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下肢动脉钙化与下肢动脉硬化闭塞症患者血流动力学及外周血管支架联合巴曲酶治疗效果的关系

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中国医药 2024年第10期19卷 1509-1514页

作者：赵峰邓默河北大学附属医院介入血管外科保定071000 河北大学附属医院麻醉科保定071000

目的探讨下肢动脉钙化与下肢动脉硬化闭塞症(ASO)患者血流动力学及外周血管支架联合巴曲酶治疗效果的关系。方法筛选2022年2月至2024年2月于河北大学附属医院接受外周血管支架联合巴曲酶治疗的120例ASO患者作为观察组,另选取60例踝肱指... 详细信息

目的探讨下肢动脉钙化与下肢动脉硬化闭塞症(ASO)患者血流动力学及外周血管支架联合巴曲酶治疗效果的关系。方法筛选2022年2月至2024年2月于河北大学附属医院接受外周血管支架联合巴曲酶治疗的120例ASO患者作为观察组,另选取60例踝肱指数≥0.9的患者纳入对照组(非ASO患者)。根据治疗后6个月再狭窄是否>50%的情况将ASO患者分为预后良好组(62例,再狭窄程度≤50%)和预后不良组(58例,再狭窄程度>50%)。比较观察组与对照组的临床资料,分层回归分析血流动力学参数与股浅动脉钙化评分(SFACS)、膝下动脉钙化评分(BKACS)的关系;比较预后良好组与预后不良组的临床资料及治疗前后的踝肱指数、趾肱指数;Cox回归分析评估SFACS、BKACS与患者预后不良的关系;多元线性回归分析SFACS、BKACS与踝肱指数、趾肱指数的关系;限制性立方样条模型分析SFACS、BKACS与ASO患者预后不良风险的剂量-效应关系。结果观察组年龄、男性比例、吸烟史比例、胫后动脉收缩期血流速度峰值(Vs)、足背动脉Vs、SFACS、BKACS明显高于对照组,胫后动脉血管内径、足背动脉血管内径明显低于对照组(均P<0.05)。胫后动脉血管内径、足背动脉血管内径均对SFACS、BKACS产生显著的负向影响,胫后动脉Vs、足背动脉Vs均对SFACS、BKACS产生显著的正向影响(均P<0.05)。预后良好组和预后不良组C反应蛋白、白蛋白、纤维蛋白原、SFACS[2282(856,3259)分比4236(1547,6325)分]和BKACS[1024(526,1730)分比1951(1157,2968)分]比较差异均有统计学意义(均P<0.05)。预后良好组治疗后6个月和治疗后1、2年踝肱指数和趾肱指数均明显高于预后不良组(均P<0.05)。调整混杂因素前后,SFACS、BKACS均与患者预后不良风险呈正相关,与踝肱指数、趾肱指数呈负相关(均P<0.05)。ASO患者预后不良风险随SFACS、BKACS增加而增加(非线性P值分别为0.762和0.395)。结论下肢动脉钙化水平与ASO患者血流动力学有关,在一定程度上能够评估外周血管支架联合巴曲酶的治疗效果,因此在ASO的治疗过程中,可将其作为临床治疗的检查标志之一,用以及时优化治疗方案。

关键词：下肢动脉硬化闭塞症下肢动脉钙化外周血管支架巴曲酶

纤维蛋白原水平、踝肱指数与外周血管支架治疗下肢动脉硬化闭塞症后再狭窄的关系

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中华临床医师杂志（电子版） 2024年第2期18卷 144-151页

作者：赵峰邓默河北大学附属医院介入血管外科河北保定071000 河北大学附属医院麻醉科河北保定071000

目的探究影响外周血管支架治疗下下肢动脉硬化闭塞症(LEASO)后发生支架内再狭窄(ISR)的危险因素,分析纤维蛋白原(FIB)水平、踝肱指数(ABI)与ISR的关系。方法选取2021年1月~2022年10月于河北大学附属医院就诊的LEASO患者121例,根据术后IS... 详细信息

