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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu deng Mingbo Nie Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu deng Jie Shen Jinxing Lu Chuqiang Huang Zhuoyuan Chen Feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

Robust adaptive precision motion control of tank horizontal stabilizer based on unknown actuator backlash compensation

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Defence Technology（防务技术） 2023年第2期20卷 72-83页

作者： Shu-sen Yuan Wen-Xiang deng Jian-yong Yao Guo-Lai Yang School of Mechanical Engineering Nanjing University of Science and TechnologyNanjingChina

Backlash nonlinearity inevitably exists in the actuator of tank horizontal stabilizer and has adverse effect on the system control performance,however,how to effectively eliminate its effect remains a pending *** solve this problem,a robust adaptive precision motion controller is presented in this paper to address uncertainties and unknown actuator backlash of tank horizontal *** controller handles the modeling uncertainties including parameter uncertainties and unmodeled disturbances by integrating adaptive feedforward compensation and continuous nonlinear robust *** on the backstepping method,a smooth backlash inverse model is constructed by combining the adaptive ***,the unknown backlash parameters of the system can be approximated through the parameter adaptation,and the impact of the actuator backlash nonlinearity is effectively compensated via the inverse operation,which can availably improve the tracking ***,the adaptive law can update the disturbance ranges of tank horizontal stabilizer online in real time,which enhances the feasibility in practical engineering ***,the stability analysis based on Lyapunov function shows that with the existence of unmodeled disturbances and unknown actuator backlash,the designed controller guarantees excellent asymptotic output tracking *** comparative results verify the effectiveness of the proposed control strategy.

关键词： Tank Horizontal stabilizer Adaptive control Robust control Backlash inverse

Brainstorming in Beijing

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China Today 2025年第1期74卷 36-38页

作者： deng DI 不详

Entrepreneurs from home and abroad discuss how to cooperate and compete amicably to keep the global industrial and supply chains ***’AN,a city in Fujian Province in southeast China,is a pioneer in China’s valve *** the last four decades,with the support of national policies and the help of the local government,it has formed a large-scale industrial cluster with a complete industrial chain that has over 200 local enterprises.

关键词： enterprises southeast chains

Uncertainty measure in evidence theory

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Science China(Information Sciences) 2020年第11期63卷 5-23页

作者： yong deng School of Education Shannxi Normal University The Institute of Fundamental and Frontier Science University of Electronic Science and Technology of China

As an extension of probability theory, evidence theory is able to better handle unknown and imprecise information. Owing to its advantages, evidence theory has more flexibility and effectiveness for modeling and processing uncertain information. Uncertainty measure plays an essential role both in evidence theory and probability theory. In probability theory, Shannon entropy provides a novel perspective for measuring uncertainty. Various entropies exist for measuring the uncertainty of basic probability assignment(BPA) in evidence theory. However, from the standpoint of the requirements of uncertainty measurement and physics, these entropies are controversial. Therefore, the process for measuring BPA uncertainty currently remains an open issue in the literature. Firstly, this paper reviews the measures of uncertainty in evidence theory followed by an analysis of some related controversies. Secondly, we discuss the development of deng entropy as an effective way to measure uncertainty, including introducing its definition, analyzing its properties, and comparing it to other measures. We also examine the concept of maximum deng entropy, the pseudo-Pascal triangle of maximum deng entropy, generalized belief entropy, and measures of divergence. In addition, we conduct an analysis of the application of deng entropy and further examine the challenges for future studies on uncertainty measurement in evidence theory. Finally, a conclusion is provided to summarize this study.

关键词： evidence theory uncertainty measure deng entropy Shannon entropy

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

融合知识图谱和大模型的高校科研管理问答系统设计

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计算机科学与探索 2025年第1期19卷 107-117页

作者：王永秦嘉俊黄有锐邓江洲重庆邮电大学电子商务与现代物流重点实验室

科研管理是高校管理中的重要组成部分，但现有的科研管理系统难以满足用户的个性化需求。以高校科研管理向智能化转型为需求导向，将知识图谱、传统模型和大语言模型相结合，共同构建新一代高校科研管理问答系统。采集科研知识用于构建... 详细信息

科研管理是高校管理中的重要组成部分，但现有的科研管理系统难以满足用户的个性化需求。以高校科研管理向智能化转型为需求导向，将知识图谱、传统模型和大语言模型相结合，共同构建新一代高校科研管理问答系统。采集科研知识用于构建科研知识图谱。利用同时进行意图分类和实体提取的多任务模型进行语义解析。借助解析结果来生成查询语句，并从知识图谱中检索信息来回复常规问题。将大语言模型与知识图谱相结合，以辅助处理开放性问题。在意图和实体具有关联的数据集上的实验结果表明，采用的多任务模型在意图分类和实体识别任务上的F1值分别为0.958和0.937，优于其他对比模型和单任务模型。Cypher生成测试表明了自定义Prompt在激发大语言模型涌现能力方面的成效，利用大语言模型实现文本生成Cypher的准确率达到85.8%，有效处理了基于知识图谱的开放性问题。采用知识图谱、传统模型和大语言模型搭建的问答系统的准确性为0.935，很好地满足了智能问答的需求。

关键词：知识图谱多任务模型意图分类命名实体识别大语言模型

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半潜式风机变桨距控制优化研究

水力发电 2025年第1期51卷 88-92页

作者：邓森葛双义王锋国家电投集团江苏电力有限公司江苏南京210003 国家电投集团江苏海上风力发电有限公司江苏盐城224000

以半潜浮式风机为研究对象,应用控制系统仿真软件MATLAB/Simulink和基于水动力和空气动力耦合的FAST软件进行联合仿真计算。以最小化功率波动和抑制平台运动为控制目标,利用人工蚁群算法来对变桨控制的PID控制器参数进行优化,得到了风... 详细信息

以半潜浮式风机为研究对象,应用控制系统仿真软件MATLAB/Simulink和基于水动力和空气动力耦合的FAST软件进行联合仿真计算。以最小化功率波动和抑制平台运动为控制目标,利用人工蚁群算法来对变桨控制的PID控制器参数进行优化,得到了风浪联合作用下的海上浮式风机变桨距ACO-PID控制器,并将其与基线PI控制器在功率输出、转子转速、叶片桨距角和平台纵摇角参数方面进行了对比分析。结果显示,ACO-PID控制器较好的抑制了功率的波动和平台的纵摇运动,并一定程度的降低了风机主要部位的疲劳载荷,提高了风机结构的安全性,增加了风电机组的使用寿命。

关键词：半潜式风机数值仿真变桨距控制人工蚁群算法动力响应