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Drug-delivery and multifunction possibilities of hypocrellin photosensitizers

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 27-39页

作者： hong deng Jie Xie Jingquan Zhao Beijing National Laboratory for Molecular Sciences(BNLMS)Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences P.O.Box 101No.21st North Street ZhongguancunBeijing 100190P.R.China

Photodynamic therapy(PDT)has been a routine treatment of tumors and some microvascular diseases,but clinically available photosensitizers are still *** all kinds of photo-sensitizers,hypocellins possess the most characteristics of ideal photosensitizers,such as,high photo-activity but low dark toxicity,fast clearance from *** review is focused on two main topics,drug-delivery problem of hypocrellins and how the environment-sensitive fluorescence of bypecrellins was used for recognition of various ***-delivery of hypocrellins was mainly achieved in two strategies一preparing the drugdelivery vehicles and finding quantitatively amphiphilic *** fAuorescence originated from the intramolecular proton transfer is very distinct from other kinds of ***,it was proved that quan-titative hypocrellin ftuorescence could not only reoognize various biomolecules,including proteins,polysaocharides and lipids,but also distinguish the specific binding from nonspedifie binding with some kind of ***,hypocrellin fluorescence was pH *** is known that tumor cells or tses have the features of a large amount of lipid,neonatal collagen,over expression of polysaccharides,and lower pH values compared to normal *** to the relative but not absolute specifcity,further studies on quantitative recognition of various biomolecules at a cellular level,may find a new clue to treat tumors by joint usage of photodynamic diagnosis(PDD)and PDT.

关键词： Hypocrellins photodynamie therapy drug delivery biomolecular recognition

High-risk endometrial cancer may be benefit from adjuvant radiotherapy plus chemotherapy

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Chinese Journal of Cancer Research 2012年第4期24卷 332-339页

作者： Jin-Wei Miao Xiao-hong deng Department of Gynecologic Oncology Beijing Obstetrics and Gynecology HospitalCapital Medical University

Objective： To present patterns of practice and outcomes in the adjuvant treatment of intermediate- and high-risk endometrial cancer. Methods： Retrospective data on 224 women with intermediate-risk and high-risk endometrial cancer from 1999 to 2006 were reviewed. All patients underwent surgical staging. Patterns of adjuvant treatment, consisting of pelvic radiotherapy, chemotherapy, and radiotherapy plus chemotherapy, were assessed. The 3- and 5-year disease-specific survival （DSS） rates were calculated using the Kaplan-Meier method. Results： The difference in 5-year DSS rate was statistically significant between adjuvant group and non-adjuvant group （80.65% vs. 63.80%, P=0.040）. In 110 high-risk patients who underwent adjuvant treatment, both 5-year DSS rate and recurrent rate were significantly different in combined radiotherapy and chemotherapy group compared with radiotherapy alone and chemotherapy alone groups （DSS rate, P=0.049; recurrent rate, P=0.047）. In 83 intermediate-risk women who underwent adjuvant treatment, there was no significant difference in 5-year DSS rate and recurrence rate among the combined radiotherapy and chemotherapy, radiotherapy alone and chemotherapy alone groups （DSS rate, P=0.776; recurrent rate, P=0.937）.

关键词： Adjuvant treatment chemotherapy endometrial cancer radiotherapy recurrence

Fast motion estimation algorithm of video stabilization system

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Journal of Beijing Institute of Technology 2014年第1期23卷 102-107页

作者： WU Hao deng hong-bin School of Information and Electronics Beijing Institute of Technology Beijing 100081 China School of Mechatronical Engineering Beijing Institute of Technology Beijing 100081 China

A real-time electronic image stabilization motion estimation method based on fast sub- block gray projection algorithm is proposed. In the method, each image is divided into a number of sub-blocks, and sub-blocks are sifted with their gray gradients. After removing sub-blocks whose gray gradients are lower than the given threshold, the calculation amount of projection is reduced and the motion estimation accuracy is improved. Then gray projection is done in each remained sub- block, and global motion vector of the image is calculated according to the local motion vectors of sub-blocks and the affine motion model. The drawbacks as the local motions reducing the global mo- tion estimation accuracy and traditional gray projection algorithm could not deal with rotation are re- solved well by this algorithm. The experiment results show that the algorithm is more accurate and efficient than the gray projection algorithm.