目的探究影响外周血管支架治疗下下肢动脉硬化闭塞症(LEASO)后发生支架内再狭窄(ISR)的危险因素,分析纤维蛋白原(FIB)水平、踝肱指数(ABI)与ISR的关系。方法选取2021年1月~2022年10月于河北大学附属医院就诊的LEASO患者121例,根据术后ISR是否发生将患者分为ISR组(n=48)和非ISR组(n=73)2组。采用受试者工作特征(ROC)曲线评价模型区分度并确定FIB和ABI的最佳切点,采用Kaplan-Meier生存分析模型分析分别以ABI、FIB最佳切点评价组间ISR发生率,并采用log-rank检验评价组间差异。构建多因素Logistic回归模型,通过调整混杂因素分别分析ABI、FIB对ISR的独立预测价值,构建非条件多因素Logistic回归模型分析ISR危险因素。构建ISR预测模型,Hosmer-Lemeshow检验模型的准确性;利用相加模型和相乘模型分析ABI与FIB的交互作用类型。结果调整混杂因素前和调整混杂因素后不论ABI、FIB作为名义变量还是连续变量高水平的FIB和低水平ABI是ISR独立风险预测因素(P<0.05),ROC曲线确定FIB和ABI的最佳切点,分别统计高水平FIB患者和低水平ABI患者ISR发生率(38.89%,48.08%),较低水平FIB患者和高水平ABI患者(18.52%,17.31%)明显升高(P<0.05)。ABI、白蛋白为ISR风险预测保护因素(P<0.05)。C反应蛋白(CRP)、C反应蛋白/白蛋白比值(CAR)、FIB、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)为危险因素(P<0.05)。构建的预测模型经Hosmer-Lemeshow检验和ROC曲线校验后显示准确度和区分度均较高,当P值切点为0.65时,预测一致率达到最高,认为当P值大于0.65时,该患者被判定ISR患者;而P值小于或等于0.65的患者,被判定为非ISR患者。模型的准确性检验结果显示一致率为81.82%,误判率为18.18%。FIB与ABI具有相加交互效应,当ABI<0.69与FIB≥3.41时提示ISR发生风险升高(OR=2.413,95%CI:1.345~2.890,P<0.05)。结论ABI、白蛋白是预测ISR风险的保护因素,CRP、CAR、FIB、NLR、PLR为危险因素。构建的预测模型显示当P值大于0.65时,该患者被判定ISR患者;而P值小于或等于0.65的患者,被判定为非ISR。FIB与ABI在预测ISR风险方面具有相加交互效应。

关键词：纤维蛋白原踝肱指数下肢动脉硬化闭塞症外周血管支架治疗支架内再狭窄

Short Cycle Structure of Graphs on Surfaces (1)-the Uniqueness Theorems

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Acta Mathematicae Applicatae Sinica 2008年第4期24卷 677-680页

作者： Han Ren mo deng Department of Mathematics East China Normal University Shanghai 200062 China

In this paper we investigate cycle base structures of a （weighted） graph and show that much information of short cycles is contained in a MCB （minimum cycle base）. After setting up a Hall type theorem for base-transformation, we give a sufficient and necessary condition for a cycle base to be a MCB. Further more, we show that the structure of MCB in a （weighted） graph is unique. In the case of nonnegative weight, every pair of MCB have the same number of k-cycles for each integer k ≥ 3. The property is also true for those having longest length （although much work has been down in evaluating MCB, little is known for those having longest length）.

关键词： Cycle base facial cycle graph embedding

Learning to synthesize:robust phase retrieval at low photon counts

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Light(Science & Applications) 2020年第1期9卷 1657-1672页

作者： mo deng Shuai Li Alexandre Goy Iksung Kang George Barbastathis Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMA 02139USA Sensebrain Technology Limited LLC 2550 N 1st StreetSuite 300San JoseCA 95131USA Omnisens SA Riond Bosson 31110 MorgesVDSwitzerland Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Singapore-MIT Alliance for Research and Technology(SMART)Centre Singapore 117543Singapore

The quality of inverse problem solutions obtained through deep learning is limited by the nature of the priors learned from examples presented during the training *** in the case of quantitative phase retrieval,spatial frequencies that are underrepresented in the training database,most often at the high band,tend to be suppressed in the *** hoc solutions have been proposed,such as pre-amplifying the high spatial frequencies in the examples;however,while that strategy improves the resolution,it also leads to high-frequency artefacts,as well as low-frequency distortions in the ***,we present a new approach that learns separately how to handle the two frequency bands,low and high,and learns how to synthesize these two bands into full-band *** show that this“learning to synthesize”(LS)method yields phase reconstructions of high spatial resolution and without artefacts and that it is resilient to high-noise conditions,e.g.,in the case of very low photon *** addition to the problem of quantitative phase retrieval,the LS method is applicable,in principle,to any inverse problem where the forward operator treats different frequency bands unevenly,i.e.,is ill-posed.

