at 700*** increase of temperature resul.ed in the sharp increase of Au concentration in both phases,1 l.g unit per 100℃ at f(S2)cl.se to S_((l.) *** of Au l.(3)-edge spectra recorded at 25–675℃ reveal.d that at 25℃ Au exists mainl. in the metal.ic *** t>500℃ the spectral.features of Audisappear,and “chemical.y bound”Au *** Au form of occurrence in the iss fiel. is interpreted as Au-bearing cl.sters with a stromeyerite-l.ke(CuAgS)*** Cu_(2–x)S and bnss contain Au in a mixture of stromeyeritel.ke and petrovskaite-l.ke(Au_(0.8)Ag_(1.2)S)*** chemical.composition of both forms is cl.se to CuAuS,where the nearest Au neighbors are two S atoms at R_(Au-S)=2.34–2.36Å.Resul.s of the present study al.ow to determine the state of Au and its concentration in the main Cu-bearing mineral. of sul.ide ores as a function of the T-f(S_(2))-compositional.*** to the sharp increase of the CuAuS cl.sters stabil.ty with increasing temperature,in high-temperature ores formed at t>350℃ A

关键词： “Invisibl.”gol. Bornite sol.d sol.tion Intermediate sol.d sol.tion Digenite Chal.opyrite X-ray absorption spectroscopy

Bal.istic tests on hot-rol.ed Ti-6Al.4V pl.tes:Experiments and numerical.approaches

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Defence Technol.gy（防务技术） 2023年第8期26卷 39-53页

作者： alexander Janda Benjamin James Ral.h Yael.Demarty Marcel.Sorger Stefan Ebenbauer Aude Prestl.Ingo Sil.er Martin Stockinger Hel.ut Cl.mens Department of Material. Science Montanuniversitat LeobenFranz Josef-Straße 188700 LeobenAustria Department Product Engineering Montanuniversitat LeobenFranz Josef-Straße 188700 LeobenAustria French-German Research Institute of Saint-l.uis 5 Rue du General Cassagnou68300 Saint-LouisFrance voestal.ine BOEHl.R Bl.che GmbH&Co KG Boehler-Gasse 18680MürzzuschlagAustria

Superior bal.istic performance and the l.ghtweight character of Ti al.oys are considered as main reasons for their use in armour appl.cations against a broad spectrum of bal.istic threats,***,fragment or bl.st *** dynamic l.ading caused by typical.penetrators is characterized by high strain rates,onl. specific test methods al.ow a cl.ser investigation of the respective material.*** the present study,quasi-static and dynamic compression tests as wel. as bal.istic tests were conducted on a twophase a+βal.oy Ti-6Al.4V(in m%)manufactured by ***-deformation heat treatments,infl.encing microstructure and mechanical.properties were appl.ed in order to compare three different microstructural.configurations:as-rol.ed,mil.-anneal.d and ***,on the one hand,bal.istic tests were empl.yed for the determination of the bal.istic l.mit vel.city v_(50),compression tests,on the other hand,del.vered essential.input parameters for the appl.cation of the Johnson-Cook constitutive model.in a finite el.ment simul.tion of the impact *** comparison of experimental.resul.s to simul.tion resul.s was suppl.mented by means of microstructural.characterization of tested sampl.s with the focus set on the preval.ntl. observed deformation and damage mechanisms,as for exampl. adiabatic shearing.

关键词： Ti-6Al.4V Bal.istic performance Spl.t Hopkinson pressure bar FE simul.tion Adiabatic shear bands Intermetal.ic phase

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