关键词： video stabilization motion estimation gray projection algorithm gray gradient

Thermal partition of two asymmetric discrete heat sources by cold air curtain

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Journal of Central South University of Technology 2005年第Z1期12卷 268-273页

作者： deng Quan-wei deng Qi-hong School of Energy and Power Engineering Central South University Changsha 410083 China School of Energy and Power Engineering Central South University Changsha 410083 China

A partition solution implemented by a cold air curtain for two asymmetric discrete heat sources in a twodimensional rectangular enclosure was numerically studied. Main attentions were focused on the effects of Reynolds number, Grashof number, separation distance between heat sources, and buoyancy ratio. It is found that the airflow and heat transfer are not only determined by governing parameters, but also affected by boundary conditions. It is also found that nearly symmetry of flow structure corresponds to nearly thermal partition, and the symmetry can be enhanced when Reynolds number, separation distance and buoyancy ratio increase. In addition, it is observed that there is a minimum Reynolds number for obtaining nearly thermal partition, which increases when Grashof number increases.

关键词： cold air curtain asymmetric discrete heat sources critical partition Reynolds number mixed convection

Calcium channel blockers and Alzheimer's disease

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Neural Regeneration Research 2012年第2期7卷 137-140页

作者： Yi Tan Yulin deng hong Qing School of Life Science Beijing Institute of Technology Beijing 100081 China

Alzheimer＇s disease is characterized by two pathological hallmarks： amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer＇s disease. Calcium channel blockers are effective therapeutics for treating Alzheimer＇s disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer＇s disease theraov.

关键词： Alzheimer's disease caic-ium channel calcium homeostasis Alzheimer's diseasepathogenesis β-amyloid calcium channel blocker

Quantum Phase Transitions in Spin Star Configuration

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Communications in Theoretical Physics 2008年第5期49卷 1353-1356页

作者： deng hong-Liang FANG Xi-Ming Key Laboratory of Quantum Structure and Quantum Control of Ministry of Education and Department of Physics Hunan Normal University Changsha 410081 China

We consider a generalized spin star configuration that can be solved exactly, with the central spin-1/2 system embedded in an outer ring of N spin-1/2 particles （denoted as spin bath）. In this model, we consider a modified version of the spin star model, by taking into account, besides the interaction of the central spin with the bath, the interactions between the spins of the bath as well. The general expressions of the eigenstates as well as the eigenvalues of the model are derived with the use of the symmetries of system. We then investigate the properties of the ground quantum phase transitions in some limiting cases in the model and show that the occurrence of quantum phase transitions and the desired ground states can be obtained by varying the external control parameters.

关键词： quantum phase transitions ground state

HMGB1 gene polymorphisms in patients with chronic hepatitis B virus infection

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World Journal of Gastroenterology 2013年第31期19卷 5144-5149页

作者： Chun-Qing deng Guo-hong deng Yu-Ming Wang Institute of Infectious Diseases Southwest Hospital Third Military Medical University Department of Infectious Diseases the First Affiliated Hospital of Shanxi Medical University

AIM: To characterize high mobility group box chromosomal protein 1(HMGB1) polymorphisms in patients infected with hepatitis B virus(HBV) and determine the different patterns in patient ***: A total of 1495 unrelated Han Chinese HBV carriers were recruited in this hospital-based casecontrol *** HMGB1 1176 G/C polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism ***: A significant association was observed between HMGB1 1176 G/C polymorphism and outcome of HBV *** subjects bearing 1176G/G genotype had an increased risk of susceptibility to chronic hepatitis B,liver cirrhosis and severe hepatitis B when compared with those bearing at least one 1176C ***: Patients with 1176G/G genotype of HMGB1 gene are more likely to have a progressive status in HBV infection.