关键词： synthesize bands phase

Synthesis of novel biodegradable poly(ethylene glycol) analogue:Water-soluble aliphatic polyester with pendant oligo(ethylene glycol) chains

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Chinese Chemical Letters 2009年第12期20卷 1502-1505页

作者： Lei Feng Jian Yuan Hao Cheng Dong Xiong Xian mo deng Chengdu Institute of Organic Chemistry Chinese Academy of Sciences P.O. Box 415 Chengdu 610041 China School of Microeletronics and Solid State Electronics University of Electronic Science and Technology of China Chengdu 610054 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

A novel poly（ethylene glycol）（PEG） analogue composed of aliphatic polyester backbone and pendant oligo（ethylene glycol） short chains is reported. The PEG analogue is a copolymer synthesized by ring-opening alternating copolymerization of succinic anhydride with 2-（（2-（2-metho xyethoxy）ethoxy）methyl）oxirane. The structure of the copolymer was confirmed by ^1H NMR spectrum. The effects of the monomer feed ratio on the copolymerization were studied and the polymerization mechanism was given. The PEG analogue disclosed is water-soluble and expected to have promising applications in biomedical fields as a substitute of PEG due to the existence of degradable ester bond in the backbone.

关键词： Water-soluble PEG analogue 2-((2-(2-Methoxyethoxy)ethoxy)methyl)oxirane Ring-opening alternating copolymerization Polyester

Rapid synthesis of biodegradable poly(epsilon-caprolactone-co-p-dioxanone) random copolymers under microwave irradiation

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Chinese Chemical Letters 2010年第2期21卷 249-252页

作者： Chen, Rui Hao, Jian Yuan Xiong, Cheng Dong deng, Xian mo Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China Univ Elect Sci & Technol China Sch Microeletron & Solid State Elect Chengdu 610054 Peoples R China Chinese Acad Sci Grad Sch Beijing 100039 Peoples R China

Biodegradable poly(epsilon-caprolactone-co-p-dioxanone)(PCDO) random copolymers have been synthesized by ring-opening polymerization of epsilon-caprolactone(CL) and p-dioxanone(PDO) under microwave *** effects of irradiation time and different CL/PDO molar feed ratios on the microwave-assisted ring-opening polymerization(MROP) of PCDO have been *** resultant products were characterized by ~1H NMR,GPC and *** was found that the polymerization was completed within 20 min at 140℃.In th...

关键词： Biodegradable p-Dioxanone Microwave irradiation Random copolymer

Synthesis and Luminescent Properties of LuAG:Ce^(3+) Transparent Ceramics by Solvo-Thermal Method

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光谱学与光谱分析 2011年第2期31卷 308-313页

作者： WANG Lin-xiang ZHU Heng-jiang WU Ling-yuan deng Kai-mo GUO Chang-xin YIN Min Physics Department University of Science and Technology of China Hefei 230026 China Department of Physics Xinjiang Normal University Urumqi 830054 China Hefei National Laboratory for Physical Sciences at Microscale Chinese Academy of Sciences Hefei 230026 China

The precursor powders of LuAG∶Ce3+ transparent ceramics were synthesized by solvo-thermal *** crystal structure and morphology of powders were analyzed by means of Fourier transform infra-red spectroscopy,X-ray diffraction and scanning electron *** precursor powders were sintered into transparent ceramics in vacuum and then in nitrogen without any *** surface morphology of the transparent unpolished ceramics was characterized using scanning electron *** factors that affect the transparency of ceramics were *** UV-Vis fluorescence excitation and emission spectra of LuAG∶Ce3+ transparent ceramics were *** vacuum ultraviolet spectra of transparent ceramics were investigated using the synchrotron radiation as the excitation *** excitation mechanism of Ce3+ was discussed at different excitation wavelength.