关键词： High mobility group box chromosomal protein 1 Hepatitis B virus Polymorphism Intron

Immobilization of antimony in soil and groundwater using ferro-magnesium bimetallic organic frameworks

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Journal of Environmental Sciences 2023年第3期125卷 194-204页

作者： Le Yuan JianleWang Zuqi Zhong Jiguang Li hong deng School of Environment and Energy Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Resource RecyclingSouth China University of TechnologyGuangzhou 510006China Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation Beibu Gulf UniversityQinzhou 535000China Guangdong Engineering and Technology Research Center for Environmental Nanomaterials South China University of TechnologyGuangzhou 510006China

Sb(Ⅲ) is often detected in contaminated soil and groundwater. Hence, high-efficiency technology is needed. In this study, bimetallic organic frameworks were used for the first time to immobilize Sb(Ⅲ) from contaminated soil and groundwater. The materials were synthesized by the hydrothermal method. Both ends of the prepared material were hexagonal tip rods,and the length became shorter as the ratio of Fe/Mg decreased. The bimetallic organic framework with a Fe/Mg feeding ratio of 0.5 was the optimum material for Sb(Ⅲ) removal, which could effectively immobilize Sb(Ⅲ). The adsorption isotherm was fitted well with the Freundlich model, and the optimal adsorption capacity can reach 106.97 mg/g. The adsorption capacity of 84% can be completed in 10 min, which conformed to the pseudo-second-order kinetics. The Fe^(3+)could enhance the stability of the material, and the Mg^(2+)was conducive to freeing up adsorption sites for binding Sb(Ⅲ) and forming stable chemical adsorption. Ion exchange is the predominant mechanism to remove Sb(Ⅲ). After 14 days of remediation of Sb(Ⅲ) contaminated soil, the Toxicity Characteristic Leaching Procedure(TCLP)-leached concentrations of Sb(Ⅲ) were reduced by 86%, 91% and 94% when the material dosages were1%, 2% and 3%, respectively. Immobilization of Sb(Ⅲ) in soil resulted in a conversion of antimony speciation from more easily bioavailable species to less bioavailable species, further contributing to reduce the environmental risk of antimony. The results indicate that ferromagnesium bimetallic organic frameworks may serve as a kind of promising materials for the immobilization of Sb(Ⅲ) in contaminated soil and groundwater.

关键词： Antimony Ferro-magnesium bimetallic organic frameworks(MOFs) Soil Groundwater

Application of strength reduction method to dynamic anti-sliding stability analysis of high gravity dam with complex dam foundation

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Water Science and Engineering 2011年第2期4卷 212-224页

作者： deng-hong CHEN Cheng-bin DU Department of Engineering Mechanics College of Mechanics and Materials Hohai University Nanjing 210098 P. R. China

Considering that there are some limitations in analyzing the anti-sliding seismic stability of dam-foundation systems with the traditional pseudo-static method and response spectrum method, the dynamic strength reduction method was used to study the deep anti-sliding stability of a high gravity dam with a complex dam foundation in response to strong earthquake-induced ground action. Based on static anti-sliding stability analysis of the dam foundation undertaken by decreasing the shear strength parameters of the rock mass in equal proportion, the seismic time history analysis was carried out. The proposed instability criterion for the dynamic strength reduction method was that the peak values of dynamic displacements and plastic strain energy change suddenly with the increase of the strength reduction factor. The elasto-plastic behavior of the dam foundation was idealized using the Drucker-Prager yield criterion based on the associated flow rule assumption. The result of elasto-plastic time history analysis of an overflow dam monolith based on the dynamic strength reduction method was compared with that of the dynamic linear elastic analysis, and the reliability of elasto-plastic time history analysis was confirmed. The results also show that the safety factors of the dam-foundation system in the static and dynamic cases are 3.25 and 3.0, respectively, and that the F2 fault has a significant influence on the anti-sliding stability of the high gravity dam. It is also concluded that the proposed instability criterion for the dynamic strength reduction method is feasible.

关键词： dynamic anti-sliding stability complex dam foundation dynamic strength reduction method instability criteria elasto-plastie model dynamic time history analysis gravity dam