关键词： Solvo-thermal LuAG∶Ce3+ Transparent ceramics Photoluminescence

Different crystallinity of poly(d,l-lactide-co-p-dioxanone) copolymers acquired by control of chain microstructure

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Chinese Chemical Letters 2009年第12期20卷 1506-1509页

作者： Hui Zhen Zhao Jian Yuan Hao Cheng Dong Xiong Xian mo deng Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China School of Microeletronics and Solid State Electronics University of Electronic Science and Technology of China Chengdu 610054 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

Poly（d,l-lactide-co-p-dioxanone）（P（LA-co-PDO）） copolymers with different chain microstructures were synthesized by onestep or two-step bulk ring-opening polymerizations of d,l-lactide （LA） and p-dioxanone （PDO） monomers using stannous octoate [Sn（Oct）2]/n-dodecanol as the initiating system. The average sequence lengths of the lactidyl （LLA） and dioxanyl （LpDo） units were calculated from the ^1H NMR spectra. It was found that both LLA and Lpoo values from the two-step syntheses were significantly longer than those from the corresponding one-step syntheses, indicating more blocky structure achieved for the twostep copolymers. Corresponding to this difference in microstructure, the two-step copolymers were semi-crystalline, while the one-step copolymers were completely amorphous. In conclusion, the crystallinity of P（LA-co-PDO） copolymers could be adjusted conveniently to meet specific applications by changing the microstructure of the copolymers via different polymerization routes.

关键词： Poly(d,l-lactide-co-p-dioxanone) Copolymerization Chain microstructure Crystallinity

Nanoscale Pore Characteristics of the Upper Permian Mudrocks from a Transitional Environment in and around Eastern Sichuan Basin, China

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Acta Geologica Sinica(English Edition) 2019年第4期93卷 1025-1046页

作者： CAO Taotao LIU Guangxiang LIU Hu deng mo HAN Yuanhong HUANG Yanran Andrew S.HURSTHOUSE Hunan Provincial Key Laboratory of Shale Gas Resource Utilization Hunan University of Science and TechnologyXiangtanHunan 411201China Department of Geology Hunan University of Science and TechnologyXiangtanHunan 411201China Wuxi Research Institute of Petroleum Geology Petroleum Exploration and Production Research InstituteSINOPECWuxiJiangsu 214126China Sichuan Key Laboratory of Shale Gas Evaluation and Exploration Chengdu 600091China Key Laboratory of Coal Resources Exploration and Comprehensive Utilization Ministry of Land and ResourcesXi’an 710021China School of Science and Sport University of the West of ScotlandPaisley P A12BEUK

Nanoscale pore characteristics of the Upper Permian Longtan transitional mudrocks and their equivalent strata Wujiaping Formation marine mudrocks in and around the eastern Sichuan Basin was investigated using field emission scanning electron microscopy(FE-SEM)and low-pressure N2 adsorption *** results indicate that the Upper Permian mudrock is at a mature stage with total organic carbon(TOC)values ranging between 0.47%and 12.3%.The Longtan mudrocks mainly contain vitrinite,and their mineral composition is primarily *** contrast,the Wujiaping mudrocks are dominated by sapropelinite and solid bitumen,and their mineral compositions are mainly quartz and a notably high amount of *** FE-SEM reveals that clay mineral pores and microcracks are the common pore types in the Longtan *** specific surface area and pore volume depend on the clay content but are negatively correlated with the *** generation of nanometer pores in the Longtan mudrocks is caused by high clay mineral ***,the Wujiaping mudrock mainly contains OM pores,and the pore parameters are positively correlated with the *** OM pore development exhibits remarkable differences in the Longtan and Wujiaping mudrocks,which might be related to their sedimentary facies and maceral *** and inertinite appear as discrete particles in these mudrocks and cannot generate pores during thermal *** often contains many secondary pores,and solid bitumen with large particles,usually with several pores,is not the major contributor to the pore system of the investigated mudrock.

关键词： nanoscale pore characteristics FE-SEM low-pressure N2 adsorption transitional mudrock Longtan/Wujiaping Formation eastern Sichuan Basin